Research Funding

  • April 1, 2019 - March 31, 2021 - Developing astrocyte, neuron, and microglial 3D organoids to model key aspects of human pathology, Principal Investigator. Sponsor: NIH/NIA, Sponsor Award ID: R03AG063157
  • December 20, 2012 - November 30, 2015 - Investigating Astrocyte Diversity and Function in Midbrain Dopaminergic Circuits, Principal Investigator. Sponsor: NIH/NIMH, Sponsor Award ID: R01MH099595
  • September 30, 2009 - June 30, 2014 - THE ROLE OF ASTROCYTES IN PLASTICITY AND DISEASE., Principal Investigator. Sponsor: NIH, Sponsor Award ID: DP2OD006507
  • April 1, 2008 - March 31, 2011 - Role of Micro-RNAs in Neuronal Circuit Formation and Function, Principal Investigator. Sponsor: NIH/NIMH, Sponsor Award ID: R21MH083090

Education

University of Chicago, Chicago, Ill, BA, 1991, Biological Science
University California San Francisco, CA, Ph.D., 1997, Neuroscience
Stanford University, Postdoc, 2004, Neurobiology

Honors & Awards

  • 2001
    Epilepsy training grant award
  • 2002
    Zaffaroni research fellowship in addiction research
  • 2004
    Sandler Award
  • 2005
    Alfred P. Sloan Fellowship
  • 2006
    March of Dimes Basil O’Connor Award
  • 2006
    Research to Prevent Blindness- New Investigator Award
  • 2009
    NIH New Innovator Award
  • 2014
    Walt and Lilly Disney Award for Amblyopia Research, RPB
  • 2015
    Allen Distnguished Investigator Award, Paul G Allen Foundation

Selected Publications

  1. Magill ST, Vasudevan HN, Seo K, Villanueva-Meyer JE, Choudhury A, John Liu S, Pekmezci M, Findakly S, Hilz S, Lastella S, Demaree B, Braunstein SE, Bush NAO, Aghi MK, Theodosopoulos PV, Sneed PK, Abate AR, Berger MS, McDermott MW, Lim DA, Ullian EM, Costello JF, Raleigh DR Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma.  View on PubMed
  2. Zhang J, Velmeshev D, Hashimoto K, Huang YH, Hofmann JW, Shi X, Chen J, Leidal AM, Dishart JG, Cahill MK, Kelley KW, Liddelow SA, Seeley WW, Miller BL, Walther TC, Farese RV, Taylor JP, Ullian EM, Huang B, Debnath J, Wittmann T, Kriegstein AR, Huang EJ Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency.  View on PubMed
  3. Liu SJ, Malatesta M, Lien BV, Saha P, Thombare SS, Hong SJ, Pedraza L, Koontz M, Seo K, Horlbeck MA, He D, Birk HS, Jain M, Olsen HE, Akeson M, Weissman JS, Monje M, Gupta N, Raleigh DR, Ullian EM, Lim DA CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma.  View on PubMed
  4. Bayraktar OA, Bartels T, Holmqvist S, Kleshchevnikov V, Martirosyan A, Polioudakis D, Ben Haim L, Young AMH, Batiuk MY, Prakash K, Brown A, Roberts K, Paredes MF, Kawaguchi R, Stockley JH, Sabeur K, Chang SM, Huang E, Hutchinson P, Ullian EM, Hemberg M, Coppola G, Holt MG, Geschwind DH, Rowitch DH Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map.  View on PubMed
  5. de Majo M, Koontz M, Rowitch D, Ullian EM An update on human astrocytes and their role in development and disease.  View on PubMed
  6. S John Liu, Martina Malatesta, Kyounghee Seo, Brian Lien, Sung Hong, Mark Koontz, David Raleigh, Erik Ullian, Daniel Lim GENE-39. CRISPRi-BASED RADIATION MODIFIER SCREEN IDENTIFIES LONG NON-CODING RNA THERAPEUTIC TARGETS IN GLIOMA.  View on PubMed
  7. Stephen Magill, Harish Vasudevan, Kyounghee Seo, S John Liu, Stephanie Hilz, Javier Villanueva-Meyer, Abrar Choudhury, Benjamin Demaree, Daniel Lim, Steve Braunstein, Nancy Ann Oberheim-Bush, Erik Ullian, Manish Aghi, Philip Theodosopoulos, Patricia Sneed, Adam Abate, Mitchel Berger, Mike McDermott, Joseph Costello, David Raleigh TMOD-27. A NEURAL CREST CELL SUBPOPULATION UNDERLIES INTRATUMOR HETEROGENEITY IN MENINGIOMA.  View on PubMed
  8. Labelle-Dumais C, Schuitema V, Hayashi G, Hoff K, Gong W, Dao DQ, Ullian EM, Oishi P, Margeta M, Gould DB COL4A1 Mutations Cause Neuromuscular Disease with Tissue-Specific Mechanistic Heterogeneity.  View on PubMed
  9. Martina Malatesta, John Liu, Leslie Pedraza, Kyounghee Seo, Elizabeth DiLullo, David Raleigh, Arnold Kriegstein, Erik Ullian, Daniel Lim TMOD-04. TARGETING A GLIOMA SPECIFIC lncRNA IN A HUMAN BRAIN ORGANOID TUMOR MODEL.  View on PubMed
  10. Rauen KA, Schoyer L, Schill L, Stronach B, Albeck J, Andresen BS, Cavé H, Ellis M, Fruchtman SM, Gelb BD, Gibson CC, Gripp K, Hefner E, Huang WYC, Itkin M, Kerr B, Linardic CM, McMahon M, Oberlander B, Perlstein E, Ratner N, Rogers L, Schenck A, Shankar S, Shvartsman S, Stevenson DA, Stites EC, Stork PJS, Sun C, Therrien M, Ullian EM, Widemann BC, Yeh E, Zampino G, Zenker M, Timmer W, McCormick F Proceedings of the fifth international RASopathies symposium: When development and cancer intersect.  View on PubMed
  11. Kelley KW, Ben Haim L, Schirmer L, Tyzack GE, Tolman M, Miller JG, Tsai HH, Chang SM, Molofsky AV, Yang Y, Patani R, Lakatos A, Ullian EM, Rowitch DH Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength.  View on PubMed
  12. Cree BAC, Niu J, Hoi KK, Zhao C, Caganap SD, Henry RG, Dao DQ, Zollinger DR, Mei F, Shen YA, Franklin RJM, Ullian EM, Xiao L, Chan JR, Fancy SPJ Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury.  View on PubMed
  13. Deshpande A, Yadav S, Dao DQ, Wu ZY, Hokanson KC, Cahill MK, Wiita AP, Jan YN, Ullian EM, Weiss LA Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder.  View on PubMed
  14. Krencik R, Seo K, van Asperen JV, Basu N, Cvetkovic C, Barlas S, Chen R, Ludwig C, Wang C, Ward ME, Gan L, Horner PJ, Rowitch DH, Ullian EM Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes.  View on PubMed
  15. Yeh E, Dao DQ, Wu ZY, Kandalam SM, Camacho FM, Tom C, Zhang W, Krencik R, Rauen KA, Ullian EM, Weiss LA Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment.  View on PubMed
  16. Krejciova Z, Alibhai J, Zhao C, Krencik R, Rzechorzek NM, Ullian EM, Manson J, Ironside JW, Head MW, Chandran S Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner.  View on PubMed
  17. Retallack H, Di Lullo E, Arias C, Knopp KA, Laurie MT, Sandoval-Espinosa C, Mancia Leon WR, Krencik R, Ullian EM, Spatazza J, Pollen AA, Mandel-Brehm C, Nowakowski TJ, Kriegstein AR, DeRisi JL Zika virus cell tropism in the developing human brain and inhibition by azithromycin.  View on PubMed
  18. Ou Y, Jo RE, Ullian EM, Wong RO, Della Santina L Selective Vulnerability of Specific Retinal Ganglion Cell Types and Synapses after Transient Ocular Hypertension.  View on PubMed
  19. Josowitz R, Mulero-Navarro S, Rodriguez NA, Falce C, Cohen N, Ullian EM, Weiss LA, Rauen KA, Sobie EA, Gelb BD Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes.  View on PubMed
  20. Krencik R, van Asperen JV, Ullian EM Human astrocytes are distinct contributors to the complexity of synaptic function.  View on PubMed

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