Sharof M. Tugizov, DVM, PhD, DSc
Professor, Department of Medicine, UCSF
My research focus is investigation of the interactions of human viruses, including human cytomegalovirus (HCMV), Epstein–Barr virus (EBV), Herpes simplex virus (HSV), human immunodeficiency virus (HIV), and human papillomavirus (HPV), with monostratified and multistratified oral epithelia. We have made significant contributions to current knowledge about entry, transcytosis, intracellular transport, egress, and cell-to-cell transmission of these viruses in oral epithelial cells by establishing and using polarized epithelial cells, as well as ex vivo oral mucosal tissue explants. Currently, we are investigating the potential interactions of HIV with other viral pathogens, including human papillomavirus HPV. The incidence of HPV-associated oral cancer in human immunodeficiency virus (HIV)-positive individuals is substantially higher than in HIV-uninfected individuals. Our data show that oral epithelial biopsies from HIV-infected individuals and oral keratinocytes grown in tissue culture from HIV-infected individuals have multiple changes consistent with epithelial-mesenchymal transition (EMT), a multistep epigenetic process characterized by loss of cell adhesion and increased proliferation and mobility of epithelial cells. EMT is important in cell differentiation during embryogenesis. However, it is also plays a critical role in progression of neoplastic processes. We expect that our research may led to better understanding the role of HIV-associated EMT in development of HPV-associated neoplasia.
Institute of Agriculture, School of Veterinary Medicine, Samarkand, Uzbekistan (former Soviet Union), DVM 1981, Veterinary Medicine
Institute of Experimental Veterinary Medicine and Ivanosky Institute of Virology, Moscow, Russia, PhD, 1985, Virology, Cell Biology
Ivanosky Institute of Virology, Russian Academy of Medical Sciences, Moscow, Russia, DSc, 1996, Medical Virology Infectious Disease