Research Summary

Dr. Smith is Director of the UCSF Male Reproductive Health practice dedicated to providing outstanding reproductive clinical care, conducting cutting edge research, and improving access to reproductive care. His research program is dedicated to helping men and boys with cancer become fathers after surviving cancer treatment. He and his partners conduct basic science investigations of sperm physiology, sperm stem cells, and semen physiology; translational research focused on fertility restoration by means of testicular and stem cell transplantation; and clinical research into reproductive effects of targeted cancer therapies such as tyrosine kinase inhibitors and MTOR inhibitors., Clinically, Dr. Smith treats men with fertility problems, need for fertility preservation, erectile dysfunction, orchalgia, and hypogonadism in the Center for Reproductive Health. Dr. Smith specializes in the use of minimally invasive vasectomy, microsurgical vasovasostomy, vasoepididymostomy, sperm retrieval techniques, spermatic cord denervation, and varicocelectomy.

Research Funding

  • April 1, 2015 - November 30, 2020 - Molecular identity of human sperm potassium channel and its role in male fertility , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM111802

Education

University of California, Berkeley B.A. 1996 Molecular Biology
UC Berkeley, UCSF Joint Medical Program M.S. 2000 Public Health, Medicine
University of California, San Francisco M.D. 2002 Medicine
University of Utah Urology Residency 2007 Urology
University of California, San Francisco Male Reproductive and Sexual Medicine Fellowship 2009 Urology

Selected Publications

  1. Su HI, Lacchetti C, Letourneau J, Partridge AH, Qamar R, Quinn GP, Reinecke J, Smith JF, Tesch M, Wallace WH, Wang ET, Loren AW Erratum: Fertility Preservation in People With Cancer: ASCO Guideline Update.  View on PubMed
  2. Morris JR, Belarmino A, Reinecke J, Davis L, Quinn GP, Flyckt R, Halpern J, Milette B, Smith JF. Sperm cryopreservation best practices prior to gonadotoxic treatment: Recommendations from leaders in fertility preservation. Fertil Steril. 2025 May 07.  View on PubMed
  3. Su HI, Lacchetti C, Letourneau J, Partridge AH, Qamar R, Quinn GP, Reinecke J, Smith JF, Tesch M, Wallace WH, Wang ET, Loren AW. Erratum: Fertility Preservation in People With Cancer: ASCO Guideline Update. J Clin Oncol. 2025 May 20; 43(15):1847.  View on PubMed
  4. Huang S, Hart JC, Smith JF, Bench S, Yepes LR, Griscom B, Clark-Langone KM. Tissue of origin characterization of cell free DNA in seminal plasma: Implications for new liquid biopsies. PLoS One. 2025; 20(3):e0317712.  View on PubMed
  5. Su HI, Lacchetti C, Letourneau J, Partridge AH, Qamar R, Quinn GP, Reinecke J, Smith JF, Tesch M, Wallace WH, Wang ET, Loren AW. Fertility Preservation in People With Cancer: ASCO Guideline Update. J Clin Oncol. 2025 Apr 20; 43(12):1488-1515.  View on PubMed
  6. Nahata L, Halpern JA, Bendle K, Frias O, Orwig K, Reinecke J, Smith JF, Woodard T, Levine J The Case for Pre-Treatment Sperm Banking as Standard of Care for All Post-Pubertal Males with Cancer.  View on PubMed
  7. Gu C, Belarmino A, Kenfield SA, Nolte D, Civello D, Smith JF, Honig S, Mehta A, Punjani N, Lerner LB. Postvasectomy Semen Analysis Compliance With Utilization of a Mail-In Semen Analysis Kit. J Urol. 2024 Dec; 212(6):899-906.  View on PubMed
  8. Zuntini AR, Carruthers T, Maurin O, Bailey PC, Leempoel K, Brewer GE, Epitawalage N, Françoso E, Gallego-Paramo B, McGinnie C, Negrão R, Roy SR, Simpson L, Toledo Romero E, Barber VMA, Botigué L, Clarkson JJ, Cowan RS, Dodsworth S, Johnson MG, Kim JT, Pokorny L, Wickett NJ, Antar GM, DeBolt L, Gutierrez K, Hendriks KP, Hoewener A, Hu AQ, Joyce EM, Kikuchi IABS, Larridon I, Larson DA, de Lírio EJ, Liu JX, Malakasi P, Przelomska NAS, Shah T, Viruel J, Allnutt TR, Ameka GK, Andrew RL, Appelhans MS, Arista M, Ariza MJ, Arroyo J, Arthan W, Bachelier JB, Bailey CD, Barnes HF, Barrett MD, Barrett RL, Bayer RJ, Bayly MJ, Biffin E, Biggs N, Birch JL, Bogarín D, Borosova R, Bowles AMC, Boyce PC, Bramley GLC, Briggs M, Broadhurst L, Brown GK, Bruhl JJ, Bruneau A, Buerki S, Burns E, Byrne M, Cable S, Calladine A, Callmander MW, Cano Á, Cantrill DJ, Cardinal-McTeague WM, Carlsen MM, Carruthers AJA, de Castro Mateo A, Chase MW, Chatrou LW, Cheek M, Chen S, Christenhusz MJM, Christin PA, Clements MA, Coffey SC, Conran JG, Cornejo X, Couvreur TLP, Cowie ID, Csiba L, Darbyshire I, Davidse G, Davies NMJ, Davis AP, van Dijk KJ, Downie SR, Duretto MF, Duvall MR, Edwards SL, Eggli U, Erkens RHJ, Escudero M, de la Estrella M, Fabriani F, Fay MF, Ferreira PL, Ficinski SZ, Fowler RM, Frisby S, Fu L, Fulcher T, Galbany-Casals M, Gardner EM, German DA, Giaretta A, Gibernau M, Gillespie LJ, González CC, Goyder DJ, Graham SW, Grall A, Green L, Gunn BF, Gutiérrez DG, Hackel J, Haevermans T, Haigh A, Hall JC, Hall T, Harrison MJ, Hatt SA, Hidalgo O, Hodkinson TR, Holmes GD, Hopkins HCF, Jackson CJ, James SA, Jobson RW, Kadereit G, Kahandawala IM, Kainulainen K, Kato M, Kellogg EA, King GJ, Klejevskaja B, Klitgaard BB, Klopper RR, Knapp S, Koch MA, Leebens-Mack JH, Lens F, Leon CJ, Léveillé-Bourret É, Lewis GP, Li DZ, Li L, Liede-Schumann S, Livshultz T, Lorence D, Lu M, Lu-Irving P, Luber J, Lucas EJ, Luján M, Lum M, Macfarlane TD, Magdalena C, Mansano VF, Masters LE, Mayo SJ, McColl K, McDonnell AJ, McDougall AE, McLay TGB, McPherson H, Meneses RI, Merckx VSFT, Michelangeli FA, Mitchell JD, Monro AK, Moore MJ, Mueller TL, Mummenhoff K, Munzinger J, Muriel P, Murphy DJ, Nargar K, Nauheimer L, Nge FJ, Nyffeler R, Orejuela A, Ortiz EM, Palazzesi L, Peixoto AL, Pell SK, Pellicer J, Penneys DS, Perez-Escobar OA, Persson C, Pignal M, Pillon Y, Pirani JR, Plunkett GM, Powell RF, Prance GT, Puglisi C, Qin M, Rabeler RK, Rees PEJ, Renner M, Roalson EH, Rodda M, Rogers ZS, Rokni S, Rutishauser R, de Salas MF, Schaefer H, Schley RJ, Schmidt-Lebuhn A, Shapcott A, Al-Shehbaz I, Shepherd KA, Simmons MP, Simões AO, Simões ARG, Siros M, Smidt EC, Smith JF, Snow N, Soltis DE, Soltis PS, Soreng RJ, Sothers CA, Starr JR, Stevens PF, Straub SCK, Struwe L, Taylor JM, Telford IRH, Thornhill AH, Tooth I, Trias-Blasi A, Udovicic F, Utteridge TMA, Del Valle JC, Verboom GA, Vonow HP, Vorontsova MS, de Vos JM, Al-Wattar N, Waycott M, Welker CAD, White AJ, Wieringa JJ, Williamson LT, Wilson TC, Wong SY, Woods LA, Woods R, Worboys S, Xanthos M, Yang Y, Zhang YX, Zhou MY, Zmarzty S, Zuloaga FO, Antonelli A, Bellot S, Crayn DM, Grace OM, Kersey PJ, Leitch IJ, Sauquet H, Smith SA, Eiserhardt WL, Forest F, Baker WJ Phylogenomics and the rise of the angiosperms.  View on PubMed
  9. Savoie MB, Paciorek A, Van Loon K, Anwar M, Atreya CE, Johnson PC, Kenfield SA, Laffan A, Levin AO, Smith JF, Stanfield D, Venook A, Zhang L, Van Blarigan EL, Rowen T. Sexual function remains persistently low in women after treatment for colorectal cancer and anal squamous cell carcinoma. J Sex Med. 2023 03 31; 20(4):439-446.  View on PubMed
  10. Adeleye AJ, Stark BA, Jalalian L, Mok-Lin E, Smith JF. Evidence of Spermatogenesis in the Presence of Hypothalamic Suppression and Low Testosterone in an Adolescent Transgender Female: A Case Report. Transgend Health. 2023 Feb; 8(1):104-107.  View on PubMed
  11. Hakam N, Lui J, Shaw NM, Nabavizadeh B, Smith JF, Eisenberg ML, Breyer BN. Hematospermia is rarely associated with urologic malignancy: Analysis of United States claims data. Andrology. 2022 07; 10(5):919-925.  View on PubMed
  12. Baker KC, Steiner AZ, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, Krawetz SA, Usadi R, Baker VL, Coward RM, Sun F, Wild R, Masson P, Smith JF, Santoro N, Zhang H. Poor reproducibility of percentage of normally shaped sperm using the World Health Organization Fifth Edition strict grading criteria. F S Rep. 2022 Jun; 3(2):110-115.  View on PubMed
  13. Ho JR, Aghajanova L, Mok-Lin E, Hoffman JR, Smith JF, Herndon CN. Public attitudes in the United States toward insurance coverage for in vitro fertilization and the provision of infertility services to lower income patients. F S Rep. 2022 May; 3(2 Suppl):122-129.  View on PubMed
  14. Asanad K, Matthew Coward R, Mehta A, Smith JF, Vij SC, Nusbaum DJ, Rodman JCS, Samplaski MK. Factors Influencing the Decision for Fresh vs Cryopreserved Microdissection Testicular Sperm Extraction for Non-Obstructive Azoospermia. Urology. 2021 11; 157:131-137.  View on PubMed
  15. Chen AB, Jarvi KA, Lajkosz K, Smith JF, Lo KC, Grober ED, Lau S, Bieniek JM, Brannigan RE, Chow VDW, Domes T, Dupree JM, Goldstein M, Hedges JC, Hotaling JM, Ko EY, Kolettis PN, Nangia AK, Sandlow JI, Shin D, Spitz A, Trussell JC, Zeitlin SI, Zini AS, Fisher MA, Walsh TJ, Hsieh TM, Fuchs EF, Samplaski MK. One size does not fit all: variations by ethnicity in demographic characteristics of men seeking fertility treatment across North America. Fertil Steril. 2021 11; 116(5):1287-1294.  View on PubMed
  16. Banks N, Sun F, Krawetz SA, Coward RM, Masson P, Smith JF, Trussell JC, Santoro N, Zhang H, Steiner AZ. Male vitamin D status and male factor infertility. Fertil Steril. 2021 10; 116(4):973-979.  View on PubMed
  17. Rios JS, Coward RM, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, Krawetz SA, Usadi R, Baker VL, Sun F, Wild R, Smith JF, Santoro N, Zhang H, Steiner AZ. Sperm deoxyribonucleic acid fragmentation: predictors, fertility outcomes, and assays among infertile males. F S Rep. 2021 Sep; 2(3):282-288.  View on PubMed
  18. Yang H, Lindsey JP, Gillis-Buck EM, Srirangapatanam S, Rosen JE, Hussein AA, Smith JF. Ex vivo human testes as a practical model to simulate ultrasound-guided testicular cell transplantation for human fertility restoration. F S Sci. 2021 05; 2(2):135-140.  View on PubMed
  19. Dupree JM, Coward RM, Hsieh TC, Tanrikut C, Shin P, Mehta A, Hotaling JM, Pastuszak AW, Williams D, Alukal J, Lipshultz LI, Schlegel P, Walsh TJ, Eisenberg ML, Shin D, Honig S, Nagler HM, Samplaski M, Nangia AK, Sandlow J, Smith JF, Society for the Study of Male Reproduction (SSMR) and Society for Male Reproduction and Urology (SMR. The Impact of Physician Productivity Models on Access to Subspecialty Care: A White Paper From the Society for the Study of Male Reproduction and the Society for Male Reproduction and Urology. Urology. 2021 07; 153:28-34.  View on PubMed
  20. Samplaski MK, Falk O, Honig S, Shin D, Matthews W, Smith JF. Development and validation of a novel mail-in semen analysis system and the correlation between one hour and delayed semen analysis testing. Fertil Steril. 2021 04; 115(4):922-929.  View on PubMed

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