University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Eric K. Nakakura, MD, PhD

Eric K. Nakakura, MD, PhD

Associate Professor, Department of Surgery, UCSF

Cancer Center Program Memberships

Experimental Therapeutics

Research Summary

Dr. Eric Nakakura is a gastrointestinal cancer surgeon who specializes in tumors of the pancreas, bile ducts, liver, and GI tract. He also treats soft tissue sarcomas, including tumors of the retroperitoneum, trunk and extremities. Dr. Nakakura is a leading authority on neuroendocrine carcinoid tumors of the gastrointestinal tract and pancreas. In 2017, he was awarded a $1.2m grant from the Neuroendocrine Tumor Research Foundation (NETRF) to elucidate the causes of small intestinal neuroendocrine tumors (SI-NETs).

Dr. Nakakura earned a medical degree at Stanford Medical School and a doctorate degree in cellular and molecular medicine at the Johns Hopkins University. He completed a residency in general surgery at the Johns Hopkins Medical Institutions and was a specialist registrar in surgery at the John Radcliffe Hospital in Oxford, England. He also completed a fellowship in surgical oncology at the Johns Hopkins Medical Institutions.

Neuroendocrine tumors (NETs) of the small intestine and pancreas frequently spread throughout the body (i.e., metastasize). Surgery is often not possible for patients with advanced disease, and current therapies are ineffective for shrinking tumors and durable palliation of debilitating symptoms, often caused by the release of hormones into the blood. Dr. Nakakura and his colleagues' long-term goal is to find the causes of NETs of the small intestine and pancreas, which can lead to earlier diagnosis and ultimately a cure.

Education

University of California, San Diego, La Jolla, CA, BS, 1990, Bioengineering-Premedic
Stanford Medical School, Stanford, CA, MD, 1995, Medicine
Johns Hopkins University, Baltimore, PhD, 2001, Cellular/Molecular Medicine


Professional Experience

  • 1995-1996
    Intern, General Surgery, Johns Hopkins Medical Institutions, Baltimore, MD
  • 1996-2003
    Resident, General Surgery, Johns Hopkins Medical Institutions, Baltimore, MD
  • 2003-2004
    Fellow, Surgical Oncology, Johns Hopkins Medical Institutions, Baltimore, MD
  • 2003-2004
    Assistant Chief of Service/Instructor, General Surgery, Johns Hopkins Medical Institutions
  • 2004-2011
    Assistant Professor, Department of Surgery, University of California, San Francisco
  • 2011-present
    Associate Professor, Department of Surgery, University of California, San Francisco

Honors & Awards

  • 1988
    Phi Beta Kappa, University of California, San Diego
  • 1990
    Magna Cum Laude, University of California, San Diego
  • 1991
    Stanford Medical Student Scholars Program Research Fellow
  • 1992
    International Society for Heart and Lung Transplantation Poster Award Recipient
  • 1992
    American Heart Association Medical Student Research Fellow
  • 2000
    George D. Zuidema Award for Laboratory Research, Department of Surgery, Johns Hopkins Medical Institutions
  • 2003
    John L. Cameron Technical Excellence Award, Department of Surgery, Johns Hopkins Medical Institutions
  • 2007
    Excellence in Teaching Award, Department of Surgery, University of California, San Francisco School of Medicine
  • 2009
    Excellence in Teaching Award, The Haile T. Debas Academy of Medical Educators
    Memberships

Selected Publications

  1. Kasai Y, Mahuron K, Hirose K, Corvera CU, Kim GE, Hope TA, Shih BE, Warren RS, Bergsland EK, Nakakura EK. Prognostic impact of a large mesenteric mass >2?cm in ileal neuroendocrine tumors. J Surg Oncol. 2019 Oct 15.
    View on PubMed
  2. Donner DB, Nakakura EK, Venook AP, Lenz HJ, Zhang W, Hwang J, Bergsland EK, Lin MH, Toriguchi K, Antonia RJ, Warren RS. High thymidylate synthase gene expression predicts poor outcome after resection of hepatocellular carcinoma. PLoS One. 2019; 14(7):e0219469.
    View on PubMed
  3. Ko AH, Nakakura EK. Adjuvant Therapy for Ampullary Cancer. JAMA Surg. 2019 May 29.
    View on PubMed
  4. Kwon DH, Paciorek A, Mulvey CK, Chan H, Fidelman N, Meng L, Nakakura EK, Zhang L, Bergsland EK, Van Loon K. Periprocedural Management of Patients Undergoing Liver Resection or Embolotherapy for Neuroendocrine Tumor Metastases. Pancreas. 2019 04; 48(4):496-503.
    View on PubMed
  5. Kim SS, Ko AH, Nakakura EK, Wang ZJ, Corvera CU, Harris HW, Kirkwood KS, Hirose R, Tempero MA, Kim GE. Comparison of Tumor Regression Grading of Residual Pancreatic Ductal Adenocarcinoma Following Neoadjuvant Chemotherapy Without Radiation: Would Fewer Tier-Stratification Be Favorable Toward Standardization? Am J Surg Pathol. 2019 Mar; 43(3):334-340.
    View on PubMed
  6. Tempero MA, Malafa MP, Chiorean EG, Czito B, Scaife C, Narang AK, Fountzilas C, Wolpin BM, Al-Hawary M, Asbun H, Behrman SW, Benson AB, Binder E, Cardin DB, Cha C, Chung V, Dillhoff M, Dotan E, Ferrone CR, Fisher G, Hardacre J, Hawkins WG, Ko AH, LoConte N, Lowy AM, Moravek C, Nakakura EK, O'Reilly EM, Obando J, Reddy S, Thayer S, Wolff RA, Burns JL, Zuccarino-Catania G. Pancreatic Adenocarcinoma, Version 1.2019. J Natl Compr Canc Netw. 2019 Mar 01; 17(3):202-210.
    View on PubMed
  7. Donner DB, Ruan DT, Toriguchi K, Bergsland EK, Nakakura EK, Lin MH, Antonia RJ, Warren RS. Mitogen Inducible Gene-6 Is a Prognostic Marker for Patients with Colorectal Liver Metastases. Transl Oncol. 2019 Mar; 12(3):550-560.
    View on PubMed
  8. Chamberlain CE, German MS, Yang K, Wang J, VanBrocklin H, Regan M, Shokat KM, Ducker GS, Kim GE, Hann B, Donner DB, Warren RS, Venook AP, Bergsland EK, Lee D, Wang Y, Nakakura EK. A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors. Mol Cancer Ther. 2018 12; 17(12):2702-2709.
    View on PubMed
  9. Luu HY, Wang ED, Syed SM, Xu X, Hansen SL, Eichler CM, Nakakura EK. Outcomes of arterial bypass preceding resection of retroperitoneal masses involving major vessels. J Surg Res. 2018 10; 230:34-39.
    View on PubMed
  10. Nakakura EK. Progress in the March to Precision Cancer Medicine: Left, Right, Left. JAMA Surg. 2018 01 01; 153(1):67-68.
    View on PubMed
  11. Nakakura EK. Challenges Staging Neuroendocrine Tumors of the Pancreas, Jejunum and Ileum, and Appendix. Ann Surg Oncol. 2018 Mar; 25(3):591-593.
    View on PubMed
  12. Tempero MA, Malafa MP, Al-Hawary M, Asbun H, Bain A, Behrman SW, Benson AB, Binder E, Cardin DB, Cha C, Chiorean EG, Chung V, Czito B, Dillhoff M, Dotan E, Ferrone CR, Hardacre J, Hawkins WG, Herman J, Ko AH, Komanduri S, Koong A, LoConte N, Lowy AM, Moravek C, Nakakura EK, O'Reilly EM, Obando J, Reddy S, Scaife C, Thayer S, Weekes CD, Wolff RA, Wolpin BM, Burns J, Darlow S. Pancreatic Adenocarcinoma, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2017 08; 15(8):1028-1061.
    View on PubMed
  13. Greene C, Nakakura EK, Ko AH. Gastrocutaneous Fistula in a Patient with Locally Recurrent MSI-High Colorectal Cancer: Local Complications Arising from Therapeutic Response to Immune Checkpoint Blockade. Anticancer Res. 2017 07; 37(7):3679-3684.
    View on PubMed
  14. Howe JR, Cardona K, Fraker DL, Kebebew E, Untch BR, Wang YZ, Law CH, Liu EH, Kim MK, Menda Y, Morse BG, Bergsland EK, Strosberg JR, Nakakura EK, Pommier RF. The Surgical Management of Small Bowel Neuroendocrine Tumors: Consensus Guidelines of the North American Neuroendocrine Tumor Society. Pancreas. 2017 07; 46(6):715-731.
    View on PubMed
  15. Mulvey CK, Van Loon K, Bergsland EK, Masharani U, Nakakura EK. Complicated Case Presentation: Management of Pancreatic Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1. Pancreas. 2017 03; 46(3):416-426.
    View on PubMed
  16. Kim SS, Nakakura EK, Wang ZJ, Kim GE, Corvera CU, Harris HW, Kirkwood KS, Hirose R, Tempero MA, Ko AH. Preoperative FOLFIRINOX for borderline resectable pancreatic cancer: Is radiation necessary in the modern era of chemotherapy? J Surg Oncol. 2016 Oct; 114(5):587-596.
    View on PubMed
  17. Nakakura EK. Finding the Common Thread in Rare Diseases. JAMA Surg. 2016 Apr; 151(4):355.
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  18. Hope TA, Verdin EF, Bergsland EK, Ohliger MA, Corvera CU, Nakakura EK. Correcting for respiratory motion in liver PET/MRI: preliminary evaluation of the utility of bellows and navigated hepatobiliary phase imaging. EJNMMI Phys. 2015 Dec; 2(1):21.
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  19. Yee AM, Kelly BG, Gonzalez-Velez JM, Nakakura EK. Solid pseudopapillary neoplasm of the pancreas head in a pregnant woman: safe pancreaticoduodenectomy postpartum. J Surg Case Rep. 2015 Aug 20; 2015(8).
    View on PubMed
  20. Hope TA, Pampaloni MH, Nakakura E, VanBrocklin H, Slater J, Jivan S, Aparici CM, Yee J, Bergsland E. Simultaneous (68)Ga-DOTA-TOC PET/MRI with gadoxetate disodium in patients with neuroendocrine tumor. Abdom Imaging. 2015 Aug; 40(6):1432-40.
    View on PubMed

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