Research Summary

Javier Villanueva­-Meyer, MD, is an Assistant Professor of Clinical Radiology in the Neuroradiology subspecialty section in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. He received his medical degree from Baylor College of Medicine in Houston, Texas, and he completed his one-year internship at Virginia Tech Carilion School of Medicine in Roanoke. Dr. Villanueva-­Meyer completed his four-year diagnostic radiology residency at the UCSF, followed by a Neuroradiology fellowship at UCSF. He also completed a NIH T32 post-doctoral fellowship in the UCSF Department of Radiology and Biomedical Imaging.

Dr. Villanueva-Meyer’s interests focus on advanced MR imaging and imaging based tools to better delineate and characterize brain tumors. His research also involves molecular imaging where he works with collaborators within and outside of our department to develop and implement the use of PET radiotracers in both brain tumors and spinal infection.

Dr. Villanueva­-Meyer has experience in CT, MRI and plain film radiography of the brain, head and neck, spine, and peripheral nervous system in both the inpatient and outpatient settings. As well as diagnostic and therapeutic neuroradiology procedures, including percutaneous biopsy, lumbar puncture, myelography, cisternography, epidural and selective nerve root injection.

Expertise:
Neuroradiology

Specialty:
Brain Tumor Radiology

Professional Interests:
MRI of brain tumors, imaging of infection, molecular imaging

Education

Texas Tech University, Lubbock TX, B.B.A., 06/2007, Management
Baylor College of Medicine, Houston TX, M.D., 06/2011, Medicine
Virginia Tech Carilion, Roanoke VA, 06/2012, Internship
Dept of Radiology, UCSF Medical Center, San Francisco, CA, 06/2016, Radiology Residency
Dept of Radiology, UCSF Medical Center, San Francisco, CA, 06/2017, Neuroradiology Fellowship

Honors & Awards

  • 2007
    Summa cum laude, Texas Tech University
  • 2007
    Full merit scholarship, Baylor College of Medicine
  • 2013
    Margulis Society Resident Research Award, UCSF
  • 2014
    AUR Radiology Resident Academic Leadership Development Grant
  • 2015
    Chief Resident, Diagnostic Radiology Residency Program, UCSF
  • 2016
    ACR - AUR Research Scholar
  • 2016
    NIH - NIBIB T32 Research Grant Fellow
  • 2016
    Outstanding Podium Presentation, Imaging Research Symposium, UCSF
  • 2016
    Elmer Ng MD Award for Outstanding Resident in Diagnostic Radiology, UCSF
  • 2017
    Trainee Award, American Society of Neuroradiology
  • 2018
    John A. Watson Scholar, UCSF
  • 2020
    Diane D. Ralston Neuroscience Clinical and Basic Neuroscience Teaching Award, UCSF Neurological Surgery

Selected Publications

  1. Choudhury A, Magill ST, Eaton CD, Prager BC, Chen WC, Cady MA, Seo K, Lucas CG, Casey-Clyde TJ, Vasudevan HN, Liu SJ, Villanueva-Meyer JE, Lam TC, Pu JK, Li LF, Leung GK, Swaney DL, Zhang MY, Chan JW, Qiu Z, Martin MV, Susko MS, Braunstein SE, Bush NAO, Schulte JD, Butowski N, Sneed PK, Berger MS, Krogan NJ, Perry A, Phillips JJ, Solomon DA, Costello JF, McDermott MW, Rich JN, Raleigh DR. Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities. Nat Genet. 2022 May 09.  View on PubMed
  2. Mark IT, Dillon WP, Richie MB, Villanueva-Meyer JE. MRI Findings after Recent Image-Guided Lumbar Puncture: The Rate of Dural Enhancement and Subdural Collections. AJNR Am J Neuroradiol. 2022 Apr 28.  View on PubMed
  3. Calabrese E, Rudie JD, Rauschecker AM, Villanueva-Meyer JE, Clarke JL, Solomon DA, Cha S. Combining radiomics and deep convolutional neural network features from preoperative MRI for predicting clinically relevant genetic biomarkers in glioblastoma. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac060.  View on PubMed
  4. Zhang Y, Lucas CG, Young JS, Morshed RA, McCoy L, Oberheim Bush NA, Taylor JW, Daras M, Butowski NA, Villanueva-Meyer JE, Cha S, Wrensch M, Wiencke JK, Lee JC, Pekmezci M, Phillips JJ, Perry A, Bollen AW, Aghi MK, Theodosopoulos P, Chang EF, Hervey-Jumper SL, Berger MS, Clarke JL, Chang SM, Molinaro AM, Solomon DA. Prospective genomically-guided identification of 'early/evolving' and 'undersampled' IDH-wildtype glioblastoma leads to improved clinical outcomes. Neuro Oncol. 2022 Apr 08.  View on PubMed
  5. Cluceru J, Interian Y, Phillips JJ, Molinaro AM, Luks TL, Alcaide-Leon P, Olson MP, Nair D, LaFontaine M, Shai A, Chunduru P, Pedoia V, Villanueva-Meyer JE, Chang SM, Lupo JM. Improving the noninvasive classification of glioma genetic subtype with deep learning and diffusion-weighted imaging. Neuro Oncol. 2022 Apr 01; 24(4):639-652.  View on PubMed
  6. Smith ER, Caton MT, Villanueva-Meyer JE, Remer J, Eisenmenger LB, Baker A, Shah VN, Tu-Chan A, Meisel K, Amans MR. Brain herniation (encephalocele) into arachnoid granulations: prevalence and association with pulsatile tinnitus and idiopathic intracranial hypertension. Neuroradiology. 2022 Mar 25.  View on PubMed
  7. Luks TL, Villanueva-Meyer JE, Weyer-Jamora C, Gehring K, Jakary A, Hervey-Jumper SL, Braunstein SE, Bracci PM, Brie MS, Smith EM, Chang SM, Taylor JW. T2 FLAIR Hyperintensity Volume Is Associated With Cognitive Function and Quality of Life in Clinically Stable Patients With Lower Grade Gliomas. Front Neurol. 2021; 12:769345.  View on PubMed
  8. Rudie JD, Gleason T, Barkovich MJ, Wilson DM, Shankaranarayanan A, Zhang T, Wang L, Gong E, Zaharchuk G, Villanueva-Meyer JE. Clinical Assessment of Deep Learning-based Super-Resolution for 3D Volumetric Brain MRI. Radiol Artif Intell. 2022 Mar; 4(2):e210059.  View on PubMed
  9. Shroff N, Choi W, Villanueva-Meyer J, Palacio DM, Bhargava P. Corrigendum to 'Pulmonary vein occlusion: A delayed complication following radio frequency ablation for atrial fibrillation' [Radiology Case Reports 16 (2021) 3666-3671]. Radiol Case Rep. 2022 Mar; 17(3):1031.  View on PubMed
  10. Sloan EA, Gupta R, Koelsche C, Chiang J, Villanueva-Meyer JE, Alexandrescu S, Eschbacher JM, Wang W, Mafra M, Ud Din N, Carr-Boyd E, Watson M, Punsoni M, Oviedo A, Gilani A, Kleinschmidt-DeMasters BK, Coss DJ, Lopes MB, Reddy A, Mueller S, Cho SJ, Horvai AE, Lee JC, Pekmezci M, Tihan T, Bollen AW, Rodriguez FJ, Ellison DW, Perry A, von Deimling A, Chang SM, Berger MS, Solomon DA. Intracranial mesenchymal tumors with FET-CREB fusion are composed of at least two epigenetic subgroups distinct from meningioma and extracranial sarcomas. Brain Pathol. 2021 Nov 25; e13037.  View on PubMed
  11. Yu Y, Villanueva-Meyer J, Grimmer MR, Hilz S, Solomon DA, Choi S, Wahl M, Mazor T, Hong C, Shai A, Phillips JJ, Wainer BH, McDermott M, Haas-Kogan D, Taylor JW, Butowski N, Clarke JL, Berger MS, Molinaro AM, Chang SM, Costello JF, Oberheim Bush NA. Temozolomide-induced hypermutation is associated with distant recurrence and reduced survival after high-grade transformation of low-grade IDH-mutant gliomas. Neuro Oncol. 2021 11 02; 23(11):1872-1884.  View on PubMed
  12. Shroff N, Choi W, Villanueva-Meyer J, Palacio DM, Bhargava P. Pulmonary vein occlusion: A delayed complication following radiofrequency ablation for atrial fibrillation. Radiol Case Rep. 2021 Dec; 16(12):3666-3671.  View on PubMed
  13. Young JS, Gogos AJ, Aabedi AA, Morshed RA, Pereira MP, Lashof-Regas S, Mansoori Z, Luks T, Hervey-Jumper SL, Villanueva-Meyer JE, Berger MS. Resection of supplementary motor area gliomas: revisiting supplementary motor syndrome and the role of the frontal aslant tract. J Neurosurg. 2021 Oct 01; 1-7.  View on PubMed
  14. Geng H, Tsang M, Subbaraj L, Cleveland J, Chen L, Lu M, Sharma J, Vigneron DB, Kurhanewicz J, LaFontaine M, Luks T, Barshop BA, Gangoiti J, Villanueva-Meyer JE, Rubenstein JL. Tumor metabolism and neurocognition in CNS lymphoma. Neuro Oncol. 2021 10 01; 23(10):1668-1679.  View on PubMed
  15. Bhargava P, Ikwuagwu N, Villanueva-Meyer J. Direct Spread of Primary Testicular Lymphoma along the Gonadal Vessels Detected on F-18 Fluorodeoxyglucose Positron-Emission Tomography/Computed Tomography Imaging. Indian J Nucl Med. 2021 Jul-Sep; 36(3):340-342.  View on PubMed
  16. Villanueva-Meyer J. Editorial Comment: Timing of FDG PET/CT After Pegfilgrastim Administration. AJR Am J Roentgenol. 2022 02; 218(2):358.  View on PubMed
  17. Morin O, Vallières M, Braunstein S, Ginart JB, Upadhaya T, Woodruff HC, Zwanenburg A, Chatterjee A, Villanueva-Meyer JE, Valdes G, Chen W, Hong JC, Yom SS, Solberg TD, Löck S, Seuntjens J, Park C, Lambin P. An artificial intelligence framework integrating longitudinal electronic health records with real-world data enables continuous pan-cancer prognostication. Nat Cancer. 2021 07; 2(7):709-722.  View on PubMed
  18. Jiam NT, David AP, Formeister EJ, Gurrola J, Aghi M, Theodosopoulos P, Villanueva-Meyer J, McDermott MW, El-Sayed IH. Presentation and management of post-operative cerebrospinal fluid leaks after sphenoclival expanded endonasal surgery: A single institution experience. J Clin Neurosci. 2021 Sep; 91:13-19.  View on PubMed
  19. Kim Y, Chen HY, Autry AW, Villanueva-Meyer J, Chang SM, Li Y, Larson PEZ, Brender JR, Krishna MC, Xu D, Vigneron DB, Gordon JW. Denoising of hyperpolarized 13 C MR images of the human brain using patch-based higher-order singular value decomposition. Magn Reson Med. 2021 11; 86(5):2497-2511.  View on PubMed
  20. Susko MS, Chen WC, Vasudevan HN, Magill ST, Lucas CG, Oberheim Bush NA, Solomon DA, Theodosopoulos PV, McDermott MW, Villanueva-Meyer JE, Boreta L, Nakamura JL, Sneed PK, Braunstein SE, Raleigh DR. Letter: Patterns of Intermediate- and High-Risk Meningioma Recurrence After Treatment With Postoperative External Beam Radiotherapy. Neurosurgery. 2021 06 15; 89(1):E99-E101.  View on PubMed

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