Research Summary

I am an Assistant Professor and Physician Scientist in the Department of Radiation Oncology at the University of California-San Francisco (UCSF), where I specialize in the treatment and investigation of adult and pediatric brain tumors. Eighty percent of my time is protected for laboratory research, and I am also therefore a Principle Investigator in the UCSF Department of Neurological Surgery Brain Tumor Center. My research examines how developmental signaling pathways function in cancer with the overall objectives of shedding light on the fundamental mechanisms of developmental biology, and identifying novel biomarkers and therapeutic targets to improve patient outcomes. To accomplish those goals, my laboratory makes use of biochemistry, molecular biology, cell biology, mouse genetics, genomics, bioinformatics and pharmacology. Our work has identified novel activators and effectors of oncogenic Hedgehog signaling in medulloblastoma, and revealed a FOXM1/WNT signaling axis that underlies meningioma proliferation. Each of these discoveries serves as the foundation for clinical trials of molecular therapy in medulloblastoma and meningioma patients that are currently under development.

Research Funding

  • August 1, 2021 - July 31, 2026 - Understanding druggable drivers of meningioma tumorigenesis , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA262311
  • July 1, 2021 - April 30, 2026 - Mechanisms of Hedgehog signaling in glioblastoma , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA251221
  • July 1, 2017 - June 30, 2022 - Understanding How Ciliary Hedgehog Signaling Causes Medulloblastoma , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K08CA212279

Education

University of California-Berkeley, B.A. (Honors), 08/00-05/04, Molecular Cell Biology
University of California-Berkeley B.A. (Honors) 08/00 05/04 Cognitive Science
University of Chicago-Chicago M.D. 05/05 06/12 Medicine
University of Chicago-Chicago Ph.D. 07/07 05/10 Pathology
Kaiser Permanente-Santa Clara, Intern, 07/12-06/13, Internal Medicine
University of California-San Francisco, Resident, 07/13-06/17, Radiation Oncology
University of California-San Francisco, Postdoctoral Fellow, 01/15-06/17, Cancer Biology

Honors & Awards

  • 2009
    FASEB Travel Award, FASEB Gastrointestinal Tract XIII Meeting
  • 2009
    DDW Poster of Distinction, Digestive Disease Week Annual Meeting
  • 2009
    Outstanding Graduate Student Oral Presentation, University of Chicago
  • 2010
    Takeda Travel Award, Experimental Biology Annual Meeting
  • 2011
    Naomi Ragins Goldsmith Career Development Award, University of Chicago
  • 2012
    Outstanding Performance in Radiation and Cellular Oncology, University of Chicago
  • 2013
    Teaching Award in Recognition of Excellent Medical Student Education, Kaiser Permanente
  • 2015
    Clinical & Translational Science Institute Resident Research Travel Program Award, UCSF
  • 2016
    Career Award for Medical Scientists Semifinalist, Burroughs Wellcome Fund
  • 2016
    Radiological Society of North America Roentgen Resident/Fellow Research Award, UCSF
  • 2016
    Biology Abstract Travel Award, American Society for Radiation Oncology Annual Meeting
  • 2016
    Poster Walk Award, Association of Residents in Radiation Oncology
  • 2016
    Top Young Investigator Awardee, ASCO Scientific Career Development Retreat
  • 2017
    Young Oncologist Travel Grant Recipient, American Radium Society Annual Meeting
  • 2017
    Poster of Distinction, American Radium Society Annual Meeting
  • 2017
    Biology Abstract Travel Award, American Society for Radiation Oncology Annual Meeting

Selected Publications

  1. Sneed PK, Chan JW, Ma L, Braunstein SE, Theodosopoulos PV, Fogh SE, Nakamura JL, Boreta L, Raleigh DR, Ziemer BP, Morin O, Hervey-Jumper SL, McDermott MW. Adverse radiation effect and freedom from progression following repeat stereotactic radiosurgery for brain metastases. J Neurosurg. 2022 May 20; 1-9.  View on PubMed
  2. Choudhury A, Magill ST, Eaton CD, Prager BC, Chen WC, Cady MA, Seo K, Lucas CG, Casey-Clyde TJ, Vasudevan HN, Liu SJ, Villanueva-Meyer JE, Lam TC, Pu JK, Li LF, Leung GK, Swaney DL, Zhang MY, Chan JW, Qiu Z, Martin MV, Susko MS, Braunstein SE, Bush NAO, Schulte JD, Butowski N, Sneed PK, Berger MS, Krogan NJ, Perry A, Phillips JJ, Solomon DA, Costello JF, McDermott MW, Rich JN, Raleigh DR. Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities. Nat Genet. 2022 May 09.  View on PubMed
  3. Driver J, Hoffman SE, Tavakol S, Woodward E, Maury EA, Bhave V, Greenwald NF, Nassiri F, Aldape K, Zadeh G, Choudhury A, Vasudevan HN, Magill ST, Raleigh DR, Abedalthagafi M, Aizer AA, Alexander BM, Ligon KL, Reardon DA, Wen PY, Al-Mefty O, Ligon AH, Dubuc AM, Beroukhim R, Claus EB, Dunn IF, Santagata S, Linda Bi W. A molecularly integrated grade for meningioma. Neuro Oncol. 2022 May 04; 24(5):796-808.  View on PubMed
  4. Lo M, Sharir A, Paul MD, Torosyan H, Agnew C, Li A, Neben C, Marangoni P, Xu L, Raleigh DR, Jura N, Klein OD. CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids. Nat Commun. 2022 May 03; 13(1):2407.  View on PubMed
  5. Chen WC, Lafreniere M, Phuong C, Liu SJ, Baal JD, Lometti M, Morin O, Ziemer B, Vasudevan HN, Lucas CG, Hervey-Jumper SL, Theodosopoulos PV, Magill ST, Fogh S, Nakamura JL, Boreta L, Sneed PK, McDermott MW, Raleigh DR, Braunstein SE. Resection with intraoperative cesium-131 brachytherapy as salvage therapy for recurrent brain tumors. J Neurosurg. 2022 Jan 21; 1-7.  View on PubMed
  6. Babikir H, Wang L, Shamardani K, Catalan F, Sudhir S, Aghi MK, Raleigh DR, Phillips JJ, Diaz AA. ATRX regulates glial identity and the tumor microenvironment in IDH-mutant glioma. Genome Biol. 2021 11 11; 22(1):311.  View on PubMed
  7. Meher N, Seo K, Wang S, Bidkar AP, Fogarty M, Dhrona S, Huang X, Tang R, Blaha C, Evans MJ, Raleigh DR, Jun YW, VanBrocklin HF, Desai TA, Wilson DM, Ozawa T, Flavell RR. Synthesis and Preliminary Biological Assessment of Carborane-Loaded Theranostic Nanoparticles to Target Prostate-Specific Membrane Antigen. ACS Appl Mater Interfaces. 2021 Nov 24; 13(46):54739-54752.  View on PubMed
  8. Haddad AF, Young JS, Amara D, Berger MS, Raleigh DR, Aghi MK, Butowski NA. Mouse models of glioblastoma for the evaluation of novel therapeutic strategies. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab100.  View on PubMed
  9. Chen WC, Baal UH, Baal JD, Pai JS, Boreta L, Braunstein SE, Raleigh DR. Efficacy and Safety of Stereotactic Radiosurgery for Brainstem Metastases: A Systematic Review and Meta-analysis. JAMA Oncol. 2021 Jul 01; 7(7):1033-1040.  View on PubMed
  10. Ni L, Thomas HR, Raleigh DR, Boreta LC, Park CC, Braunstein SE. Residents-as-Teachers Curriculum for Radiation Oncology: A Targeted Needs Assessment. Int J Radiat Oncol Biol Phys. 2021 11 01; 111(3):638-642.  View on PubMed
  11. Susko MS, Chen WC, Vasudevan HN, Magill ST, Lucas CG, Oberheim Bush NA, Solomon DA, Theodosopoulos PV, McDermott MW, Villanueva-Meyer JE, Boreta L, Nakamura JL, Sneed PK, Braunstein SE, Raleigh DR. Letter: Patterns of Intermediate- and High-Risk Meningioma Recurrence After Treatment With Postoperative External Beam Radiotherapy. Neurosurgery. 2021 06 15; 89(1):E99-E101.  View on PubMed
  12. Bush NAO, Young JS, Zhang Y, Dalle Ore CL, Molinaro AM, Taylor J, Clarke J, Prados M, Braunstein SE, Raleigh DR, Chang SM, Berger MS, Butowski NA. A single institution retrospective analysis on survival based on treatment paradigms for patients with anaplastic oligodendroglioma. J Neurooncol. 2021 Jul; 153(3):447-454.  View on PubMed
  13. Daggubati V, Raleigh DR, Sever N. Sterol regulation of developmental and oncogenic Hedgehog signaling. Biochem Pharmacol. 2022 02; 196:114647.  View on PubMed
  14. Daggubati V, Hochstelter J, Bommireddy A, Choudhury A, Krup AL, Kaur P, Tong P, Li A, Xu L, Reiter JF, Raleigh DR. Smoothened-activating lipids drive resistance to CDK4/6 inhibition in Hedgehog-associated medulloblastoma cells and preclinical models. J Clin Invest. 2021 03 15; 131(6).  View on PubMed
  15. Vasudevan HN, Lucas CG, Villanueva-Meyer JE, Theodosopoulos PV, Raleigh DR. Genetic Events and Signaling Mechanisms Underlying Schwann Cell Fate in Development and Cancer. Neurosurgery. 2021 01 13; 88(2):234-245.  View on PubMed
  16. Findakly S, Daggubati V, Garcia G, LaStella SA, Choudhury A, Tran C, Li A, Tong P, Garcia JQ, Puri N, Reiter JF, Xu L, Raleigh DR. Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway. J Cell Biol. 2021 01 04; 220(1).  View on PubMed
  17. Chen WC, Vasudevan HN, Choudhury A, Pekmezci M, Lucas CG, Phillips J, Magill ST, Susko MS, Braunstein SE, Oberheim Bush NA, Boreta L, Nakamura JL, Villanueva-Meyer JE, Sneed PK, Perry A, McDermott MW, Solomon DA, Theodosopoulos PV, Raleigh DR. A Prognostic Gene-Expression Signature and Risk Score for Meningioma Recurrence After Resection. Neurosurgery. 2020 12 15; 88(1):202-210.  View on PubMed
  18. Lucas CG, Vasudevan HN, Chen WC, Magill ST, Braunstein SE, Jacques L, Dahiya S, Rodriguez FJ, Horvai AE, Perry A, Pekmezci M, Raleigh DR. Histopathologic findings in malignant peripheral nerve sheath tumor predict response to radiotherapy and overall survival. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa131.  View on PubMed
  19. Magill ST, Vasudevan HN, Seo K, Villanueva-Meyer JE, Choudhury A, John Liu S, Pekmezci M, Findakly S, Hilz S, Lastella S, Demaree B, Braunstein SE, Bush NAO, Aghi MK, Theodosopoulos PV, Sneed PK, Abate AR, Berger MS, McDermott MW, Lim DA, Ullian EM, Costello JF, Raleigh DR. Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma. Nat Commun. 2020 09 23; 11(1):4803.  View on PubMed
  20. Haddad AF, Young JS, Kanungo I, Sudhir S, Chen JS, Raleigh DR, Magill ST, McDermott MW, Aghi MK. WHO Grade I Meningioma Recurrence: Identifying High Risk Patients Using Histopathological Features and the MIB-1 Index. Front Oncol. 2020; 10:1522.  View on PubMed

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