Research Summary

Dr. Matthew L. Springer received his BA from the University of California, Berkeley in 1985 and his PhD from Stanford University in 1992. He did postdoctoral research at Stanford and continued his research there as a senior scientist until joining the UCSF faculty in 2003, where he is currently one of two non-clinicians on the faculty of the Division of Cardiology. The close juxtaposition of his basic research background with the clinical cardiologists in the Division has resulted in an active translational research program.

Dr. Springer's research interests include cell therapy and gene therapy approaches to studying cardiovascular disease, with the goals of exploring potential treatments and understanding underlying mechanisms involved in angiogenesis, vascular function, and treatments for myocardial infarction. The laboratory is studying the therapeutic effects of ultrasound-guided bone marrow cell implantation into the heart after myocardial infarction, with a special emphasis on the therapeutic implications of the age and cardiac disease state of the cell donor. Similarly, the lab is studying the effects of age and disease on circulating angiogenic cells (sometimes called endothelial progenitor cells), with a focus on the roles of endothelial nitric oxide synthase and nitric oxide in the function of these cells. The main angiogenesis interest is how cardiac motion and cyclical forces influences angiogenic gene expression and cell behavior. Currently, a large effort involves the study of vascular reactivity using a rat model of endothelium-dependent flow-mediated vasodilation that they developed, and how vascular endothelial function is affected by exposure to secondhand smoke from tobacco and marijuana.

Research Funding

  • July 1, 2021 - October 13, 2023 - Effects of Chronic Cannabis Use on Endothelial Function , Principal Investigator . Sponsor: CA Department of Cannabis Control, Sponsor Award ID: Grant RG-1603151328-913
  • September 1, 2018 - June 30, 2023 - Integrated Health, Behavioral and Economic Research on Current and Emerging Tobacco Products , PI of Project 3, Cardiovascular Health Effects of Emerging Heat-Not-Burn Tobacco Products . Sponsor: NIH/NHLBI, Sponsor Award ID: U54HL147127
  • November 25, 2020 - March 31, 2022 - Upregulation of SARS-CoV-2 receptor and activation proteases by marijuana smoke and e-cigarette aerosols , Principal Investigator . Sponsor: NIH/NIDA, Sponsor Award ID: R21DA050995-S (supplement)
  • April 15, 2020 - March 31, 2022 - Validation of NIDA research marijuana as a model for cardiovascular research , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21DA050995


University of California, Berkeley, CA, B.A., 1981-1985, Molecular Biology
Stanford University, Stanford, CA, Ph.D., 1985-1991, Biological Sciences
Stanford University, Stanford, CA, (postdoctoral), 1991-1993, Cell Biology/Biochemistry
Stanford University, Stanford, CA, (postdoctoral), 1993-1997, Molecular Pharmacology

Honors & Awards

  • 1985
    President, Molecular Biology Undergraduate Society, UC Berkeley
  • 1985
    Selected graduation speaker, Department of Molecular Biology, UC Berkeley
  • 1985
    Graduated with distinction, UC Berkeley
  • 1987
    Award for Exceptional Contributions in Teaching, Department of Biological Sciences, Stanford University
  • 1988-1989
    Elected Graduate Student Representative, Dept. of Biological Sciences, Stanford University
  • 2008
    4th place winner (out of >2000), Nikon Small World Competition for microscopy
  • 2012
    3rd Annual Vascular Biology Center Student’s Choice Speaker, Georgia Health Sciences University
  • 2019
    Dean's Apple Award (teaching), School of Pharmacy, UCSF

Selected Publications

  1. Wang X, Chacon LI, Derakhshandeh R, Rodriguez HJ, Han DD, Kostyushev DS, Henry TD, Traverse JH, Moyé L, Simari RD, Taylor DA, Springer ML; Impaired therapeutic efficacy of bone marrow cells from post-myocardial infarction patients in the TIME and LateTIME clinical trials.; PloS One; 2020.
    View in PubMed
  2. Rao P, Liu J, Springer ML; JUUL and Combusted Cigarettes Comparably Impair Endothelial Function.; Tobacco Regulatory Science; 2020.
    View in PubMed
  3. Nabavizadeh P, Liu J, Havel CM, Ibrahim S, Derakhshandeh R, Jacob Iii P, Springer ML; Vascular endothelial function is impaired by aerosol from a single IQOS HeatStick to the same extent as by cigarette smoke.; Tobacco Control; 2018.
    View in PubMed
  4. An S, Wang X, Ruck MA, Rodriguez HJ, Kostyushev DS, Varga M, Luu E, Derakhshandeh R, Suchkov SV, Kogan SC, Hermiston ML, Springer ML; Age-Related Impaired Efficacy of Bone Marrow Cell Therapy for Myocardial Infarction Reflects a Decrease in B Lymphocytes.; Molecular Therapy : The Journal Of The American Society Of Gene Therapy; 2018.
    View in PubMed
  5. Wang X, Derakhshandeh R, Liu J, Narayan S, Nabavizadeh P, Le S, Danforth OM, Pinnamaneni K, Rodriguez HJ, Luu E, Sievers RE, Schick SF, Glantz SA, Springer ML; One Minute of Marijuana Secondhand Smoke Exposure Substantially Impairs Vascular Endothelial Function.; Journal Of The American Heart Association; 2016.
    View in PubMed
  6. Chen Q, Varga M, Wang X, Haddad DJ, An S, Medzikovic L, Derakhshandeh R, Kostyushev DS, Zhang Y, Clifford BT, Luu E, Danforth OM, Rafikov R, Gong W, Black SM, Suchkov SV, Fineman JR, Heiss C, Aschbacher K, Yeghiazarians Y, Springer ML; Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction.; Journal Of The American Heart Association; 2016
    View in PubMed
  7. Pinnamaneni K, Sievers RE, Sharma R, Selchau AM, Gutierrez G, Nordsieck EJ, Su R, An S, Chen Q, Wang X, Derakhshandeh R, Aschbacher K, Heiss C, Glantz SA, Schick SF, Springer ML; Brief exposure to secondhand smoke reversibly impairs endothelial vasodilatory function.; Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco; 2013.
    View in PubMed
  8. Fang Q, Mok PY, Thomas AE, Haddad DJ, Saini SA, Clifford BT, Kapasi NK, Danforth OM, Usui M, Ye W, Luu E, Sharma R, Bartel MJ, Pathmanabhan JA, Ang AA, Sievers RE, Lee RJ, Springer ML; Pleiotrophin gene therapy for peripheral ischemia: evaluation of full-length and truncated gene variants.; PloS One; 2013.
    View in PubMed
  9. Wang X, Takagawa J, Lam VC, Haddad DJ, Tobler DL, Mok PY, Zhang Y, Clifford BT, Pinnamaneni K, Saini SA, Su R, Bartel MJ, Sievers RE, Carbone L, Kogan S, Yeghiazarians Y, Hermiston M, Springer ML; Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response.; Science Translational Medicine; 2011.
    View in PubMed
  10. Yeghiazarians Y, Zhang Y, Prasad M, Shih H, Saini SA, Takagawa J, Sievers RE, Wong ML, Kapasi NK, Mirsky R, Koskenvuo J, Minasi P, Ye J, Viswanathan MN, Angeli FS, Boyle AJ, Springer ML, Grossman W; Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy.; Molecular Therapy : The Journal Of The American Society Of Gene Therapy; 2009.
    View in PubMed
  11. Heiss C, Sievers RE, Amabile N, Momma TY, Chen Q, Natarajan S, Yeghiazarians Y, Springer ML; In vivo measurement of flow-mediated vasodilation in living rats using high-resolution ultrasound.;American Journal Of Physiology. Heart And Circulatory Physiology; 2007.
    View in PubMed
  12. Springer ML, Sievers RE, Viswanathan MN, Yee MS, Foster E, Grossman W, Yeghiazarians Y; Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography.;American Journal Of Physiology. Heart And Circulatory Physiology; 2005.
    View in PubMed
  13. Springer ML, Chen AS, Kraft PE, Bednarski M, Blau HM; VEGF gene delivery to muscle: potential role for vasculogenesis in adults.; Molecular Cell; 1998.
    View in PubMed

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