Kole Roybal, PhD

Education

Austin College, B.A., 05/2005, Biology
UT Southwestern Medical Center at Dallas, Ph.D., 01/2013, Molecular Immunology

Honors & Awards

• 2007
  Ruth L. Kirschstein National Research Service Award, National Institutes of Health
• 2011
  Eliot Golding’s Award for thesis in Immunology, UT Southwestern Medical Center
• 2012
  Dean’s Award for Academic and Research Excellence, UT Southwestern Medical Center
• 2016
  Keynote Address at the UAB Comprehensive Cancer Center Retreat
• 2017
  Named to first cohort of Chan Zuckerberg Biohub Investigators

Selected Publications

1. Hyrenius-Wittsten A, Su Y, Park M, Garcia JM, Alavi J, Perry N, Montgomery G, Liu B, Roybal KT SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models.  View on PubMed
2. Choe JH, Watchmaker PB, Simic MS, Gilbert RD, Li AW, Krasnow NA, Downey KM, Yu W, Carrera DA, Celli A, Cho J, Briones JD, Duecker JM, Goretsky YE, Dannenfelser R, Cardarelli L, Troyanskaya O, Sidhu SS, Roybal KT, Okada H, Lim WA SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma.  View on PubMed
3. Huang X, Williams JZ, Chang R, Li Z, Burnett CE, Hernandez-Lopez R, Setiady I, Gai E, Patterson DM, Yu W, Roybal KT, Lim WA, Desai TA DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation.  View on PubMed
4. Williams JZ, Allen GM, Shah D, Sterin IS, Kim KH, Garcia VP, Shavey GE, Yu W, Puig-Saus C, Tsoi J, Ribas A, Roybal KT, Lim WA Precise T cell recognition programs designed by transcriptionally linking multiple receptors.  View on PubMed
5. Payal Watchmaker, Joseph Choe, Milos Simic, Ryan Gilbert, Aileen li, Nira Krasnow, Diego Carrera, Wei Yu, Kira Downey, Anna Celli, Juhyun Cho, Jessica Briones, Ruth Dannenfelser, Lia Cardarelli, Sachdev Sidhu, Kole Roybal, Wendell Lim, Hideho Okada IMMU-33. MULTI-ANTIGEN RECOGNITION CIRCUITS OVERCOME CHALLENGES OF SPECIFICITY, HETEROGENEITY, AND DURABILITY IN T-CELL THERAPY FOR GLIOBLASTOMA.  View on PubMed
6. August Dietrich, Cassandra Burnett, Thomas Martin, Arun Wiita, Kole Roybal, Justin Eyquem MM-378: Inhibitory and Stimulatory Interplay Between Myeloma Tumor and T Cells.  View on PubMed
7. Ramkumar P, Abarientos AB, Tian R, Seyler M, Leong JT, Chen M, Choudhry P, Hechler T, Shah N, Wong SW, Martin TG, Wolf JL, Roybal KT, Pahl A, Taunton J, Wiita AP, Kampmann M CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma.  View on PubMed
8. Landgraf KE, Williams SR, Steiger D, Gebhart D, Lok S, Martin DW, Roybal KT, Kim KC convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting.  View on PubMed
9. Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, Ye CJ, Roybal K, Shifrut E, Marson A Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies.  View on PubMed
10. Payal Watchmaker, Joseph Choe, Diego Carrera, Ryan Gilbert, Wei Yu, Kira Downey, Kole Roybal, Wendell Lim, Hideho Okada IMMU-21. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION.  View on PubMed
11. Hyrenius-Wittsten A, Roybal KT Paving New Roads for CARs.  View on PubMed
12. Azimi CS, Tang Q, Roybal KT, Bluestone JA NextGen cell-based immunotherapies in cancer and other immune disorders.  View on PubMed
13. Pai CS, Huang JT, Lu X, Simons DM, Park C, Chang A, Tamaki W, Liu E, Roybal KT, Seagal J, Chen M, Hagihara K, Wei XX, DuPage M, Kwek SS, Oh DY, Daud A, Tsai KK, Wu C, Zhang L, Fasso M, Sachidanandam R, Jayaprakash A, Lin I, Casbon AJ, Kinsbury GA, Fong L Clonal Deletion of Tumor-Specific T Cells by Interferon-? Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade.  View on PubMed
14. Shalini T. Low-Nam, Jenny JY Lin, Darren B. McAffee, Steven A. Alvarez, Scott D. Hansen, Kole T. Roybal, Jay T. Groves Beyond the TCR, Antigen Discrimination in T Cells Continues in the LAT:GRB2:SOS Protein Condensate.  View on PubMed
15. Poornima Ramkumar, Jaime Leong, Meghan Seyler, Stratton J Georgoulis, Axel Hyrenius Wittsten, Priya Choudhry, Kole Roybal, Arun P Wiita, Martin Kampmann Identifying Factors in Multiple Myeloma Controlling Response to B-Cell Maturation Antigen (BCMA)-Targeted Immunotherapy Using CRISPR-Based Functional Genomics.  View on PubMed
16. Payal Watchmaker, Joseph Choe, Diego Carrera, Kira Downey, Maryam Shahin, Kole Roybal, Wendell Lim, Hideho Okada IMMU-57. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION.  View on PubMed
17. Roybal KT Refining cell therapy.  View on PubMed
18. Roybal KT, Lim WA Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities.  View on PubMed
19. Rupp LJ, Schumann K, Roybal KT, Gate RE, Ye CJ, Lim WA, Marson A CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells.  View on PubMed
20. Roybal KT, Williams JZ, Morsut L, Rupp LJ, Kolinko I, Choe JH, Walker WJ, McNally KA, Lim WA Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors.  View on PubMed

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