Research Summary

Dr. Lena Winestone is clinically focused on pediatric blood and marrow transplant for high risk leukemias. Dr. Winestone's research explores racial, ethnic, and socioeconomic disparities in access to care and outcome of leukemia and lymphoma treatment. She studies access to care across the continuum of pediatric cancer from diagnosis and clinical trial enrollment through treatment and relapse to salvage therapies. Her research has shown that African American children with acute lymphoblastic leukemia, acute myeloid leukemia, and mature B cell lymphoma are two times more likely to present with organ failure at the time of a new cancer diagnosis. Her ongoing work investigates access to highly specialized and complex therapies such as stem cell transplant, chimeric antigen receptor T cells, and MIBG therapy.

Research Funding

  • June 1, 2017 - December 1, 2020 - In Depth Interviews regarding the Path to a Leukemia Diagnosis , Principal Investivator . Sponsor: Alex's Lemonade Stand Foundation, Bear Necessities Pediatric Cancer Foundation, Sponsor Award ID:
  • July 1, 2020 - September 20, 2023 - Barriers to Care Questionnaire for Pediatric Patients with Leukemia , Principal Investigator . Sponsor: American Cancer Society, American Society of Hematology, Sponsor Award ID:
  • June 15, 2020 - September 20, 2023 - Work Flexibility and Financial Impact Among Families of Children with Cancer , Supervisor . Sponsor: UCSF Clinical & Translational Science Institute, Sponsor Award ID:
  • February 1, 2020 - September 20, 2023 - Access to MIBG Therapy for High Risk Neuroblastoma Patients , Principal Investigator . Sponsor: Cannonball Kids' cancer, American Cancer Society, Sponsor Award ID:

Education

University of Pennsylvania, B.A., 2000-2004, Biochemistry
University of Pennsylvania, M.S., 2002-2004, Immunology
Stanford University School of Medicine, M.D., 2005-2009, Medicine
Lucile Packard Children’s Hospital, Residency, 2009-2012, Pediatrics
The Children’s Hospital of Philadelphia, Fellowship, 2013-2016, Hematology/Oncology
University of Pennsylvania, M.S., 2014-2016, Health Policy

Honors & Awards

  • 2000
    Vagelos Scholars Fellowship in Molecular Life Sciences, University of Pennsylvania
  • 2004
    Helix Prize, University of Pennsylvania Biochemistry Program
  • 2006
    Medical Scholars Research Fellowship, Stanford Medical School
  • 2006
    Fulbright-Hays Fellowship–Intensive Advanced Swahili, U.S. Department of Education
  • 2007
    Traveling Scholar Research Fellowship, Stanford Medical School
  • 2008
    Foreign Language Area Studies Fellowship, U.S. Department of Education
  • 2010 - 2012
    Mary Duke Biddle Clinical Scholars Program
  • 2011 - 2012
    Yale/Stanford Johnson & Johnson Global Health Scholars Program
  • 2015
    Children's Oncology Group Young Investigator Abstract Award
  • 2015
    American Society of Hematology Abstract Achievement Award
  • 2016
    Paul Calabresi Career Development Award for Clinical Oncology, Abramson Cancer Center
  • 2016
    Clinical Research Training Institute, American Society of Hematology
  • 2016
    Alex's Lemonade Stand Foundation Young Investigator Award
  • 2016 - 2017
    Fellow Award, Bear Necessities Pediatric Cancer Foundation
  • 2022 - 2024
    Winn Diversity in Clinical Trials Award, BMSF
  • 2016 - 2019
    Young Investigator Award, Alex's Lemonade Stand Foundation
  • 2020 - 2022
    Fellow to Faculty Scholar Award, American Society of Hematology
  • 2022 - 2026
    Clinician Scientist Development Grant, American Cancer Society
  • 2022 - 2024
    Winn Diversity in Clinical Trials Award, BMSF

Selected Publications

  1. Winestone LE, Beauchemin MP, Bona K, Kahn J, Prasad P, Robles JM, Velez MC, Diversity and Health Disparities Committee. Children's Oncology Group's 2023 blueprint for research: Diversity and health disparities. Pediatr Blood Cancer. 2023 Jul 28; e30592.  View on PubMed
  2. Wadhwani SI, Pantell MS, Winestone LE. Subspecialty pediatrics: An unmet opportunity to address unmet social risks. Acad Pediatr. 2023 Jul 25.  View on PubMed
  3. Evans EM, Lin J, Sanchez-Alvarez J, Agrawal AK, Winestone LE. Disparities in household material hardship, financial toxicity, and income loss in pediatric cancer. Pediatr Blood Cancer. 2023 Jul 02; e30496.  View on PubMed
  4. Emily Jones, Arlene Naranjo, Lena E. Winestone, Puja J Umaretiya, Rahela Aziz-Bose, Lenka Anne Skaidrite Ilcisin, Emily Gustava Greengard, Steven G. DuBois, Rochelle Bagatell, Kira Bona. Feasibility and acceptability of social determinants of health data collection in the context of a Children’s Oncology Group trial. Journal of Clinical Oncology. 2023 Jun 1; 41(16_suppl):10010-10010.  View on PubMed
  5. Lena Winestone, Brent R. Logan, Xuerong Liu, Rebecca H. Buckley, Richard J O’Reilly, Linda M. Griffith, Jennifer Puck, Christopher C. Dvorak, Morton J Cowan, Elie Haddad. Racial and Ethnic Disparities in Outcomes following Hematopoietic Stem Cell Transplant (HCT) in Patients with Severe Combined Immunodeficiency (SCID). Clinical Immunology. 2023 May 1; 250:109361.  View on PubMed
  6. Hall AG, Winestone LE, Sullivan EM, Wu Q, Lamble AJ, Walters MC, Aguayo-Hiraldo P, Baez Conde L, Coker TR, Dornsife D, Keating AK, Merino DM, Ramsey B, Park JR, Agrawal AK. Access to Chimeric Antigen Receptor T Cell Clinical Trials in Underrepresented Populations: A Multicenter Cohort Study of Pediatric and Young Adult Acute Lymphobastic Leukemia Patients. Transplant Cell Ther. 2023 06; 29(6):356.e1-356.e7.  View on PubMed
  7. Castellanos MI, Oluyomi AO, Chambers TM, Gramatges MM, Winestone LE, Lupo PJ, Scheurer ME. Ethnic disparities in childhood leukemia survival by border residence: A Texas population-based analysis. Cancer. 2023 04 15; 129(8):1276-1286.  View on PubMed
  8. Newman H, Li Y, Liu H, Myers RM, Tam V, DiNofia A, Wray L, Rheingold SR, Callahan C, White C, Baniewicz D, Winestone LE, Kadauke S, Diorio C, June CH, Getz KD, Aplenc R, Teachey DT, Maude SL, Grupp SA, Bona K, Leahy AB. Impact of poverty and neighborhood opportunity on outcomes for children treated with CD19-directed CAR T-cell therapy. Blood. 2023 02 09; 141(6):609-619.  View on PubMed
  9. Gabriel Salinas Cisneros, Christopher C. Dvorak, Sandhya Kharbanda, Kristin A. Shimano, Alexis Melton, Julia Chu, Lena E. Winestone, Jasmeen Dara, James N. Huang, Michelle Hermiston, Christine S. Higham. 172 Diagnosing and Grading of SOS: Which Criteria Are Best?. Transplantation and Cellular Therapy. 2023 Feb 1; 29(2):s138-s139.  View on PubMed
  10. Kevin O. McNerney, Amy Moskop, Lena E. Winestone, Julie Talano, Deborah Schiff, Michael R. Verneris, Theodore W Laetsch, Liora Michal Schultz. 266 Clinical Practice Patterns and Factors Driving Usage of Consolidative Stem Cell Transplantation Post-Tisagenlecleucel. Transplantation and Cellular Therapy. 2023 Feb 1; 29(2):s205-s206.  View on PubMed
  11. Soohee Cho, Christopher C. Dvorak, Christine S. Higham, Gabriel Salinas Cisneros, Julia Chu, Alexis Melton, Lena E. Winestone, Kristin A. Shimano, Jasmeen Dara, Michelle Hermiston, James N. Huang, Janel Renee Long-Boyle, Sandhya Kharbanda. 345 Prophylactic Tocilizumab Decreases Incidence of Acute Graft-Versus-Host Disease Following Alpha/Beta T-Cell Depleted Haploidentical Hematopoietic Stem Cell Transplantation in Children and Young Adults. Transplantation and Cellular Therapy. 2023 Feb 1; 29(2):s263-s264.  View on PubMed
  12. Gupta S, Dai Y, Chen Z, Winestone LE, Teachey DT, Bona K, Aplenc R, Rabin KR, Zweidler-McKay P, Carroll AJ, Heerema NA, Gastier-Foster J, Borowitz MJ, Wood BL, Maloney KW, Mattano LA, Larsen EC, Angiolillo AL, Burke MJ, Salzer WL, Winter SS, Brown PA, Guest EM, Dunsmore KP, Kairalla JA, Winick NJ, Carroll WL, Raetz EA, Hunger SP, Loh ML, Devidas M. Racial and ethnic disparities in childhood and young adult acute lymphocytic leukaemia: secondary analyses of eight Children's Oncology Group cohort trials. Lancet Haematol. 2023 Feb; 10(2):e129-e141.  View on PubMed
  13. Wyatt KD, Noyd DH, Wood NM, Phillips CA, Miller TP, Rubin EM, Winestone LE, Waanders AJ, Perentesis JP, Aplenc R. Data standards in pediatric oncology: Past, present, and future. Pediatr Blood Cancer. 2022 Dec 10; e30128.  View on PubMed
  14. Jackie Jin Lin, Erica Evans, Kathleen Praxedes, Chika Ihenakwe, Anya Platt, Anurag K. Agrawal, Lena E. Winestone. Financial Coping Strategies and Financial Assistance Following a Pediatric Hematologic Malignancy. Blood. 2022 Nov 15; 140(Supplement 1):5062-5063.  View on PubMed
  15. Chattip Prueksapraopong, Trevor Hirata, Lauryn Liao, Kyle Ishikawa, John J. Chen, Wade Kyono, Darryl W. Glaser, Randal Wada, Rodolfo Bégué, Brian T. Fisher, Lena E. Winestone, Kelley C. Okimoto, Stephanie Si Lim. High Incidence and Mortality of Invasive Fungal Disease in Children and Young Adults with Hematologic Malignancies in Hawaii and Pacific Islands. Blood. 2022 Nov 15; 140(Supplement 1):8042-8043.  View on PubMed
  16. Jenny Ruiz, Yimei Li, Yuan-Shung V. Huang, Lusha Cao, Vicky Tam, Heather M. Griffis, Lena E. Winestone, Brian T. Fisher, Todd A. Alonzo, Anders E. Kolb, Karen Glanz, Kelly D. Getz, Richard Aplenc, Alix E. Seif. Septic Shock and Septic Shock Mortality in Relation to Social Disorganization Index Among Children Being Treated for De Novo Acute Myeloid Leukemia on COG Clinical Trials. Blood. 2022 Nov 15; 140(Supplement 1):11029-11031.  View on PubMed
  17. Haley Newman, Shawn Lee, Petri Pölönen, Rawan Shraim, Yimei Li, Hongyan Liu, Tiffaney L. Vincent, Richard Aplenc, Changya Chen, Zhiguo Chen, Caroline Diorio, Kimberly P. Dunsmore, Sumit Gupta, Gang Wu, Kai Tan, Meenakshi Devidas, Stuart S. Winter, Brent L. Wood, Lena E. Winestone, Jason Xu, Elizabeth A. Raetz, Mignon L. Loh, Stephen P. Hunger, Stanley B. Pounds, Kira O Bona, Charles G. Mullighan, Jun J. Yang, David T. Teachey. The Influence of Genetic Ancestry on Disease Biology in Pediatric T-Cell Acute Lymphoblastic Leukemia. Blood. 2022 Nov 15; 140(Supplement 1):3458-3460.  View on PubMed
  18. Boyiadzis M, Zhang MJ, Chen K, Abdel-Azim H, Abid MB, Aljurf M, Bacher U, Badar T, Badawy SM, Battiwalla M, Bejanyan N, Bhatt VR, Brown VI, Castillo P, Cerny J, Copelan EA, Craddock C, Dholaria B, Perez MAD, Ebens CL, Gale RP, Ganguly S, Gowda L, Grunwald MR, Hashmi S, Hildebrandt GC, Iqbal M, Jamy O, Kharfan-Dabaja MA, Khera N, Lazarus HM, Lin R, Modi D, Nathan S, Nishihori T, Patel SS, Pawarode A, Saber W, Sharma A, Solh M, Wagner JL, Wang T, Williams KM, Winestone LE, Wirk B, Zeidan A, Hourigan CS, Litzow M, Kebriaei P, de Lima M, Page K, Weisdorf DJ. Impact of pre-transplant induction and consolidation cycles on AML allogeneic transplant outcomes: a CIBMTR analysis in 3113 AML patients. Leukemia. 2023 05; 37(5):1006-1017.  View on PubMed
  19. Chow EJ, Winestone LE, Lupo PJ, Diller LR, Henderson TO, Kadan-Lottick NS, Levine JM, Ness KK, Bhatia S, Armenian SH. Leveraging Clinical Trial Populations and Data from the Children's Oncology Group for Cancer Survivorship Research. Cancer Epidemiol Biomarkers Prev. 2022 09 02; 31(9):1675-1682.  View on PubMed
  20. Namjoshi NS, Keegan THM, Li QC, Chung JH, Rosenthal JL, Winestone LE, Muffly L, Malogolowkin MH, Alvarez EM. Treatment-related toxicities associated with hospitalization in children, adolescents, and young adults with acute lymphoblastic leukemia: population level analysis. Leuk Lymphoma. 2022 Aug 23; 1-9.  View on PubMed

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