Research Summary

Javier Villanueva­-Meyer, MD, is an Assistant Professor of Clinical Radiology in the Neuroradiology subspecialty section in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. He received his medical degree from Baylor College of Medicine in Houston, Texas, and he completed his one-year internship at Virginia Tech Carilion School of Medicine in Roanoke. Dr. Villanueva-­Meyer completed his four-year diagnostic radiology residency at the UCSF, followed by a Neuroradiology fellowship at UCSF. He also completed a NIH T32 post-doctoral fellowship in the UCSF Department of Radiology and Biomedical Imaging.

Dr. Villanueva-Meyer’s interests focus on advanced MR imaging and imaging based tools to better delineate and characterize brain tumors. His research also involves molecular imaging where he works with collaborators within and outside of our department to develop and implement the use of PET radiotracers in both brain tumors and spinal infection.

Dr. Villanueva­-Meyer has experience in CT, MRI and plain film radiography of the brain, head and neck, spine, and peripheral nervous system in both the inpatient and outpatient settings. As well as diagnostic and therapeutic neuroradiology procedures, including percutaneous biopsy, lumbar puncture, myelography, cisternography, epidural and selective nerve root injection.

Expertise:
Neuroradiology

Specialty:
Brain Tumor Radiology

Professional Interests:
MRI of brain tumors, imaging of infection, molecular imaging

Education

Texas Tech University, Lubbock TX, B.B.A., 06/2007, Management
Baylor College of Medicine, Houston TX, M.D., 06/2011, Medicine
Virginia Tech Carilion, Roanoke VA, 06/2012, Internship
Dept of Radiology, UCSF Medical Center, San Francisco, CA, 06/2016, Radiology Residency
Dept of Radiology, UCSF Medical Center, San Francisco, CA, 06/2017, Neuroradiology Fellowship

Honors & Awards

  • 2007
    Summa cum laude, Texas Tech University
  • 2007
    Full merit scholarship, Baylor College of Medicine
  • 2013
    Margulis Society Resident Research Award, UCSF
  • 2014
    AUR Radiology Resident Academic Leadership Development Grant
  • 2015
    Chief Resident, Diagnostic Radiology Residency Program, UCSF
  • 2016
    ACR - AUR Research Scholar
  • 2016
    NIH - NIBIB T32 Research Grant Fellow
  • 2016
    Outstanding Podium Presentation, Imaging Research Symposium, UCSF
  • 2016
    Elmer Ng MD Award for Outstanding Resident in Diagnostic Radiology, UCSF
  • 2017
    Trainee Award, American Society of Neuroradiology
  • 2018
    John A. Watson Scholar, UCSF
  • 2020
    Diane D. Ralston Neuroscience Clinical and Basic Neuroscience Teaching Award, UCSF Neurological Surgery

Selected Publications

  1. Susko MS, Chen WC, Vasudevan HN, Magill ST, Lucas CG, Oberheim Bush NA, Solomon DA, Theodosopoulos PV, McDermott MW, Villanueva-Meyer JE, Boreta L, Nakamura JL, Sneed PK, Braunstein SE, Raleigh DR. Letter: Patterns of Intermediate- and High-Risk Meningioma Recurrence After Treatment With Postoperative External Beam Radiotherapy. Neurosurgery. 2021 Jun 15; 89(1):E99-E101.  View on PubMed
  2. Pekmezci M, Morshed RA, Chunduru P, Pandian B, Young J, Villanueva-Meyer JE, Tihan T, Sloan EA, Aghi MK, Molinaro AM, Berger MS, Hervey-Jumper SL. Detection of glioma infiltration at the tumor margin using quantitative stimulated Raman scattering histology. Sci Rep. 2021 Jun 09; 11(1):12162.  View on PubMed
  3. Morshid A, Moshksar A, Das A, Duarte AG, Palacio D, Villanueva-Meyer J. HRCT Diagnosis of Pleuroparenchymal fibroelastosis: Report of two cases. Radiol Case Rep. 2021 Jun; 16(6):1564-1569.  View on PubMed
  4. Yu Y, Villanueva-Meyer J, Grimmer MR, Hilz S, Solomon DA, Choi S, Wahl M, Mazor T, Hong C, Shai A, Phillips JJ, Wainer BH, McDermott M, Haas-Kogan D, Taylor JW, Butowski N, Clarke JL, Berger MS, Molinaro AM, Chang SM, Costello JF, Oberheim Bush NA. Temozolomide-induced hypermutation is associated with distant recurrence and reduced survival after high-grade transformation of low-grade IDH-mutant gliomas. Neuro Oncol. 2021 Apr 05.  View on PubMed
  5. Rudie JD, Weiss DA, Colby JB, Rauschecker AM, Laguna B, Braunstein S, Sugrue LP, Hess CP, Villanueva-Meyer JE. Three-dimensional U-Net Convolutional Neural Network for Detection and Segmentation of Intracranial Metastases. Radiol Artif Intell. 2021 May; 3(3):e200204.  View on PubMed
  6. Hope TA, Graves CE, Calais J, Ehman E, Johnson GB, Thompson D, Aslam M, Duh QY, Gosnell J, Shen W, Roman S, Sosa JA, Kluijfhout W, Seib CS, Villanueva-Meyer J, Pampaloni MH, Suh I. Accuracy of 18F-fluorocholine PET for the detection of parathyroid adenomas: prospective single center study. J Nucl Med. 2021 Mar 05.  View on PubMed
  7. Geng H, Tsang M, Subbaraj L, Cleveland J, Chen L, Lu M, Sharma J, Vigneron DB, Kurhanewicz J, LaFontaine M, Luks T, Barshop BA, Gangoiti J, Villanueva-Meyer JE, Rubenstein JL. Tumor Metabolism and Neurocognition in CNS Lymphoma. Neuro Oncol. 2021 Feb 24.  View on PubMed
  8. Magill ST, Nguyen MP, Aghi MK, Theodosopoulos PV, Villanueva-Meyer JE, McDermott MW. Postoperative diffusion-weighted imaging and neurological outcome after convexity meningioma resection. J Neurosurg. 2021 Jan 29; 1-8.  View on PubMed
  9. Sloan EA, Chiang J, Villanueva-Meyer JE, Alexandrescu S, Eschbacher JM, Wang W, Mafra M, Ud Din N, Carr-Boyd E, Watson M, Punsoni M, Oviedo A, Gilani A, Kleinschmidt-DeMasters BK, Coss DJ, Lopes MB, Raffel C, Berger MS, Chang SM, Reddy A, Ramani B, Ferris SP, Lee JC, Hofmann JW, Cho SJ, Horvai AE, Pekmezci M, Tihan T, Bollen AW, Rodriguez FJ, Ellison DW, Perry A, Solomon DA. Intracranial mesenchymal tumor with FET-CREB fusion-A unifying diagnosis for the spectrum of intracranial myxoid mesenchymal tumors and angiomatoid fibrous histiocytoma-like neoplasms. Brain Pathol. 2021 Jul; 31(4):e12918.  View on PubMed
  10. Vasudevan HN, Lucas CG, Villanueva-Meyer JE, Theodosopoulos PV, Raleigh DR. Genetic Events and Signaling Mechanisms Underlying Schwann Cell Fate in Development and Cancer. Neurosurgery. 2021 01 13; 88(2):234-245.  View on PubMed
  11. Chen WC, Vasudevan HN, Choudhury A, Pekmezci M, Lucas CG, Phillips J, Magill ST, Susko MS, Braunstein SE, Oberheim Bush NA, Boreta L, Nakamura JL, Villanueva-Meyer JE, Sneed PK, Perry A, McDermott MW, Solomon DA, Theodosopoulos PV, Raleigh DR. A Prognostic Gene-Expression Signature and Risk Score for Meningioma Recurrence After Resection. Neurosurgery. 2020 12 15; 88(1):202-210.  View on PubMed
  12. Kalita M, Villanueva-Meyer J, Ohkawa Y, Kalyanaraman C, Chen K, Mohamed E, Parker MFL, Jacobson MP, Phillips JJ, Evans MJ, Wilson DM. Synthesis and Screening of a-Xylosides in Human Glioblastoma Cells. Mol Pharm. 2021 01 04; 18(1):451-460.  View on PubMed
  13. Mueller S, Taitt JM, Villanueva-Meyer JE, Bonner ER, Nejo T, Lulla RR, Goldman S, Banerjee A, Chi SN, Whipple NS, Crawford JR, Gauvain K, Nazemi KJ, Watchmaker PB, Almeida ND, Okada K, Salazar AM, Gilbert RD, Nazarian J, Molinaro AM, Butterfield LH, Prados MD, Okada H. Mass cytometry detects H3.3K27M-specific vaccine responses in diffuse midline glioma. J Clin Invest. 2020 12 01; 130(12):6325-6337.  View on PubMed
  14. Agrawal P, Roberts JT, Bezold S, Villanueva-Meyer J, Nguyen QD. Effective Use of F-18-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography to Rule Out Prosthetic Aortic Valve as the Source of Infection. Cureus. 2020 Nov 17; 12(11):e11520.  View on PubMed
  15. Weyer-Jamora C, Brie MS, Luks TL, Smith EM, Braunstein SE, Villanueva-Meyer JE, Bracci PM, Chang S, Hervey-Jumper SL, Taylor JW. Cognitive impact of lower-grade gliomas and strategies for rehabilitation. Neurooncol Pract. 2021 Apr; 8(2):117-128.  View on PubMed
  16. Schulte JD, Buerki RA, Lapointe S, Molinaro AM, Zhang Y, Villanueva-Meyer JE, Perry A, Phillips JJ, Tihan T, Bollen AW, Pekmezci M, Butowski N, Oberheim Bush NA, Taylor JW, Chang SM, Theodosopoulos P, Aghi MK, Hervey-Jumper SL, Berger MS, Solomon DA, Clarke JL. Clinical, radiologic, and genetic characteristics of histone H3 K27M-mutant diffuse midline gliomas in adults. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa142.  View on PubMed
  17. Lawhn-Heath C, Yom SS, Liu C, Villanueva-Meyer JE, Aslam M, Smith R, Narwal M, Juarez R, Behr SC, Pampaloni MH, Chan JW, Glastonbury CM, Hope TA, Flavell RR. Gallium-68 prostate-specific membrane antigen ([68Ga]Ga-PSMA-11) PET for imaging of thyroid cancer: a feasibility study. EJNMMI Res. 2020 Oct 22; 10(1):128.  View on PubMed
  18. Alcaide-Leon P, Cluceru J, Lupo JM, Yu TJ, Luks TL, Tihan T, Bush NA, Villanueva-Meyer JE. Centrally Reduced Diffusion Sign for Differentiation between Treatment-Related Lesions and Glioma Progression: A Validation Study. AJNR Am J Neuroradiol. 2020 11; 41(11):2049-2054.  View on PubMed
  19. Cluceru J, Nelson SJ, Wen Q, Phillips JJ, Shai A, Molinaro AM, Alcaide-Leon P, Olson MP, Nair D, LaFontaine M, Chunduru P, Villanueva-Meyer JE, Cha S, Chang SM, Berger MS, Lupo JM. Recurrent tumor and treatment-induced effects have different MR signatures in contrast enhancing and non-enhancing lesions of high-grade gliomas. Neuro Oncol. 2020 10 14; 22(10):1516-1526.  View on PubMed
  20. Magill ST, Vasudevan HN, Seo K, Villanueva-Meyer JE, Choudhury A, John Liu S, Pekmezci M, Findakly S, Hilz S, Lastella S, Demaree B, Braunstein SE, Bush NAO, Aghi MK, Theodosopoulos PV, Sneed PK, Abate AR, Berger MS, McDermott MW, Lim DA, Ullian EM, Costello JF, Raleigh DR. Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma. Nat Commun. 2020 09 23; 11(1):4803.  View on PubMed

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