Research Funding

  • August 1, 2018 - July 31, 2023 - Platforms for the Synthesis of Bacterial Protein Synthesis Inhibitors , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R35GM128656
  • September 1, 2011 - August 31, 2014 - Preparation of a Solid-Phase Polyketide Synthase Mimic , Principal Investigator . Sponsor: NIH, Sponsor Award ID: F32GM099233


Postdoctoral, 2015 - Chemistry and Chemical Biology, Harvard University
Ph.D., 2011 - Chemistry, The Scripps Research Institute
BS, 2006 - Chemistry, UC Berkeley

Honors & Awards

  • 2021
    Invited Speaker, ACS National Meeting
  • 2021
    Amgen Young Investigator Award
  • 2021
    Camille Dreyfus Teacher Scholar Award
  • 2020
    Invited Speaker, ACS National Meeting
  • 2019
    UCSF Catalyst Award for Translational Research
  • 2019
    UCSF Program for Breakthroughs in Biomedical Research, New Frontier Research Award
  • 2018
    Packard Fellowship in Science and Engineering
  • 2018
    Beckman Young Investigator’s Award
  • 2018
    NIH NIGMS Maximizing Investigators’ Research Award (MIRA)

Selected Publications

  1. Díaz RE, Ecker AK, Correy GJ, Asthana P, Young ID, Faust B, Thompson MC, Seiple IB, Van Dyken SJ, Locksley RM, Fraser JS. Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase. bioRxiv. 2023 Jun 28.  View on PubMed
  2. Tolani B, Celli A, Yao Y, Tan YZ, Fetter R, Liem CR, de Smith AJ, Vasanthakumar T, Bisignano P, Cotton AD, Seiple IB, Rubinstein JL, Jost M, Weissman JS. Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice. Nat Biotechnol. 2022 Jul 25.  View on PubMed
  3. Gramespacher JA, Cotton AD, Burroughs PWW, Seiple IB, Wells JA. Roadmap for Optimizing and Broadening Antibody-Based PROTACs for Degradation of Cell Surface Proteins. ACS Chem Biol. 2022 05 20; 17(5):1259-1268.  View on PubMed
  4. Prasad NK, Seiple IB, Cirz RT, Rosenberg OS. Leaks in the Pipeline: a Failure Analysis of Gram-Negative Antibiotic Development from 2010 to 2020. Antimicrob Agents Chemother. 2022 05 17; 66(5):e0005422.  View on PubMed
  5. Cotton AD, Seiple IB. Examining Gender Imbalance in Chemistry Authorship. ACS Chem Biol. 2021 11 19; 16(11):2042-2046.  View on PubMed
  6. Cotton AD, Wells JA, Seiple IB. Biotin as a Reactive Handle to Selectively Label Proteins and DNA with Small Molecules. ACS Chem Biol. 2021 Aug 19.  View on PubMed
  7. Shi X, Li Q, Dai Z, Tran AA, Feng S, Ramirez AD, Lin Z, Wang X, Chow TT, Chen J, Kumar D, McColloch AR, Reiter JF, Huang EJ, Seiple IB, Huang B. Label-retention expansion microscopy. J Cell Biol. 2021 09 06; 220(9).  View on PubMed
  8. Zhao X, Garcia JQ, Tong K, Chen X, Yang B, Li Q, Dai Z, Shi X, Seiple IB, Huang B, Guo S. Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division. Sci Adv. 2021 06; 7(24).  View on PubMed
  9. Cai L, Seiple IB, Li Q. Modular Chemical Synthesis of Streptogramin and Lankacidin Antibiotics. Acc Chem Res. 2021 04 20; 54(8):1891-1908.  View on PubMed
  10. Cotton AD, Nguyen DP, Gramespacher JA, Seiple IB, Wells JA. Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1. J Am Chem Soc. 2021 01 20; 143(2):593-598.  View on PubMed
  11. Boyce JH, Dang B, Ary B, Edmondson Q, Craik CS, DeGrado WF, Seiple IB. Platform to Discover Protease-Activated Antibiotics and Application to Siderophore-Antibiotic Conjugates. J Am Chem Soc. 2020 12 23; 142(51):21310-21321.  View on PubMed
  12. Li Q, Seiple IB. Modular synthesis of streptogramin antibiotics. Synlett. 2021 Apr; 32(7):647-654.  View on PubMed
  13. Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H. Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness. Bioorg Med Chem Lett. 2020 11 15; 30(22):127578.  View on PubMed
  14. Li Q, Pellegrino J, Lee DJ, Tran AA, Chaires HA, Wang R, Park JE, Ji K, Chow D, Zhang N, Brilot AF, Biel JT, van Zundert G, Borrelli K, Shinabarger D, Wolfe C, Murray B, Jacobson MP, Mühle E, Chesneau O, Fraser JS, Seiple IB. Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature. 2020 10; 586(7827):145-150.  View on PubMed
  15. Cai L, Yao Y, Yeon SK, Seiple IB. Modular Approaches to Lankacidin Antibiotics. J Am Chem Soc. 2020 09 02; 142(35):15116-15126.  View on PubMed
  16. Liu J, Cai L, Sun W, Cheng R, Wang N, Jin L, Rozovsky S, Seiple IB, Wang L. Photocaged Quinone Methide Crosslinkers for Light-Controlled Chemical Crosslinking of Protein-Protein and Protein-DNA Complexes. Angew Chem Int Ed Engl. 2019 12 19; 58(52):18839-18843.  View on PubMed
  17. Li Q, Seiple IB. A concise route to virginiamycin M2. Tetrahedron. 2019 Jun 14; 75(24):3309-3318.  View on PubMed
  18. Yao Y, Cai L, Seiple IB. Synthesis, Structural Reassignment, and Antibacterial Evaluation of 2,18-Seco-Lankacidinol B. Angew Chem Int Ed Engl. 2018 10 08; 57(41):13551-13554.  View on PubMed
  19. Li Q, Seiple IB. Modular, Scalable Synthesis of Group A Streptogramin Antibiotics. J Am Chem Soc. 2017 09 27; 139(38):13304-13307.  View on PubMed
  20. Seiple IB, Zhang Z, Jakubec P, Langlois-Mercier A, Wright PM, Hog DT, Yabu K, Allu SR, Fukuzaki T, Carlsen PN, Kitamura Y, Zhou X, Condakes ML, Szczypinski FT, Green WD, Myers AG. A platform for the discovery of new macrolide antibiotics. Nature. 2016 05 19; 533(7603):338-45.  View on PubMed

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