Research Summary

Jeremy Reiter is the chairperson of the Department of Biochemistry and Biophysics. His lab investigates how cilia form, signal and function in intercellular communication. Their achievements include:
1. The discovery that Smoothened, a critical component of the Hedgehog pathway, localizes to and works in cilia. This was the first demonstration that the Hedgehog signal transduction machinery functions at cilia.
2. They were the first to show that cancers can be ciliated and that cancers can require cilia for growth.
3. They helped show that the region at the base of the cilium called the transition zone is a gate that controls ciliary composition. For example, the transition zone regulates the ciliary localization of Smoothened and, therefore, is required for Hedgehog signaling.
4. They identified many transition zone components and discovered that some ciliopathies are caused by inherited human mutations in these transition zone components.
5. They found a phosphoinositide that marks the ciliary membrane and helps direct which proteins localize to cilia. This was the first identification of a specific cilia-enriched lipid.
6. They investigated how cilia regulate adult tissue homeostasis. Recently, they have shown how cilia of hypothalamic neurons signal to regulate satiety and how cilia restrict adipogenesis.

Research Funding

  • June 1, 2016 - July 31, 2026 - Obesity in Ciliopathies: How Neuronal Primary Cilia Control Appetite , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DK106404
  • August 1, 2015 - July 31, 2025 - UCSF Nutrition Obesity Research Center , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P30DK098722
  • December 1, 2006 - June 30, 2025 - Hedgehog signaling at the cell's antenna: Smoothened and the primary cilium , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AR054396
  • July 1, 1994 - April 30, 2024 - Predoctoral Training in Developmental Biology , Principal Investigator . Sponsor: NIH, Sponsor Award ID: T32HD007470
  • July 18, 2011 - August 31, 2023 - Transition zone control of ciliary signaling , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DE029454
  • May 1, 2021 - April 30, 2022 - Illuminating the function of the understudied kinase DYRK2 in ciliary Hedgehog signal transduction , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R03TR003705
  • December 10, 2016 - November 30, 2021 - Understanding Ciliary Functions in Mammalian Development , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HD089918
  • July 15, 2018 - June 30, 2021 - How Zika virus disrupts neuronal cellular architecture , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21NS104633
  • March 8, 2017 - February 29, 2020 - Restoring ciliogenesis as a novel approach to blocking breast cancer growth , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21CA207659
  • March 23, 2016 - February 29, 2020 - A high content screen dissecting ciliogenesis and oncogenic Hedgehog signaling , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA181231
  • July 18, 2011 - April 30, 2019 - Transition zone control of ciliary signaling , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM095941
  • September 27, 2010 - August 31, 2012 - A novel high content screen for regulators of ciliogenesis and Hedgehog signaling , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21NS066448
  • September 30, 2004 - July 31, 2007 - Embryonic Stem Cell Formation of Definitive Endoderm , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21DK069423
  • February 5, 2003 - January 1, 2004 - Semaphorin-plexin signaling &vertebrate cell movement , Principal Investigator . Sponsor: NIH, Sponsor Award ID: F32HD043591

Education

Yale College, New Haven, CT, BA, 1989-1993, Molecular Biochemistry and Biophysics
University of California, San Francisco, PhD, 1995-1999, Genetics
University of California, San Francisco, MD, 1993-1995, 2000-2001, Medicine
University of California, Berkeley, Postdoctoral Fellowship, 2001-2003, Developmental Biology
University of California, San Francisco, UCSF Fellow, 2003-2006, Developmental and Stem Cell Biology Program

Honors & Awards

  • 2001
    Alpha Omega Alpha Honor Medical Society
  • 2004
    March of Dimes Basil O’Connor Research Award
  • 2005
    Burroughs Wellcome Fund Career Award in the Biomedical Sciences
  • 2007
    Packard Fellow for Science and Engineering
  • 2009
    Presidential Early Career Award for Scientists and Engineers (PECASE)
  • 2010
    American Society for Clinical Investigation (ASCI)
  • 2011
    National Academy of Science Kavli Fellow
  • 2012
    American Association of Anatomists R. R. Bensley Award in Cell Biology
  • 2015
    Grace Boyer Junior Faculty Endowed Chair
  • 2017
    Albert Bowers Endowed Chair
  • 2017
    Achievement Rewards for College Scientists (ARCS) Distinguished Scholar Alumni Award

Selected Publications

  1. Jung HJ, Dixon EE, Coleman R, Watnick T, Reiter J, Outeda P, Cebotaru V, Woodward OM, Welling PA. Polycystin-2 dependent transcriptome reveals early response of autosomal dominant polycystic kidney disease. Physiol Genomics. 2023 Sep 18.  View on PubMed
  2. Clearman KR, Timpratoom N, Patel D, Rains AB, Haycraft CJ, Croyle MJ, Reiter JF, Yoder BK. Rab35 is required for embryonic development and kidney and ureter homeostasis through regulation of epithelial cell junctions. bioRxiv. 2023 Sep 12.  View on PubMed
  3. Coyle MC, Tajima AM, Leon F, Choksi SP, Yang A, Espinoza S, Hughes TR, Reiter JF, Booth DS, King N. An RFX transcription factor regulates ciliogenesis in the closest living relatives of animals. Curr Biol. 2023 09 11; 33(17):3747-3758.e9.  View on PubMed
  4. Daggubati V, Vykunta A, Choudhury A, Qadeer Z, Mirchia K, Saulnier O, Zakimi N, Hines K, Paul M, Wang L, Jura N, Xu L, Reiter J, Taylor M, Weiss W, Raleigh D. Hedgehog target genes regulate lipid metabolism to drive basal cell carcinoma and medulloblastoma. Res Sq. 2023 Aug 03.  View on PubMed
  5. Derderian C, Canales GI, Reiter JF. Seriously cilia: A tiny organelle illuminates evolution, disease, and intercellular communication. Dev Cell. 2023 08 07; 58(15):1333-1349.  View on PubMed
  6. Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter J, Dror RO, Evers AS, Mukhopadhyay S, Manglik A. GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. bioRxiv. 2023 May 24.  View on PubMed
  7. Brewer KM, Engle SE, Bansal R, Brewer KK, Jasso KR, McIntyre JC, Vaisse C, Reiter JF, Berbari NF. Physiological Condition-Dependent Changes in Ciliary GPCR Localization in the Brain. eNeuro. 2023 03; 10(3).  View on PubMed
  8. Hall EA, Kumar D, Prosser SL, Yeyati PL, Herranz-Pérez V, García-Verdugo JM, Rose L, McKie L, Dodd DO, Tennant PA, Megaw R, Murphy LC, Ferreira MF, Grimes G, Williams L, Quidwai T, Pelletier L, Reiter JF, Mill P. Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis. Elife. 2023 02 15; 12.  View on PubMed
  9. Bernard A, Ojeda Naharros I, Yue X, Mifsud F, Blake A, Bourgain-Guglielmetti F, Ciprin J, Zhang S, McDaid E, Kim K, Nachury MV, Reiter JF, Vaisse C. MRAP2 regulates energy homeostasis by promoting primary cilia localization of MC4R. JCI Insight. 2023 Jan 24; 8(2).  View on PubMed
  10. Kodani A, Knopp KA, Di Lullo E, Retallack H, Kriegstein AR, DeRisi JL, Reiter JF. Zika virus alters centrosome organization to suppress the innate immune response. EMBO Rep. 2022 09 05; 23(9):e52211.  View on PubMed
  11. Kumar D, Reiter JF. A kinesin mimics DNA. Nat Cell Biol. 2022 07; 24(7):1015-1016.  View on PubMed
  12. Nguyen TD, Truong ME, Reiter JF. The Intimate Connection Between Lipids and Hedgehog Signaling. Front Cell Dev Biol. 2022; 10:876815.  View on PubMed
  13. Tabula Sapiens Consortium*, Jones RC, Karkanias J, Krasnow MA, Pisco AO, Quake SR, Salzman J, Yosef N, Bulthaup B, Brown P, Harper W, Hemenez M, Ponnusamy R, Salehi A, Sanagavarapu BA, Spallino E, Aaron KA, Concepcion W, Gardner JM, Kelly B, Neidlinger N, Wang Z, Crasta S, Kolluru S, Morri M, Tan SY, Travaglini KJ, Xu C, Alcántara-Hernández M, Almanzar N, Antony J, Beyersdorf B, Burhan D, Calcuttawala K, Carter MM, Chan CKF, Chang CA, Chang S, Colville A, Culver RN, Cvijovic I, D'Amato G, Ezran C, Galdos FX, Gillich A, Goodyer WR, Hang Y, Hayashi A, Houshdaran S, Huang X, Irwin JC, Jang S, Juanico JV, Kershner AM, Kim S, Kiss B, Kong W, Kumar ME, Kuo AH, Li B, Loeb GB, Lu WJ, Mantri S, Markovic M, McAlpine PL, de Morree A, Mrouj K, Mukherjee S, Muser T, Neuhöfer P, Nguyen TD, Perez K, Puluca N, Qi Z, Rao P, Raquer-McKay H, Schaum N, Scott B, Seddighzadeh B, Segal J, Sen S, Sikandar S, Spencer SP, Steffes LC, Subramaniam VR, Swarup A, Swift M, Van Treuren W, Trimm E, Veizades S, Vijayakumar S, Vo KC, Vorperian SK, Wang W, Weinstein HNW, Winkler J, Wu TTH, Xie J, Yung AR, Zhang Y, Detweiler AM, Mekonen H, Neff NF, Sit RV, Tan M, Yan J, Bean GR, Charu V, Forgó E, Martin BA, Ozawa MG, Silva O, Toland A, Vemuri VNP, Afik S, Awayan K, Botvinnik OB, Byrne A, Chen M, Dehghannasiri R, Gayoso A, Granados AA, Li Q, Mahmoudabadi G, McGeever A, Olivieri JE, Park M, Ravikumar N, Stanley G, Tan W, Tarashansky AJ, Vanheusden R, Wang P, Wang S, Xing G, Dethlefsen L, Ezran C, Gillich A, Hang Y, Ho PY, Irwin JC, Jang S, Leylek R, Liu S, Maltzman JS, Metzger RJ, Phansalkar R, Sasagawa K, Sinha R, Song H, Swarup A, Trimm E, Veizades S, Wang B, Beachy PA, Clarke MF, Giudice LC, Huang FW, Huang KC, Idoyaga J, Kim SK, Kuo CS, Nguyen P, Rando TA, Red-Horse K, Reiter J, Relman DA, Sonnenburg JL, Wu A, Wu SM, Wyss-Coray T. The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. Science. 2022 05 13; 376(6594):eabl4896.  View on PubMed
  14. Xie C, Abrams SR, Herranz-Pérez V, García-Verdugo JM, Reiter JF. Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity. Dev Cell. 2021 12 20; 56(24):3334-3348.e6.  View on PubMed
  15. Bentley-Ford MR, Andersen RS, Croyle MJ, Haycraft CJ, Clearman KR, Foote JB, Reiter JF, Yoder BK. ATXN10 Is Required for Embryonic Heart Development and Maintenance of Epithelial Cell Phenotypes in the Adult Kidney and Pancreas. Front Cell Dev Biol. 2021; 9:705182.  View on PubMed
  16. Yang Y, Paivinen P, Xie C, Krup AL, Makela TP, Mostov KE, Reiter JF. Ciliary Hedgehog signaling patterns the digestive system to generate mechanical forces driving elongation. Nat Commun. 2021 12 10; 12(1):7186.  View on PubMed
  17. Abrams SR, Reiter JF. Ciliary Hedgehog signaling regulates cell survival to build the facial midline. Elife. 2021 10 21; 10.  View on PubMed
  18. Kumar D, Rains A, Herranz-Pérez V, Lu Q, Shi X, Swaney DL, Stevenson E, Krogan NJ, Huang B, Westlake C, Garcia-Verdugo JM, Yoder BK, Reiter JF. A ciliopathy complex builds distal appendages to initiate ciliogenesis. J Cell Biol. 2021 09 06; 220(9).  View on PubMed
  19. Shi X, Li Q, Dai Z, Tran AA, Feng S, Ramirez AD, Lin Z, Wang X, Chow TT, Chen J, Kumar D, McColloch AR, Reiter JF, Huang EJ, Seiple IB, Huang B. Label-retention expansion microscopy. J Cell Biol. 2021 09 06; 220(9).  View on PubMed
  20. Wang Y, Bernard A, Comblain F, Yue X, Paillart C, Zhang S, Reiter JF, Vaisse C. Melanocortin 4 receptor signals at the neuronal primary cilium to control food intake and body weight. J Clin Invest. 2021 05 03; 131(9).  View on PubMed

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