Ma Somsouk, MD, MAS

Dean M. Craig Endowed Chair in Gastrointestinal Medicine, UCSF

Professor of Medicine in Residence, UCSF Division of Gastroenterology at ZSFG; Core Faculty, UCSF Center for Vulnerable Populations

Cancer Center Program Membership

Cancer Control

Research Summary

1. Leveraging digital health and care coordination to improve health services delivery to vulnerable populations. We embrace big data and technology to design, develop, and deliver economic and effective services for patients in the area of cancer screening and follow-up.

2. Development of intestinal organoids from humans to understand barrier function, systemic inflammation, inflammatory bowel disease, HIV persistence, infection, and microbiome. Approaches employed: organoid models, isolation of epithelial cells, lymphocytes, microbiota, and interventional trials such as fecal transplant.

Research Funding

  • March 15, 2021 - February 28, 2026 - Cytomegalovirus (CMV), the gut barrier and immune dysfunction in HIV , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01AI155680
  • August 12, 2020 - July 31, 2025 - In Vivo PET Imaging of HIV Infection , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01AI152932
  • January 10, 2020 - December 31, 2024 - Modeling intestinal dysfunction in HIV infection with organoid technology , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DK123746
  • August 16, 2019 - July 31, 2024 - Understanding the Multilevel Drivers of Liver Cancer Disparities , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01CA225478

Education

Pomona College, Claremont, CA, BA, 1993-1997, Chemistry
Harvard Medical School, Boston, MA, MD, 1997-2002, Medicine
Harbor-UCLA Medical Center, Torrance, CA, Residency, 2002-2005, Internal Medicine
University of California, San Francisco, CA, Fellowship, 2005-2008, Gastroenterology
University of California, San Francisco, CA, MAS, 2006-2008, Epidemiology and Biostatistics

Honors & Awards

  • Sigma Xi
  • Phi Beta Kappa
  • Magna Cum Laude
  • Paul Dudley White / Andrew Sellard Fellowship
  • UCSF Distinction in Mentoring Award
  • Fellow of the American Gastroenterological Association
  • Dean M. Craig Endowed Chair in Gastrointestinal Medicine
  • UCSF TICR Program Award for Excellence in Faculty Advising
  • UCSF Holly Smith Award for Exceptional Service to the School of Medicine Nominee

Selected Publications

  1. Altinbas A, Holmes JA, Salloum S, Lidofsky A, Alatrakchi N, Somsouk M, Hunt P, Deeks S, Chew KW, Lauer G, Kruger A, Lin W, Chung RT. LOXL-2 and TNC-C are markers of liver fibrogenesis in HCV/HIV-, HIV- and HCV-infected patients. Biomark Med. 2022 Jul 05.  View on PubMed
  2. Khoong EC, Rivadeneira NA, Pacca L, Schillinger D, Lown D, Babaria P, Gupta N, Pramanik R, Tran H, Whitezell T, Somsouk M, Sarkar U. Extent of Follow-Up on Abnormal Cancer Screening in Multiple California Public Hospital Systems: A Retrospective Review. J Gen Intern Med. 2022 May 31.  View on PubMed
  3. Hiatt RA, Sibley A, Venkatesh B, Cheng J, Dixit N, Fox R, Ling P, Nguyen T, Oh D, Palmer NR, Pasick RJ, Potter MB, Somsouk M, Vargas RA, Vijayaraghavan M, Ashworth A. From Cancer Epidemiology to Policy and Practice: the Role of a Comprehensive Cancer Center. Curr Epidemiol Rep. 2022; 9(1):10-21.  View on PubMed
  4. Chang HW, Yan D, Singh R, Bui A, Lee K, Truong A, Milush JM, Somsouk M, Liao W. Multiomic Analysis of the Gut Microbiome in Psoriasis Reveals Distinct Host‒Microbe Associations. JID Innov. 2022 May; 2(3):100115.  View on PubMed
  5. Sharma AE, Lyson HC, Cherian R, Somsouk M, Schillinger D, Sarkar U. A Root Cause Analysis of Barriers to Timely Colonoscopy in California Safety-Net Health Systems. J Patient Saf. 2022 01 01; 18(1):e163-e171.  View on PubMed
  6. Sangaramoorthy M, Yang J, Guan A, DeRouen MC, Tana MM, Somsouk M, Thompson CA, Gibbons J, Ho C, Chu JN, Cheng I, Gomez SL, Shariff-Marco S. Asian American/Pacific Islander and Hispanic Ethnic Enclaves, Neighborhood Socioeconomic Status, and Hepatocellular Carcinoma Incidence in California: An Update. Cancer Epidemiol Biomarkers Prev. 2022 02; 31(2):382-392.  View on PubMed
  7. Wu G, Zuck P, Goh SL, Milush JM, Vohra P, Wong JK, Somsouk M, Yukl SA, Shacklett BL, Chomont N, Haase AT, Hatano H, Schacker TW, Deeks SG, Hazuda DJ, Hunt PW, Howell BJ. Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates With Immune Response. J Infect Dis. 2021 11 16; 224(9):1593-1598.  View on PubMed
  8. Dai B, Hackney JA, Ichikawa R, Nguyen A, Elstrott J, Orozco LD, Sun KH, Modrusan Z, Gogineni A, Scherl A, Gubatan J, Habtezion A, Deswal M, Somsouk M, Faubion WA, Chai A, Sharafali Z, Hassanali A, Oh YS, Tole S, McBride J, Keir ME, Yi T. Dual targeting of lymphocyte homing and retention through α4β7 and αEβ7 inhibition in inflammatory bowel disease. Cell Rep Med. 2021 08 17; 2(8):100381.  View on PubMed
  9. Lee B, Keyes E, Rachocki C, Grimes B, Chen E, Vittinghoff E, Ladabaum U, Somsouk M. Increased Colorectal Cancer Screening Sustained with Mailed Fecal Immunochemical Test Outreach. Clin Gastroenterol Hepatol. 2022 06; 20(6):1326-1333.e4.  View on PubMed
  10. Zullo KM, Douglas B, Maloney NM, Ji Y, Wei Y, Herbine K, Cohen R, Pastore C, Cramer Z, Wang X, Wei W, Somsouk M, Hung LY, Lengner C, Kohanski MH, Cohen NA, Herbert DR. LINGO3 regulates mucosal tissue regeneration and promotes TFF2 dependent recovery from colitis. Scand J Gastroenterol. 2021 Jul; 56(7):791-805.  View on PubMed
  11. Ge J, Najafi N, Zhao W, Somsouk M, Fang M, Lai JC. A Methodology to Generate Longitudinally Updated Acute-On-Chronic Liver Failure Prognostication Scores From Electronic Health Record Data. Hepatol Commun. 2021 Jun; 5(6):1069-1080.  View on PubMed
  12. Wang A, Lee B, Patel S, Whitaker E, Issaka RB, Somsouk M. Selection of patients for large mailed fecal immunochemical test colorectal cancer screening outreach programs: A systematic review. J Med Screen. 2021 12; 28(4):379-388.  View on PubMed
  13. Patel S, Issaka RB, Chen E, Somsouk M. Colorectal Cancer Screening and COVID-19. Am J Gastroenterol. 2021 02 01; 116(2):433-434.  View on PubMed
  14. Yukl SA, Khan S, Chen TH, Trapecar M, Wu F, Xie G, Telwatte S, Fulop D, Pico AR, Laird GM, Ritter KD, Jones NG, Lu CM, Siliciano RF, Roan NR, Milush JM, Somsouk M, Deeks SG, Hunt PW, Sanjabi S. Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103+ and Gut CD4+ T Cells. J Virol. 2020 12 22; 95(2).  View on PubMed
  15. Telwatte S, Kim P, Chen TH, Milush JM, Somsouk M, Deeks SG, Hunt PW, Wong JK, Yukl SA. Mechanistic differences underlying HIV latency in the gut and blood contribute to differential responses to latency-reversing agents. AIDS. 2020 11 15; 34(14):2013-2024.  View on PubMed
  16. Neidleman J, Luo X, Frouard J, Xie G, Hsiao F, Ma T, Morcilla V, Lee A, Telwatte S, Thomas R, Tamaki W, Wheeler B, Hoh R, Somsouk M, Vohra P, Milush J, James KS, Archin NM, Hunt PW, Deeks SG, Yukl SA, Palmer S, Greene WC, Roan NR. Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir. Elife. 2020 09 29; 9.  View on PubMed
  17. Jiang C, Lian X, Gao C, Sun X, Einkauf KB, Chevalier JM, Chen SMY, Hua S, Rhee B, Chang K, Blackmer JE, Osborn M, Peluso MJ, Hoh R, Somsouk M, Milush J, Bertagnolli LN, Sweet SE, Varriale JA, Burbelo PD, Chun TW, Laird GM, Serrao E, Engelman AN, Carrington M, Siliciano RF, Siliciano JM, Deeks SG, Walker BD, Lichterfeld M, Yu XG. Distinct viral reservoirs in individuals with spontaneous control of HIV-1. Nature. 2020 09; 585(7824):261-267.  View on PubMed
  18. Lee B, Patel S, Rachocki C, Issaka R, Vittinghoff E, Shapiro JA, Ladabaum U, Somsouk M. Advanced Notification Calls Prior to Mailed Fecal Immunochemical Test in Previously Screened Patients: a Randomized Controlled Trial. J Gen Intern Med. 2020 10; 35(10):2858-2864.  View on PubMed
  19. SahBandar IN, Chew GM, Corley MJ, Pang APS, Tsai N, Hanks N, Khadka VS, Klatt NR, Hensley-McBain T, Somsouk M, Vujkovic-Cvijin I, Chow DC, Shikuma CM, Ndhlovu LC. Changes in gastrointestinal microbial communities influence HIV-specific CD8+ T-cell responsiveness to immune checkpoint blockade. AIDS. 2020 08 01; 34(10):1451-1460.  View on PubMed
  20. Huynh MP, Bradshaw PT, Tana MM, Rachocki C, Somsouk M. Obesity and metabolic outcomes in a safety-net health system. Biodemography Soc Biol. 2020 Jul-Sep; 65(3):257-267.  View on PubMed

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