April 1, 2019 - March 31, 2021 - Developing astrocyte, neuron, and microglial 3D organoids to model key aspects of human pathology, Principal Investigator. Sponsor: NIH/NIA, Sponsor Award ID: R03AG063157
December 20, 2012 - November 30, 2015 - Investigating Astrocyte Diversity and Function in Midbrain Dopaminergic Circuits, Principal Investigator. Sponsor: NIH/NIMH, Sponsor Award ID: R01MH099595
September 30, 2009 - June 30, 2014 - THE ROLE OF ASTROCYTES IN PLASTICITY AND DISEASE., Principal Investigator. Sponsor: NIH, Sponsor Award ID: DP2OD006507
April 1, 2008 - March 31, 2011 - Role of Micro-RNAs in Neuronal Circuit Formation and Function, Principal Investigator. Sponsor: NIH/NIMH, Sponsor Award ID: R21MH083090
Education
University of Chicago, Chicago, Ill, BA, 1991, Biological Science University California San Francisco, CA, Ph.D., 1997, Neuroscience Stanford University, Postdoc, 2004, Neurobiology
Honors & Awards
2001 Epilepsy training grant award
2002 Zaffaroni research fellowship in addiction research
2004 Sandler Award
2005 Alfred P. Sloan Fellowship
2006 March of Dimes Basil O’Connor Award
2006 Research to Prevent Blindness- New Investigator Award
2009 NIH New Innovator Award
2014 Walt and Lilly Disney Award for Amblyopia Research, RPB
2015 Allen Distnguished Investigator Award, Paul G Allen Foundation
Selected Publications
Magill ST, Vasudevan HN, Seo K, Villanueva-Meyer JE, Choudhury A, John Liu S, Pekmezci M, Findakly S, Hilz S, Lastella S, Demaree B, Braunstein SE, Bush NAO, Aghi MK, Theodosopoulos PV, Sneed PK, Abate AR, Berger MS, McDermott MW, Lim DA, Ullian EM, Costello JF, Raleigh DR
Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma.
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Zhang J, Velmeshev D, Hashimoto K, Huang YH, Hofmann JW, Shi X, Chen J, Leidal AM, Dishart JG, Cahill MK, Kelley KW, Liddelow SA, Seeley WW, Miller BL, Walther TC, Farese RV, Taylor JP, Ullian EM, Huang B, Debnath J, Wittmann T, Kriegstein AR, Huang EJ
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency.
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Liu SJ, Malatesta M, Lien BV, Saha P, Thombare SS, Hong SJ, Pedraza L, Koontz M, Seo K, Horlbeck MA, He D, Birk HS, Jain M, Olsen HE, Akeson M, Weissman JS, Monje M, Gupta N, Raleigh DR, Ullian EM, Lim DA
CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma.
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Bayraktar OA, Bartels T, Holmqvist S, Kleshchevnikov V, Martirosyan A, Polioudakis D, Ben Haim L, Young AMH, Batiuk MY, Prakash K, Brown A, Roberts K, Paredes MF, Kawaguchi R, Stockley JH, Sabeur K, Chang SM, Huang E, Hutchinson P, Ullian EM, Hemberg M, Coppola G, Holt MG, Geschwind DH, Rowitch DH
Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map.
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de Majo M, Koontz M, Rowitch D, Ullian EM
An update on human astrocytes and their role in development and disease.
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S John Liu, Martina Malatesta, Kyounghee Seo, Brian Lien, Sung Hong, Mark Koontz, David Raleigh, Erik Ullian, Daniel Lim
GENE-39. CRISPRi-BASED RADIATION MODIFIER SCREEN IDENTIFIES LONG NON-CODING RNA THERAPEUTIC TARGETS IN GLIOMA.
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Stephen Magill, Harish Vasudevan, Kyounghee Seo, S John Liu, Stephanie Hilz, Javier Villanueva-Meyer, Abrar Choudhury, Benjamin Demaree, Daniel Lim, Steve Braunstein, Nancy Ann Oberheim-Bush, Erik Ullian, Manish Aghi, Philip Theodosopoulos, Patricia Sneed, Adam Abate, Mitchel Berger, Mike McDermott, Joseph Costello, David Raleigh
TMOD-27. A NEURAL CREST CELL SUBPOPULATION UNDERLIES INTRATUMOR HETEROGENEITY IN MENINGIOMA.
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Labelle-Dumais C, Schuitema V, Hayashi G, Hoff K, Gong W, Dao DQ, Ullian EM, Oishi P, Margeta M, Gould DB
COL4A1 Mutations Cause Neuromuscular Disease with Tissue-Specific Mechanistic Heterogeneity.
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Martina Malatesta, John Liu, Leslie Pedraza, Kyounghee Seo, Elizabeth DiLullo, David Raleigh, Arnold Kriegstein, Erik Ullian, Daniel Lim
TMOD-04. TARGETING A GLIOMA SPECIFIC lncRNA IN A HUMAN BRAIN ORGANOID TUMOR MODEL.
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Rauen KA, Schoyer L, Schill L, Stronach B, Albeck J, Andresen BS, Cavé H, Ellis M, Fruchtman SM, Gelb BD, Gibson CC, Gripp K, Hefner E, Huang WYC, Itkin M, Kerr B, Linardic CM, McMahon M, Oberlander B, Perlstein E, Ratner N, Rogers L, Schenck A, Shankar S, Shvartsman S, Stevenson DA, Stites EC, Stork PJS, Sun C, Therrien M, Ullian EM, Widemann BC, Yeh E, Zampino G, Zenker M, Timmer W, McCormick F
Proceedings of the fifth international RASopathies symposium: When development and cancer intersect.
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Kelley KW, Ben Haim L, Schirmer L, Tyzack GE, Tolman M, Miller JG, Tsai HH, Chang SM, Molofsky AV, Yang Y, Patani R, Lakatos A, Ullian EM, Rowitch DH
Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength.
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Cree BAC, Niu J, Hoi KK, Zhao C, Caganap SD, Henry RG, Dao DQ, Zollinger DR, Mei F, Shen YA, Franklin RJM, Ullian EM, Xiao L, Chan JR, Fancy SPJ
Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury.
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Deshpande A, Yadav S, Dao DQ, Wu ZY, Hokanson KC, Cahill MK, Wiita AP, Jan YN, Ullian EM, Weiss LA
Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder.
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Krencik R, Seo K, van Asperen JV, Basu N, Cvetkovic C, Barlas S, Chen R, Ludwig C, Wang C, Ward ME, Gan L, Horner PJ, Rowitch DH, Ullian EM
Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes.
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Yeh E, Dao DQ, Wu ZY, Kandalam SM, Camacho FM, Tom C, Zhang W, Krencik R, Rauen KA, Ullian EM, Weiss LA
Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment.
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Krejciova Z, Alibhai J, Zhao C, Krencik R, Rzechorzek NM, Ullian EM, Manson J, Ironside JW, Head MW, Chandran S
Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner.
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Retallack H, Di Lullo E, Arias C, Knopp KA, Laurie MT, Sandoval-Espinosa C, Mancia Leon WR, Krencik R, Ullian EM, Spatazza J, Pollen AA, Mandel-Brehm C, Nowakowski TJ, Kriegstein AR, DeRisi JL
Zika virus cell tropism in the developing human brain and inhibition by azithromycin.
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Ou Y, Jo RE, Ullian EM, Wong RO, Della Santina L
Selective Vulnerability of Specific Retinal Ganglion Cell Types and Synapses after Transient Ocular Hypertension.
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Josowitz R, Mulero-Navarro S, Rodriguez NA, Falce C, Cohen N, Ullian EM, Weiss LA, Rauen KA, Sobie EA, Gelb BD
Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes.
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Krencik R, van Asperen JV, Ullian EM
Human astrocytes are distinct contributors to the complexity of synaptic function.
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