Research Summary

Jeremy Reiter is the chairperson of the Department of Biochemistry and Biophysics. His lab investigates how cilia form, signal and function in intercellular communication. Their achievements include:
1. The discovery that Smoothened, a critical component of the Hedgehog pathway, localizes to and works in cilia. This was the first demonstration that the Hedgehog signal transduction machinery functions at cilia.
2. They were the first to show that cancers can be ciliated and that cancers can require cilia for growth.
3. They helped show that the region at the base of the cilium called the transition zone is a gate that controls ciliary composition. For example, the transition zone regulates the ciliary localization of Smoothened and, therefore, is required for Hedgehog signaling.
4. They identified many transition zone components and discovered that some ciliopathies are caused by inherited human mutations in these transition zone components.
5. They found a phosphoinositide that marks the ciliary membrane and helps direct which proteins localize to cilia. This was the first identification of a specific cilia-enriched lipid.
6. They investigated how cilia regulate adult tissue homeostasis. Recently, they have shown how cilia of hypothalamic neurons signal to regulate satiety and how cilia restrict adipogenesis.

Research Funding

  • July 18, 2011 - August 31, 2023 - Transition zone control of ciliary signaling, Principal Investigator. Sponsor: NIH/NIDCR, Sponsor Award ID: R01DE029454
  • December 10, 2016 - November 30, 2021 - Understanding Ciliary Functions in Mammalian Development, Principal Investigator. Sponsor: NIH/NICHD, Sponsor Award ID: R01HD089918
  • August 1, 2015 - July 31, 2020 - UCSF Nutrition Obesity Research Center, Co-Investigator. Sponsor: NIH/NIDDK, Sponsor Award ID: P30DK098722
  • July 15, 2018 - June 30, 2020 - How Zika virus disrupts neuronal cellular architecture, Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: R21NS104633

Education

Yale College, New Haven, CT, BA, 1989-1993, Molecular Biochemistry and Biophysics
University of California, San Francisco, PhD, 1995-1999, Genetics
University of California, San Francisco, MD, 1993-1995, 2000-2001, Medicine
University of California, Berkeley, Postdoctoral Fellowship, 2001-2003, Developmental Biology
University of California, San Francisco, UCSF Fellow, 2003-2006, Developmental and Stem Cell Biology Program

Honors & Awards

  • 2001
    Alpha Omega Alpha Honor Medical Society
  • 2004
    March of Dimes Basil O’Connor Research Award
  • 2005
    Burroughs Wellcome Fund Career Award in the Biomedical Sciences
  • 2007
    Packard Fellow for Science and Engineering
  • 2009
    Presidential Early Career Award for Scientists and Engineers (PECASE)
  • 2010
    American Society for Clinical Investigation (ASCI)
  • 2011
    National Academy of Science Kavli Fellow
  • 2012
    American Association of Anatomists R. R. Bensley Award in Cell Biology
  • 2015
    Grace Boyer Junior Faculty Endowed Chair
  • 2017
    Albert Bowers Endowed Chair
  • 2017
    Achievement Rewards for College Scientists (ARCS) Distinguished Scholar Alumni Award

Selected Publications

  1. Kumar D, Rains A, Herranz-Pérez V, Lu Q, Shi X, Swaney DL, Stevenson E, Krogan NJ, Huang B, Westlake C, Garcia-Verdugo JM, Yoder BK, Reiter JF. A ciliopathy complex builds distal appendages to initiate ciliogenesis. J Cell Biol. 2021 Sep 06; 220(9).  View on PubMed
  2. Shi X, Li Q, Dai Z, Tran AA, Feng S, Ramirez AD, Lin Z, Wang X, Chow TT, Chen J, Kumar D, McColloch AR, Reiter JF, Huang EJ, Seiple IB, Huang B. Label-retention expansion microscopy. J Cell Biol. 2021 Sep 06; 220(9).  View on PubMed
  3. Wang Y, Bernard A, Comblain F, Yue X, Paillart C, Zhang S, Reiter JF, Vaisse C. Melanocortin 4 receptor signals at the neuronal primary cilium to control food intake and body weight. J Clin Invest. 2021 05 03; 131(9).  View on PubMed
  4. Truong ME, Bilekova S, Choksi SP, Li W, Bugaj LJ, Xu K, Reiter JF. Vertebrate cells differentially interpret ciliary and extraciliary cAMP. Cell. 2021 May 27; 184(11):2911-2926.e18.  View on PubMed
  5. Daggubati V, Hochstelter J, Bommireddy A, Choudhury A, Krup AL, Kaur P, Tong P, Li A, Xu L, Reiter JF, Raleigh DR. Smoothened-activating lipids drive resistance to CDK4/6 inhibition in Hedgehog-associated medulloblastoma cells and preclinical models. J Clin Invest. 2021 Mar 15; 131(6).  View on PubMed
  6. Findakly S, Daggubati V, Garcia G, LaStella SA, Choudhury A, Tran C, Li A, Tong P, Garcia JQ, Puri N, Reiter JF, Xu L, Raleigh DR. Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway. J Cell Biol. 2021 01 04; 220(1).  View on PubMed
  7. Kumar D, Reiter J. How the centriole builds its cilium: of mothers, daughters, and the acquisition of appendages. Curr Opin Struct Biol. 2021 02; 66:41-48.  View on PubMed
  8. Hasenpusch-Theil K, Laclef C, Colligan M, Fitzgerald E, Howe K, Carroll E, Abrams SR, Reiter JF, Schneider-Maunoury S, Theil T. A transient role of the ciliary gene Inpp5e in controlling direct versus indirect neurogenesis in cortical development. Elife. 2020 08 25; 9.  View on PubMed
  9. Hilgendorf KI, Johnson CT, Mezger A, Rice SL, Norris AM, Demeter J, Greenleaf WJ, Reiter JF, Kopinke D, Jackson PK. Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis. Cell. 2019 11 27; 179(6):1289-1305.e21.  View on PubMed
  10. Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Schurmans S, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T. Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision. Cell. 2019 06 27; 178(1):261.  View on PubMed
  11. Kodani A, Moyer T, Chen A, Holland A, Walsh CA, Reiter JF. SFI1 promotes centriole duplication by recruiting USP9X to stabilize the microcephaly protein STIL. J Cell Biol. 2019 07 01; 218(7):2185-2197.  View on PubMed
  12. Bansal R, Engle SE, Antonellis PJ, Whitehouse LS, Baucum AJ, Cummins TR, Reiter JF, Berbari NF. Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures. Front Cell Neurosci. 2019; 13:266.  View on PubMed
  13. Shi X, Garcia G, Wang Y, Reiter JF, Huang B. Deformed alignment of super-resolution images for semi-flexible structures. PLoS One. 2019; 14(3):e0212735.  View on PubMed
  14. Raleigh DR, Reiter JF. Misactivation of Hedgehog signaling causes inherited and sporadic cancers. J Clin Invest. 2019 02 01; 129(2):465-475.  View on PubMed
  15. Raleigh DR, Sever N, Choksi PK, Sigg MA, Hines KM, Thompson BM, Elnatan D, Jaishankar P, Bisignano P, Garcia-Gonzalo FR, Krup AL, Eberl M, Byrne EFX, Siebold C, Wong SY, Renslo AR, Grabe M, McDonald JG, Xu L, Beachy PA, Reiter JF. Cilia-Associated Oxysterols Activate Smoothened. Mol Cell. 2018 10 18; 72(2):316-327.e5.  View on PubMed
  16. Park SM, Lim JS, Ramakrishina S, Kim SH, Kim WK, Lee J, Kang HC, Reiter JF, Kim DS, Kim HH, Lee JH. Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination. Neuron. 2018 07 11; 99(1):83-97.e7.  View on PubMed
  17. Garcia G, Raleigh DR, Reiter JF. How the Ciliary Membrane Is Organized Inside-Out to Communicate Outside-In. Curr Biol. 2018 04 23; 28(8):R421-R434.  View on PubMed
  18. Siljee JE, Wang Y, Bernard AA, Ersoy BA, Zhang S, Marley A, Von Zastrow M, Reiter JF, Vaisse C. Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity. Nat Genet. 2018 02; 50(2):180-185.  View on PubMed
  19. Sigg MA, Menchen T, Lee C, Johnson J, Jungnickel MK, Choksi SP, Garcia G, Busengdal H, Dougherty GW, Pennekamp P, Werner C, Rentzsch F, Florman HM, Krogan N, Wallingford JB, Omran H, Reiter JF. Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways. Dev Cell. 2017 12 18; 43(6):744-762.e11.  View on PubMed
  20. Raleigh DR, Choksi PK, Krup AL, Mayer W, Santos N, Reiter JF. Hedgehog signaling drives medulloblastoma growth via CDK6. J Clin Invest. 2018 01 02; 128(1):120-124.  View on PubMed

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