Research Summary

I have over 25 years’ experience with the preparation and application of radiopharmaceuticals. I have developed several imaging agents targeting cell surface proteins (receptors, enzymes and transporters) including receptor-based imaging agents for hormone receptors, growth factor receptors, neuroreceptors, and prostate-specific membrane antigen. I have developed imaging agents for cardiac blood flow and metabolism. These imaging agents have included a broad range of molecular motifs from small molecules, antibodies, antibody fragments (e.g., Fabs, scFv, and diabodies), and aptamers, to proteins and peptides. These molecules have been labeled with a variety of isotopes for PET and SPECT imaging. As part of the development of these imaging agents, I have been engaged in the evaluation and validation of the tracer mechanism of localization and retention at the target site. I have prepared several in vitro and in vivo model systems and interpreted the data collected from these systems to determine the utility of the probes. I have successfully translated many of these tracers into humans. I have helped to write and secure several INDs for first-in-human tracer studies.

Over the last 10 years, I have been working on the development of PSMA targeting prostate cancer imaging agents in collaboration with Dr. Clifford Berkman at Washington State University. I am currently PI on a DoD PCRP-funded proposal to prepare these agents for human imaging studies. I am also UCSF PI on an NIH SBIR funded to perform the first-in-man PET/MRI imaging studies. I am currently also evaluating a new agent to measure T cell activation, 18F-FAraG. The pharmacokinetics of agent has been assessed in normal human subjects and will be further evaluated following immunotherapy response."

Research Funding

  • August 12, 2020 - July 31, 2025 - In Vivo PET Imaging of HIV Infection, Co-Principal Investigator. Sponsor: NIH/NIAID, Sponsor Award ID: R01AI152932
  • September 18, 2019 - August 31, 2020 - Improving availability of ImmunoPET via automation of radio-synthesis and quality control of antibody-based cancer imaging PET tracers on a single platform., Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R43CA235909
  • August 1, 2015 - July 31, 2020 - Molecular Imaging of Chemical Threats and Countermeasures, Co-Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: U01NS092495
  • September 1, 2018 - August 31, 2019 - Astroglial EAAT2 Changes in Live TBI Brain Determined by PET Imaging, Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: R41NS105309

Education

Rensselaer Polytechnic Institute, Troy, NY, B.S., 1984, Chemistry
Rensselaer Polytechnic Institute, Troy, NY, M.S., 1986, Nuclear Chemistry
Washington University, St. Louis, MO, M.A., 1988, Nuclear Chemistry
Washington University, St. Louis, MO, Ph.D., 1990, Radiopharm. Chemistry
University of Illinois, Urbana, IL, Postdoctoral, 1992, Radiopharm. Chemistry

Honors & Awards

  • 1990-1992
    DOE Alexander Hollaender Distinguished Postdoctoral Fellowship
    Lawrence Berkeley National Laboratory Outstanding Performance Award (1993, 1997, 1998, 2000)
  • 2006
    SNM President's Distinguished Service Award

Selected Publications

  1. Hayes TR, Chao CK, Blecha JE, Huynh TL, Zinn KR, Thompson CM, Gerdes JM, VanBrocklin HF Biological Distribution and Metabolic Profiles of Carbon-11 and Fluorine-18 Tracers of VX- and Sarin-Analogs in Sprague-Dawley Rats.  View on PubMed
  2. Wei J, Wang YH, Lee CY, Truillet C, Oh DY, Xu Y, Ruggero D, Flavell RR, VanBrocklin HF, Seo Y, Craik CS, Fong L, Wang CI, Evans MJ An Analysis of Isoclonal Antibody Formats Suggests a Role for Measuring PD-L1 with Low Molecular Weight PET Radiotracers.  View on PubMed
  3. Hayes TR, Blecha JE, Chao CK, Huynh TL, VanBrocklin HF, Zinn KR, Taylor PW, Gerdes JM, Thompson CM Positron emission tomography evaluation of oxime countermeasures in live rats using the tracer O-(2-[18 F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate [18 F]-VXS.  View on PubMed
  4. Aboian M, Huang SY, Pampaloni MH, Hawkins RA, Huh Y, Vo K, Gustafson C, Matthay K, Seo Y 124I-MIBG PET-CT to monitor metastatic disease in children with relapsed neuroblastoma.  View on PubMed
  5. Huang Y, Zhao N, Wang YH, Truillet C, Wei J, Blecha JE, VanBrocklin HF, Seo Y, Sayeed M, Feldman BJ, Aggarwal R, Behr SC, Shao H, Wilson DM, Villanueva-Meyer JE, Gestwicki JE, Evans MJ A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography.  View on PubMed
  6. Kalita M, Parker MFL, Luu JM, Stewart MN, Blecha JE, VanBrocklin HF, Evans MJ, Flavell RR, Rosenberg OS, Ohliger MA, Wilson DM Arabinofuranose-derived positron-emission tomography radiotracers for detection of pathogenic microorganisms.  View on PubMed
  7. Beckford-Vera DR, Gonzalez-Junca A, Janneck JS, Huynh TL, Blecha JE, Seo Y, Li X, VanBrocklin HF, Franc BL PET/CT Imaging of Human TNFa Using [89Zr]Certolizumab Pegol in a Transgenic Preclinical Model of Rheumatoid Arthritis.  View on PubMed
  8. Stewart MN, Parker MFL, Jivan S, Luu JM, Huynh TL, Schulte B, Seo Y, Blecha JE, Villanueva-Meyer JE, Flavell RR, VanBrocklin HF, Ohliger MA, Rosenberg O, Wilson DM High Enantiomeric Excess In-Loop Synthesis of d-[methyl-11C]Methionine for Use as a Diagnostic Positron Emission Tomography Radiotracer in Bacterial Infection.  View on PubMed
  9. Beckford Vera DR, Fontaine SD, VanBrocklin HF, Hearn BR, Reid R, Ashley GW, Santi DV PET Imaging of the EPR Effect in Tumor Xenografts Using Small 15 nm Diameter Polyethylene Glycols Labeled with Zirconium-89.  View on PubMed
  10. Wang S, Blaha C, Santos R, Huynh T, Hayes TR, Beckford-Vera DR, Blecha JE, Hong AS, Fogarty M, Hope TA, Raleigh DR, Wilson DM, Evans MJ, VanBrocklin HF, Ozawa T, Flavell RR Synthesis and Initial Biological Evaluation of Boron-Containing Prostate-Specific Membrane Antigen Ligands for Treatment of Prostate Cancer Using Boron Neutron Capture Therapy.  View on PubMed
  11. Hayes TR, Blecha JE, Thompson CM, Gerdes JM, VanBrocklin HF Divergent synthesis of organophosphate [11C]VX- and [11C]Sarin-surrogates from a common set of starting materials.  View on PubMed
  12. Levi J, Lam T, Goth SR, Yaghoubi S, Bates J, Ren G, Jivan S, Huynh TL, Blecha JE, Khattri R, Schmidt KF, Jennings D, VanBrocklin H Imaging of Activated T Cells as an Early Predictor of Immune Response to Anti-PD-1 Therapy.  View on PubMed
  13. Behr SC, Aggarwal R, VanBrocklin HF, Flavell RR, Gao K, Small EJ, Blecha J, Jivan S, Hope TA, Simko JP, Kurhanewicz J, Noworolski SM, Korn NJ, De Los Santos R, Cooperberg MR, Carroll PR, Nguyen HG, Greene KL, Langton-Webster B, Berkman CE, Seo Y Phase I Study of CTT1057, an 18F-Labeled Imaging Agent with Phosphoramidate Core Targeting Prostate-Specific Membrane Antigen in Prostate Cancer.  View on PubMed
  14. Hayes TR, Thompson CM, Blecha JE, Gerdes JM, VanBrocklin HF Radiosynthesis of O-(1-[18 F]fluoropropan-2-yl)-O-(4-nitrophenyl)methylphosphonate: A novel PET tracer surrogate of sarin.  View on PubMed
  15. Chamberlain CE, German MS, Yang K, Wang J, VanBrocklin H, Regan M, Shokat KM, Ducker GS, Kim GE, Hann B, Donner DB, Warren RS, Venook AP, Bergsland EK, Lee D, Wang Y, Nakakura EK A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors.  View on PubMed
  16. Neumann KD, Blecha JE, Hayes TR, Huynh T, Chao CK, Guilloteau N, Zinn KR, VanBrocklin HF, Thompson CM, Gerdes JM Radiosynthesis, ex Vivo Biodistribution, and in Vivo Positron Emission Tomography Imaging Evaluations of [11C]2-Pyridinealdoxime Methiodide ([11C]2-PAM): A First-In-Class Antidote Tracer for Organophosphate Intoxication.  View on PubMed
  17. Taglang C, Korenchan DE, von Morze C, Yu J, Najac C, Wang S, Blecha JE, Subramaniam S, Bok R, VanBrocklin HF, Vigneron DB, Ronen SM, Sriram R, Kurhanewicz J, Wilson DM, Flavell RR Late-stage deuteration of 13C-enriched substrates for T1 prolongation in hyperpolarized 13C MRI.  View on PubMed
  18. Jordan CD, Han M, Kondapavulur S, Vera DB, Neumann KD, Moore T, Stillson C, Krug R, Behr S, Seo Y, VanBrocklin HF, Larson PEZ, Wilson M, Martin AJ, Hetts SW Quantification of 89 Zr-Iron oxide nanoparticle biodistribution using PET-MR and ultrashort TE sequences.  View on PubMed
  19. Mutch CA, Ordonez AA, Qin H, Parker M, Bambarger LE, Villanueva-Meyer JE, Blecha J, Carroll V, Taglang C, Flavell R, Sriram R, VanBrocklin H, Rosenberg O, Ohliger MA, Jain SK, Neumann KD, Wilson DM [11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism.  View on PubMed
  20. Neumann KD, Villanueva-Meyer JE, Mutch CA, Flavell RR, Blecha JE, Kwak T, Sriram R, VanBrocklin HF, Rosenberg OS, Ohliger MA, Wilson DM Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers.  View on PubMed

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