Research Summary

I am one of the senior solid tumor faculty at UCSF, having joined the institution in 2019. My scholarly and clinical practice have focused on the treatment of pediatric liver cancers and rare cancers. I was the US National PI for the International Hepatoblastoma therapeutic trials, SIOPEL 4 and SIOPEL 6.I am currently the senior sub-PI for the Hepatocellular Carcinoma treatment arm of the Pediatric Hepatic tumors International Therapeutic Trial (PHITT). I am also the Co-chair of the Children's Hepatic tumors International Collaboration (CHIC), the largest extant database for pediatric rare tumors.
I facilitate an International Hepatobiliary Multicenter Tumor Board, where we consider therapeutic strategies for children with relapsed and refractory liver cancers from around the world, with expert participants from North America, Europe, and Asia.


  • Johns Hopkins University, Baltimore, BA, 1986 Biology, Biomedical Engineering
  • Washington University, St. Louis, MD, 1990, Medicine
  • St. Louis Children’s Hospital at Washington University, St. Louis, 1991, Intern, Pediatrics
  • Children’s Hospital at Washington University, St. Louis, 1993, Resident, Pediatrics
  • Lucille Packard Children’s Hospital, Palo Alto, 1996, Fellow, Pediatric Hematology-Oncology
  • Stanford University, 1996, Fellow, Pediatric Hematology-Oncology

Honors & Awards

  • 1998
    C. John Tupper Award for teaching Excellence, UC Davis School of Medicine

Selected Publications

  1. Trobaugh-Lotrario AD, Maibach R, Aronson DC, Rangaswami A, Häberle B, O'Neill AF, Schmid I, Ansari M, Hishiki T, Ranganathan S, Alaggio R, de Krijger RR, Tanaka Y, Cho SJ, Vokuhl C, Maxwell R, Krailo M, Hiyama E, Czauderna P, Finegold M, Feusner JH, Malogolowkin MH, Meyers RL, Lopez-Terrada D. Outcomes of Patients Treated for Hepatoblastoma with Low Alpha-Fetoprotein and/or Small Cell Undifferentiated Histology: A Report from the Children's Hepatic Tumors International Collaboration (CHIC). Cancers (Basel). 2023 Jan 11; 15(2).  View on PubMed
  2. Nelson AT, Harris AK, Watson D, Miniati D, Finch M, Kamihara J, Mitchell SG, Wilson DB, Gettinger K, Rangaswami AA, Campos JM, Lederman S, Feltis BA, Vasta LM, Harney LA, Stewart DR, Dehner LP, Messinger YH, Hill DA, Schultz KAP. Type I and Ir pleuropulmonary blastoma (PPB): A report from the International PPB/DICER1 Registry. Cancer. 2023 02 15; 129(4):600-613.  View on PubMed
  3. Schultz KAP, Harris AK, Nelson AT, Watson D, Lucas JT, Miniati D, Stewart DR, Hagedorn KN, Mize W, Kamihara J, Mitchell SG, Wilson DB, Gettinger K, Rangaswami AA, Harney LA, Rodriguez Galindo C, Bisogno G, Dehner LP, Hill DA, Messinger YH. Outcomes for Children With Type II and Type III Pleuropulmonary Blastoma Following Chemotherapy: A Report From the International PPB/DICER1 Registry. J Clin Oncol. 2023 02 01; 41(4):778-789.  View on PubMed
  4. Song H, Bucher S, Rosenberg K, Tsui M, Burhan D, Hoffman D, Cho SJ, Rangaswami A, Breese M, Leung S, Ventura MVP, Sweet-Cordero EA, Huang FW, Nijagal A, Wang B. Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids. Nat Commun. 2022 08 25; 13(1):4878.  View on PubMed
  5. Sumazin P, Peters TL, Sarabia SF, Kim HR, Urbicain M, Hollingsworth EF, Alvarez KR, Perez CR, Pozza A, Najaf Panah MJ, Epps JL, Scorsone K, Zorman B, Katzenstein H, O'Neill AF, Meyers R, Tiao G, Geller J, Ranganathan S, Rangaswami AA, Woodfield SE, Goss JA, Vasudevan SA, Heczey A, Roy A, Fisher KE, Alaggio R, Patel KR, Finegold MJ, López-Terrada DH. Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults. J Hepatol. 2022 10; 77(4):1026-1037.  View on PubMed
  6. Weiel JJ, Forgo B, Sage J, Rangaswami A, Hazard FK. The Use of Fluorescence in situ Hybridization to Confirm PRKACA Gene Rearrangement in Fibrolamellar Hepatocellular Carcinoma: A Validation Study. Ann Clin Lab Sci. 2022 May; 52(3):475-483.  View on PubMed
  7. Wu PV, Rangaswami A. Current Approaches in Hepatoblastoma-New Biological Insights to Inform Therapy. Curr Oncol Rep. 2022 09; 24(9):1209-1218.  View on PubMed
  8. Wintering A, Smith S, Fuh B, Rangaswami A, Dahl G, Chien M, Gruber TA, Dang J, Li LS, Lenzen A, Savelli S, Dvorak CC, Agrawal AK, Stieglitz E. Therapy-related myeloid neoplasms resembling juvenile myelomonocytic leukemia: a case series and review of the literature. Pediatr Blood Cancer. 2022 05; 69(5):e29499.  View on PubMed
  9. Shah AT, Azad TD, Breese MR, Chabon JJ, Hamilton EG, Straessler K, Kurtz DM, Leung SG, Spillinger A, Liu HY, Behroozfard IH, Wittber FM, Hazard FK, Cho SJ, Daldrup-Link HE, Vo KT, Rangaswami A, Pribnow A, Spunt SL, Lacayo NJ, Diehn M, Alizadeh AA, Sweet-Cordero EA. A Comprehensive Circulating Tumor DNA Assay for Detection of Translocation and Copy-Number Changes in Pediatric Sarcomas. Mol Cancer Ther. 2021 10; 20(10):2016-2025.  View on PubMed
  10. Hui C, Shin DH, Wakeling A, Donaldson SS, Hazard FK, Rangaswami A, Hiniker SM. Multimodality treatment including whole pleura radiation therapy for DICER1-associated pediatric pleuropulmonary blastoma. Pediatr Blood Cancer. 2021 06; 68(6):e29004.  View on PubMed
  11. Aronson M, Colas C, Shuen A, Hampel H, Foulkes WD, Baris Feldman H, Goldberg Y, Muleris M, Wolfe Schneider K, McGee RB, Jasperson K, Rangaswami A, Brugieres L, Tabori U. Diagnostic criteria for constitutional mismatch repair deficiency (CMMRD): recommendations from the international consensus working group. J Med Genet. 2022 04; 59(4):318-327.  View on PubMed
  12. Haeberle B, Rangaswami A, Krailo M, Czauderna P, Hiyama E, Maibach R, Lopez-Terrada D, Aronson DC, Alaggio R, Ansari M, Malogolowkin MH, Perilongo G, O'Neill AF, Trobaugh-Lotrario AD, Watanabe K, Schmid I, von Schweinitz D, Ranganathan S, Yoshimura K, Hishiki T, Tanaka Y, Piao J, Feng Y, Rinaldi E, Saraceno D, Derosa M, Meyers RL. The importance of age as prognostic factor for the outcome of patients with hepatoblastoma: Analysis from the Children's Hepatic tumors International Collaboration (CHIC) database. Pediatr Blood Cancer. 2020 08; 67(8):e28350.  View on PubMed
  13. Lim TR, Rangaswami AA, Dubin AM, Kapphahn KI, Sakarovitch C, Long J, Motonaga KS, Trela T, Ceresnak SR. QTc Prolongation and Risk of Torsades de Pointes in Hospitalized Pediatric Oncology Patients. J Pediatr. 2020 02; 217:33-38.  View on PubMed
  14. Sanders LM, Rangaswami A, Bjork I, Lam DL, Beale HC, Kephart ET, Durbin A, Learned K, Currie R, Lyle AG, Pfeil J, Shah AT, Lee AG, Leung SG, Behroozfard IH, Breese MR, Peralez J, Hazard FK, Lacayo N, Spunt SL, Haussler D, Salama SR, Sweet-Cordero EA, Vaske OM. Comparative RNA-seq analysis aids in diagnosis of a rare pediatric tumor. Cold Spring Harb Mol Case Stud. 2019 10; 5(5).  View on PubMed
  15. Vaske OM, Bjork I, Salama SR, Beale H, Tayi Shah A, Sanders L, Pfeil J, Lam DL, Learned K, Durbin A, Kephart ET, Currie R, Newton Y, Swatloski T, McColl D, Vivian J, Zhu J, Lee AG, Leung SG, Spillinger A, Liu HY, Liang WS, Byron SA, Berens ME, Resnick AC, Lacayo N, Spunt SL, Rangaswami A, Huynh V, Torno L, Plant A, Kirov I, Zabokrtsky KB, Rassekh SR, Deyell RJ, Laskin J, Marra MA, Sender LS, Mueller S, Sweet-Cordero EA, Goldstein TC, Haussler D. Comparative Tumor RNA Sequencing Analysis for Difficult-to-Treat Pediatric and Young Adult Patients With Cancer. JAMA Netw Open. 2019 10 02; 2(10):e1913968.  View on PubMed
  16. Chen E, Rangaswami A, Esquivel CO, Concepcion W, Lungren M, Thakor AS, Yoo CH, Donaldson SS, Hiniker SM. Orthotopic Liver Transplantation After Stereotactic Body Radiotherapy for Pediatric Hepatocellular Carcinoma with Central Biliary Obstruction and Nodal Involvement. Cureus. 2018 Oct 26; 10(10):e3499.  View on PubMed
  17. Brock PR, Maibach R, Childs M, Rajput K, Roebuck D, Sullivan MJ, Laithier V, Ronghe M, Dall'Igna P, Hiyama E, Brichard B, Skeen J, Mateos ME, Capra M, Rangaswami AA, Ansari M, Rechnitzer C, Veal GJ, Covezzoli A, Brugières L, Perilongo G, Czauderna P, Morland B, Neuwelt EA. Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss. N Engl J Med. 2018 Jun 21; 378(25):2376-2385.  View on PubMed
  18. Weiss KE, Sze DY, Rangaswami AA, Esquivel CO, Concepcion W, Lebowitz EA, Kothary N, Lungren MP. Transarterial chemoembolization in children to treat unresectable hepatocellular carcinoma. Pediatr Transplant. 2018 06; 22(4):e13187.  View on PubMed
  19. Cooney T, Wei MC, Rangaswami A, Xu L, Sage J, Hazard FK. CD47 is not Over-Expressed in Fibrolamellar Hepatocellular Carcinoma. Ann Clin Lab Sci. 2017 Aug; 47(4):395-402.  View on PubMed
  20. Meyers RL, Maibach R, Hiyama E, Häberle B, Krailo M, Rangaswami A, Aronson DC, Malogolowkin MH, Perilongo G, von Schweinitz D, Ansari M, Lopez-Terrada D, Tanaka Y, Alaggio R, Leuschner I, Hishiki T, Schmid I, Watanabe K, Yoshimura K, Feng Y, Rinaldi E, Saraceno D, Derosa M, Czauderna P. Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration. Lancet Oncol. 2017 01; 18(1):122-131.  View on PubMed

Go to UCSF Profiles, powered by CTSI