Research Summary
Zhen Jane Wang, MD received her undergraduate degree in Electrical Engineering from Brown University, and her medical degree from Northwestern University Medical School. She completed her residency training in Diagnostic Radiology at UCSF in 2007, serving as a Chief Resident from 2006-2007. Dr. Wang also completed a NIH T32 research training fellowship from 2006-2007, followed by a clinical fellowship in Abdominal Imaging at UCSF 2007-2008. She joined the UCSF faculty in 2008.
Dr Wang is currently the Associate Director for the T32 Clinician Scientist Training Program, and the Associate Chair for Strategic Planning in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco.
Dr. Wang's research interests primarily focus on identification of novel imaging techniques and their development into practical and clinically useful diagnostic tools. Her research program includes hyperpolarized 13C MRI to assess renal tumor aggressiveness and diffuse renal disease (nephropathy), as well as quantitative imaging in pancreatic cancer. She has received numerous research awards, including the Distinguish Investigator Award in 2019 from the Academy for Radiology & Biomedical Imaging Research which honors radiologists and imaging scientists for outstanding accomplishments in imaging research.
Dr. Wang is regularly invited to lecture on various topics in Abdominal Imaging at multiple national radiology societies, including the Society of Abdominal Radiology, American Roentgen Ray Society, Radiological Society of North America. She has also been invited to lecture internationally including at the Asian-Oceanian Congress of Radiology, International Education Conference Program, and the Brazilian Congress of Radiology. Dr. Wang has served in a number of leadership roles in national radiology societies including as the Chair for the Radiological Society of North America Scientific Program Committee in 2020. She has also served as a grant reviewer for agencies including the NIH and European Research Council, and as a member of the External Advisory Board for the Department of Defense Kidney Cancer Research Program from 2018-2020.
Research Funding
- April 1, 2021 - March 31, 2026 - Optimizing Pancreatic Cancer Management with Next Generation Imaging and Liquid Biopsy , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA256969
- January 1, 2021 - December 31, 2025 - Translating Hyperpolarized 13C Metabolic MRI to Predict Renal Tumor Aggressiveness , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA249909
- July 12, 2021 - April 30, 2023 - Hyperpolarized 13C Metabolic MRI for Noninvasive Monitoring of Kidney Injury , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21DK130002
- September 20, 2013 - July 31, 2019 - Hyperpolarized 13C Markers of Diabetic Nephropathy and Treatment Response , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DK097357
Education
Brown University, Providence, RI, B.S., 1993-1997, Electrical Engineering
Northwestern University Medical School, Chicago, IL, M.D., 1997-2002, Medicine
Dept of Medicine, UCSF Medical Center, San Francisco, CA, 2002-2003, Medicine Internship
Dept of Radiology, UCSF Medical Center, San Francisco, CA, 2003-2007, Radiology Residency
Dept of Radiology, UCSF Medical Center, San Francisco, CA, 2007-2008, Abdominal Imaging Fellowship
Department of Radiology, UCSF Medical Center, San Francisco, CA, 2006-2007, NIH T32 Clinician Scientist Research Training Fellowship
Honors & Awards
- 2006
Society of Uroradiology Research Award - 2006-7
Chief Resident, Department of Radiology, UCSF Medical Center - 2007
UCSF Department of Radiology Margulis Society Resident Research Award - 2007
Radiological Society of North America Trainee Research Prize - 2007
Radiological Society of North America Research Fellow Award - 2008
Co-recipient: Cum Laude Award, Society of Computed Body Tomography/Magnetic Resonance - 2009
Berdon Award - 2010
Radiological Society of North America Research Scholar Award - 2011
Co-recipient: Cum Laude Award for presentation at the 2012 Radiological Society of North America annual meeting - 2013
Society of Abdominal Radiology Morton A. Bosniak Research Award - 2013
Second Place Prize in Basic Science Category, Society of Nuclear Medicine and Molecular Imaging Young Professionals - 2014
Inducted as a Fellow of the Society of Abdominal Radiology - 2018
Roscoe E Miller Best Paper Award, Society of Abdominal Radiology - 2019
Distinguished Investigator Award, the Academy for Radiology & Biomedical Imaging Research
Selected Publications
- Wang ZJ, Arif-Tiwari H, Zaheer A, Ameli S, Bhosale PR, Do RK, Goenka AH, Guimares AR, Sangster GP, Soloff EV, Tamm EP, Zins M, Kambadakone AR. Therapeutic response assessment in pancreatic ductal adenocarcinoma: society of abdominal radiology review paper on the role of morphological and functional imaging techniques. Abdom Radiol (NY). 2020 Sep 16.
View on PubMed - Wang ZJ, Zhang TT, An C, Ko A, Tempero M, Collisson E, Yeh BM. Estimation of Fractional Extracellular Space at CT for Predicting Chemotherapy Response and Survival in Pancreatic Ductal Adenocarcinoma. AJR Am J Roentgenol 2020;215(3):610-616.
View on PubMed - Silverman SG, Pedrosa I, Ellis JH, Hindman NM, Schieda N, Smith AD, Remer EM, Shinagare AB, Curci NE, Raman SS, Wells SA, Kaffenberger SD, Wang ZJ, Chandarana H, Davenport MS. Bosniak Classification of Cystic Renal Masses, Version 2019: An Update Proposal and Needs Assessment. Radiology 2019;292(2):475-488.
View on PubMed - Wang ZJ, Ohliger MA, Larson PEZ, Gordon JW, Bok RA, Slater J, Villanueva-Meyer JE, Hess CP, Kurhanewicz J, Vigneron DB. Hyperpolarized 13C Magnetic Resonance Imaging: State-of-the-Art and Future Directions. Radiology 2019;291(2):273-284.
View on PubMed - Yeh BM, Obmann MM, Westphalen AC, Ohliger MA, Yee J, Sun Y, Wang ZJ. Dual Energy Computed Tomography Scans of the Bowel: Benefits, Pitfalls, and Future Directions. Radiol Clin North Am. 56(5):805-819.
View on PubMed - Sriram R, Gordon J, Baligand C, Ahamed F, Delos Santos J, Qin H, Bok RA, Vigneron DB, Kurhanewicz J, Larson PEZ, Wang ZJ. Non-Invasive Assessment of Lactate Production and Compartmentalization in Renal Cell Carcinomas Using Hyperpolarized 13C Pyruvate MRI. Cancers (Basel) 2018; 10(9).
View on PubMed - Jha P, Yeh BM, Zagoria R, Collisson, E, Wang ZJ. The role of MR imaging in pancreatic cancer. Magn Reson Imaging Clin N Am 2018; 26(3):363-373.
View on PubMed - Wang ZJ, Behr S, Consunji MV, Yeh BM, Ohliger MA, Gao K, Ko AH, Cinar P, Tempero MA, Collisson EA. Early Response Assessment in Pancreatic Ductal Adenocarcinoma Through Integrated PET/MR Imaging. AJR Am J Roentgenol 2018; 211(5):1010-1019.
View on PubMed - Wang ZJ, Westphalen AC, Zagoria R. CT and MRI of Small Renal Masses. Br J Radiol 2018; 91(1087):20180131.
View on PubMed - Von Morze C, Ohliger MA, Marco-Rius I, Wilson DM, Flavell RR, Pearce D, Vigenron DB, Kurhanewicz J, Wang ZJ. Direct assessment of renal mitochondrial redox state using hyperpolarized 13C-Acetoacetate. Magnetic Resonance in Medicine, 2018; 79(4):1862-1869.
View on PubMed - Torphy R, Wang ZJ, True-Yasaki A, Volmar KE, Rashid N, Yeh BM, Anderson JM, Johansen JS, Hollingsworth MA, Yeh JJ, Collisson EA. Stromal content is correlated with tissue site, contrast retention and survival in pancreatic adenocarcinoma. (# equal contribution) JCO Precision Oncology 2018; 2,1-12.
View on PubMed - Baligand C, Qin H, True-Yasaki A, Gordon J, Von Morze C, DeLosSantos J, Wilson DM, Raffai R, Cowley PM, Baker AJ, Kurhanewicz J, Lovett DH, Wang ZJ. Hyperpolarized 13C magnetic resonance evaluation of renal ischemia reperfusion injury in a murine model. NMR Biomed 2017; Oct;30(10).
View on PubMed - Sriram R, VanCriekinge M, Delos Santos J, Keshari KR, Wilson DM, Peehl D, Kurhanewicz J, Wang ZJ. Noninvasive differentiation of benign renal tumors from clear cell renal cell carcinomas using clinically translatable hyperpolarized 13C pyruvate magnetic resonance. Tomography 2016; 2(1):35-42.
View on PubMed - Wu EH, Wojciechowski D, Chandran S, Yeh BM, Park M, Westphalen A, Wang ZJ. Prevalence of abdominal aortic calcifications in older living renal donors and its effect on graft function and histology. Transplant International 2015; 28(10):1172-1178.
View on PubMed - Keshari KR, Wilson DM, Sai V, Bok R, Jen KY, Larson P, Van Criekinge M, Kurhanewicz J, Wang ZJ. Non-invasive in vivo imaging of diabetes-induced renal oxidative stress and response to therapy using hyperpolarized 13C dehydroascorbate magnetic resonance. Diabetes 2015; 64(2):344-352.
View on PubMed - Keshari KR, Sriram R, Koelsch BL, Van Criekinge M, Wilson DM, Kurhanewicz J, Wang ZJ. Hyperpolarized 13C-Pyruvate Magnetic Resonance Reveals Rapid Lactate Export in Metastatic Renal Cell Carcinomas. Cancer Research 2013;73(2):529-538.
View on PubMed - Kumar R, Wang ZJ, Forsythe C, Fu Y, Chen Y, Yeh BM. Dual Energy CT Monitoring of the Renal Corticomedullary Sodium Gradient in Swine. European Journal of Radiology 2012; 81:423-429.
View on PubMed - Wang ZJ, Kumar R, Banerjee S, Hsu CY. Blood Oxygen-Level Dependent (BOLD) MR Imaging of Diabetic Nephropathy-Preliminary Experience. Journal of Magnetic Resonance Imaging 2011; 33:655-660.
View on PubMed - Wang ZJ, Joe BN, Coakley FV, Zaharchuk G, Busse R, Yeh BM. Urinary Oxygen Tension Measurement in Humans Using MR Imaging. Academic Radiology 2008; 15(11):1467-1473.
View on PubMed - Wang ZJ, Vigneron DB, Miller SP, Mukherjee P, Charlton NN, Lu Y, Barkovich AJ. Brain Metabolite Levels Assessed by Lactate-Edited MR Spectroscopy in Premature Neonates With and Without Pentobarbital Sedation. American Journal of Neuroradiology. 29(4):798-801, 2008.
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