University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Elad Ziv, MD

Elad Ziv, MD

Professor, Department of Medicine, UCSF

Cancer Center Program Memberships

Cancer Genetics

Research Summary

I am a professor of medicine at UCSF, and I focus my research on human genetics of cancer susceptibility and hematological traits. My research synthesizes concepts and data from human population genetics and epidemiology. A particular focus is on the genetics of admixed populations such as Latinos and African Americans. My research group was the first to demonstrate that breast cancer risk is associated with ancestry among Latina women; in particular, we showed that Native American genetic ancestry among Latina women was associated with protection from breast cancer. Subsequently, I led the group that mapped this difference to a locus on chromosome 6q25, and then performed fine mapping and found a single nucleotide polymorphism (SNP) that explains a large fraction of this risk difference. I have also recently led a group to identify a set of SNP’s associated with survival among multiple myeloma patients.

Education

Yale University, New Haven, CT, BS, 1991, Magna cum Lauda, Biology
University of California, San Francisco, CA, MD, 1996, Medicine
University of California, San Francisco, CA, Intern, 1996-1997, Medicine
University of California, San Francisco, CA, Resident, 1997-1999, Medicine
University of California, San Francisco, CA, 1999-2001, Fellow, General Internal Medicine and Clinical Epidemiology


Professional Experience

  • 2001-2003
    Assistant Adjunct Professor, Department of Medicine, University of California, San Francisco
  • 2003-2007
    Assistant Professor in Residence, Department of Medicine, University of California, San Francisco
  • 2007-present
    Associate Professor in Residence, Department of Medicine, University of California, San Francisco
  • 2007-2013
    Associate Professor in Residence, Department of Epidemiology and Biostatistics, University of California, San Francisco
  • 2013-present
    Professor in Residence, Department of Epidemiology and Biostatistics, University of California, San Francisco

Honors & Awards

  • 1988-1991
    IBM Thomas J. Watson Scholarship
  • 1991
    Distinction in Biology, Yale University
  • 1991
    Magna cum Laude, Yale University
  • 2001-2003
    UCSF Women's Health Research Scholar
  • 2002-2004
    Clinical Research Training Grant Award, American Cancer Society
  • 2003
    Best Breast Cancer Clinical Investigation, UCSF Breast Oncology Program Retreat
  • 2004-2007
    National Cancer Institute Career Transition Award
  • 2005
    Robert Crede Award for Clinical Research, UCSF Division of General Internal Medicine
  • 2012-2017
    National Cancer Mid-Career Investigator Award for Patient Oriented Research

Selected Publications

  1. Koga Y, Song H, Chalmers ZR, Newberg J, Kim E, Carrot-Zhang J, Piou D, Polak P, Abdulkadir SA, Ziv E, Meyerson M, Frampton GM, Campbell JD, Huang FW. Genomic Profiling of Prostate Cancers from Men with African and European Ancestry. Clin Cancer Res. 2020 Jul 10.
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  2. Clay-Gilmour AI, Hildebrandt MAT, Brown EE, Hofmann JN, Spinelli JJ, Giles GG, Cozen W, Bhatti P, Wu X, Waller RG, Belachew AA, Robinson DP, Norman AD, Sinnwell JP, Berndt SI, Rajkumar SV, Kumar SK, Chanock SJ, Machiela MJ, Milne RL, Slager SL, Camp NJ, Ziv E, Vachon CM. Coinherited genetics of multiple myeloma and its precursor, monoclonal gammopathy of undetermined significance. Blood Adv. 2020 Jun 23; 4(12):2789-2797.
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  3. Liu J, Prager-van der Smissen WJC, Collée JM, Bolla MK, Wang Q, Michailidou K, Dennis J, Ahearn TU, Aittomäki K, Ambrosone CB, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Arnold N, Aronson KJ, Augustinsson A, Auvinen P, Becher H, Beckmann MW, Behrens S, Bermisheva M, Bernstein L, Bogdanova NV, Bogdanova-Markov N, Bojesen SE, Brauch H, Brenner H, Briceno I, Brucker SY, Brüning T, Burwinkel B, Cai Q, Cai H, Campa D, Canzian F, Castelao JE, Chang-Claude J, Chanock SJ, Choi JY, Christiaens M, Clarke CL, Couch FJ, Czene K, Daly MB, Devilee P, Dos-Santos-Silva I, Dwek M, Eccles DM, Eliassen AH, Fasching PA, Figueroa J, Flyger H, Fritschi L, Gago-Dominguez M, Gapstur SM, García-Closas M, García-Sáenz JA, Gaudet MM, Giles GG, Goldberg MS, Goldgar DE, Guénel P, Haiman CA, Håkansson N, Hall P, Harrington PA, Hart SN, Hartman M, Hillemanns P, Hopper JL, Hou MF, Hunter DJ, Huo D, Ito H, Iwasaki M, Jakimovska M, Jakubowska A, John EM, Kaaks R, Kang D, Keeman R, Khusnutdinova E, Kim SW, Kraft P, Kristensen VN, Kurian AW, Le Marchand L, Li J, Lindblom A, Lophatananon A, Luben RN, Lubinski J, Mannermaa A, Manoochehri M, Manoukian S, Margolin S, Mariapun S, Matsuo K, Maurer T, Mavroudis D, Meindl A, Menon U, Milne RL, Muir K, Mulligan AM, Neuhausen SL, Nevanlinna H, Offit K, Olopade OI, Olson JE, Olsson H, Orr N, Park SK, Peterlongo P, Peto J, Plaseska-Karanfilska D, Presneau N, Rack B, Rau-Murthy R, Rennert G, Rennert HS, Rhenius V, Romero A, Ruebner M, Saloustros E, Schmutzler RK, Schneeweiss A, Scott C, Shah M, Shen CY, Shu XO, Simard J, Sohn C, Southey MC, Spinelli JJ, Tamimi RM, Tapper WJ, Teo SH, Terry MB, Torres D, Truong T, Untch M, Vachon CM, van Asperen CJ, Wolk A, Yamaji T, Zheng W, Ziogas A, Ziv E, Torres-Mejía G, Dörk T, Swerdlow AJ, Hamann U, Schmidt MK, Dunning AM, Pharoah PDP, Easton DF, Hooning MJ, Martens JWM, Hollestelle A. Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk. Sci Rep. 2020 Jun 16; 10(1):9688.
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  4. Chenan Zhang, Quinn T Ostrom, Helen M Hansen, Julio Gonzalez-Maya, Donglei Hu, Elad Ziv, Libby Morimoto, Adam J de Smith, Ivo S Muskens, Cassie N Kline, Zalman Vaksman, Hakon Hakonarson, Sharon J Diskin, Carol Kruchko, Jill S Barnholtz-Sloan, Vijay Ramaswamy, Francis Ali-Osman, Melissa L Bondy, Michael D Taylor, Catherine Metayer, Joseph L Wiemels, Kyle M Walsh. European genetic ancestry associated with risk of childhood ependymoma. Neuro-Oncology. 2020 Jun 2.
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  5. Zhang C, Ostrom QT, Hansen HM, Gonzalez-Maya J, Hu D, Ziv E, Morimoto L, de Smith AJ, Muskens IS, Kline CN, Vaksman Z, Hakonarson H, Diskin SJ, Kruchko C, Barnholtz-Sloan JS, Ramaswamy V, Ali-Osman F, Bondy ML, Taylor MD, Metayer C, Wiemels JL, Walsh KM. European genetic ancestry associated with risk of childhood ependymoma. Neuro Oncol. 2020 Jun 02.
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  6. Shieh Y, Fejerman L, Lott PC, Marker K, Sawyer SD, Hu D, Huntsman S, Torres J, Echeverry M, Bohórquez ME, Martínez-Chéquer JC, Polanco-Echeverry G, Estrada-Flórez AP, Haiman CA, John EM, Kushi LH, Torres-Mejía G, Vidaurre T, Weitzel JN, Zambrano SC, Carvajal-Carmona LG, Ziv E, Neuhausen SL. A Polygenic Risk Score for Breast Cancer in US Latinas and Latin American Women. J Natl Cancer Inst. 2020 Jun 01; 112(6):590-598.
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  7. Kachuri L, Francis SS, Morrison M, Bossé Y, Cavazos TB, Rashkin SR, Ziv E, Witte JS. The landscape of host genetic factors involved in infection to common viruses and SARS-CoV-2. medRxiv. 2020 May 30.
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  8. Lee EY, Mak AC, Hu D, Sajuthi S, White MJ, Keys KL, Eckalbar W, Bonser L, Huntsman S, Urbanek C, Eng C, Jain D, Abecasis G, Kang HM, Germer S, Zody MC, Nickerson DA, Erle D, Ziv E, Rodriguez-Santana J, Seibold MA, Burchard EG. Whole Genome Sequencing Identifies Novel Functional Loci Associated with Lung Function in Puerto Rican Youth. Am J Respir Crit Care Med. 2020 May 27.
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  9. Carrot-Zhang J, Chambwe N, Damrauer JS, Knijnenburg TA, Robertson AG, Yau C, Zhou W, Berger AC, Huang KL, Newberg JY, Mashl RJ, Romanel A, Sayaman RW, Demichelis F, Felau I, Frampton GM, Han S, Hoadley KA, Kemal A, Laird PW, Lazar AJ, Le X, Oak N, Shen H, Wong CK, Zenklusen JC, Ziv E, Cherniack AD, Beroukhim R. Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer. Cancer Cell. 2020 May 11; 37(5):639-654.e6.
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  10. Mak ACY, Sajuthi S, Joo J, Xiao S, Sleiman PM, White MJ, Lee EY, Saef B, Hu D, Gui H, Keys KL, Lurmann F, Jain D, Abecasis G, Kang HM, Nickerson DA, Germer S, Zody MC, Winterkorn L, Reeves C, Huntsman S, Eng C, Salazar S, Oh SS, Gilliland FD, Chen Z, Kumar R, Martínez FD, Wu AC, Ziv E, Hakonarson H, Himes BE, Williams LK, Seibold MA, Burchard EG. Novel KITLG/SCF Regulatory Variants Are Associated with Lung Function in African American Children with Asthma. Genetics. 2020 Apr 23.
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  11. Marker KM, Zavala VA, Vidaurre T, Lott PC, Vásquez JN, Casavilca-Zambrano S, Calderón M, Abugattas JE, Gómez HL, Fuentes HA, Picoaga RL, Cotrina JM, Neciosup SP, Castañeda CA, Morante Z, Valencia F, Torres J, Echeverry M, Bohórquez ME, Polanco-Echeverry G, Estrada-Florez AP, Serrano-Gómez SJ, Carmona-Valencia JA, Alvarado-Cabrero I, Sanabria-Salas MC, Velez A, Donado J, Song S, Cherry D, Tamayo LI, Huntsman S, Hu D, Ruiz-Cordero R, Balassanian R, Ziv E, Zabaleta J, Carvajal-Carmona L, Fejerman L. Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Is Associated with Indigenous American Ancestry in Latin American Women. Cancer Res. 2020 May 01; 80(9):1893-1901.
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  12. Shieh Y, Ziv E, Kerlikowske K. Interval breast cancers - insights into a complex phenotype. Nat Rev Clin Oncol. 2020 03; 17(3):138-139.
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  13. Angel Mak, Satria Sajuthi, Jaehyun Joo, Shujie Xiao, Patrick Sleiman, Marquitta J White, Eunice Y Lee, Benjamin Saef, Donglei Hu, Hongsheng Gui, Kevin L Keys, Fred Lurmann, Deepti Jain, Goncalo Abecasis, Hyun Min Kang, Deborah A Nickerson, Soren Germer, Michael C Zody, Lara Winterkorn, Catherine Reeves, Scott Huntsman, Celeste Eng, Sandra Salazar, Sam S Oh, Frank Gilliland, Zhanghua Chen, Rajesh Kumar, Fernando D Martinez, Ann Chen Wu, Elad Ziv, Hakon Hakonarson, Blanca E Himes, L Keoki Williams, Max A Seibold, Esteban G Burchard. Novel KITLG/SCF regulatory variants are associated with lung function in African American children with asthma. medRxiv. 2020 Feb 23; 2020.02.20.20019588.
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  14. Du Z, Weinhold N, Song GC, Rand KA, Van Den Berg DJ, Hwang AE, Sheng X, Hom V, Ailawadhi S, Nooka AK, Singhal S, Pawlish K, Peters ES, Bock C, Mohrbacher A, Stram A, Berndt SI, Blot WJ, Casey G, Stevens VL, Kittles R, Goodman PJ, Diver WR, Hennis A, Nemesure B, Klein EA, Rybicki BA, Stanford JL, Witte JS, Signorello L, John EM, Bernstein L, Stroup AM, Stephens OW, Zangari M, Van Rhee F, Olshan A, Zheng W, Hu JJ, Ziegler R, Nyante SJ, Ingles SA, Press MF, Carpten JD, Chanock SJ, Mehta J, Colditz GA, Wolf J, Martin TG, Tomasson M, Fiala MA, Terebelo H, Janakiraman N, Kolonel L, Anderson KC, Le Marchand L, Auclair D, Chiu BC, Ziv E, Stram D, Vij R, Bernal-Mizrachi L, Morgan GJ, Zonder JA, Huff CA, Lonial S, Orlowski RZ, Conti DV, Haiman CA, Cozen W. A meta-analysis of genome-wide association studies of multiple myeloma among men and women of African ancestry. Blood Adv. 2020 Jan 14; 4(1):181-190.
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  15. Ziv E. Systems Biology for Multiplatform Data Integration: An Overview. Methods Mol Biol. 2020; 2055:641-647.
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  16. Jingxuan Shan, Aziz Chouchane, Younes Mokrab, Mohamad Saad, Salha Boujassoum, Rosalyn W. Sayaman, Elad Ziv, Noureddine Bouaouina, Yasmine Remadi, Sallouha Gabbouj, Jessica Roelands, Xiaojing Ma, Davide Bedognetti, Lotfi Chouchane. Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications. Frontiers in Oncology. 2019 Dec 6; 9:1328.
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  17. Shan J, Chouchane A, Mokrab Y, Saad M, Boujassoum S, Sayaman RW, Ziv E, Bouaouina N, Remadi Y, Gabbouj S, Roelands J, Ma X, Bedognetti D, Chouchane L. Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications. Front Oncol. 2019; 9:1328.
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  18. Alyssa I. Clay-Gilmour, Michelle Hildebrandt, Yan Asmann, Elizabeth E. Brown, Jonathan N Hofmann, John Spinelli, Graham Giles, Parveen Bhatti, Wendy Cozen, Dennis P. Robinson, Daniel R O'Brien, S. Vincent Rajkumar, Shulan Tian, Sonja I Berndt, Stephen J Chanock, Mitchell Machiela, Aaron D. Norman, Jason P Sinnwell, Xifeng Wu, Rosalie Griffin Waller, Roger L Milne, Susan L Slager, Shaji K. Kumar, Nicola J Camp, Elad Ziv, Celine M. Vachon. Association between a Polygenic Risk Score for Multiple Myeloma Risk and Overall Survival. Blood. 2019 Nov 13; 134(Supplement_1):4366-4366.
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  19. Linda Kachuri, Zhaohui Du, Niels Weinhold, Gregory Song, Kristin Alyse Rand, David Van Den Berg, Amie Hwang, Xin Sheng, Victor Hom, Sikander Ailawadhi, Ajay K Nooka, Seema Singhal, Edward S. Peters, Cathryn Bock, Ann Mohrbacher, Alexander Stram, Sonja I Berndt, William J. Blot, Esther M. John, Leslie Bernstein, Antoinette Stroup, Maurizio Zangari, Frits van Rhee, Andrew Olshan, Wei Zheng, Sue Ann Ingles, Michael Press, John David Carpten, Stephen J Chanock, Jayesh Mehta, Graham A Colditz, Jeffrey Wolf, Thomas G. Martin, Mark A. Fiala, Howard R. Terebelo, Nalini Janakiraman, Laurence Kolonel, Kenneth C. Anderson, Loic Le Marchand, Daniel Auclair, Brian C.-H. Chiu, Daniel Stram, Ravi Vij, Leon Bernal-Mizrachi, Gareth Morgan, Jeffrey A. Zonder, Carol Ann Huff, Sagar Lonial, Robert Z. Orlowski, David Conti, Christopher A. Haiman, Elad Ziv, John S Witte, Wendy Cozen. Comprehensive Investigation of White Blood Cell and Gene Expression Profiles As Risk Factors for Multiple Myeloma in African Americans. Blood. 2019 Nov 13; 134(Supplement_1):4379-4379.
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  20. Kyle Roter, Donglei Hu, Alyssa Clay-Gilmour, Scott Huntsman, Nina D. Shah, Sandy W. Wong, Thomas G. Martin, Jeffrey Lee Wolf, Moritz Binder, Shaji K. Kumar, S. Vincent Rajkumar, Susan L. Slager, Celine M. Vachon, Elad Ziv. Germline Variation Predicts Treatment Response in Multiple Myeloma. Blood. 2019 Nov 13; 134(Supplement_1):4397-4397.
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