Ma Somsouk, MD, MAS

Ma Somsouk, MD, MAS

Dean M. Craig Endowed Chair in Gastrointestinal Medicine, UCSF

Professor of Medicine in Residence, UCSF Division of Gastroenterology at ZSFG; Core Faculty, UCSF Action Research Center (ARC) for Health Equity

Cancer Center Program Membership

Cancer Control

[email protected]

Phone: (628) 206-6480

Box 0862, UCSF
San Francisco, CA 94143-0862

UCSF Profiles

Research Summary

1. Programmatic implementation of population-based colorectal cancer screening and follow-up of abnormal screening results. We embrace big data and technology to design, develop, and deliver economic and effective services for patients and health systems.

2. Use of human gut samples to study HIV, Covid-19, barrier function, systemic inflammation, inflammatory bowel disease, and microbiome. Approaches employed: organoid models, isolation of epithelial cells and lymphocytes, single cell, spatial transcriptomic analysis, microbial profiling, and blood-based profiling.

Research Funding

  • March 8, 2024 - February 28, 2029 - Understanding and targeting the HIV-expressing reservoir to reduce immune activation , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01AI183666
  • January 1, 2024 - December 31, 2028 - Learning Health System Embedded Scientist Training and Research Center , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P30HS029738
  • September 20, 2023 - August 31, 2028 - LISTOS for Cancer Control - Leveraging Implementation Science To Optimize Strategies for Cancer Control , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U54CA284109
  • May 16, 2022 - February 28, 2027 - IMProving Adherence to Colonoscopy through Teams and Technology (IMPACTT) , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA271031
  • July 18, 2016 - June 30, 2026 - Clinical and Translational Science Institute , Co-Investigator . Sponsor: NIH, Sponsor Award ID: UL1TR001872
  • March 15, 2021 - February 28, 2026 - Cytomegalovirus (CMV), the gut barrier and immune dysfunction in HIV , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01AI155680
  • August 12, 2020 - July 31, 2025 - In Vivo PET Imaging of HIV Infection , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01AI152932
  • January 10, 2020 - December 31, 2024 - Modeling intestinal dysfunction in HIV infection with organoid technology , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DK123746
  • August 16, 2019 - July 31, 2024 - Understanding the Multilevel Drivers of Liver Cancer Disparities , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01CA225478
  • May 24, 2021 - May 23, 2023 - OTA-21-015A Post-Acute Sequelae of SARS-CoV-2 Infection Initiative: NYU Langone Health Clinical Science Core, Data Resource Core, and PASC Biorepository Core , Co-Investigator . Sponsor: NIH, Sponsor Award ID: OT2HL161847
  • May 15, 2018 - April 30, 2023 - Targeting Non Viral Markers of HIV Persistence , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01AI141003
  • May 1, 2018 - April 30, 2023 - Evaluation of epithelial growth in response to soluble factors , . Sponsor: Genentech, Sponsor Award ID: A129674
  • September 22, 2015 - August 31, 2021 - Intestinal MAIT Cells in HIV Infection , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01DK108350
  • September 21, 2015 - August 31, 2021 - Investigating Mechanisms of HIV Persistence in the Gut , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01DK108349
  • July 14, 2016 - June 30, 2021 - Delaney AIDS Research Enterprise to Cure HIV , Co-Investigator . Sponsor: NIH, Sponsor Award ID: UM1AI126611
  • February 4, 2015 - January 31, 2021 - Timing of ART and homeostasis of the persistent HIV reservoir in the adult , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01AI116368
  • January 1, 2016 - December 31, 2020 - Institute for HIV CURE Research , Co-Investigator . Sponsor: amfAR, Sponsor Award ID: 109301-59-RGRL
  • June 1, 2014 - May 31, 2020 - Determinants of Functional Immune Defects in Treated HIV Infection and Aging , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01AI110271
  • September 1, 2014 - August 31, 2019 - Effective and Cost of Organized Outreach to Improve Colorectal Cancer Screening , Principal Investigator . Sponsor: CDC, Sponsor Award ID: U48DP004998-14-012
  • July 11, 2003 - May 31, 2019 - HIV-Specific T Cell Responses in Rectal Mucosa , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01AI057020
  • August 1, 2015 - July 31, 2018 - Fecal microbial transplantation to reduce HIV-associated inflammation , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21DK104664
  • September 22, 2011 - August 31, 2016 - HIV, Gut Mucosal Turnover and Inflammation, and the Risk of Colorectal Neoplasia , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K23CA157929
  • September 1, 2014 - March 31, 2016 - Understanding barriers to colorectal cancer screening in South Asians , Principal Investigator . Sponsor: CDC, Sponsor Award ID: U48DP004998-01S4

Education

Pomona College, Claremont, CA, BA, 1993-1997, Chemistry
Harvard Medical School, Boston, MA, MD, 1997-2002, Medicine
Harbor-UCLA Medical Center, Torrance, CA, Residency, 2002-2005, Internal Medicine
University of California, San Francisco, CA, Fellowship, 2005-2008, Gastroenterology
University of California, San Francisco, CA, MAS, 2006-2008, Epidemiology and Biostatistics

Honors & Awards

  • Sigma Xi
  • Phi Beta Kappa
  • Magna Cum Laude
  • Paul Dudley White / Andrew Sellard Fellowship
  • UCSF Distinction in Mentoring Award
  • Fellow of the American Gastroenterological Association
  • Dean M. Craig Endowed Chair in Gastrointestinal Medicine
  • UCSF TICR Program Award for Excellence in Faculty Advising
  • UCSF Holly Smith Award for Exceptional Service to the School of Medicine Nominee
  • UCSF Division of Gastroenterology Teaching Award

Selected Publications

  1. Wang K, Wong J, Avilez L, Olazo K, Olanrewaju S, McCulloch CE, Pasick R, Patel S, Somsouk M, Sarkar U. Multilevel intervention for follow-up of abnormal FIT in the safety-net: IMProving Adherence to Colonoscopy through Teams and Technology (IMPACTT). Contemp Clin Trials. 2025 Mar; 150:107810.  View on PubMed
  2. Peluso MJ, Ryder D, Flavell RR, Wang Y, Levi J, LaFranchi BH, Deveau TM, Buck AM, Munter SE, Asare KA, Aslam M, Koch W, Szabo G, Hoh R, Deswal M, Rodriguez AE, Buitrago M, Tai V, Shrestha U, Lu S, Goldberg SA, Dalhuisen T, Vasquez JJ, Durstenfeld MS, Hsue PY, Kelly JD, Kumar N, Martin JN, Gambhir A, Somsouk M, Seo Y, Deeks SG, Laszik ZG, VanBrocklin HF, Henrich TJ. Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection. Sci Transl Med. 2024 Jul 03; 16(754):eadk3295.  View on PubMed
  3. McClellan SP, Patel S, Uy-Smith E, Gregory B, Neuhaus JM, Potter MB, Somsouk M. Colorectal Cancer Screening: A Multicomponent Intervention to Increase Uptake in Patients Aged 45-49. J Am Board Fam Med. 2024 Jul-Aug; 37(4):660-670.  View on PubMed
  4. Colquhoun DA, Somsouk M, Chen CL. Does Propofol Improve Polyp Detection during Colonoscopy? The Promise and Peril of Clinical Registry Data. Anesthesiology. 2024 Jun 01; 140(6):1062-1064.  View on PubMed
  5. McClellan SP, Khan T, Rafferty H, Wong J, La S, Patel S, Somsouk M. The effect of mailed outreach on FIT completion among patients aged 45-50 in a safety net healthcare system. Cancer Causes Control. 2024 Oct; 35(10):1311-1317.  View on PubMed
  6. Burns S, Griffith M, Patel S, Sarkar U, Somsouk M. Electronic Coding for Abnormal Fecal Immunochemical Test Is Associated With Increased Colonoscopy Completion. Am J Gastroenterol. 2024 07 01; 119(7):1431-1432.  View on PubMed
  7. Odufalu FD, Sewell JL, Rudrapatna V, Somsouk M, Mahadevan U. Assessing the Impact of COVID-19 on IBD Outcomes Among Vulnerable Patient Populations in a Large Metropolitan Center. Inflamm Bowel Dis. 2024 01 05; 30(1):29-37.  View on PubMed
  8. Viramontes O, Martinez D, Somsouk M. Intestinal Metaplasia Associated with Symptoms of Dyspepsia. Res Sq. 2023 Oct 03.  View on PubMed
  9. Patel S, Sewell JL, Bhuket T, Somsouk M. Delivering High-Quality, Efficient Gastroenterology Care to Vulnerable and Underserved Populations: Special Considerations and Possible Solutions. Clin Gastroenterol Hepatol. 2023 12; 21(13):3213-3216.e1.  View on PubMed
  10. Peluso MJ, Ryder D, Flavell R, Wang Y, Levi J, LaFranchi BH, Deveau TM, Buck AM, Munter SE, Asare KA, Aslam M, Koch W, Szabo G, Hoh R, Deswal M, Rodriguez A, Buitrago M, Tai V, Shrestha U, Lu S, Goldberg SA, Dalhuisen T, Durstenfeld MS, Hsue PY, Kelly JD, Kumar N, Martin JN, Gambir A, Somsouk M, Seo Y, Deeks SG, Laszik ZG, VanBrocklin HF, Henrich TJ. Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to 2 Years Following COVID-19. medRxiv. 2023 Jul 31.  View on PubMed
  11. Santiago-Rodríguez EJ, Hoeft KS, Lugtu K, McGowen M, Ofman D, Adler J, Somsouk M, Potter MB. Implementation of a novel program to support colorectal cancer screening in a community health center consortium before and after the onset of COVID-19: a qualitative study of stakeholders' perspectives. Implement Sci Commun. 2023 May 22; 4(1):54.  View on PubMed
  12. Duarte MJ, Tien PC, Somsouk M, Price JC. The human microbiome and gut-liver axis in people living with HIV. Curr HIV/AIDS Rep. 2023 06; 20(3):170-180.  View on PubMed
  13. Burns S, Wang J, Somsouk M. Effect of Mailed Fecal Immunochemical Test Outreach for Patients Newly Eligible for Colorectal Cancer Screening. Dig Dis Sci. 2023 06; 68(6):2315-2317.  View on PubMed
  14. McClellan SP, Canchola AJ, Potter MB, Gomez SL, Somsouk M. Neighborhood socioeconomic status and the effectiveness of colorectal cancer screening outreach with mailed fecal immunochemical tests within a safety net healthcare system in San Francisco, CA: A subgroup analysis of a randomized controlled trial. Prev Med. 2023 02; 167:107388.  View on PubMed
  15. Burns S, Somsouk M. Durability of FIT Screening After Cessation of a Screening Outreach Intervention. Dig Dis Sci. 2023 05; 68(5):1777-1779.  View on PubMed
  16. Altinbas A, Holmes JA, Salloum S, Lidofsky A, Alatrakchi N, Somsouk M, Hunt P, Deeks S, Chew KW, Lauer G, Kruger A, Lin W, Chung RT. LOXL-2 and TNC-C are markers of liver fibrogenesis in HCV/HIV-, HIV- and HCV-infected patients. Biomark Med. 2022 08; 16(11):839-846.  View on PubMed
  17. Khoong EC, Rivadeneira NA, Pacca L, Schillinger D, Lown D, Babaria P, Gupta N, Pramanik R, Tran H, Whitezell T, Somsouk M, Sarkar U. Extent of Follow-Up on Abnormal Cancer Screening in Multiple California Public Hospital Systems: A Retrospective Review. J Gen Intern Med. 2023 01; 38(1):21-29.  View on PubMed
  18. Mukherjea A, Shariff-Marco S, Yang J, Tseng W, Palaniappan L, Li J, Ivey SL, Somsouk M, Gomez SL. Determinants of Colorectal Cancer Screening among South Asian Americans. J Asian Health. 2022 Apr; 10(e202202):1-12.  View on PubMed
  19. Hiatt RA, Sibley A, Venkatesh B, Cheng J, Dixit N, Fox R, Ling P, Nguyen T, Oh D, Palmer NR, Pasick RJ, Potter MB, Somsouk M, Vargas RA, Vijayaraghavan M, Ashworth A. From Cancer Epidemiology to Policy and Practice: the Role of a Comprehensive Cancer Center. Curr Epidemiol Rep. 2022; 9(1):10-21.  View on PubMed
  20. Chang HW, Yan D, Singh R, Bui A, Lee K, Truong A, Milush JM, Somsouk M, Liao W. Multiomic Analysis of the Gut Microbiome in Psoriasis Reveals Distinct Host‒Microbe Associations. JID Innov. 2022 May; 2(3):100115.  View on PubMed

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