University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
B. Matija Peterlin, MD

B. Matija Peterlin, MD

Professor, Departments of Medicine and Microbiology/Immunology, UCSF

Cancer Center Program Memberships

Affiliate Member

Education

Duke University, Durham, NC, B.S, 1968, Chemistry
Harvard Medical School, Boston, MA, M.D., 1973, Medicine


Professional Experience

  • 1973-1975
    Intern, Assistant Resident, Medicine, Stanford University Medical Center, Stanford, CA
  • 1975-1977
    Research Associate, LMG, NICHD, NIH, Bethesda, Maryland Lt. Cmdr., USPHS
    Instructor, Georgetown University Medical School, Washington, DC
  • 1977-1981
    Resident, Internal Medicine, Fellow, Rheumatology, Stanford University Medical Center, Stanford, CA
  • 1981-1989
    Assistant Professor, Medicine, Microbiology and Immunology, University of California San Francisco, San Francisco, CA
  • 1984-1990
    Associate Investigator, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA
  • 1989-1994
    Associate Professor, Medicine, Microbiology and Immunology, University of California San Francisco, San Francisco, CA
  • 1991-1995
    Associate Investigator, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA
  • 1994-present
    Professor of Medicine, Medicine, Microbiology and Immunology, University California San Francisco, San Francisco, CA
  • 1995-2001
    Investigator, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA

Honors & Awards

  • 1972-1973
    CoSTEP, USPHS, Harvard Medical School, Boston, MA
  • 1978-1980
    Leukemia Society Fellow, Stanford U., Stanford, CA
  • 1980-1981
    American Cancer Society Senior Fellow, Stanford U., Stanford, CA
  • 1981-1982
    Rosalind Russell Scholar, UCSF, SF, CA
  • 1995-present
    Alexander von Humboldt Prize, Bonn, Germany
  • 1998-present
    Honorary Professor, U. Ljubljana, Slovenia

Selected Publications

  1. Cary DC, Rheinberger M, Rojc A, Peterlin BM. HIV Transcription Is Independent of Mediator Kinases. AIDS Res Hum Retroviruses. 2019 Aug; 35(8):710-717.
    View on PubMed
  2. Cary DC, Peterlin BM. Procyanidin trimer C1 reactivates latent HIV as a triple combination therapy with kansui and JQ1. PLoS One. 2018; 13(11):e0208055.
    View on PubMed
  3. Leoz M, Kukanja P, Luo Z, Huang F, Cary DC, Peterlin BM, Fujinaga K. HEXIM1-Tat chimera inhibits HIV-1 replication. PLoS Pathog. 2018 11; 14(11):e1007402.
    View on PubMed
  4. Huang F, Shao W, Fujinaga K, Peterlin BM. Bromodomain-containing protein 4-independent transcriptional activation by autoimmune regulator (AIRE) and NF-?B. J Biol Chem. 2018 04 06; 293(14):4993-5004.
    View on PubMed
  5. Ferdin J, Goricar K, Dolžan V, Plemenitaš A, Martin JN, Peterlin BM, Deeks SG, Lenassi M. Viral protein Nef is detected in plasma of half of HIV-infected adults with undetectable plasma HIV RNA. PLoS One. 2018; 13(1):e0191613.
    View on PubMed
  6. Cary DC, Peterlin BM. Natural Products and HIV/AIDS. AIDS Res Hum Retroviruses. 2018 01; 34(1):31-38.
    View on PubMed
  7. Binning JM, Smith AM, Hultquist JF, Craik CS, Caretta Cartozo N, Campbell MG, Burton L, La Greca F, McGregor MJ, Ta HM, Bartholomeeusen K, Peterlin BM, Krogan NJ, Sevillano N, Cheng Y, Gross JD. Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors. PLoS Pathog. 2018 01; 14(1):e1006830.
    View on PubMed
  8. Pužar Dominkuš P, Ferdin J, Plemenitaš A, Peterlin BM, Lenassi M. Nef is secreted in exosomes from Nef.GFP-expressing and HIV-1-infected human astrocytes. J Neurovirol. 2017 10; 23(5):713-724.
    View on PubMed
  9. Peterlin BM, Liu P, Wang X, Cary D, Shao W, Leoz M, Hong T, Pan T, Fujinaga K. Hili Inhibits HIV Replication in Activated T Cells. J Virol. 2017 06 01; 91(11).
    View on PubMed
  10. Cary DC, Fujinaga K, Peterlin BM. Euphorbia Kansui Reactivates Latent HIV. PLoS One. 2016; 11(12):e0168027.
    View on PubMed
  11. Shao W, Zumer K, Fujinaga K, Peterlin BM. FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator). J Biol Chem. 2016 08 19; 291(34):17953-63.
    View on PubMed
  12. Cary DC, Peterlin BM. Targeting the latent reservoir to achieve functional HIV cure. F1000Res. 2016; 5.
    View on PubMed
  13. Pak V, Eifler TT, Jäger S, Krogan NJ, Fujinaga K, Peterlin BM. CDK11 in TREX/THOC Regulates HIV mRNA 3' End Processing. Cell Host Microbe. 2015 Nov 11; 18(5):560-70.
    View on PubMed
  14. Eifler TT, Shao W, Bartholomeeusen K, Fujinaga K, Jäger S, Johnson JR, Luo Z, Krogan NJ, Peterlin BM. Cyclin-dependent kinase 12 increases 3' end processing of growth factor-induced c-FOS transcripts. Mol Cell Biol. 2015 Jan; 35(2):468-78.
    View on PubMed
  15. Pandeló José D, Bartholomeeusen K, da Cunha RD, Abreu CM, Glinski J, da Costa TB, Bacchi Rabay AF, Pianowski Filho LF, Dudycz LW, Ranga U, Peterlin BM, Pianowski LF, Tanuri A, Aguiar RS. Reactivation of latent HIV-1 by new semi-synthetic ingenol esters. Virology. 2014 Aug; 462-463:328-39.
    View on PubMed
  16. Liu P, Xiang Y, Fujinaga K, Bartholomeeusen K, Nilson KA, Price DH, Peterlin BM. Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription. J Biol Chem. 2014 Apr 04; 289(14):9918-25.
    View on PubMed
  17. Bartholomeeusen K, Fujinaga K, Xiang Y, Peterlin BM. Histone deacetylase inhibitors (HDACis) that release the positive transcription elongation factor b (P-TEFb) from its inhibitory complex also activate HIV transcription. J Biol Chem. 2013 May 17; 288(20):14400-7.
    View on PubMed
  18. Stanley DJ, Bartholomeeusen K, Crosby DC, Kim DY, Kwon E, Yen L, Cartozo NC, Li M, Jäger S, Mason-Herr J, Hayashi F, Yokoyama S, Krogan NJ, Harris RS, Peterlin BM, Gross JD. Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G. PLoS Pathog. 2012 Dec; 8(12):e1003085.
    View on PubMed
  19. Bartholomeeusen K, Xiang Y, Fujinaga K, Peterlin BM. Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein. J Biol Chem. 2012 Oct 19; 287(43):36609-16.
    View on PubMed
  20. Fujinaga K, Barboric M, Li Q, Luo Z, Price DH, Peterlin BM. PKC phosphorylates HEXIM1 and regulates P-TEFb activity. Nucleic Acids Res. 2012 Oct; 40(18):9160-70.
    View on PubMed

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