Research Summary

Aaron D. Tward M.D., Ph.D., is a board-certified, fellowship-trained surgeon who specializes in the diagnosis and treatment of disorders of the ear and skull base.

Dr. Tward has particular clinical interests in cochlear implantation, management of benign and malignant tumors of the skull base including acoustic neuroma (vestibular schwannoma), surgery for chronic otitis media, stapedectomy, superior semi-circular canal dehiscence repair, and endoscopic surgery of the ear and skull base.

Dr. Twardʻs research interests include tumor biology, the genetics and genomics of disorders of the head and neck, and clinical outcomes of surgery of the ear and skull base.

Education

UCLA, B.S., 06/99, Microbiology and Molecular Genetics
UCLA, M.A., 06/99, Microbiology and Molecular Genetics
UCSF School of Medicine, Ph.D., 06/05, Biomedical Sciences
UCSF School of Medicine, M.D., 06/07, Medicine Brigham and Women's Hospital
Harvard Medical School Internship, 06/08, General Surgery

Honors & Awards

  • 1995
    National Merit Scholar
  • 1995
    UCLA Regents Scholar
  • 1996
    UCLA Stone prize for excellence in first year chemistry
  • 1997
    Departmental Scholar - UCLA Dept. of Microbiology and Molecular Genetics
  • 1999
    Medical Scientist Training Program
  • 2006
    Student Delegate, Academy of Achievement
  • 2006
    Alpha Omega Alpha
  • 2007
    UCSF Medical School Homecoming speaker
  • 2012
    J. P. Harris Award for Excellence in Resident Research, Harvard Otolaryngology Residency Program

Selected Publications

  1. Suresh K, Chari DA, Bartholomew RA, Tward AD, Kozin ED, Barshak MB, Holbrook EH, Lee DJ. A Rare Complication of Chronic Otitis Media: Central Skull Base Osteomyelitis Managed With Combined Endoscopic Transmastoid and Transsphenoidal Debridement. Otol Neurotol. 2022 Mar 01; 43(3):e344-e347.  View on PubMed
  2. Rust K, Byrnes LE, Yu KS, Park JS, Sneddon JB, Tward AD, Nystul TG. Author Correction: A single-cell atlas and lineage analysis of the adult Drosophila ovary. Nat Commun. 2021 Oct 06; 12(1):5951.  View on PubMed
  3. Belote RL, Le D, Maynard A, Lang UE, Sinclair A, Lohman BK, Planells-Palop V, Baskin L, Tward AD, Darmanis S, Judson-Torres RL. Human melanocyte development and melanoma dedifferentiation at single-cell resolution. Nat Cell Biol. 2021 09; 23(9):1035-1047.  View on PubMed
  4. C. Mahieu, A. Mancini, C. beckett, A. Tward. Scalable genome engineering of adult keratinocytes for the development of novel cell therapeutics. Cytotherapy. 2021 May 1; 23(5):s153.  View on PubMed
  5. Frumm SM, Yu SK, Chang J, Artichoker JA, Scaria SM, Lee KP, Byrnes LE, Sneddon JB, Tward AD. A Hierarchy of Proliferative and Migratory Keratinocytes Maintains the Tympanic Membrane. Cell Stem Cell. 2021 02 04; 28(2):315-330.e5.  View on PubMed
  6. Rust K, Byrnes LE, Yu KS, Park JS, Sneddon JB, Tward AD, Nystul TG. A single-cell atlas and lineage analysis of the adult Drosophila ovary. Nat Commun. 2020 11 06; 11(1):5628.  View on PubMed
  7. Adams CR, Htwe HH, Marsh T, Wang AL, Montoya ML, Subbaraj L, Tward AD, Bardeesy N, Perera RM. Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer. Elife. 2019 05 28; 8.  View on PubMed
  8. Dahlgren MW, Jones SW, Cautivo KM, Dubinin A, Ortiz-Carpena JF, Farhat S, Yu KS, Lee K, Wang C, Molofsky AV, Tward AD, Krummel MF, Peng T, Molofsky AB. Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches. Immunity. 2019 03 19; 50(3):707-722.e6.  View on PubMed
  9. Chari DA, Frumm SM, Akil O, Tward AD. Cellular Dynamics in Early Healing of Mouse Tympanic Membranes. Otol Neurotol. 2019 02; 40(2):e160-e166.  View on PubMed
  10. Breshears JD, Chang J, Molinaro AM, Sneed PK, McDermott MW, Tward A, Theodosopoulos PV. Temporal Dynamics of Pseudoprogression After Gamma Knife Radiosurgery for Vestibular Schwannomas-A Retrospective Volumetric Study. Neurosurgery. 2019 01 01; 84(1):123-131.  View on PubMed
  11. Chang J, Breshears JD, Molinaro AM, Sneed PK, McDermott MW, Theodosopoulos PV, Tward AD. Impact of pretreatment growth on Tumor control for vestibular schwannomas following gamma knife. Laryngoscope. 2019 03; 129(3):743-747.  View on PubMed
  12. Byrnes LE, Wong DM, Subramaniam M, Meyer NP, Gilchrist CL, Knox SM, Tward AD, Ye CJ, Sneddon JB. Lineage dynamics of murine pancreatic development at single-cell resolution. Nat Commun. 2018 09 25; 9(1):3922.  View on PubMed
  13. Sanchez-Vega F, Mina M, Armenia J, Chatila WK, Luna A, La KC, Dimitriadoy S, Liu DL, Kantheti HS, Saghafinia S, Chakravarty D, Daian F, Gao Q, Bailey MH, Liang WW, Foltz SM, Shmulevich I, Ding L, Heins Z, Ochoa A, Gross B, Gao J, Zhang H, Kundra R, Kandoth C, Bahceci I, Dervishi L, Dogrusoz U, Zhou W, Shen H, Laird PW, Way GP, Greene CS, Liang H, Xiao Y, Wang C, Iavarone A, Berger AH, Bivona TG, Lazar AJ, Hammer GD, Giordano T, Kwong LN, McArthur G, Huang C, Tward AD, Frederick MJ, McCormick F, Meyerson M, Cancer Genome Atlas Research Network, Van Allen EM, Cherniack AD, Ciriello G, Sander C, Schultz N. Oncogenic Signaling Pathways in The Cancer Genome Atlas. Cell. 2018 04 05; 173(2):321-337.e10.  View on PubMed
  14. Emmerson E, May AJ, Berthoin L, Cruz-Pacheco N, Nathan S, Mattingly AJ, Chang JL, Ryan WR, Tward AD, Knox SM. Salivary glands regenerate after radiation injury through SOX2-mediated secretory cell replacement. EMBO Mol Med. 2018 03; 10(3).  View on PubMed
  15. Jonathan Breshears, Joseph Chang, Annette Molinaro, Penny Sneed, Michael Mcdermott, Aaron Tward, Philip Theodosopoulos. Duration and Timing of Transient Tumor Enlargement after Gamma Knife Radiosurgery for Vestibular Schwannomas. Journal of Neurological Surgery Part B Skull Base. 2018 Feb 1; 79(S 01):s1-s188.  View on PubMed
  16. Stephen T. Magill, Philip V. Theodosopoulos, Aaron D. Tward, Steven W. Cheung, Michael W. McDermott. Meningiomas of the Cerebellopontine Angle. Skull Base Surgery of the Posterior Fossa. 2018 Jan 1; 103-113.  View on PubMed
  17. Farmer DT, Nathan S, Finley JK, Shengyang Yu K, Emmerson E, Byrnes LE, Sneddon JB, McManus MT, Tward AD, Knox SM. Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland. Development. 2017 07 01; 144(13):2517-2528.  View on PubMed
  18. Camarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, Nomura DK, Goga A. Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. Nat Med. 2016 04; 22(4):427-32.  View on PubMed
  19. Puram SV, Tward AD, Jung DH, Dilger AE, Herrmann BS, Duhaime AC, Barker FG, Lee DJ. Auditory brainstem implantation in a 16-month-old boy with cochlear hypoplasia. Otol Neurotol. 2015 Apr; 36(4):618-24.  View on PubMed
  20. Li J, Chanrion M, Sawey E, Wang T, Chow E, Tward A, Su Y, Xue W, Lucito R, Zender L, Lowe SW, Bishop JM, Powers S. Reciprocal interaction of Wnt and RXR-α pathways in hepatocyte development and hepatocellular carcinoma. PLoS One. 2015; 10(3):e0118480.  View on PubMed

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