Research Funding

  • January 1, 1998 - February 29, 2024 - Maximizing Opportunities for Research Excellence , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R25GM056847
  • September 25, 2017 - August 31, 2022 - Studies of the antibacterial activity of and resistance to molecules targeting the ClpP peptidase , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI123400


07/2006 - Bacterial Genetics, John Innes Centre
4/2004 - Enzymology, Harvard Medical School
06/2002 - Biophysics, Harvard University
B.S., 05/1997 - Biology, Morehouse College

Honors & Awards

  • 2019
    Chan-Zuckerberg BioHub Investigator
  • 2014
    Inaugural Lecture of the National Organization of Black Chemists and Chemical Engineers (NOBCCHE) at the University of Pennsylvania
  • 2013
    M. L. K., Jr. Visiting Professor of Biology, Massachusetts Institute of Technology
  • 2011
    National Science Foundation CAREER Award
  • 2003
    Burroughs Wellcome Fund Career Award at the Scientific Interface
  • 2000
    Certificate of Distinction in Teaching, Harvard University
  • 1998
    Glaxo-Wellcome-UNCF Scientific Achievement Award

Selected Publications

  1. Alabi PE, Gautier C, Murphy TP, Gu X, Lepas M, Aimanianda V, Sello JK, Ene IV. Small molecules restore azole activity against drug-tolerant and drug-resistant Candida isolates. mBio. 2023 08 31; 14(4):e0047923.  View on PubMed
  2. Wang S, Li Z, Aispuro D, Guevara N, Van Valkenburgh J, Chen B, Zhou X, McCarroll MN, Ji F, Cong X, Sarkar P, Chaudhuri R, Guo Z, Perkins NP, Shao S, Sello JK, Chen K, Xue M. Hydroxyl-Rich Hydrophilic Endocytosis-Promoting Peptide with No Positive Charge. J Am Chem Soc. 2022 11 09; 144(44):20288-20297.  View on PubMed
  3. Schmitz KR, Handy EL, Compton CL, Gupta S, Bishai WR, Sauer RT, Sello JK. Acyldepsipeptide Antibiotics and a Bioactive Fragment Thereof Differentially Perturb Mycobacterium tuberculosis ClpXP1P2 Activity in Vitro. ACS Chem Biol. 2023 04 21; 18(4):724-733.  View on PubMed
  4. Craig E, Calarco A, Conte R, Ambrogi V, d'Ayala GG, Alabi P, Sello JK, Cerruti P, Kima PE. Thermoresponsive Copolymer Nanovectors Improve the Bioavailability of Retrograde Inhibitors in the Treatment of Leishmania Infections. Front Cell Infect Microbiol. 2021; 11:702676.  View on PubMed
  5. Priyamvada L, Alabi P, Leon A, Kumar A, Sambhara S, Olson VA, Sello JK, Satheshkumar PS. Discovery of Retro-1 Analogs Exhibiting Enhanced Anti-vaccinia Virus Activity. Front Microbiol. 2020; 11:603.  View on PubMed
  6. Rosenstein JK, Rose C, Reda S, Weber PM, Kim E, Sello J, Geiser J, Kennedy E, Arcadia C, Dombroski A, Oakley K, Chen SL, Tann H, Rubenstein BM. Principles of Information Storage in Small-Molecule Mixtures. IEEE Trans Nanobioscience. 2020 07; 19(3):378-384.  View on PubMed
  7. Arcadia CE, Kennedy E, Geiser J, Dombroski A, Oakley K, Chen SL, Sprague L, Ozmen M, Sello J, Weber PM, Reda S, Rose C, Kim E, Rubenstein BM, Rosenstein JK. Multicomponent molecular memory. Nat Commun. 2020 02 04; 11(1):691.  View on PubMed
  8. Morgens DW, Chan C, Kane AJ, Weir NR, Li A, Dubreuil MM, Tsui CK, Hess GT, Lavertu A, Han K, Polyakov N, Zhou J, Handy EL, Alabi P, Dombroski A, Yao D, Altman RB, Sello JK, Denic V, Bassik MC. Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins. Elife. 2019 11 01; 8.  View on PubMed
  9. Thorn RJ, Dombroski A, Eller K, Dominguez-Gonzalez TM, Clift DE, Baek P, Seto RJ, Kahn ES, Tucker SK, Colwill RM, Sello JK, Creton R. Analysis of vertebrate vision in a 384-well imaging system. Sci Rep. 2019 Sep 27; 9(1):13989.  View on PubMed
  10. McCarroll MN, Gendelev L, Kinser R, Taylor J, Bruni G, Myers-Turnbull D, Helsell C, Carbajal A, Rinaldi C, Kang HJ, Gong JH, Sello JK, Tomita S, Peterson RT, Keiser MJ, Kokel D. Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation. Nat Commun. 2019 09 09; 10(1):4078.  View on PubMed
  11. Zhang R, Lord DM, Bajaj R, Peti W, Page R, Sello JK. A peculiar IclR family transcription factor regulates para-hydroxybenzoate catabolism in Streptomyces coelicolor. Nucleic Acids Res. 2018 02 16; 46(3):1501-1512.  View on PubMed
  12. Craig E, Huyghues-Despointes CE, Yu C, Handy EL, Sello JK, Kima PE. Structurally optimized analogs of the retrograde trafficking inhibitor Retro-2cycl limit Leishmania infections. PLoS Negl Trop Dis. 2017 May; 11(5):e0005556.  View on PubMed
  13. Totaro KA, Barthelme D, Simpson PT, Jiang X, Lin G, Nathan CF, Sauer RT, Sello JK. Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome. ACS Infect Dis. 2017 02 10; 3(2):176-181.  View on PubMed
  14. Arvanitis M, Li G, Li DD, Cotnoir D, Ganley-Leal L, Carney DW, Sello JK, Mylonakis E. A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus. PLoS One. 2016; 11(4):e0153912.  View on PubMed
  15. Amor AJ, Schmitz KR, Sello JK, Baker TA, Sauer RT. Highly Dynamic Interactions Maintain Kinetic Stability of the ClpXP Protease During the ATP-Fueled Mechanical Cycle. ACS Chem Biol. 2016 06 17; 11(6):1552-1560.  View on PubMed
  16. Carney DW, Schmitz KR, Scruse AC, Sauer RT, Sello JK. Examination of a Structural Model of Peptidomimicry by Cyclic Acyldepsipeptide Antibiotics in Their Interaction with the ClpP Peptidase. Chembiochem. 2015 Sep 07; 16(13):1875-1879.  View on PubMed
  17. Totaro KA, Barthelme D, Simpson PT, Sauer RT, Sello JK. Substrate-guided optimization of the syringolins yields potent proteasome inhibitors with activity against leukemia cell lines. Bioorg Med Chem. 2015 Sep 15; 23(18):6218-22.  View on PubMed
  18. Compton CL, Fernandopulle MS, Nagari RT, Sello JK. Genetic and Proteomic Analyses of Pupylation in Streptomyces coelicolor. J Bacteriol. 2015 Sep; 197(17):2747-53.  View on PubMed
  19. Compton CL, Carney DW, Groomes PV, Sello JK. Fragment-Based Strategy for Investigating and Suppressing the Efflux of Bioactive Small Molecules. ACS Infect Dis. 2015 Jan 09; 1(1):53-8.  View on PubMed
  20. Schmitz KR, Carney DW, Sello JK, Sauer RT. Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):E4587-95.  View on PubMed

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