University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Daniel Lim, MD, PhD

Daniel Lim, MD, PhD

Associate Professor of Neurological Surgery, UCSF

Cancer Center Program Memberships

Neurologic Oncology

Education

  • University of California, Berkeley, B.A., 05/1994, Biochemistry
  • The Rockefeller University, Ph.D., 06/2001, Neurobiology
  • Cornell Medical College, M.D., 06/2002, Medicine
  • University of California, San Francisco, Postdoctoral, 06/2007, Epigenetics/Stem cells
  • University of California, San Francisco, Residency, 06/2008, Neurological Surgery

Professional Experience

  • 2008-2015
    Assistant Professor, UCSF
  • 2008-present
    Staff Neurosurgeon, Veteran’s Affairs Medical Center, San Francisco
  • 2008-present
    Faculty, Biomedical Sciences Graduate School Program (BMS), UCSF
  • 2008-present
    Faculty, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCSF
  • 2008-present
    Director, Restorative Neurosurgery, Dept. of Neurological Surgery, UCSF
  • 2015-present
    Associate Professor, UCSF

Honors & Awards

  • 1990
    National Merit scholarship
  • 1990-1994
    University of California, Regent’s scholarship
  • 2009-2013
    Sontag Foundation Distinguished Researcher Award
  • 2009-2014
    NIH Director’s New Innovator Award
  • 2010
    Kavli Fellow, U.S. National Academy of Sciences

Selected Publications

  1. Delgado RN, Mansky B, Ahanger SH, Lu C, Andersen RE, Dou Y, Alvarez-Buylla A, Lim DA. Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1. Science. 2020 04 03; 368(6486):48-53.
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  2. Liu SJ, Malatesta M, Lien BV, Saha P, Thombare SS, Hong SJ, Pedraza L, Koontz M, Seo K, Horlbeck MA, He D, Birk HS, Jain M, Olsen HE, Akeson M, Weissman JS, Monje M, Gupta N, Raleigh DR, Ullian EM, Lim DA. CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma. Genome Biol. 2020 Mar 31; 21(1):83.
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  3. Chen W, de Hemptinne C, Miller AM, Leibbrand M, Little SJ, Lim DA, Larson PS, Starr PA. Prefrontal-Subthalamic Hyperdirect Pathway Modulates Movement Inhibition in Humans. Neuron. 2020 May 20; 106(4):579-588.e3.
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  4. Horlbeck MA, Liu SJ, Chang HY, Lim DA, Weissman JS. Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes. Nat Biotechnol. 2020 May; 38(5):573-576.
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  5. Bhaduri A, Di Lullo E, Jung D, Müller S, Crouch EE, Espinosa CS, Ozawa T, Alvarado B, Spatazza J, Cadwell CR, Wilkins G, Velmeshev D, Liu SJ, Malatesta M, Andrews MG, Mostajo-Radji MA, Huang EJ, Nowakowski TJ, Lim DA, Diaz A, Raleigh DR, Kriegstein AR. Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma. Cell Stem Cell. 2020 01 02; 26(1):48-63.e6.
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  6. S John Liu, Harish Vasudevan, Melike Pekmezci, Abrar Choudhury, Brian Lien, Jonathan Breshears, Danielle Swaney, Stephen Magill, Ursula Lang, William Chen, Chetna Gopinath, Maria Castro, Javier Villanueva-Meyer, Steve Braunstein, Patricia Sneed, Daniel Lim, Arie Perry, Nevan Krogran, Mike McDermott, Mitchel Berger, Philip Theodosopoulos, David Raleigh. GENE-37. VESTIBULAR SCHWANNOMA IS COMPRISED OF NEURAL CREST AND IMMUNE SUBGROUPS. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi105-vi105.
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  7. S John Liu, Martina Malatesta, Kyounghee Seo, Brian Lien, Sung Hong, Mark Koontz, David Raleigh, Erik Ullian, Daniel Lim. GENE-39. CRISPRi-BASED RADIATION MODIFIER SCREEN IDENTIFIES LONG NON-CODING RNA THERAPEUTIC TARGETS IN GLIOMA. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi106-vi106.
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  8. Stephen Magill, Harish Vasudevan, Kyounghee Seo, S John Liu, Stephanie Hilz, Javier Villanueva-Meyer, Abrar Choudhury, Benjamin Demaree, Daniel Lim, Steve Braunstein, Nancy Ann Oberheim-Bush, Erik Ullian, Manish Aghi, Philip Theodosopoulos, Patricia Sneed, Adam Abate, Mitchel Berger, Mike McDermott, Joseph Costello, David Raleigh. TMOD-27. A NEURAL CREST CELL SUBPOPULATION UNDERLIES INTRATUMOR HETEROGENEITY IN MENINGIOMA. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi268-vi268.
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  9. Gupta N, Henry RG, Kang SM, Strober J, Lim DA, Ryan T, Perry R, Farrell J, Ulman M, Rajalingam R, Gage A, Huhn SL, Barkovich AJ, Rowitch DH. Long-Term Safety, Immunologic Response, and Imaging Outcomes following Neural Stem Cell Transplantation for Pelizaeus-Merzbacher Disease. Stem Cell Reports. 2019 08 13; 13(2):254-261.
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  10. Andersen RE, Hong SJ, Lim JJ, Cui M, Harpur BA, Hwang E, Delgado RN, Ramos AD, Liu SJ, Blencowe BJ, Lim DA. The Long Noncoding RNA Pnky Is a Trans-acting Regulator of Cortical Development In Vivo. Dev Cell. 2019 05 20; 49(4):632-642.e7.
    View on PubMed
  11. Ethan A. Winkler, Daniel A. Lim. Chapter 17 Stem Cell Transplantation for Neurological Disease: Technical Considerations and Delivery Devices. Nervous System Drug Delivery. 2019 Jan 1; 351-364.
    View on PubMed
  12. Liu SJ, Lim DA. Modulating the expression of long non-coding RNAs for functional studies. EMBO Rep. 2018 12; 19(12).
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  13. Soeren Mueller, Aparna Bhaduri, Elizabeth DiLullo, Garima Yagnik, Daniel Lim, Manish Aghi, Arnold Kriegstein, Aaron Diaz. STEM-06. A DRAFT SINGLE-CELL ATLAS OF HUMAN GLIOBLASTOMA REVEALS SPATIAL AND DIFFERENTIATION GRADIENTS OF STEM-LIKE CELLS. Neuro-Oncology. 2018 Nov 5; 20(suppl_6):vi244-vi245.
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  14. Martina Malatesta, John Liu, Leslie Pedraza, Kyounghee Seo, Elizabeth DiLullo, David Raleigh, Arnold Kriegstein, Erik Ullian, Daniel Lim. TMOD-04. TARGETING A GLIOMA SPECIFIC lncRNA IN A HUMAN BRAIN ORGANOID TUMOR MODEL. Neuro-Oncology. 2018 Nov 5; 20(suppl_6):vi269-vi269.
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  15. Müller S, Cho A, Liu SJ, Lim DA, Diaz A. CONICS integrates scRNA-seq with DNA sequencing to map gene expression to tumor sub-clones. Bioinformatics. 2018 09 15; 34(18):3217-3219.
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  16. Cho SW, Xu J, Sun R, Mumbach MR, Carter AC, Chen YG, Yost KE, Kim J, He J, Nevins SA, Chin SF, Caldas C, Liu SJ, Horlbeck MA, Lim DA, Weissman JS, Curtis C, Chang HY. Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element. Cell. 2018 05 31; 173(6):1398-1412.e22.
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  17. Müller S, Kohanbash G, Liu SJ, Alvarado B, Carrera D, Bhaduri A, Watchmaker PB, Yagnik G, Di Lullo E, Malatesta M, Amankulor NM, Kriegstein AR, Lim DA, Aghi M, Okada H, Diaz A. Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment. Genome Biol. 2017 Dec 20; 18(1):234.
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  18. Nowakowski TJ, Bhaduri A, Pollen AA, Alvarado B, Mostajo-Radji MA, Di Lullo E, Haeussler M, Sandoval-Espinosa C, Liu SJ, Velmeshev D, Ounadjela JR, Shuga J, Wang X, Lim DA, West JA, Leyrat AA, Kent WJ, Kriegstein AR. Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex. Science. 2017 12 08; 358(6368):1318-1323.
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  19. Delgado RN, Lim DA. Maintenance of Positional Identity of Neural Progenitors in the Embryonic and Postnatal Telencephalon. Front Mol Neurosci. 2017; 10:373.
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  20. Soeren Mueller, Daniel He, Josie Hayes, Siyuan Liu, Martina Malatesta, Arnold Kriegstein, Manish Aghi, Daniel Lim, Aaron Diaz. GENE-06. EXPRESSION OF LINC00152, A PUTATIVE SPONGE FOR TUMOR-SUPPRESSIVE micro-RNA, CORRELATES WITH GLIOMA GRADE. Neuro-Oncology. 2017 Nov 6; 19(suppl_6):vi93-vi93.
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