Research Summary

I am an Assistant Professor and Physician Scientist in the Department of Radiation Oncology at the University of California-San Francisco (UCSF), where I specialize in the treatment and investigation of adult and pediatric brain tumors. Eighty percent of my time is protected for laboratory research, and I am also therefore a Principle Investigator in the UCSF Department of Neurological Surgery Brain Tumor Center. My research examines how developmental signaling pathways function in cancer with the overall objectives of shedding light on the fundamental mechanisms of developmental biology, and identifying novel biomarkers and therapeutic targets to improve patient outcomes. To accomplish those goals, my laboratory makes use of biochemistry, molecular biology, cell biology, mouse genetics, genomics, bioinformatics and pharmacology. Our work has identified novel activators and effectors of oncogenic Hedgehog signaling in medulloblastoma, and revealed a FOXM1/WNT signaling axis that underlies meningioma proliferation. Each of these discoveries serves as the foundation for clinical trials of molecular therapy in medulloblastoma and meningioma patients that are currently under development.

Research Funding

  • July 1, 2017 - June 30, 2022 - Understanding How Ciliary Hedgehog Signaling Causes Medulloblastoma, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: K08CA212279
  • July 1, 2017 - June 30, 2022 - Understanding How Ciliary Hedgehog Signaling Causes Medulloblastoma, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: K08CA212279
  • July 1, 2017 - June 30, 2022 - Understanding How Ciliary Hedgehog Signaling Causes Medulloblastoma, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: K08CA212279
  • July 1, 2017 - June 30, 2022 - Understanding How Ciliary Hedgehog Signaling Causes Medulloblastoma, Principal Investigator. Sponsor: NIH, Sponsor Award ID: K08CA212279

Education

University of California-Berkeley, B.A. (Honors), 08/00-05/04, Molecular Cell Biology
University of California-Berkeley B.A. (Honors) 08/00 05/04 Cognitive Science
University of Chicago-Chicago M.D. 05/05 06/12 Medicine
University of Chicago-Chicago Ph.D. 07/07 05/10 Pathology
Kaiser Permanente-Santa Clara, Intern, 07/12-06/13, Internal Medicine
University of California-San Francisco, Resident, 07/13-06/17, Radiation Oncology
University of California-San Francisco, Postdoctoral Fellow, 01/15-06/17, Cancer Biology

Honors & Awards

  • 2009
    FASEB Travel Award, FASEB Gastrointestinal Tract XIII Meeting
  • 2009
    DDW Poster of Distinction, Digestive Disease Week Annual Meeting
  • 2009
    Outstanding Graduate Student Oral Presentation, University of Chicago
  • 2010
    Takeda Travel Award, Experimental Biology Annual Meeting
  • 2011
    Naomi Ragins Goldsmith Career Development Award, University of Chicago
  • 2012
    Outstanding Performance in Radiation and Cellular Oncology, University of Chicago
  • 2013
    Teaching Award in Recognition of Excellent Medical Student Education, Kaiser Permanente
  • 2015
    Clinical & Translational Science Institute Resident Research Travel Program Award, UCSF
  • 2016
    Career Award for Medical Scientists Semifinalist, Burroughs Wellcome Fund
  • 2016
    Radiological Society of North America Roentgen Resident/Fellow Research Award, UCSF
  • 2016
    Biology Abstract Travel Award, American Society for Radiation Oncology Annual Meeting
  • 2016
    Poster Walk Award, Association of Residents in Radiation Oncology
  • 2016
    Top Young Investigator Awardee, ASCO Scientific Career Development Retreat
  • 2017
    Young Oncologist Travel Grant Recipient, American Radium Society Annual Meeting
  • 2017
    Poster of Distinction, American Radium Society Annual Meeting
  • 2017
    Biology Abstract Travel Award, American Society for Radiation Oncology Annual Meeting

Selected Publications

  1. Daggubati V, Hochstetler J, Bommireddy A, Choudhury A, Krup AL, Choksi PK, Tong P, Li A, Xu L, Reiter JF, Raleigh DR Smoothened-activating lipids drive resistance to CDK4/6 inhibition in Hedgehog-associated medulloblastoma cells and preclinical models.  View on PubMed
  2. Vasudevan HN, Lucas CG, Villanueva-Meyer JE, Theodosopoulos PV, Raleigh DR Genetic Events and Signaling Mechanisms Underlying Schwann Cell Fate in Development and Cancer.  View on PubMed
  3. Findakly S, Daggubati V, Garcia G, LaStella SA, Choudhury A, Tran C, Li A, Tong P, Garcia JQ, Puri N, Reiter JF, Xu L, Raleigh DR Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway.  View on PubMed
  4. Chen WC, Vasudevan HN, Choudhury A, Pekmezci M, Lucas CG, Phillips J, Magill ST, Susko MS, Braunstein SE, Oberheim Bush NA, Boreta L, Nakamura JL, Villanueva-Meyer JE, Sneed PK, Perry A, McDermott MW, Solomon DA, Theodosopoulos PV, Raleigh DR A Prognostic Gene-Expression Signature and Risk Score for Meningioma Recurrence After Resection.  View on PubMed
  5. Magill ST, Vasudevan HN, Seo K, Villanueva-Meyer JE, Choudhury A, John Liu S, Pekmezci M, Findakly S, Hilz S, Lastella S, Demaree B, Braunstein SE, Bush NAO, Aghi MK, Theodosopoulos PV, Sneed PK, Abate AR, Berger MS, McDermott MW, Lim DA, Ullian EM, Costello JF, Raleigh DR Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma.  View on PubMed
  6. Haddad AF, Young JS, Kanungo I, Sudhir S, Chen JS, Raleigh DR, Magill ST, McDermott MW, Aghi MK WHO Grade I Meningioma Recurrence: Identifying High Risk Patients Using Histopathological Features and the MIB-1 Index.  View on PubMed
  7. Prager BC, Vasudevan HN, Dixit D, Bernatchez JA, Wu Q, Wallace LC, Bhargava S, Lee D, King BH, Morton AR, Gimple RC, Pekmezci M, Zhu Z, Siqueira-Neto JL, Wang X, Xie Q, Chen C, Barnett GH, Vogelbaum MA, Mack SC, Chavez L, Perry A, Raleigh DR, Rich JN The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies.  View on PubMed
  8. Findakly S, Choudhury A, Daggubati V, Pekmezci M, Lang UE, Raleigh DR Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals.  View on PubMed
  9. Vasudevan HN, Castro MRH, Lee JC, Villanueva-Meyer JE, Bush NAO, McDermott MW, Solomon DA, Perry A, Magill ST, Raleigh DR DNA methylation profiling demonstrates superior diagnostic classification to RNA-sequencing in a case of metastatic meningioma.  View on PubMed
  10. Liu SJ, Malatesta M, Lien BV, Saha P, Thombare SS, Hong SJ, Pedraza L, Koontz M, Seo K, Horlbeck MA, He D, Birk HS, Jain M, Olsen HE, Akeson M, Weissman JS, Monje M, Gupta N, Raleigh DR, Ullian EM, Lim DA CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma.  View on PubMed
  11. Liu SJ, Magill ST, Vasudevan HN, Hilz S, Villanueva-Meyer JE, Lastella S, Daggubati V, Spatz J, Choudhury A, Orr BA, Demaree B, Seo K, Ferris SP, Abate AR, Oberheim Bush NA, Bollen AW, McDermott MW, Costello JF, Raleigh DR Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma.  View on PubMed
  12. Choudhury A, Neumann NM, Raleigh DR, Lang UE Clinical Implications of Primary Cilia in Skin Cancer.  View on PubMed
  13. Chen WC, Baal JD, Baal U, Pai J, Gottschalk A, Boreta L, Braunstein SE, Raleigh DR Stereotactic Body Radiation Therapy of Adrenal Metastases: A Pooled Meta-Analysis and Systematic Review of 39 Studies with 1006 Patients.  View on PubMed
  14. Bhaduri A, Di Lullo E, Jung D, Müller S, Crouch EE, Espinosa CS, Ozawa T, Alvarado B, Spatazza J, Cadwell CR, Wilkins G, Velmeshev D, Liu SJ, Malatesta M, Andrews MG, Mostajo-Radji MA, Huang EJ, Nowakowski TJ, Lim DA, Diaz A, Raleigh DR, Kriegstein AR Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma.  View on PubMed
  15. Choudhury A, Raleigh DR Preclinical models of meningioma: Cell culture and animal systems.  View on PubMed
  16. Susko MS, Garcia MA, Ma L, Nakamura JL, Raleigh DR, Fogh S, Theodosopoulos P, McDermott M, Sneed PK, Braunstein SE Stereotactic Radiosurgery to More Than 10 Brain Metastases: Evidence to Support the Role of Radiosurgery for Ideal Hippocampal Sparing in the Treatment of Multiple Brain Metastases.  View on PubMed
  17. Sloan EA, Cooney T, Oberheim Bush NA, Buerki R, Taylor J, Clarke JL, Torkildson J, Kline C, Reddy A, Mueller S, Banerjee A, Butowski N, Chang S, Mummaneni PV, Chou D, Tan L, Theodosopoulos P, McDermott M, Berger M, Raffel C, Gupta N, Sun PP, Li Y, Shah V, Cha S, Braunstein S, Raleigh DR, Samuel D, Scharnhorst D, Fata C, Guo H, Moes G, Kim JYH, Koschmann C, Van Ziffle J, Onodera C, Devine P, Grenert JP, Lee JC, Pekmezci M, Phillips JJ, Tihan T, Bollen AW, Perry A, Solomon DA Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas.  View on PubMed
  18. Morin O, Chen WC, Nassiri F, Susko M, Magill ST, Vasudevan HN, Wu A, Vallières M, Gennatas ED, Valdes G, Pekmezci M, Alcaide-Leon P, Choudhury A, Interian Y, Mortezavi S, Turgutlu K, Bush NAO, Solberg TD, Braunstein SE, Sneed PK, Perry A, Zadeh G, McDermott MW, Villanueva-Meyer JE, Raleigh DR Integrated models incorporating radiologic and radiomic features predict meningioma grade, local failure, and overall survival.  View on PubMed
  19. Wang S, Blaha C, Santos R, Huynh T, Hayes TR, Beckford-Vera DR, Blecha JE, Hong AS, Fogarty M, Hope TA, Raleigh DR, Wilson DM, Evans MJ, VanBrocklin HF, Ozawa T, Flavell RR Synthesis and Initial Biological Evaluation of Boron-Containing Prostate-Specific Membrane Antigen Ligands for Treatment of Prostate Cancer Using Boron Neutron Capture Therapy.  View on PubMed
  20. Streckert EMS, Hess K, Sporns PB, Adeli A, Brokinkel C, Kriz J, Holling M, Eich HT, Paulus W, Spille DC, van Eck ATCJ, Raleigh DR, McDermott MW, Stummer W, Brokinkel B Clinical, radiological, and histopathological predictors for long-term prognosis after surgery for atypical meningiomas.  View on PubMed

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