University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Lena Winestone, MD

Lena Winestone, MD

Assistant Professor, Dept. of Pediatrics, UCSF

Cancer Center Program Memberships

Pediatric Malignancies

Research Summary

Dr. Lena Winestone is clinically focused on pediatric blood and marrow transplant for high risk leukemias. Dr. Winestone's research explores racial, ethnic, and socioeconomic disparities in access to care and outcome of leukemia and lymphoma treatment. She studies access to care across the continuum of pediatric cancer from diagnosis and clinical trial enrollment through treatment and relapse to salvage therapies. Her research has shown that African American children with acute lymphoblastic leukemia, acute myeloid leukemia, and mature B cell lymphoma are two times more likely to present with organ failure at the time of a new cancer diagnosis. Her ongoing work investigates access to highly specialized and complex therapies such as stem cell transplant, chimeric antigen receptor T cells, and MIBG therapy.

Education

University of Pennsylvania, B.A., 2000-2004, Biochemistry
University of Pennsylvania, M.S., 2002-2004, Immunology
Stanford University School of Medicine, M.D., 2005-2009, Medicine
Lucile Packard Children’s Hospital, Residency, 2009-2012, Pediatrics
The Children’s Hospital of Philadelphia, Fellowship, 2013-2016, Hematology/Oncology
University of Pennsylvania, M.S., 2014-2016, Health Policy

Professional Experience

  • 1999 – 2000
    Intern, Department of Molecular Pharmacology, National Cancer Institute, National Institutes of Health
  • 2001 – 2004
    Student Researcher, Abramson Cancer Center, University of Pennsylvania Medical School
  • 2004 – 2005
    Clinical Research Assistant, Nabi Biopharmaceuticals, Inc., Rockville, MD
  • 2009
    Intern, Reproductive Health and Research, World Health Organization, Geneva, Switzerland
  • 2009 – 2012
    Intern and Resident, Department of Pediatrics, Lucile Packard Children’s Hospital at Stanford
  • 2010 – 2012
    Resident Researcher, Pediatric Advocacy Program, Center for Policy, Outcomes and Prevention, Stanford University
  • 2012
    Johnson and Johnson Visiting Physician, Church of Scotland Hospital, South Africa
  • 2012 – 2013
    Pediatrics Consultant, Mamohou Hospital, Partners in Health-Lesotho
  • 2012 – 2013
    Clinical Instructor, Bone Marrow Transplant Hospitalist, Stanford University
  • 2013 – 2016
    Fellow, Division of Pediatric Hematology/Oncology, Children’s Hospital of Philadelphia
  • 2016 – 2018
    Instructor A, Division of Pediatric Oncology, Children’s Hospital of Philadelphia
  • 2018 – present
    Assistant Professor, Dept. of Pediatrics, UCSF

Honors & Awards

  • 2000
    Vagelos Scholars Fellowship in Molecular Life Sciences, University of Pennsylvania
  • 2004
    Helix Prize, University of Pennsylvania Biochemistry Program
  • 2006
    Medical Scholars Research Fellowship, Stanford Medical School
  • 2006
    Fulbright-Hays Fellowship–Intensive Advanced Swahili, U.S. Department of Education
  • 2007
    Traveling Scholar Research Fellowship, Stanford Medical School
  • 2008
    Foreign Language Area Studies Fellowship, U.S. Department of Education
  • 2010 - 2012
    Mary Duke Biddle Clinical Scholars Program
  • 2011 - 2012
    Yale/Stanford Johnson & Johnson Global Health Scholars Program
  • 2015
    Children's Oncology Group Young Investigator Abstract Award
  • 2015
    American Society of Hematology Abstract Achievement Award
  • 2016
    Paul Calabresi Career Development Award for Clinical Oncology, Abramson Cancer Center
  • 2016
    Clinical Research Training Institute, American Society of Hematology
  • 2016
    Alex's Lemonade Stand Foundation Young Investigator Award
  • 2016
    Bear Necessities Fellow Award

Selected Publications

  1. Dandoy CE, Davies SM, Ahn KW, He Y, Kolb AE, Levine J, Bo-Subait S, Abdel-Azim H, Bhatt N, Chewing J, Gadalla S, Gloude N, Hayashi R, Lalefar NR, Law J, MacMillan M, O'Brien T, Prestidge T, Sharma A, Shaw P, Winestone L, Eapen M. Comparison of total body irradiation versus non- total body irradiation containing regimens for de novo acute myeloid leukemia in children. Haematologica. 2020 Jun 18.
    View on PubMed
  2. Julie Anna Wolfson, Smita Bhatia, Jill P. Ginsberg, Laura Becker, David Bernstein, Henry J. Henk, Gary H. Lyman, Paul C. Nathan, Diane Puccetti, Jennifer J Wilkes, Lena Winestone, Kelly Kenzik. Health plan expenditures young adults with newly-diagnosed Hodgkin lymphoma (HL) by care at NCI-designated comprehensive cancer centers (CCC) vs. other treatment sites (non-CCC). Journal of Clinical Oncology. 2020 May 20; 38(15_suppl):7081-7081.
    View on PubMed
  3. Cahen VC, Li Y, Getz KD, Elgarten CW, DiNofia AM, Wilkes JJ, Winestone LE, Huang YV, Miller TP, Gramatges MM, Rabin KR, Fisher BT, Aplenc R, Seif AE. Identifying relapses and stem cell transplants in pediatric acute lymphoblastic leukemia using administrative data: Capturing national outcomes irrespective of trial enrollment. Pediatr Blood Cancer. 2020 May 11; e28315.
    View on PubMed
  4. Penumarthy NL, Goldsby RE, Shiboski SC, Wustrack R, Murphy P, Winestone LE. Insurance impacts survival for children, adolescents, and young adults with bone and soft tissue sarcomas. Cancer Med. 2020 Feb; 9(3):951-958.
    View on PubMed
  5. Friend BD, Bailey-Olson M, Melton A, Shimano KA, Kharbanda S, Higham C, Winestone LE, Huang J, Stieglitz E, Dvorak CC. The impact of total body irradiation-based regimens on outcomes in children and young adults with acute lymphoblastic leukemia undergoing allogeneic hematopoietic stem cell transplantation. Pediatr Blood Cancer. 2020 02; 67(2):e28079.
    View on PubMed
  6. Lena E. Winestone, Kelly D Getz, Kira O Bona, Brian T. Fisher, Alan S Gamis, Alix E. Seif, Lillian Sung, Yi-Cheng Wang, Todd A. Alonzo, Richard Aplenc. Area-Based Socioeconomic Disparities in Survival of Children with Newly Diagnosed Acute Myeloid Leukemia: A Report from the Children's Oncology Group. Blood. 2019 Nov 13; 134(Supplement_1):703-703.
    View on PubMed
  7. Tamara P. Miller, Kelly D Getz, Biniyam Demissei, Karen R. Rabin, Marla Daves, Philip J. Lupo, Michael E. Scheurer, Evanette Burrows, Brian T. Fisher, Robert W. Grundmeier, Judy Lee, Jennifer J. Wilkes, Lena E. Winestone, Maria Monica J. Gramatges, Richard Aplenc. Rates of Laboratory Adverse Events By Chemotherapy Course for Pediatric Acute Leukemia Patients within the Leukemia Electronic Abstraction of Records Network (LEARN). Blood. 2019 Nov 13; 134(Supplement_1):333-333.
    View on PubMed
  8. Winestone L, Cabana MD. 50 Years Ago in TheJournal ofPediatrics: Fifty-Two Forms of Childhood Cancer, United States Mortality Experience, 1960-1966. J Pediatr. 2019 10; 213:148.
    View on PubMed
  9. Winestone LE, Aplenc R. Disparities in Survival and Health Outcomes in Childhood Leukemia. Curr Hematol Malig Rep. 2019 06; 14(3):179-186.
    View on PubMed
  10. Elysia Marie Alvarez, Lena Winestone, Jeffrey McPheeters, Diane Puccetti, Jennifer Jill Wilkes, Henry J. Henk, Smita Bhatia, Jill P. Ginsberg, Theresa Keegan, Brad H. Pollock. Factors impacting time to diagnosis in pediatric, adolescent and young adult (AYA) patients with solid tumors. Journal of Clinical Oncology. 2019 May 20; 37(15_suppl):e21515-e21515.
    View on PubMed
  11. Winestone LE, Getz KD, Rao P, Li Y, Hall M, Huang YV, Seif AE, Fisher BT, Aplenc R. Disparities in pediatric acute myeloid leukemia (AML) clinical trial enrollment. Leuk Lymphoma. 2019 09; 60(9):2190-2198.
    View on PubMed
  12. Muffly L, Li Q, Alvarez E, Kahn J, Winestone L, Cress R, Penn DC, Keegan THM. Hematopoietic Cell Transplantation in Young Adult Acute Lymphoblastic Leukemia: A United States Population-Level Analysis. J Adolesc Young Adult Oncol. 2019 06; 8(3):254-261.
    View on PubMed
  13. Li Y, Newton JG, Getz KD, Huang YS, Seif AE, Fisher BT, Aplenc R, Winestone LE. Comparable on-therapy mortality and supportive care requirements in Black and White patients following initial induction for pediatric acute myeloid leukemia. Pediatr Blood Cancer. 2019 04; 66(4):e27583.
    View on PubMed
  14. Lena E. Winestone, Alix E. Seif, Benjamin L. Laskin. Renal Complications Associated with HSCT. Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist. 2018 Jan 1; 327-332.
    View on PubMed
  15. Winestone LE, Punn R, Tamaresis JS, Buckingham J, Pinsky BA, Waggoner JJ, Kharbanda S. High human herpesvirus 6 viral load in pediatric allogeneic hematopoietic stem cell transplant patients is associated with detection in end organs and high mortality. Pediatr Transplant. 2018 03; 22(2).
    View on PubMed
  16. Winestone LE, Getz KD, Miller TP, Li Y, Huang YS, Seif AE, Fisher BT, Aplenc R. Complications preceding early deaths in Black and White children with acute myeloid leukemia. Pediatr Blood Cancer. 2017 Dec; 64(12).
    View on PubMed
  17. Prince SD, Winestone LE, Nance SJ, Friedman DF. Recurrent Donath-Landsteiner hemolytic anemia: a pediatric case report. Transfusion. 2017 06; 57(6):1401-1406.
    View on PubMed
  18. Winestone LE, Getz KD, Miller TP, Wilkes JJ, Sack L, Li Y, Huang YS, Seif AE, Bagatell R, Fisher BT, Epstein AJ, Aplenc R. The role of acuity of illness at presentation in early mortality in black children with acute myeloid leukemia. Am J Hematol. 2017 Feb; 92(2):141-148.
    View on PubMed
  19. Chamberlain LJ, Pineda N, Winestone L, Saynina O, Rangaswami A, Link M, Wise PH. Increased utilization of pediatric specialty care: a population study of pediatric oncology inpatients in California. J Pediatr Hematol Oncol. 2014 Mar; 36(2):99-107.
    View on PubMed
  20. Winestone LE, Bukusi EA, Cohen CR, Kwaro D, Schmidt NC, Turan JM. Acceptability and feasibility of integration of HIV care services into antenatal clinics in rural Kenya: a qualitative provider interview study. Glob Public Health. 2012; 7(2):149-63.
    View on PubMed

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