Aleksandar Rajkovic, MD, PhD

Stuart Lindsay Distinguished Professor in Experimental Pathology, UCSF

Chief Genomics Officer, UCSF Health; Professor, Dept. of Pathology, Dept. of Obstetrics, Gynecology and Reproductive Sciences, UCSF

Cancer Center Program Membership

Cancer Control

Research Summary

My work focuses on implementing precision medicine tools across UCSF and evaluate its clinical significance and validity. UCSF envisions a future where we will be able to predict and prevent disease in everyone and where every person has access to comprehensive molecular screening that includes genomics and other measurements in order to precisely predict, prevent, and treat their specific health conditions, including susceptibility to pandemics such as COVID-19, childhood and adult diseases which include cancer, diabetes, heart and neurological diseases. It is our vision that preventive precision medicine that incorporates genomics, epigenomics, metabolomics and other advanced molecular tools can predict and prevent vast majority of human disease. To this end we are building computational, analytical, and other tools to implement our vision.

As a first step, we have launched the pilot Whole Genome Sequencing Program for all to evaluate its utility in clinical and research setting. By integrating data from the electronic health record, biological samples stored in our biobank, and other data sets for approximately 1,000 volunteers from the UCSF, we will immediately provide our patients with their predisposition to cancer and other actionable diseases as well as build analytics for continuous re-analysis to refine and provide novel predictions.

The UCSF genomic database will strive to match the diversity of UCSF patient population to ensure that precision medicine at UCSF serves our entire community and we have engaged community leaders to better understand cultural and racial barriers to our precision medicine efforts.

UCSF established first nationwide Preventive Genomics clinic to counsel and test individuals interested in learning about their genomes. UCSF is now one of the first institutions to offer whole genome sequencing in quest to return actionable results and better understand how the unknown 99% of the genome contributes to health. This clinic will serve as the nidus for our efforts to build molecular preventive care.

Research Funding

  • April 1, 2019 - March 31, 2024 - The Origin and cellular heterogeneity of uterine leiomyomas, Principal Investigator. Sponsor: NICHD, Sponsor Award ID: P50 HD098580 01
  • April 1, 2019 - March 31, 2024 - Project 2 PI: The Origin and Cellular Heterogeneity of Uterine Leiomyomas, . Sponsor: NIH, Sponsor Award ID: P50 HD098580-01
  • July 1, 2017 - June 30, 2022 - Med12 mechanisms of uterine leiomyoma formation, Principal Investigator. Sponsor: NIH/NICHD, Sponsor Award ID: R01HD088629
  • August 8, 2018 - July 31, 2020 - Small molecule GPR10 antagonists for the treatment of uterine fibroids, Co-Principal Investigator. Sponsor: NIH/NICHD, Sponsor Award ID: R01HD094373

Education

The Johns Hopkins University, BA, 05/85/ Chemistry
Case Western Reserve School of Medicine, PhD, 01/91, Molecular Biology
Case Western Reserve School of Medicine, MD, 05/92/ Doctor of Medicine

Honors & Awards

  • 1985
    Phi Beta Kappa
  • 1983
    American Chemical Society Award for Outstanding Achievement in Chemistry
  • 1997
    First Place Award, Research Day, Cleveland Society of Obstetrics and Gynecology
  • 1997
    Peter Adam Research Award, Metrohealth Medical Center, Cleveland, Ohio
  • 2013
    Elected to the American Society of Clinical Investigators (ASCI)
  • 2018
    Elected to American Association of Physicians (AAP)
  • 2020
    Elected to the National Academy of Medicine (NAM)

Selected Publications

  1. Gregg AR, Aarabi M, Klugman S, Leach NT, Bashford MT, Goldwaser T, Chen E, Sparks TN, Reddi HV, Rajkovic A, Dungan JS, ACMG Professional Practice and Guidelines Committee . Correction to: Screening for autosomal recessive and X-linked conditions during pregnancy and preconception: a practice resource of the American College of Medical Genetics and Genomics (ACMG). Genet Med. 2021 Aug 27.  View on PubMed
  2. Rydze RT, Patton B, Briley SM, Salazar-Torralba H, Gipson G, James R, Rajkovic A, Thompson T, Pangas SA. Deletion of Gremlin-2 alters estrous cyclicity and disrupts female fertility in mice. Biol Reprod. 2021 Aug 02.  View on PubMed
  3. Gregg AR, Aarabi M, Klugman S, Leach NT, Bashford MT, Goldwaser T, Chen E, Sparks TN, Reddi HV, Rajkovic A, Dungan JS, ACMG Professional Practice and Guidelines Committee . Screening for autosomal recessive and X-linked conditions during pregnancy and preconception: a practice resource of the American College of Medical Genetics and Genomics (ACMG). Genet Med. 2021 Jul 20.  View on PubMed
  4. Verdoni A, Hu J, Surti U, Babcock M, Sheehan E, Clemens M, Drewes S, Walsh L, Clark R, Katari S, Sanfilippo J, Saller DN, Rajkovic A, Yatsenko SA. Reproductive outcomes in individuals with chromosomal reciprocal translocations. Genet Med. 2021 May 10.  View on PubMed
  5. Liao J, Coffman KA, Locker J, Padiath QS, Nmezi B, Filipink RA, Hu J, Sathanoori M, Madan-Khetarpal S, McGuire M, Schreiber A, Moran R, Friedman N, Hoffner L, Rajkovic A, Yatsenko SA, Surti U. Deletion of conserved non-coding sequences downstream from NKX2-1: A novel disease-causing mechanism for benign hereditary chorea. Mol Genet Genomic Med. 2021 Apr; 9(4):e1647.  View on PubMed
  6. McKinzey DR, Gomathinayagam S, Griffin WC, Klinzing KN, Jeffries EP, Rajkovic A, Trakselis MA. Motifs of the C-terminal domain of MCM9 direct localization to sites of mitomycin-C damage for RAD51 recruitment. J Biol Chem. 2021 Jan-Jun; 296:100355.  View on PubMed
  7. Goad J, Rudolph J, Rajkovic A. Female reproductive tract has low concentration of SARS-CoV2 receptors. PLoS One. 2020; 15(12):e0243959.  View on PubMed
  8. Yatsenko SA, Aarabi M, Hu J, Surti U, Ortiz D, Madan-Khetarpal S, Saller DN, Bellissimo D, Rajkovic A. Copy number alterations involving 59 ACMG-recommended secondary findings genes. Clin Genet. 2020 12; 98(6):577-588.  View on PubMed
  9. Yatsenko SA, Quesada-Candela C, Saller DN, Beck S, Jaffe R, Kostadinov S, Yanowitz J, Rajkovic A. Cytogenetic signatures of recurrent pregnancy losses. Prenat Diagn. 2021 01; 41(1):70-78.  View on PubMed
  10. Goad J, Rudolph J, Rajkovic A. Female reproductive tract has low concentration of SARS-CoV2 receptors. bioRxiv. 2020 Jun 22.  View on PubMed
  11. Eozenou C, Gonen N, Touzon MS, Jorgensen A, Yatsenko SA, Fusee L, Kamel AK, Gellen B, Guercio G, Singh P, Witchel S, Berman AJ, Mainpal R, Totonchi M, Mohseni Meybodi A, Askari M, Merel-Chali T, Bignon-Topalovic J, Migale R, Costanzo M, Marino R, Ramirez P, Perez Garrido N, Berensztein E, Mekkawy MK, Schimenti JC, Bertalan R, Mazen I, McElreavey K, Belgorosky A, Lovell-Badge R, Rajkovic A, Bashamboo A. Testis formation in XX individuals resulting from novel pathogenic variants in Wilms' tumor 1 (WT1) gene. Proc Natl Acad Sci U S A. 2020 06 16; 117(24):13680-13688.  View on PubMed
  12. Hilbold E, Distl O, Hoedemaker M, Wilkening S, Behr R, Rajkovic A, Langeheine M, Rode K, Jung K, Metzger J, Brehm RHJ. Loss of Cx43 in Murine Sertoli Cells Leads to Altered Prepubertal Sertoli Cell Maturation and Impairment of the Mitosis-Meiosis Switch. Cells. 2020 03 10; 9(3).  View on PubMed
  13. Yatsenko SA, Rajkovic A. Genetics of human female infertility‚Ć. Biol Reprod. 2019 09 01; 101(3):549-566.  View on PubMed
  14. Yatsenko SA, Wood-Trageser M, Chu T, Jiang H, Rajkovic A. A high-resolution X chromosome copy-number variation map in fertile females and women with primary ovarian insufficiency. Genet Med. 2019 10; 21(10):2275-2284.  View on PubMed
  15. Gregg AR, Rajkovic A. Cell-Free DNA Screening During Pregnancy. JAMA. 2019 01 22; 321(3):308-309.  View on PubMed
  16. Yang X, Touraine P, Desai S, Humphreys G, Jiang H, Yatsenko A, Rajkovic A. Gene variants identified by whole-exome sequencing in 33 French women with premature ovarian insufficiency. J Assist Reprod Genet. 2019 Jan; 36(1):39-45.  View on PubMed
  17. Khan MJ, Pollock N, Jiang H, Castro C, Nazli R, Ahmed J, Basit S, Rajkovic A, Yatsenko AN. X-linked ADGRG2 mutation and obstructive azoospermia in a large Pakistani family. Sci Rep. 2018 11 02; 8(1):16280.  View on PubMed
  18. Aarabi M, Kessler E, Madan-Khetarpal S, Surti U, Bellissimo D, Rajkovic A, Yatsenko SA. Autism spectrum disorder in females with ARHGEF9 alterations and a random pattern of X chromosome inactivation. Eur J Med Genet. 2019 Apr; 62(4):239-242.  View on PubMed
  19. Portnoi MF, Dumargne MC, Rojo S, Witchel SF, Duncan AJ, Eozenou C, Bignon-Topalovic J, Yatsenko SA, Rajkovic A, Reyes-Mugica M, Almstrup K, Fusee L, Srivastava Y, Chantot-Bastaraud S, Hyon C, Louis-Sylvestre C, Validire P, de Malleray Pichard C, Ravel C, Christin-Maitre S, Brauner R, Rossetti R, Persani L, Charreau EH, Dain L, Chiauzzi VA, Mazen I, Rouba H, Schluth-Bolard C, MacGowan S, McLean WHI, Patin E, Rajpert-De Meyts E, Jauch R, Achermann JC, Siffroi JP, McElreavey K, Bashamboo A. Mutations involving the SRY-related gene SOX8 are associated with a spectrum of human reproductive anomalies. Hum Mol Genet. 2018 04 01; 27(7):1228-1240.  View on PubMed
  20. Katari S, Aarabi M, Kintigh A, Mann S, Yatsenko SA, Sanfilippo JS, Zeleznik AJ, Rajkovic A. Chromosomal instability in women with primary ovarian insufficiency. Hum Reprod. 2018 03 01; 33(3):531-538.  View on PubMed

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