Research Summary

My research is focused on understanding regulation of cell signaling by post-tranlational modifications in cancer cells. Specifically, we are using targeted proteomic techniques to study phosphorylation dynamics in key signaling networks such as EGFR, RAS/ERK, and AKT/mTOR. The studies are aimed at identifying key regulatory phosphorylation sites relevant to tumor development, progression, response to targeted therapies, and development of resistance. As part of this effort, we are working on novel approaches for quantifying site-specific phosphorylation of low-abundance proteins, such as transcription factors and other nuclear targets of the intracellular signal transduction pathways.

Education

University of California, Berkeley, B.A., 05/1999, Molecular and Cell Biology
University of California, San Francisco, PhD, 06/2006, Biomedical Sciences
University of California, San Francisco, MD, 05/2008, Medicine, Medical Scientist Training Program
University of California, San Francisco, Residency, 7/08-6/10, Anatomic Pathology
University of California, San Francisco, Fellowship, 7/10-6/11, Pulmonary and Surgical Pathology
University of California, San Francisco, Chief Resident, 7/10-6/11, Anatomic Pathology
University of California, San Francisco, Post-doc, 7/11-6/16, Biology of lung cancer
University of California, San Francisco, Post-doc, 7/11-6/16, Proteomics of signaling

Selected Publications

  1. Jacqueline V. Aredo, Anatoly Urisman, Matthew A. Gubens, Claire Mulvey, Greg M. Allen, Julia K. Rotow, Daniel Lucas Kerr, Turja Chakrabarti, Bianca Bacaltos, Megan Gee, Kirk Jones, Dara L. Aisner, Tejas Patil, Erin Lynn Schenk, Trever G. Bivona, Jonathan W. Riess, Melissa Coleman, Johannes Ruediger Kratz, David Jablons, Collin M. Blakely. Phase II trial of neoadjuvant osimertinib for surgically resectable EGFR -mutated non-small cell lung cancer. Journal of Clinical Oncology. 2023 Jun 1; 41(16_suppl):8508-8508.  View on PubMed
  2. Ye J, Croom N, Troxell ML, Kambham N, Zuckerman JE, Andeen N, Dall'Era M, Hsu R, Walavalkar V, Laszik ZG, Urisman A. Non-full house membranous lupus nephritis represents a clinically distinct subset. Kidney360. 2023 May 31.  View on PubMed
  3. Lopez J, Bonsor DA, Sale MJ, Urisman A, Mehalko JL, Cabanski-Dunning M, Castel P, Simanshu DK, McCormick F. The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling. J Biol Chem. 2023 06; 299(6):104789.  View on PubMed
  4. Sadiq S, Urisman A, Cil O. Case report: Short-term eculizumab use in atypical HUS associated with Lemierre's syndrome and post-infectious glomerulonephritis. Front Med (Lausanne). 2023; 10:1167806.  View on PubMed
  5. B. Bromberger, F. McLafferty, J. Smith, B. Elicker, K. Jones, C. Mulvey, A. Urisman, A. Venado, S. Hays, J. Kukreja, B. Trinh. Bilateral Lung Transplant with Recognition of Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) of rhe Donor Lungs in the Immediate Postoperative Period. The Journal of Heart and Lung Transplantation. 2023 Apr 1; 42(4):s373-s374.  View on PubMed
  6. Waldman M, Sinaii N, Lerma EV, Kurien AA, Jhaveri KD, Uppal NN, Wanchoo R, Avasare R, Zuckerman JE, Liew A, Gallan AJ, El-Meanawy A, Yagil Y, Lebedev L, Baskaran K, Vilayur E, Cohen A, Weerasinghe N, Petrakis I, Stylianou K, Gakiopoulou H, Hamilton AJ, Edney N, Millner R, Marinaki S, Rein JL, Killen JP, Rodríguez Chagolla JM, Bassil C, Lopez Del Valle R, Evans J, Urisman A, Zawaideh M, Baxi PV, Rodby R, Vankalakunti M, Mejia Vilet JM, Ramirez Andrade SE, Homan MP, Vásquez Jiménez E, Perinpanayagam N, Velez JCQ, Mohamed MMB, Mohammed KMG, Sekar A, Ollila L, Aron AW, Arellano Arteaga KJ, Islam M, Berrio EM, Maoujoud O, Morales RR, Seipp R, Schulze CE, Yenchek RH, Vancea I, Muneeb M, Howard L, Caza TN. COVID-19 Vaccination and New Onset Glomerular Disease: Results from the IRocGN2 International Registry. Kidney360. 2023 03 01; 4(3):349-362.  View on PubMed
  7. Essien F, Evans J, Kyle A, Urisman A, Adams N. 'Granulomatosis with polyangiitis after Pfizer vaccination': a case report. Ther Adv Rare Dis. 2022 Jan-Dec; 3:26330040221130084.  View on PubMed
  8. Basso P, Dang EV, Urisman A, Cowen LE, Madhani HD, Noble SM. Deep tissue infection by an invasive human fungal pathogen requires lipid-based suppression of the IL-17 response. Cell Host Microbe. 2022 11 09; 30(11):1589-1601.e5.  View on PubMed
  9. Bons J, Pan D, Shah S, Bai R, Chen-Tanyolac C, Wang X, Elliott DRF, Urisman A, O'Broin A, Basisty N, Rose J, Sangwan V, Camilleri-Broët S, Tankel J, Gascard P, Ferri L, Tlsty TD, Schilling B. Data-independent acquisition and quantification of extracellular matrix from human lung in chronic inflammation-associated carcinomas. Proteomics. 2023 04; 23(7-8):e2200021.  View on PubMed
  10. Bean GR, Najjar S, Shin SJ, Hosfield EM, Caswell-Jin JL, Urisman A, Jones KD, Chen YY, Krings G. Correction to: Genetic and immunohistochemical profiling of small cell and large cell neuroendocrine carcinomas of the breast. Mod Pathol. 2022 Oct; 35(10):1494-1495.  View on PubMed
  11. Nanjo S, Wu W, Karachaliou N, Blakely CM, Suzuki J, Chou YT, Ali SM, Kerr DL, Olivas VR, Shue J, Rotow J, Mayekar MK, Haderk F, Chatterjee N, Urisman A, Yeo JC, Skanderup AJ, Tan AC, Tam WL, Arrieta O, Hosomichi K, Nishiyama A, Yano S, Kirichok Y, Tan DS, Rosell R, Okimoto RA, Bivona TG. Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR-mutant lung cancer. J Clin Invest. 2022 07 01; 132(13).  View on PubMed
  12. Daniel L. Kerr, Wei Wu, Whitney Tamaki, Anatoly Urisman, Yu-Ting Chou, Philippe Gui, David M. Jablons, Trever G. Bivona, Collin M. Blakely. Abstract 3808: Spatially resolved transcriptomics of cellular architecture in EGFR-mutated lung cancer. Cancer Research. 2022 Jun 15; 82(12_Supplement):3808-3808.  View on PubMed
  13. Patel P, Buchanan CN, Zdradzinski MD, Sahoo PK, Kar AN, Lee SJ, Vaughn LS, Urisman A, Oses-Prieto J, Dell'Orco M, Cassidy DE, Costa ID, Miller S, Thames E, Smith TP, Burlingame AL, Perrone-Bizzozero N, Twiss JL. Intra-axonal translation of Khsrp mRNA slows axon regeneration by destabilizing localized mRNAs. Nucleic Acids Res. 2022 06 10; 50(10):5772-5792.  View on PubMed
  14. Bean GR, Najjar S, Shin SJ, Hosfield EM, Caswell-Jin JL, Urisman A, Jones KD, Chen YY, Krings G. Genetic and immunohistochemical profiling of small cell and large cell neuroendocrine carcinomas of the breast. Mod Pathol. 2022 10; 35(10):1349-1361.  View on PubMed
  15. Cuevas-Navarro A, Rodriguez-Muñoz L, Grego-Bessa J, Cheng A, Rauen KA, Urisman A, McCormick F, Jimenez G, Castel P. Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs. Elife. 2022 04 25; 11.  View on PubMed
  16. J. Maheshwari, A. Perez, N. Kolaitis, D. Calabrese, A. Venado Estrada, J. Golden, R.J. Shah, L. Leard, M. Kleinhenz, K. Jones, A. Urisman, J. Kukreja, B. Trinh, Y. Gesthalter, J. Singer, S. Hays. Immunosuppression-Induced Pulmonary Alveolar Proteinosis Following Bilateral Lung Transplantation. The Journal of Heart and Lung Transplantation. 2022 Apr 1; 41(4):s298.  View on PubMed
  17. Aguirre A, Urisman A, Margaretten M. Starting off on the Right Foot: A 22-Year-Old Woman With Leg Swelling. Arthritis Care Res (Hoboken). 2022 05; 74(5):701-708.  View on PubMed
  18. Leila Haghighat, Barbara Hamilton, Anatoly Urisman, Ramin Beygui, Kirsten Tolstrup. Abstract 10428: Bad Fall, Good Catch: Diagnosing a Rare Condition Presenting as Acute Coronary Syndrome. Circulation. 2021 Nov 16; 144(Suppl_1):a10428-a10428.  View on PubMed
  19. C. Blakely, A. Urisman, D. Kerr, W. Wu, B. Bacaltos, J. Rotow, M. Gubens, K. Jones, T. Bivona, S. Joo, J. Riess, D. Aisner, R. Doebele, T. Patil, E. Schenk, J. Kratz, D. Jablons. P26.02 A Phase II Trial of Neoadjuvant Osimertinib for Surgically Resectable EGFR-Mutant Non-Small Cell Lung Cancer: Updated Results. Journal of Thoracic Oncology. 2021 Oct 1; 16(10):s1039-s1040.  View on PubMed
  20. Castel P, Dharmaiah S, Sale MJ, Messing S, Rizzuto G, Cuevas-Navarro A, Cheng A, Trnka MJ, Urisman A, Esposito D, Simanshu DK, McCormick F. RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity. Proc Natl Acad Sci U S A. 2021 08 17; 118(33).  View on PubMed

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