University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Zhen Jane Wang, MD

Zhen Jane Wang, MD

Professor of Radiology, UCSF

Cancer Center Program Memberships

Non-aligned

Research Summary

Z. Jane Wang, MD is an associate professor and co-director of the Body Research Interest Group (RIG) in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. She received her undergraduate degree in Electrical Engineering from Brown University, and her medical degree from Northwestern University Medical School. She completed her residency training in Diagnostic Radiology at UCSF in 2007, serving as a Chief Resident from 2006-2007. Dr. Wang subsequently completed a fellowship in Abdominal Imaging at UCSF. She joined the UCSF faculty in 2008.

Dr. Wang’s research interests primarily focus on identification of novel imaging techniques and their development into practical and clinically useful diagnostic tools. Her research program includes hyperpolarized 13C MR spectroscopic imaging (MRSI) to assess renal tumor aggressiveness and diffuse renal disease (nephropathy), as well as quantitative imaging in pancreatic cancer.

Dr. Wang has been invited to lecture on various topics in Abdominal Imaging at multiple radiology societies, including the Society of Abdominal Radiology, American Roentgen Ray Society, Radiological Society of North America, as well as internationally at the Asian-Oceanian Congress of Radiology, International Education Conference Program in Mexico, and the Brazilian Congress of Radiology.

Clinical Expertise:

Computed Tomography, Magnetic Resonance Imaging, Abdominal Imaging, Oncological Imaging, Adult

Research Interests:

-Hyperpolarized C13 for characterization of renal tumors and nephropathy

-Imaging of pancreatic cancer

Education and Training:

• Medical School: Northwestern University Medical Center

• Internship: University of California, San Francisco

• Residency: University of California, San Francisco - Radiology and Medical Imaging

• Fellowship: University of California, San Francisco - Radiology and Medical Imaging, Abdominal Imaging

Education

Brown University, Providence, RI, B.S., 1993-1997, Electrical Engineering
Northwestern University Medical School, Chicago, IL, M.D., 1997-2002, Medicine
Dept of Medicine, UCSF Medical Center, San Francisco, CA, 2002-2003, Medicine Internship
Dept of Radiology, UCSF Medical Center, San Francisco, CA, 2003-2007, Radiology Residency
Dept of Radiology, UCSF Medical Center, San Francisco, CA, 2007-2008, Abdominal Imaging Fellowship

Professional Experience

  • 2008 – 2014
    Assistant Professor, Radiology and Biomedical Imaging, UCSF
  • 2014 – 2019
    Associate Professor, Radiology and Biomedical Imaging, UCSF
  • 2014 – present
    Co-Director, Body Imaging Research Interest Group, Radiology and Biomedical Imaging, UCSF
  • 2018 – present
    Associate Director, T32 Training Program, Radiology and Biomedical Imaging, UCSF
  • 2019 – present
    Professor, Radiology and Biomedical Imaging, UCSF

Honors & Awards

  • 1996
    Tau Beta Pi National Engineering Honor Society
  • 1999
    Howard Hughes Medical Institute (HHMI) Medical Student Scholar
  • 2000
    Howard Hughes Medical Institute (HHMI) Medical Student Research Award
  • 2001
    Alpha Omega Alpha (AOA) Honor Society
  • 2005
    Radiological Society of North America Roentgen Resident / Fellow Research Award
  • 2005
    Radiological Society of North America Trainee Research Prize
  • 2006
    American Roentgen Ray Society Resident in Radiology President’s Award
  • 2006-7
    Chief Resident, Department of Radiology, UCSF Medical Center
  • 2007
    UCSF Department of Radiology Margulis Society Resident Research Award
  • 2007
    Radiological Society of North America Trainee Research Prize
  • 2008
    Co-recipient: Cum Laude Award, Society of Computed Body Tomography/Magnetic Resonance
  • 2009
    Berdon Award
  • 2011
    Co-recipient: Cum Laude Award for presentation at the 2012 Radiological Society of North America annual meeting
  • 2013
    Second Place Prize in Basic Science Category, Society of Nuclear Medicine and Molecular Imaging Young Professionals
  • 2014
    Inducted as a Fellow of the Society of Abdominal Radiology
  • 2018
    Roscoe E Miller Best Paper Award, Society of Abdominal Radiology
  • 2019
    Distinguished Investigator Award, the Academy for Radiology & Biomedical Imaging Research

Selected Publications

  1. Wang ZJ, Ohliger MA, Larson PEZ, Gordon JW, Bok RA, Slater J, Villanueva-Meyer JE, Hess CP, Kurhanewicz J, Vigneron DB. Hyperpolarized 13C MRI: State of the Art and Future Directions. Radiology. 2019 May; 291(2):273-284.
    View on PubMed
  2. Sriram R, Gordon J, Baligand C, Ahamed F, Delos Santos J, Qin H, Bok RA, Vigneron DB, Kurhanewicz J, Larson PEZ, Wang ZJ. Non-Invasive Assessment of Lactate Production and Compartmentalization in Renal Cell Carcinomas Using Hyperpolarized 13C Pyruvate MRI. Cancers (Basel). 2018 Sep 05; 10(9).
    View on PubMed
  3. Lall C, Bura V, Lee TK, Bhosale P, Faria SC, Choi JI, Wang ZJ. Diffusion-weighted imaging in hemorrhagic abdominal and pelvic lesions: restricted diffusion can mimic malignancy. Abdom Radiol (NY). 2018 07; 43(7):1772-1784.
    View on PubMed
  4. Qin H, Carroll VN, Sriram R, Villanueva-Meyer JE, von Morze C, Wang ZJ, Mutch CA, Keshari KR, Flavell RR, Kurhanewicz J, Wilson DM. Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes. Sci Rep. 2018 05 21; 8(1):7928.
    View on PubMed
  5. Morze CV, Allu PKR, Chang GY, Marco-Rius I, Milshteyn E, Wang ZJ, Ohliger MA, Gleason CE, Kurhanewicz J, Vigneron DB, Pearce D. Non-invasive detection of divergent metabolic signals in insulin deficiency vs. insulin resistance in vivo. Sci Rep. 2018 02 01; 8(1):2088.
    View on PubMed
  6. Yeh R, Dercle L, Garg I, Wang ZJ, Hough DM, Goenka AH. The Role of 18F-FDG PET/CT and PET/MRI in Pancreatic Ductal Adenocarcinoma. Abdom Radiol (NY). 2018 02; 43(2):415-434.
    View on PubMed
  7. von Morze C, Ohliger MA, Marco-Rius I, Wilson DM, Flavell RR, Pearce D, Vigneron DB, Kurhanewicz J, Wang ZJ. Direct assessment of renal mitochondrial redox state using hyperpolarized 13 C-acetoacetate. Magn Reson Med. 2018 04; 79(4):1862-1869.
    View on PubMed
  8. Tzou DT, Isaacson D, Usawachintachit M, Wang ZJ, Taguchi K, Hills NK, Hsi RS, Sherer BA, Reliford-Titus S, Duty B, Harper JD, Sorensen M, Sur RL, Stoller ML, Chi T. Variation in Radiologic and Urologic Computed Tomography Interpretation of Urinary Tract Stone Burden: Results From the Registry for Stones of the Kidney and Ureter. Urology. 2018 Jan; 111:59-64.
    View on PubMed
  9. Leapman MS, Wang ZJ, Behr SC, Kurhanewicz J, Zagoria RJ, Carroll PR, Westphalen AC. Impact of the integration of proton magnetic resonance imaging spectroscopy to PI-RADS 2 for prediction of high grade and high stage prostate cancer. Radiol Bras. 2017 Sep-Oct; 50(5):299-307.
    View on PubMed
  10. Baligand C, Qin H, True-Yasaki A, Gordon JW, von Morze C, Santos JD, Wilson DM, Raffai R, Cowley PM, Baker AJ, Kurhanewicz J, Lovett DH, Wang ZJ. Hyperpolarized 13 C magnetic resonance evaluation of renal ischemia reperfusion injury in a murine model. NMR Biomed. 2017 Oct; 30(10).
    View on PubMed
  11. Wilson DM, Di Gialleonardo V, Wang ZJ, Carroll V, Von Morze C, Taylor A, Sai V, VanCriekinge M, Bok R, Ohliger MA, Keshari KR. Hyperpolarized 13C Spectroscopic Evaluation of Oxidative Stress in a Rodent Model of Steatohepatitis. Sci Rep. 2017 04 20; 7:46014.
    View on PubMed
  12. Ceron CS, Baligand C, Joshi S, Wanga S, Cowley PM, Walker JP, Song SH, Mahimkar R, Baker AJ, Raffai RL, Wang ZJ, Lovett DH. An intracellular matrix metalloproteinase-2 isoform induces tubular regulated necrosis: implications for acute kidney injury. Am J Physiol Renal Physiol. 2017 06 01; 312(6):F1166-F1183.
    View on PubMed
  13. Cai L, Yeh BM, Westphalen AC, Roberts J, Wang ZJ. 3D T2-weighted and Gd-EOB-DTPA-enhanced 3D T1-weighted MR cholangiography for evaluation of biliary anatomy in living liver donors. Abdom Radiol (NY). 2017 03; 42(3):842-850.
    View on PubMed
  14. Dotson B, Lambert JW, Wang ZJ, Sun Y, Ohliger MA, Winklhofer S, Yeh BM. Benefit of iodine density images to reduce out-of-field image artifacts at rapid kVp switching dual-energy CT. Abdom Radiol (NY). 2017 03; 42(3):735-741.
    View on PubMed
  15. Winklhofer S, Lambert JW, Sun Y, Wang ZJ, Sun DS, Yeh BM. Pelvic Beam-Hardening Artifacts in Dual-Energy CT Image Reconstructions: Occurrence and Impact on Image Quality. AJR Am J Roentgenol. 2017 Jan; 208(1):114-123.
    View on PubMed
  16. Kim SY, Wu EH, Park SH, Wang ZJ, Hope TA, Yee J, Zhao LQ, Chang WC, Yeh BM. Comparison of hepatocellular carcinoma conspicuity on hepatobiliary phase images with gadoxetate disodium vs. delayed phase images with extracellular cellular contrast agent. Abdom Radiol (NY). 2016 08; 41(8):1522-31.
    View on PubMed
  17. Winklhofer S, Lambert JW, Wang ZJ, Sun Y, Gould RG, Zagoria RJ, Yeh BM. Reduction of peristalsis-related gastrointestinal streak artifacts with dual-energy CT: a patient and phantom study. Abdom Radiol (NY). 2016 08; 41(8):1456-65.
    View on PubMed
  18. Kim SS, Nakakura EK, Wang ZJ, Kim GE, Corvera CU, Harris HW, Kirkwood KS, Hirose R, Tempero MA, Ko AH. Preoperative FOLFIRINOX for borderline resectable pancreatic cancer: Is radiation necessary in the modern era of chemotherapy? J Surg Oncol. 2016 Oct; 114(5):587-596.
    View on PubMed
  19. Koelsch BL, Sriram R, Keshari KR, Leon Swisher C, Van Criekinge M, Sukumar S, Vigneron DB, Wang ZJ, Larson PEZ, Kurhanewicz J. Separation of extra- and intracellular metabolites using hyperpolarized (13)C diffusion weighted MR. J Magn Reson. 2016 09; 270:115-123.
    View on PubMed
  20. Chang WC, Sun Y, Wu EH, Kim SY, Wang ZJ, Huang GS, Yeh BM. CT Findings for Detecting the Presence of Gangrenous Ischemia in Cholecystitis. AJR Am J Roentgenol. 2016 Aug; 207(2):302-9.
    View on PubMed

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