Research Summary

The Spitzer Lab is working to develop our understanding of how the immune system coordinates its responses across the organism with an emphasis on tumor immunology. We combine methods in experimental immunology and cancer biology with computation to understand the modes in which the immune system can respond to tumors and to rationally initiate curative immune responses against cancer.

Research Funding

  • September 21, 2016 - August 31, 2021 - Quantitatively modeling immune responses to cancer, Principal Investigator. Sponsor: NIH, Sponsor Award ID: DP5OD023056
  • July 15, 2017 - May 31, 2019 - Single-cell High-dimensional Characterization of the Bone Marrow Microenvironment in Health and Disease, Co-Principal Investigator. Sponsor: NIH/NIA, Sponsor Award ID: R21AG057224
  • September 30, 2014 - September 29, 2018 - Revealing the tumor-immune network by mass cytometry, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: F31CA189331
  • September 21, 2016 - August 31, 2021 - Quantitatively modeling immune responses to cancer, Principal Investigator. Sponsor: NIH, Sponsor Award ID: DP5OD023056

Education

Georgetown University, B.S., 05/2011, Biology
Stanford University, Ph.D., 03/2016, Immunology

Honors & Awards

  • 2008-2011
    National Merit Scholarship Recipient
  • 2009
    Student-Athlete Academic Honors, Georgetown University
  • 2009-2011
    Baker Scholar, Georgetown University
  • 2010
    Reardon Fellow, Georgetown University
  • 2010
    Phi Beta Kappa
  • 2010-2011
    Howard Hughes Undergraduate Research Scholar, Georgetown University
  • 2010-2011
    Taylor-Weber Memorial Scholar, Georgetown University
  • 2011
    Sigma Xi Medal for Most Outstanding Undergraduate Research, Georgetown University
  • 2011
    Summa Cum Laude, Georgetown University
  • 2011-2014
    George D. Smith Stanford Graduate Fellow, Stanford University
  • 2014-2016
    NIH/NCI NRSA F31 Fellow
  • 2016-2021
    Sandler Faculty Fellow, University of California, San Francisco
  • 2016-2021
    Sean N. Parker Faculty Fellow, University of California, San Francisco
  • 2016-2021
    Early Independence Award, Office of the Director, NIH

Selected Publications

  1. Hwang B, Lee DS, Tamaki W, Sun Y, Ogorodnikov A, Hartoularos GC, Winters A, Yeung BZ, Nazor KL, Song YS, Chow ED, Spitzer MH, Ye CJ. SCITO-seq: single-cell combinatorial indexed cytometry sequencing. Nat Methods. 2021 Aug; 18(8):903-911.  View on PubMed
  2. Dong S, Hiam-Galvez KJ, Mowery CT, Herold KC, Gitelman SE, Esensten JH, Liu W, Lares AP, Leinbach AS, Lee M, Nguyen V, Tamaki SJ, Tamaki W, Tamaki CM, Mehdizadeh M, Putnam AL, Spitzer MH, Ye CJ, Tang Q, Bluestone JA. The effects of low-dose IL-2 on Treg adoptive cell therapy in patients with Type 1 diabetes. JCI Insight. 2021 Jul 29.  View on PubMed
  3. Sinha M, Zhang L, Subudhi S, Chen B, Marquez J, Liu EV, Allaire K, Cheung A, Ng S, Nguyen C, Friedlander TW, Aggarwal R, Spitzer M, Allison JP, Small EJ, Sharma P, Fong L. Pre-existing immune status associated with response to combination of sipuleucel-T and ipilimumab in patients with metastatic castration-resistant prostate cancer. J Immunother Cancer. 2021 May; 9(5).  View on PubMed
  4. Hiam-Galvez KJ, Allen BM, Spitzer MH. Systemic immunity in cancer. Nat Rev Cancer. 2021 06; 21(6):345-359.  View on PubMed
  5. Levine LS, Hiam-Galvez KJ, Marquez DM, Tenvooren I, Madden MZ, Contreras DC, Dahunsi DO, Irish JM, Oluwole OO, Rathmell JC, Spitzer MH. Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response. Immunity. 2021 04 13; 54(4):829-844.e5.  View on PubMed
  6. Rahil Z, Leylek R, Schürch CM, Chen H, Bjornson-Hooper Z, Christensen SR, Gherardini PF, Bhate SS, Spitzer MH, Fragiadakis GK, Mukherjee N, Kim N, Jiang S, Yo J, Gaudilliere B, Affrime M, Bock B, Hensley SE, Idoyaga J, Aghaeepour N, Kim K, Nolan GP, McIlwain DR. Landscape of coordinated immune responses to H1N1 challenge in humans. J Clin Invest. 2020 11 02; 130(11):5800-5816.  View on PubMed
  7. Schumann K, Raju SS, Lauber M, Kolb S, Shifrut E, Cortez JT, Skartsis N, Nguyen VQ, Woo JM, Roth TL, Yu R, Nguyen MLT, Simeonov DR, Nguyen DN, Targ S, Gate RE, Tang Q, Bluestone JA, Spitzer MH, Ye CJ, Marson A. Functional CRISPR dissection of gene networks controlling human regulatory T cell identity. Nat Immunol. 2020 11; 21(11):1456-1466.  View on PubMed
  8. Atallah MB, Tandon V, Hiam KJ, Boyce H, Hori M, Atallah W, Spitzer MH, Engleman E, Mallick P. ImmunoGlobe: enabling systems immunology with a manually curated intercellular immune interaction network. BMC Bioinformatics. 2020 Aug 10; 21(1):346.  View on PubMed
  9. Oh DY, Kwek SS, Raju SS, Li T, McCarthy E, Chow E, Aran D, Ilano A, Pai CS, Rancan C, Allaire K, Burra A, Sun Y, Spitzer MH, Mangul S, Porten S, Meng MV, Friedlander TW, Ye CJ, Fong L. Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer. Cell. 2020 06 25; 181(7):1612-1625.e13.  View on PubMed
  10. Levine LS, Mahuron KM, Tsai KK, Wu C, Mattis DM, Pauli ML, Oglesby A, Lee JC, Spitzer MH, Krummel MF, Algazi AP, Rosenblum MD, Alvarado M, Daud AI. Tumor Immune Profiling-Based Neoadjuvant Immunotherapy for Locally Advanced Melanoma. Ann Surg Oncol. 2020 Oct; 27(11):4122-4130.  View on PubMed
  11. Allen BM, Hiam KJ, Burnett CE, Venida A, DeBarge R, Tenvooren I, Marquez DM, Cho NW, Carmi Y, Spitzer MH. Systemic dysfunction and plasticity of the immune macroenvironment in cancer models. Nat Med. 2020 07; 26(7):1125-1134.  View on PubMed
  12. Guo CJ, Allen BM, Hiam KJ, Dodd D, Van Treuren W, Higginbottom S, Nagashima K, Fischer CR, Sonnenburg JL, Spitzer MH, Fischbach MA. Depletion of microbiome-derived molecules in the host using Clostridium genetics. Science. 2019 12 13; 366(6471).  View on PubMed
  13. Zammit NW, Siggs OM, Gray PE, Horikawa K, Langley DB, Walters SN, Daley SR, Loetsch C, Warren J, Yap JY, Cultrone D, Russell A, Malle EK, Villanueva JE, Cowley MJ, Gayevskiy V, Dinger ME, Brink R, Zahra D, Chaudhri G, Karupiah G, Whittle B, Roots C, Bertram E, Yamada M, Jeelall Y, Enders A, Clifton BE, Mabbitt PD, Jackson CJ, Watson SR, Jenne CN, Lanier LL, Wiltshire T, Spitzer MH, Nolan GP, Schmitz F, Aderem A, Porebski BT, Buckle AM, Abbott DW, Ziegler JB, Craig ME, Benitez-Aguirre P, Teo J, Tangye SG, King C, Wong M, Cox MP, Phung W, Tang J, Sandoval W, Wertz IE, Christ D, Goodnow CC, Grey ST. Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity. Nat Immunol. 2019 10; 20(10):1299-1310.  View on PubMed
  14. Deuse T, Hu X, Agbor-Enoh S, Koch M, Spitzer MH, Gravina A, Alawi M, Marishta A, Peters B, Kosaloglu-Yalcin Z, Yang Y, Rajalingam R, Wang D, Nashan B, Kiefmann R, Reichenspurner H, Valantine H, Weissman IL, Schrepfer S. De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans. Nat Biotechnol. 2019 10; 37(10):1137-1144.  View on PubMed
  15. Hartmann FJ, Babdor J, Gherardini PF, Amir ED, Jones K, Sahaf B, Marquez DM, Krutzik P, O'Donnell E, Sigal N, Maecker HT, Meyer E, Spitzer MH, Bendall SC. Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy. Cell Rep. 2019 07 16; 28(3):819-831.e4.  View on PubMed
  16. Spitzer MH. Hacking the 'Cellular Immunology Agency': T cells caught in the act. Nat Immunol. 2019 04; 20(4):382-383.  View on PubMed
  17. Hartmann FJ, Simonds EF, Vivanco N, Bruce T, Borges L, Nolan GP, Spitzer MH, Bendall SC. Scalable Conjugation and Characterization of Immunoglobulins with Stable Mass Isotope Reporters for Single-Cell Mass Cytometry Analysis. Methods Mol Biol. 2019; 1989:55-81.  View on PubMed
  18. Gonzalez-Junca A, Driscoll KE, Pellicciotta I, Du S, Lo CH, Roy R, Parry R, Tenvooren I, Marquez DM, Spitzer MH, Barcellos-Hoff MH. Autocrine TGFß Is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment. Cancer Immunol Res. 2019 02; 7(2):306-320.  View on PubMed
  19. Han G, Spitzer MH, Bendall SC, Fantl WJ, Nolan GP. Metal-isotope-tagged monoclonal antibodies for high-dimensional mass cytometry. Nat Protoc. 2018 10; 13(10):2121-2148.  View on PubMed
  20. Hu Z, Jujjavarapu C, Hughey JJ, Andorf S, Lee HC, Gherardini PF, Spitzer MH, Thomas CG, Campbell J, Dunn P, Wiser J, Kidd BA, Dudley JT, Nolan GP, Bhattacharya S, Butte AJ. MetaCyto: A Tool for Automated Meta-analysis of Mass and Flow Cytometry Data. Cell Rep. 2018 07 31; 24(5):1377-1388.  View on PubMed

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