Hilde Schjerven, PhD
Assistant Professor, Laboratory Medicine, UCSF
The development of blood cells (hematopoiesis) depends on a complex series of events that involves many regulatory processes. Blood cancer or immunological diseases can develop if these developing cells have loss of function or gain of function mutations in genes that control development, function, growth or survival.
Ikaros (encoded by the IKZF1 gene) is a transcription factor that is required for proper development of many different blood cell lineages. It is also an important tumor suppressor in certain subtypes of pre-B ALL (leukemia) and is implicated in other human immunological diseases through recent GWAS studies.
The overall research interest is in transcriptional regulation in the immune system during development and disease, and the current ongoing and proposed future research is focused on the role of the zinc finger (ZnF) transcription factor Ikaros. Studies use in vitro and in vivo models and also include the use of genome-wide analysis of DNA-binding and chromatin status (ChIP-Seq) as well as gene expression analysis (RNA-Seq). By increasing our knowledge about the molecular mechanism of action of key transcription factors in both normal development and disease, we might guide the development of targeted therapies for diseases where known transcriptional regulators are mutated.
Norwegian University of Sports, 06/92, One-Year Study
Norwegian University of Science and Technology (NTNU), Department of Chemical Engineering, M.Sc. “Sivilingeniør” (Master of Science), 06/96, Biotechnology
One year exchange student at University of Wisconsin, Madison, 06/96, One year exchange Study
University of Oslo, Norway, Faculty of Medicine, Ph.D., 06/03, Molecular Immunology