Research Summary

I am head of the gynecological pathology service in the UCSF Department of Pathology where I am a surgical pathologist specializing in the diagnosis of gynecologic diseases, including cancers, benign tumors, pre-malignant lesions, infections, hormonal alterations, and developmental abnormalities of the ovaries, fallopian tubes, endometrium (uterus), myometrium, cervix, peritoneum, vagina, and vulva as well as gestational trophoblastic diseases. I provide diagnostic pathology service for the OB/GYN, Gynecologic Oncology, HPV/Dysplasia, and Reproductive Endocrinology and Infertility clinics, for the gynecological diseases treated in the operating rooms at Mission Bay Hospital, Moffitt Hospital and Mt Zion Cancer Center, as well as diagnostic consultation for the Genetic Counseling division.

My clinical research focuses on diagnostic classification of gynecologic neoplasms, with an aim toward improvement of personalized tailoring of treatment decisions and tailoring of risk assessment for hereditary disease (i.e. the pathology perspective of precision medicine) by evaluating roles for integrating clinical, morphologic, immunohistochemical, and molecular diagnostic data.

Inter-departmental collaboration is central to both my clinical service and research activity. I work closely with my UCSF colleagues in the OB/GYN, Gynecologic Oncology, Genetic Counseling, and Radiology departments.

My educational activity includes serving as the Program Director for the UCSF Gynecologic Pathology Fellowship; site director for medical student pathology electives at UCSF Mission Bay campus and lecturer and course director of numerous continuing education courses offered by national (USCAP, ASCP, CAP) and international (IAP, ISGyP, SSI) pathology organizations.

My professional organizational service includes being Associate Editor of the International Journal of Gynecologic Pathology, a member of the American Board of Pathology test development and advisory committee, and past Co-Chair of Education and Secretary on the executive board of the International Society of Gynecologic Pathologists.

I am an editor and co-author of the 5th edition World Health Classification system of Female Genital Tumors, a co-author of multiple consensus guidelines from the International Society of Gynecological Pathologists, International Collaboration on Cancer Reporting, and numerous international consensus panels.

Education

Harvard Medical School, MD, 1992-98, Medicine
Harvard School of Public Health, M.P.H., 1995-96, Medicine
University of California, San Francisco, Intern, 1998-99, General Surgery
University of California, San Francisco Resident, 1999-01, Anatomic Pathology
University of California, San Francisco Fellow, 2001-02, Surgical Pathology
University of California, San Francisco, Fellow, 2002-03, Cytopathology
Harvard Medical School Fellow, 2003-04, Gynecologic and Breast Pathology

Selected Publications

  1. Rahmioglu N, Mortlock S, Ghiasi M, Møller PL, Stefansdottir L, Galarneau G, Turman C, Danning R, Law MH, Sapkota Y, Christofidou P, Skarp S, Giri A, Banasik K, Krassowski M, Lepamets M, Marciniak B, Nõukas M, Perro D, Sliz E, Sobalska-Kwapis M, Thorleifsson G, Topbas-Selcuki NF, Vitonis A, Westergaard D, Arnadottir R, Burgdorf KS, Campbell A, Cheuk CSK, Clementi C, Cook J, De Vivo I, DiVasta A, Dorien O, Donoghue JF, Edwards T, Fontanillas P, Fung JN, Geirsson RT, Girling JE, Harkki P, Harris HR, Healey M, Heikinheimo O, Holdsworth-Carson S, Hostettler IC, Houlden H, Houshdaran S, Irwin JC, Jarvelin MR, Kamatani Y, Kennedy SH, Kepka E, Kettunen J, Kubo M, Kulig B, Kurra V, Laivuori H, Laufer MR, Lindgren CM, MacGregor S, Mangino M, Martin NG, Matalliotaki C, Matalliotakis M, Murray AD, Ndungu A, Nezhat C, Olsen CM, Opoku-Anane J, Padmanabhan S, Paranjpe M, Peters M, Polak G, Porteous DJ, Rabban J, Rexrode KM, Romanowicz H, Saare M, Saavalainen L, Schork AJ, Sen S, Shafrir AL, Siewierska-Górska A, Slomka M, Smith BH, Smolarz B, Szaflik T, Szyllo K, Takahashi A, Terry KL, Tomassetti C, Treloar SA, Vanhie A, Vincent K, Vo KC, Werring DJ, Zeggini E, Zervou MI, DBDS Genomic Consortium, FinnGen Study, FinnGen Endometriosis Taskforce, Celmatix Research Team, 23andMe Research Team, Adachi S, Buring JE, Ridker PM, D'Hooghe T, Goulielmos GN, Hapangama DK, Hayward C, Horne AW, Low SK, Martikainen H, Chasman DI, Rogers PAW, Saunders PT, Sirota M, Spector T, Strapagiel D, Tung JY, Whiteman DC, Giudice LC, Velez-Edwards DR, Uimari O, Kraft P, Salumets A, Nyholt DR, Mägi R, Stefansson K, Becker CM, Yurttas-Beim P, Steinthorsdottir V, Nyegaard M, Missmer SA, Montgomery GW, Morris AP, Zondervan KT. The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions. Nat Genet. 2023 03; 55(3):423-436.  View on PubMed
  2. Kayraklioglu N, Gasper C, Cho SJ, Lage J, Rabban JT. Intact Chorionic Vesicle in Very Early Products of Conception Specimens: Clinicopathologic Features of 26 Cases That May Mimic Complete Hydatidiform Mole. Am J Surg Pathol. 2023 03 01; 47(3):397-408.  View on PubMed
  3. Ladwig NR, Bean GR, Pekmezci M, Boscardin J, Joseph NM, Therrien N, Sangoi AR, Piening B, Rajamanickam V, Galvin M, Bernard B, Zaloudek C, Rabban JT, Garg K, Umetsu SE. Uterine Inflammatory Myofibroblastic Tumors: Proposed Risk Stratification Model Using Integrated Clinicopathologic and Molecular Analysis. Am J Surg Pathol. 2023 02 01; 47(2):157-171.  View on PubMed
  4. Nucci MR, Webster F, Croce S, George S, Howitt BE, Ip PPC, Lee CH, Rabban JT, Soslow RA, van der Griend R, Lax SF, McCluggage WG. Data Set for Reporting of Uterine Malignant and Potentially Malignant Mesenchymal Tumors: Recommendations From the International Collaboration on Cancer Reporting (ICCR). Int J Gynecol Pathol. 2022 Nov 01; 41(Suppl 1):S44-S63.  View on PubMed
  5. Rabban JT, Chen LM, Devine WP. Homologous Recombination Deficiency and Ovarian Cancer Treatment Decisions: Practical Implications for Pathologists for Tumor Typing and Reporting. Surg Pathol Clin. 2022 Jun; 15(2):219-234.  View on PubMed
  6. Bowman CJ, Medeiros F, Fadare O, Sangoi AR, Horvai AE, Devine WP, McCluggage WG, Rabban JT. ALK Immunoexpression is Specific for Inflammatory Myofibroblastic Tumor Among Vulvovaginal Mesenchymal Neoplasms. Int J Gynecol Pathol. 2022 Feb 18.  View on PubMed
  7. Rabban JT, Garg K, Ladwig NR, Zaloudek CJ, Devine WP. Cytoplasmic Pattern p53 Immunoexpression in Pelvic and Endometrial Carcinomas With TP53 Mutation Involving Nuclear Localization Domains: An Uncommon But Potential Diagnostic Pitfall With Clinical Implications. Am J Surg Pathol. 2021 11 01; 45(11):1441-1451.  View on PubMed
  8. Sugi MD, Penna R, Jha P, Poder L, Behr SC, Courtier J, Mok-Lin E, Rabban JT, Choi HH. Müllerian Duct Anomalies: Role in Fertility and Pregnancy. Radiographics. 2021 Oct; 41(6):1857-1875.  View on PubMed
  9. McNally L, Rabban JT, Poder L, Chetty S, Ueda S, Chen LM. Differentiating complete hydatidiform mole and coexistent fetus and placental mesenchymal dysplasia: A series of 9 cases and review of the literature. Gynecol Oncol Rep. 2021 Aug; 37:100811.  View on PubMed
  10. Schermerhorn SMV, Rosen MP, Blevins EM, Byrd KA, Rabban JT, Marsh P, Lucas DJ. Regional air transportation of ovarian tissue for cryopreservation in a prepubertal female with cancer. Pediatr Blood Cancer. 2021 09; 68(9):e29107.  View on PubMed
  11. Ladwig NR, Umetsu SE, Zaloudek C, Rabban J, Garg K. Corded and Hyalinized Endometrioid Adenocarcinoma (CHEC) of the Uterine Corpus are Characterized by CTNNB1 Mutations and Can Show Adverse Clinical Outcomes. Int J Gynecol Pathol. 2021 Mar 01; 40(2):103-115.  View on PubMed
  12. Parra-Herran C, Malpica A, Oliva E, Zannoni GF, Ramirez PT, Rabban JT. Endocervical Adenocarcinoma, Gross Examination, and Processing, Including Intraoperative Evaluation: Recommendations From the International Society of Gynecological Pathologists. Int J Gynecol Pathol. 2021 Mar 01; 40(Suppl 1):S24-S47.  View on PubMed
  13. Talia KL, Oliva E, Rabban JT, Singh N, Stolnicu S, McCluggage WG. Grading of Endocervical Adenocarcinomas: Review of the Literature and Recommendations From the International Society of Gynecological Pathologists. Int J Gynecol Pathol. 2021 Mar 01; 40(Suppl 1):S66-S74.  View on PubMed
  14. Joehlin-Price A, Van Ziffle J, Hills NK, Ladwig N, Rabban JT, Garg K. Molecularly Classified Uterine FIGO Grade 3 Endometrioid Carcinomas Show Distinctive Clinical Outcomes But Overlapping Morphologic Features. Am J Surg Pathol. 2021 03 01; 45(3):421-429.  View on PubMed
  15. Park KJ, Cabrero IA, Fadare O, Hoang L, Kiyokawa T, Oliva E, Parra-Herran C, Rabban JT, Roma A, Singh N, Soslow R, Stolnicu S, Huvila J, Leung S, Gilks CB. Online Training and Self-assessment in the Histopathologic Classification of Endocervical Adenocarcinoma and Diagnosis of Pattern of Invasion: Evaluation of Participant Performance. Int J Gynecol Pathol. 2021 Mar 01; 40(Suppl 1):S14-S23.  View on PubMed
  16. McCluggage WG, Rabban JT, Singh N, Oliva E. Survey Results on Pathologic Aspects of Endocervical Adenocarcinoma by the International Society of Gynecological Pathologists. Int J Gynecol Pathol. 2021 Mar; 40 Suppl 1:S4-S13.  View on PubMed
  17. Singh N, Rabban JT. The ISGyP Endocervical Adenocarcinoma Project: Master Plan Summary, Acknowledgment of Participants, and Participant Responses to Final Recommendations of the Expert Panels. Int J Gynecol Pathol. 2021 Mar; 40 Suppl 1:S111-S123.  View on PubMed
  18. Stewart CJR, McCluggage WG, Chua YJ, Texler M, Rabban JT. Uterine plexiform tumourlets: multifocal and solitary cases with subsets expressing melanocytic markers. Histopathology. 2021 Apr; 78(5):690-698.  View on PubMed
  19. Garg K, Rabban J. Hereditary leiomyomatosis and renal cell carcinoma syndrome associated uterine smooth muscle tumors: Bridging morphology and clinical screening. Genes Chromosomes Cancer. 2021 03; 60(3):210-216.  View on PubMed
  20. Bennett JA, Croce S, Pesci A, Niu N, Van de Vijver K, Burks EJ, Burandt E, Zannoni GF, Rabban JT, Oliva E. Inflammatory Myofibroblastic Tumor of the Uterus: An Immunohistochemical Study of 23 Cases. Am J Surg Pathol. 2020 11; 44(11):1441-1449.  View on PubMed

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