Research Summary

Dr. Michael Rosenblum is a dermatologist who specializes in caring for patients with inflammatory and autoimmune skin diseases.

One of the world's leading skin immunologists, Rosenblum's research has led to a better understanding of how immune responses are regulated in tissues. He also studies how to use this knowledge to develop better treatments for autoimmune disorders.

After completing a doctorate in immunology at the Medical College of Wisconsin, Rosenblum earned his medical degree from the same institution. He completed a residency in dermatology at UCSF.

Rosenblum is a member of the American Association of Immunologists, Society for Investigative Dermatology, American Academy of Dermatology and Federation of Clinical Immunology Societies. He has co-founded multiple biotech companies that are developing new treatments for autoimmune diseases.

Education

University of Western Ontario, Canada, HBSc, 05/1997, Cell Biology
Medical College of Wisconsin, Milwaukee, PhD, 06/2003, Immunology
Medical College of Wisconsin, Milwaukee, MD, 06/2006, Medicine
University of California, San Francisco, Residency, 07/2010, Dermatology

Honors & Awards

  • 2004
    Outstanding Doctoral Dissertation Award, Medical College of Wisconsin
  • 2006
    Armand J. Quick Award for Outstanding Senior Medical Student in Biochemistry, Medical College of Wisconsin
  • 2014
    NIH Director's New Innovator Award
  • 2015
    Charles & Daneen Stiefel Scholar Award in Autoimmune & Connective Tissue Diseases

Selected Publications

  1. Mahuron KM, Shahid O, Sao P, Wu C, Haugh AM, Huppert LA, Levine LS, Lowe MM, Alvarado M, Micu M, Tsai KK, Chow M, Singer M, Schenkel JM, Sharpe AH, Rosenblum MD, Pauken KE, Daud AI. Single-Cell Analyses Reveal a Functionally Heterogeneous Exhausted CD8+ T-cell Subpopulation That Is Correlated with Response to Checkpoint Therapy in Melanoma. Cancer Res. 2025 Apr 15; 85(8):1424-1440.  View on PubMed
  2. Leboit PE, Patel DU, Cohen JN, Moss MI, Naik HB, Yates AE, Harris HW, Klufas DM, Kim EA, Neuhaus IM, Hansen SL, Kyle RL, Kelly M, Rosenblum MD, Lowe MM. The Inflammatory Landscape of a Whole-Tissue Explant Model of Hidradenitis Suppurativa. Exp Dermatol. 2025 Feb; 34(2):e70057.  View on PubMed
  3. Merrill ED, Prudent V, Moghadam P, Rodriguez A, Hurabielle C, Wells EKC, Basso P, Scharschmidt TC, Rosenblum MD, Molofsky AB, Noble SM. The emerging fungal pathogen Candida auris induces IFNγ to colonize mammalian hair follicles. bioRxiv. 2025 Jan 18.  View on PubMed
  4. Macon CE, Yang A, Patel D, North JP, Rosenblum MD, Cohen JN. CD4+ T Cells Occupy Perivascular and Perifollicular Niches in Healthy Human Skin. Exp Dermatol. 2024 Dec; 33(12):e70023.  View on PubMed
  5. Leboit PE, Patel DU, Cohen JN, Moss MI, Naik HB, Yates AE, Harris HW, Klufas DM, Kim EA, Neuhaus IM, Hansen SL, Kyle RL, Kelly M, Rosenblum MD, Lowe MM. A Novel Whole Tissue Explant Model of Hidradenitis Suppurativa. bioRxiv. 2024 Jul 23.  View on PubMed
  6. Quandt Z, Jacob S, Fadlullah MZH, Wu C, Wu C, Huppert L, Levine LS, Sison P, Tsai KK, Chow M, Kang JH, Hwang J, Lee JC, Oglesby A, Venegas J, Brintz BJ, Tan AC, Anderson MS, Rosenblum MD, Young A, Daud AI. Phase II trial of pembrolizumab, ipilimumab, and aspirin in melanoma: clinical outcomes and translational predictors of response. BJC Rep. 2024 Jun 24; 2(1):46.  View on PubMed
  7. Sommer C, Cohen JN, Dehmel S, Neuhaus V, Schaudien D, Braun A, Sewald K, Rosenblum MD. Interleukin-2-induced skin inflammation. Eur J Immunol. 2024 Apr; 54(4):e2350580.  View on PubMed
  8. Lowe MM, Cohen JN, Moss MI, Clancy S, Adler JP, Yates AE, Naik HB, Yadav R, Pauli M, Taylor I, McKay A, Harris H, Kim E, Hansen SL, Rosenblum MD, Moreau JM. Tertiary lymphoid structures sustain cutaneous B cell activity in hidradenitis suppurativa. JCI Insight. 2024 Feb 08; 9(3).  View on PubMed
  9. Cohen JN, Gouirand V, Macon CE, Lowe MM, Boothby IC, Moreau JM, Gratz IK, Stoecklinger A, Weaver CT, Sharpe AH, Ricardo-Gonzalez RR, Rosenblum MD. Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche. Sci Immunol. 2024 01 05; 9(91):eadh0152.  View on PubMed
  10. Lowe MM, Cohen JN, Moss MI, Clancy S, Adler J, Yates A, Naik HB, Pauli M, Taylor I, McKay A, Harris H, Kim E, Hansen SL, Rosenblum MD, Moreau JM. Tertiary Lymphoid Structures Sustain Cutaneous B cell Activity in Hidradenitis Suppurativa. bioRxiv. 2023 Feb 15.  View on PubMed
  11. Lowe MM, Naik HB, Clancy S, Pauli M, Smith KM, Bi Y, Dunstan R, Gudjonsson JE, Paul M, Harris H, Kim E, Shin US, Ahn R, Liao W, Hansen SL, Rosenblum MD. Immunopathogenesis of hidradenitis suppurativa and response to anti-TNF-α therapy. JCI Insight. 2022 Oct 24; 7(20).  View on PubMed
  12. Moss MI, Pauli M, Moreau JM, Cohen JN, Rosenblum MD, Lowe MM. Xenograft Skin Model to Manipulate Human Immune Responses In Vivo. J Vis Exp. 2022 06 29; (184).  View on PubMed
  13. Moreau JM, Velegraki M, Bolyard C, Rosenblum MD, Li Z. Transforming growth factor-β1 in regulatory T cell biology. Sci Immunol. 2022 03 18; 7(69):eabi4613.  View on PubMed
  14. Gouirand V, Rosenblum MD. MTHFD2, metabolic mastermind of CD4+ T cell destiny. Sci Immunol. 2022 03 04; 7(69):eabo6765.  View on PubMed
  15. Glasgow JE, Byrnes JR, Barbee SD, Moreau JM, Rosenblum MD, Wells JA. Identifying and antagonizing the interactions between layilin and glycosylated collagens. Cell Chem Biol. 2022 04 21; 29(4):597-604.e7.  View on PubMed
  16. Ahn RS, Taravati K, Lai K, Lee KM, Nititham J, Gupta R, Chang DS, Arron ST, Rosenblum M, Liao W. Author Correction: Transcriptional landscape of epithelial and immune cell populations revealed through FACS-seq of healthy human skin. Sci Rep. 2022 Jan 17; 12(1):1172.  View on PubMed
  17. Liu J, Chang HW, Grewal R, Cummins DD, Bui A, Beck KM, Sekhon S, Yan D, Huang ZM, Schmidt TH, Yang EJ, Sanchez IM, Nakamura M, Bhattarai S, Thibodeaux Q, Ahn R, Pauli M, Bhutani T, Rosenblum MD, Liao W. Transcriptomic Profiling of Plaque Psoriasis and Cutaneous T-Cell Subsets during Treatment with Secukinumab. JID Innov. 2022 May; 2(3):100094.  View on PubMed
  18. Boothby IC, Kinet MJ, Boda DP, Kwan EY, Clancy S, Cohen JN, Habrylo I, Lowe MM, Pauli M, Yates AE, Chan JD, Harris HW, Neuhaus IM, McCalmont TH, Molofsky AB, Rosenblum MD. Early-life inflammation primes a T helper 2 cell-fibroblast niche in skin. Nature. 2021 11; 599(7886):667-672.  View on PubMed
  19. Gouirand V, Rosenblum MD. Tregs and inflammation-bring it on! Sci Immunol. 2021 10; 6(64):eabm5116.  View on PubMed
  20. Mehta P, Gouirand V, Boda DP, Zhang J, Gearty SV, Zirak B, Lowe MM, Clancy S, Boothby I, Mahuron KM, Fries A, Krummel MF, Mankoo P, Chang HW, Liu J, Moreau JM, Scharschmidt TC, Daud A, Kim E, Neuhaus IM, Harris HW, Liao W, Rosenblum MD. Layilin Anchors Regulatory T Cells in Skin. J Immunol. 2021 10 01; 207(7):1763-1775.  View on PubMed

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