Ma Somsouk, MD, MAS

Dean M. Craig Endowed Chair in Gastrointestinal Medicine, UCSF

Professor of Medicine in Residence, UCSF Division of Gastroenterology at ZSFG; Core Faculty, UCSF Center for Vulnerable Populations

Cancer Center Program Membership

Cancer Control

Research Summary

1. Leveraging digital health and care coordination to improve health services delivery to vulnerable populations. We embrace big data and technology to design, develop, and deliver economic and effective services for patients in the area of cancer screening and follow-up.

2. Development of intestinal organoids from humans to understand barrier function, systemic inflammation, inflammatory bowel disease, HIV persistence, infection, and microbiome. Approaches employed: organoid models, isolation of epithelial cells, lymphocytes, microbiota, and interventional trials such as fecal transplant.

Research Funding

  • January 10, 2020 - December 31, 2024 - Modeling intestinal dysfunction in HIV infection with organoid technology, Co-Principal Investigator. Sponsor: NIH/NIDDK, Sponsor Award ID: R01DK123746
  • July 14, 2016 - June 30, 2021 - Delaney AIDS Research Enterprise to Cure HIV, Co-Investigator. Sponsor: NIH/NIAID, Sponsor Award ID: UM1AI126611
  • January 1, 2016 - December 31, 2020 - Institute for HIV CURE Research, Co-Investigator. Sponsor: amfAR, Sponsor Award ID: 109301-59-RGRL
  • September 22, 2015 - August 31, 2020 - Intestinal MAIT Cells in HIV Infection, Co-Investigator. Sponsor: NIH, Sponsor Award ID: R01DK108350

Education

Pomona College, Claremont, CA, BA, 1993-1997, Chemistry
Harvard Medical School, Boston, MA, MD, 1997-2002, Medicine
Harbor-UCLA Medical Center, Torrance, CA, Residency, 2002-2005, Internal Medicine
University of California, San Francisco, CA, Fellowship, 2005-2008, Gastroenterology
University of California, San Francisco, CA, MAS, 2006-2008, Epidemiology and Biostatistics

Honors & Awards

  • Sigma Xi
  • Phi Beta Kappa
  • Magna Cum Laude
  • Paul Dudley White / Andrew Sellard Fellowship
  • UCSF Distinction in Mentoring Award
  • Fellow of the American Gastroenterological Association
  • Dean M. Craig Endowed Chair in Gastrointestinal Medicine
  • UCSF TICR Program Award for Excellence in Faculty Advising
  • UCSF Holly Smith Award for Exceptional Service to the School of Medicine Nominee

Selected Publications

  1. Yukl SA, Khan S, Chen TH, Trapecar M, Wu F, Xie G, Telwatte S, Fulop D, Pico AR, Laird GM, Ritter KD, Jones NG, Lu CM, Siliciano RF, Roan NR, Milush JM, Somsouk M, Deeks SG, Hunt PW, Sanjabi S Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103+ and Gut CD4+ T Cells.  View on PubMed
  2. Telwatte S, Kim P, Chen TH, Milush JM, Somsouk M, Deeks SG, Hunt PW, Wong JK, Yukl SA Mechanistic differences underlying HIV latency in the gut and blood contribute to differential responses to latency-reversing agents.  View on PubMed
  3. Patel S, Issaka RB, Chen E, Somsouk M Colorectal Cancer Screening and COVID-19.  View on PubMed
  4. Neidleman J, Luo X, Frouard J, Xie G, Hsiao F, Ma T, Morcilla V, Lee A, Telwatte S, Thomas R, Tamaki W, Wheeler B, Hoh R, Somsouk M, Vohra P, Milush J, James KS, Archin NM, Hunt PW, Deeks SG, Yukl SA, Palmer S, Greene WC, Roan NR Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir.  View on PubMed
  5. Jiang C, Lian X, Gao C, Sun X, Einkauf KB, Chevalier JM, Chen SMY, Hua S, Rhee B, Chang K, Blackmer JE, Osborn M, Peluso MJ, Hoh R, Somsouk M, Milush J, Bertagnolli LN, Sweet SE, Varriale JA, Burbelo PD, Chun TW, Laird GM, Serrao E, Engelman AN, Carrington M, Siliciano RF, Siliciano JM, Deeks SG, Walker BD, Lichterfeld M, Yu XG Distinct viral reservoirs in individuals with spontaneous control of HIV-1.  View on PubMed
  6. Lee B, Patel S, Rachocki C, Issaka R, Vittinghoff E, Shapiro JA, Ladabaum U, Somsouk M Advanced Notification Calls Prior to Mailed Fecal Immunochemical Test in Previously Screened Patients: a Randomized Controlled Trial.  View on PubMed
  7. SahBandar IN, Chew GM, Corley MJ, Pang APS, Tsai N, Hanks N, Khadka VS, Klatt NR, Hensley-McBain T, Somsouk M, Vujkovic-Cvijin I, Chow DC, Shikuma CM, Ndhlovu LC Changes in gastrointestinal microbial communities influence HIV-specific CD8+ T-cell responsiveness to immune checkpoint blockade.  View on PubMed
  8. Huynh MP, Bradshaw PT, Tana MM, Rachocki C, Somsouk M Obesity and metabolic outcomes in a safety-net health system.  View on PubMed
  9. Sharma AE, Lyson HC, Cherian R, Somsouk M, Schillinger D, Sarkar U A Root Cause Analysis of Barriers to Timely Colonoscopy in California Safety-Net Health Systems.  View on PubMed
  10. Lee SA, Telwatte S, Hatano H, Kashuba ADM, Cottrell ML, Hoh R, Liegler TJ, Stephenson S, Somsouk M, Hunt PW, Deeks SG, Yukl S, Savic RM Antiretroviral Therapy Concentrations Differ in Gut vs. Lymph Node Tissues and Are Associated With HIV Viral Transcription by a Novel RT-ddPCR Assay.  View on PubMed
  11. Issaka RB, Rachocki C, Huynh MP, Chen E, Somsouk M Standardized Workflows Improve Colonoscopy Follow-Up After Abnormal Fecal Immunochemical Tests in a Safety-Net System.  View on PubMed
  12. Somsouk M, Rachocki C, Mannalithara A, Garcia D, Laleau V, Grimes B, Issaka RB, Chen E, Vittinghoff E, Shapiro JA, Ladabaum U Effectiveness and Cost of Organized Outreach for Colorectal Cancer Screening: A Randomized, Controlled Trial.  View on PubMed
  13. Anderson JL, Khoury G, Fromentin R, Solomon A, Chomont N, Sinclair E, Milush JM, Hartogensis W, Bacchetti P, Roche M, Tumpach C, Gartner M, Pitman MC, Epling CL, Hoh R, Hecht FM, Somsouk M, Cameron PU, Deeks SG, Lewin SR Human Immunodeficiency Virus (HIV)-Infected CCR6+ Rectal CD4+ T Cells and HIV Persistence On Antiretroviral Therapy.  View on PubMed
  14. Wang Y, Lifshitz L, Gellatly K, Vinton CL, Busman-Sahay K, McCauley S, Vangala P, Kim K, Derr A, Jaiswal S, Kucukural A, McDonel P, Hunt PW, Greenough T, Houghton J, Somsouk M, Estes JD, Brenchley JM, Garber M, Deeks SG, Luban J HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells.  View on PubMed
  15. Lee E, von Stockenstrom S, Morcilla V, Odevall L, Hiener B, Shao W, Hartogensis W, Bacchetti P, Milush J, Liegler T, Sinclair E, Hatano H, Hoh R, Somsouk M, Hunt P, Boritz E, Douek D, Fromentin R, Chomont N, Deeks SG, Hecht FM, Palmer S Impact of Antiretroviral Therapy Duration on HIV-1 Infection of T Cells within Anatomic Sites.  View on PubMed
  16. Sangaramoorthy M, Yang J, DeRouen MC, Ho C, Somsouk M, Tana MM, Thompson CA, Gibbons J, Gomez SL, Shariff-Marco S Disparities in Hepatocellular Carcinoma Incidence in California: An Update.  View on PubMed
  17. Belle NM, Ji Y, Herbine K, Wei Y, Park J, Zullo K, Hung LY, Srivatsa S, Young T, Oniskey T, Pastore C, Nieves W, Somsouk M, Herbert DR TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths.  View on PubMed
  18. Selvig D, Piceno Y, Terdiman J, Zydek M, Umetsu SE, Balitzer D, Fadrosh D, Lynch K, Lamere B, Leith T, Kassam Z, Beck K, Lewin S, Ma A, Somsouk M, Lynch SV, El-Nachef N Fecal Microbiota Transplantation in Pouchitis: Clinical, Endoscopic, Histologic, and Microbiota Results from a Pilot Study.  View on PubMed
  19. Vujkovic-Cvijin I, Somsouk M HIV and the Gut Microbiota: Composition, Consequences, and Avenues for Amelioration.  View on PubMed
  20. Vásquez JJ, Aguilar-Rodriguez BL, Rodriguez L, Hogan LE, Somsouk M, McCune JM, Deeks SG, Laszik ZG, Hunt PW, Henrich TJ CD32-RNA Co-localizes with HIV-RNA in CD3+ Cells Found within Gut Tissues from Viremic and ART-Suppressed Individuals.  View on PubMed

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