University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Joachim J. Li, MD, PhD

Joachim J. Li, MD, PhD

Associate Professor, Department of Microbiology and Immunology, UCSF

Cancer Center Program Memberships

Cancer Genetics


University of Chicago, Chicago, IL, B.S., M.S., 1980, Chemistry
Johns Hopkins University School of Medicine, Baltimore, MD, M.D., Ph.D., 1988, Medicine/Molecular Biology

Honors & Awards

  • 1977
    United States Presidential Scholar
  • 1979
    Phi Beta Kappa
  • 1979-1980
    National Science Foundation Graduate Fellow
  • 1987
    Michael A. Shanoff Research Award for Ph.D. Thesis, Johns Hopkins University School of Medicine
  • 1989-1990
    Squibb Fellow, Life Sciences Research Foundation
  • 1990-1997
    Markey Scholar Award
  • 1994-1999
    Rita Allen Scholar
  • 1995-1998
    Searle Scholar
  • 1998
    Distinction in Teaching Award, UCSF

Selected Publications

  1. Bui DT, Li JJ. DNA Rereplication Is Susceptible to Nucleotide-Level Mutagenesis. Genetics. 2019 06; 212(2):445-460.
    View on PubMed
  2. Hanlon SL, Li JJ. Re-replication of a centromere induces chromosomal instability and aneuploidy. PLoS Genet. 2015 Apr; 11(4):e1005039.
    View on PubMed
  3. Richardson CD, Li JJ. Regulatory mechanisms that prevent re-initiation of DNA replication can be locally modulated at origins by nearby sequence elements. PLoS Genet. 2014 Jun; 10(6):e1004358.
    View on PubMed
  4. Finn KJ, Li JJ. Single-stranded annealing induced by re-initiation of replication origins provides a novel and efficient mechanism for generating copy number expansion via non-allelic homologous recombination. PLoS Genet. 2013; 9(1):e1003192.
    View on PubMed
  5. Green BM, Finn KJ, Li JJ. Loss of DNA replication control is a potent inducer of gene amplification. Science. 2010 Aug 20; 329(5994):943-6.
    View on PubMed
  6. Moses AM, Liku ME, Li JJ, Durbin R. Regulatory evolution in proteins by turnover and lineage-specific changes of cyclin-dependent kinase consensus sites. Proc Natl Acad Sci U S A. 2007 Nov 06; 104(45):17713-8.
    View on PubMed
  7. Green BM, Morreale RJ, Ozaydin B, Derisi JL, Li JJ. Genome-wide mapping of DNA synthesis in Saccharomyces cerevisiae reveals that mechanisms preventing reinitiation of DNA replication are not redundant. Mol Biol Cell. 2006 May; 17(5):2401-14.
    View on PubMed
  8. Liku ME, Nguyen VQ, Rosales AW, Irie K, Li JJ. CDK phosphorylation of a novel NLS-NES module distributed between two subunits of the Mcm2-7 complex prevents chromosomal rereplication. Mol Biol Cell. 2005 Oct; 16(10):5026-39.
    View on PubMed
  9. Green BM, Li JJ. Loss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damage. Mol Biol Cell. 2005 Jan; 16(1):421-32.
    View on PubMed

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