Education

Fellowship, 2010 - Pediatric Hematology/Oncology, University of California, San Francisco
Residency, 2006 - School of Medicine - Pediatrics, University of California, San Francisco
M.D., 2003 - School of Medicine, Harvard University
Fellowship, - Pediatric Hematology/Oncology, Boston Children's Hospital/Dana Farber Cancer Institute

Selected Publications

  1. Dvorak CC, Cho S, Salinas Cisneros G, Higham CS, Chu J, Winestone LE, Temple WC, Kharbanda S, Shimano KA, Avagyan S, Pauerstein PT, Huang JN, Cheng G, Lalefar N, Aguayo-Hiraldo P, Keizer RJ, Pulsipher MA, Long-Boyle JR. High Melphalan Exposure Increases the Risk of Graft-Versus-Host Disease in Pediatric Patients Undergoing Alpha-Beta T-Cell Depleted Haploidentical Transplantation. Transplant Cell Ther. 2025 Apr 02.  View on PubMed
  2. O'Farrell C, Bell Grimes A, Nakano TA, Klaassen RJ, Lambert MP, Neunert C, Rothman JA, Shimano KA, Grace RF. Working toward international consensus defining pediatric "refractory ITP". Blood Adv. 2025 Mar 11; 9(5):1244-1245.  View on PubMed
  3. Dvorak CC, Temple WC, Cisneros GS, Chu J, Winestone LE, Higham CS, Shimano KA, Kharbanda S, Avagyan S, Pauerstein P, Huang JN, Cheng G, Waters E, Winger BA, Cowan MJ, Long-Boyle JR. Younger children with nonmalignant disease have increased incidence of mixed myeloid chimerism after allogeneic hematopoietic cell transplantation with busulfan-based conditioning. Transplant Cell Ther. 2025 Apr; 31(4):259.e1-259.e15.  View on PubMed
  4. Christopher C. Dvorak, William C. Temple, Gabriel Salinas Cisneros, Julia Chu, Lena E. Winestone, Christine S. Higham, Kristin A. Shimano, Sandhya Kharbanda, Serine Avagyan, Michelle Hermiston, James N. Huang, Janel Renee Long-Boyle. Fludarabine Pharmacokinetic-Model-Based Dosing Minimizes the Risk of Graft Rejection in Pediatric Patients Undergoing Mismatched Allogeneic Hematopoietic Cell Transplantation. Transplantation and Cellular Therapy. 2025 Feb 1; 31(2):s173-s174.  View on PubMed
  5. Jessie L Alexander, Blachy J Davila Saldana, Ruta Brazauskas, Sravya Gethika Dammalapati, Linda M. Griffith, Ami J. Shah, Kristin A. Shimano, Hans D. Ochs, Jack J. Bleesing, Christen L. Ebens, Malika Kapadia, Christopher C. Dvorak, Andrea Bauchat, Neena Kapoor, Joseph H Oved, Hesham Eissa, Hannah Lust, Michael D. Keller, Hilary Haines, Shanmuganathan Chandrakasan, Julie A Talano, Ahmad Rayes, Lisa Madden, Evan Shereck, Holly K. Miller, Lisa forbes Satter, Caridad Martinez, Jacob Rozmus, Jeffrey J Bednarski, Lolie C. Yu, Elie Haddad, Deepak Chellapandian, Victor Michael Aquino, Alan P. Knutsen, Hey Jin Chong, Ashley Chopek, Alfred P. Gillio, Avni Joshi, Hemalatha Rangarajan, Theodore B. Moore, Jennifer R. Heimall, Jeffrey Andolina, Kenneth DeSantes, Mark VanderLugt, Susan E. Prockop, David C. Shyr, Kathleen E. Sullivan, Suhag Parikh, Katja G. Weinacht, Troy Torgerson, Rebecca A. Marsh, Michael A. Pulsipher, Jennifer W. Leiding, Donald B. Kohn, Jennifer Puck, Luigi D. Notarangelo, David Rawlings, Morton J. Cowan, Aleksandra Petrovic, Sung-Yun Pai, Lauri M. Burroughs, Alice Chan. Hematopoietic Cell Transplantation for Wiskott-Aldrich Syndrome - Impact of Age, Donor, and Infection: A Pidtc Report. Transplantation and Cellular Therapy. 2025 Feb 1; 31(2):s39-s41.  View on PubMed
  6. Gabriel Salinas Cisneros, Janel Renee Long-Boyle, William C. Temple, Julia Chu, Serine Avagyan, Lena E. Winestone, Christine S. Higham, Kristin A. Shimano, James N. Huang, Michelle Hermiston, Sandhya Kharbanda, Christopher C. Dvorak. High Exposure of Intravenous Alemtuzumab Is Associated with Increased Risk of Double-Stranded DNA Viral Infections in Patients with Non-Malignant Disease Undergoing Allogeneic HCT. Transplantation and Cellular Therapy. 2025 Feb 1; 31(2):s186.  View on PubMed
  7. Christopher C. Dvorak, William C. Temple, Gabriel Salinas Cisneros, Julia Chu, Lena E. Winestone, Christine S. Higham, Kristin A. Shimano, Sandhya Kharbanda, Serine Avagyan, Michelle Hermiston, James N. Huang, Janel Renee Long-Boyle. Younger Children Have Increased Mixed Myeloid Chimerism with Busulfan-Based Conditioning for Hematopoietic Cell Transplantation of Non-Malignant Disease. Transplantation and Cellular Therapy. 2025 Feb 1; 31(2):s179-s180.  View on PubMed
  8. Kim TO, Geris JM, Flanagan JM, Grace RF, Lambert MP, O'Farrell C, Rose MJ, Shimano KA, Niss O, Neunert C, Nakano TA, MacMath D, Dinu B, Kirk SE, Neufeld EJ, Despotovic JM, Scheurer ME, Grimes AB. Genetic variants in canonical Wnt signaling pathway associated with pediatric immune thrombocytopenia. Blood Adv. 2024 11 12; 8(21):5529-5538.  View on PubMed
  9. Apsel Winger B, Dowd CF, Shimano KA, Devine WP, Mathes E, Frieden I, Schaefer C, Kothari A. Effective Use of ALK Inhibitors in EML4::ALK-Positive Lymphatic Malformations. Pediatr Blood Cancer. 2025 Feb; 72(2):e31441.  View on PubMed
  10. Kristin A. Shimano, Amanda B. Grimes, Melissa J Rose, Shipra Kaicker, Sanjay J. Shah, Michael Briones, Elizabeth Gunn, Taizo A. Nakano, Jeffrey D Lebensburger, Michele P. Lambert, Stephanie A. Fritch Lilla, Rohith Jesudas, Cathy A. Lee-Miller, Alexis Thompson, Rukhmi Bhat, Stacey Rifkin-Zenenberg, Suvankar Majumdar, Manpreet Kochhar, Shelley E Crary, Kerry Hege, Jennifer A. Rothman, James B. Ford, Joshua J Bies, John Fort, Loan Hsieh, Maritza E. Ruiz, Kathryn M. Carrier, Bogdan Dinu, Julia MW Wong, Pei-Chi Kao, Wendy B. London, Staci D. Arnold, Carolyn M. Bennett, Jenny Despotovic, Robert J. Klaassen, Ellis J. Neufeld, Cindy E Neunert, Rachael F. Grace. Efficacy Findings in a Phase 3, Randomized Trial of Eltrombopag Vs. Standard First-Line Treatment for Newly Diagnosed Immune Thrombocytopenia in Children. Blood. 2024 Nov 5; 144(Supplement 1):709-709.  View on PubMed
  11. Rachael F Grace, MacGregor Steele, Tatiana Kalashnikova, Ellis Bloom, Aila Khan, Sherif M. Badawy, Hannah Elkus, Vicky R. Breakey, Sureka Pavalagantharajah, Stephanie A. Fritch Lilla, John Leister, Manpreet Kochhar, Kirsty Hillier, Lia Phillips, Jessica Chumsky, Robert J. Klaassen, Dana Ghanem, Danielle Charland, Taizo A. Nakano, Joshua Kalter, Allison Remiker, Jennifer A. Rothman, Caitlyn McComb, Brian Guedes, Sanjay J. Shah, Cassandra J. Everly, Kristin A. Shimano, Alison Matsunaga, Gerald C Tiu, Russell P Valle, Shilpa Nataraj, Stacey Rifkin-Zenenberg, Erika Tavares, Caitlin Montcrieff, Emily M Harris, Nan Chen, Wendy B. London, Michele P. Lambert. Pediatric Autoimmune Hemolytic Anemia Is Associated with a High Incidence of an Underlying Immune Disorder and High Mortality Rate. Blood. 2024 Nov 5; 144(Supplement 1):795.  View on PubMed
  12. Nakano TA, Grimes AB, Klaassen RJ, Lambert MP, Neunert C, Rothman JA, Shimano KA, Amend C, Askew M, Badawy SM, Baker JM, Breakey V, Crary S, Davini M, Fritch Lilla S, Gilbert M, Hays T, Hege K, Hillier K, Jacobson-Kelly A, Kaicker S, Kim TO, Kochhar M, Leblanc T, Martinelli M, Nunez M, Remiker A, Schultz C, Sharma R, Grace RF. What is in a name: defining pediatric refractory ITP. Blood Adv. 2024 10 08; 8(19):5112-5117.  View on PubMed
  13. Higham CS, Shimano KA, Kharbanda S, Chu J, Cisneros GS, Winestone LE, Dara J, Huang JN, Hermiston ML, Long-Boyle JR, Dvorak CC. Cyclophosphamide and Thiotepa Increases Risk of Transplant-Associated Thrombotic Microangiopathy. Transplant Cell Ther. 2024 Sep; 30(9):931.e1-931.e10.  View on PubMed
  14. Shimano KA, Sasa G, Broglie L, Gloude NJ, Myers K, Nakano TA, Sharathkumar A, Rothman JA, Pereda MA, Overholt K, Narla A, McGuinn C, Lau BW, Geddis AE, Dror Y, de Jong JLO, Castillo P, Allen SW, Boklan J. Treatment of relapsed/refractory severe aplastic anemia in children: Evidence-based recommendations. Pediatr Blood Cancer. 2024 Aug; 71(8):e31075.  View on PubMed
  15. Hayashi RJ, Hermiston ML, Wood BL, Teachey DT, Devidas M, Chen Z, Annett RD, Asselin BL, August K, Cho S, Dunsmore KP, Freedman JL, Galardy PJ, Harker-Murray P, Horton TM, Jaju A, Lam A, Messinger YH, Miles RR, Okada M, Patel S, Schafer ES, Schechter T, Shimano KA, Singh N, Steele A, Sulis ML, Vargas SL, Winter SS, Wood C, Zweidler-McKay PA, Loh ML, Hunger SP, Raetz EA, Bollard CM, Allen CE. MRD at the end of induction and EFS in T-cell lymphoblastic lymphoma: Children's Oncology Group trial AALL1231. Blood. 2024 05 16; 143(20):2053-2058.  View on PubMed
  16. Shimano KA, Rothman JA, Allen SW, Castillo P, de Jong JLO, Dror Y, Geddis AE, Lau BW, McGuinn C, Narla A, Overholt K, Pereda MA, Sharathkumar A, Sasa G, Nakano TA, Myers K, Gloude NJ, Broglie L, Boklan J. Treatment of newly diagnosed severe aplastic anemia in children: Evidence-based recommendations. Pediatr Blood Cancer. 2024 Aug; 71(8):e31070.  View on PubMed
  17. Christin Deal, Stephanie Si Lim, Kyle Ishikawa, Athanasios Tsalatsanis, Elisa Ochfeld, Aleks Petrovic, Kanwaldeep Mallhi, Avni Joshi, Kristin Shimano, Christopher Dvorak, Elie Haddad, Donald B. Kohn, Linda Griffith, Luigi Notarangelo, Michael Pulsipher, Morton Cowan, Sung-Yun Pai, Jennifer Puck, Lauri Burroughs, Jennifer Heimall, Jennifer Leiding. 13 Long-Term Medical Management of Patients with Chronic Granulomatous Disease, Wiskott-Aldrich Syndrome, and Primary Immune Regulatory Disorders: A Primary Immune Deficiency Treatment Consortium Survey. Clinical Immunology. 2024 May 1; 262:109955.  View on PubMed
  18. Stephanie Si Lim, Christin Deal, Kyle Ishikawa, Athanasios Tsalatsanis, Elisa Ochfeld, Aleks Petrovic, Kanwaldeep Mallhi, Avni Joshi, Kristin Shimano, Christopher Dvorak, Elie Haddad, Donald B. Kohn, Linda Griffith, Luigi Notarangelo, Michael Pulsipher, Morton Cowan, Sung-Yun Pai, Jennifer Puck, Jennifer Leiding, Jennifer Heimall, Lauri Burroughs. 169 Long Term Management of Transplanted Patients with Chronic Granulomatous Disease, Wiskott-Aldrich Syndrome, and Primary Immune Regulatory Disorders: A PIDTC Survey. Clinical Immunology. 2024 May 1; 262:110111.  View on PubMed
  19. Salinas Cisneros G, Dvorak CC, Long-Boyle J, Kharbanda S, Shimano KA, Melton A, Chu J, Winestone LE, Dara J, Huang JN, Hermiston ML, Zinter M, Higham CS. Diagnosing and Grading of Sinusoidal Obstructive Syndrome after Hematopoietic Stem Cell Transplant of Children, Adolescent and Young Adults treated in a Pediatric Institution with Pediatric Protocols. Transplant Cell Ther. 2024 Jul; 30(7):690.e1-690.e16.  View on PubMed
  20. Paul Castillo, Linah Omer, Steven W. Allen, Arnav Barpujari, Nicholas Joseph Gloude, Catherine McGuinn, Taizo A. Nakano, Elizabeth Ogando-Rivas, Kathleen Overholt, Kristin A. Shimano, Adrianna Vlachos, Peter Kurre, Jill de Jong. A Napaac Survey to Understand Practices in Diagnosis and Treatment of Children with Moderate Aplastic Anemia. Blood. 2023 Nov 28; 142(Supplement 1):5642.  View on PubMed

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