Research Summary

My research career is focused on the development of novel prognostic and predictive biomarkers and incorporation of these biomarkers into new clinical trials, working towards more effective and less toxic therapies in children and young adults with solid tumors.

Education

University of Notre Dame, Notre Dame, IN B.S. 2000-2004 Biological Sciences, Minor in Anthropology
Indiana University School of Medicine, Indianapolis, IN M.D. 2004-2008 Medicine
Nationwide Children’s Hospital, Ohio State University School of Medicine, Columbus, OH Residency 2008-2011 Pediatrics
UCSF Benioff Children’s Hospital, University of California, San Francisco School of Medicine, San Francisco, CA Fellowship 2012-2015 Pediatric Hematology/Oncology
University of California, San Francisco, Department of Epidemiology and Biostatistics M.A.S. 2013-2015 Clinical Research

Honors & Awards

  • 2008
    Indiana University School of Medicine Tina Kwan Scholarship Award in Pediatrics
  • 2013-present
    Developmental Therapeutics Scholar, Alex’s Lemonade Stand Foundation Center of Excellence Grant

Selected Publications

  1. Marinoff AE, Aaronson K, Agrawal AK, Braun BS, Golden C, Huang BJ, Michlitsch J, Southworth E, Thrall A, Vo KT, Stieglitz E. Venetoclax in combination with chemotherapy as treatment for pediatric advanced hematologic malignancies. Pediatr Blood Cancer. 2023 06; 70(6):e30335.  View on PubMed
  2. K.X. Liu, S. Shaaban, B.J. Lerman, J.J. Chen, R. Bagatell, S.G. Dubois, S. Shusterman, M. Ioakeim-Ioannidou, T.I. Yock, K.E. Dusenbery, K.T. Vo, M. Huang, A. Friedmann, L.R. Diller, K.J. Marcus, S. MacDonald, S.A. Terezakis, S.E. Braunstein, C.E. Hill-Kayser, D.A. Haas-Kogan. Patterns of Locoregional Relapse after Radiotherapy for High-Risk Neuroblastoma: A Multi-Institutional Study. International Journal of Radiation Oncology • Biology • Physics. 2022 Nov 1; 114(3):e488.  View on PubMed
  3. Kieuhoa Tran Vo, Katherine K. Matthay, Susan G. Groshen, Yueh-Yun Chi, Meaghan Granger, Julie R. Park, Araz Marachelian, Steven G. DuBois. Clinical and biologic predictors of response to MIBG therapy: A report from the new approaches to neuroblastoma therapy (NANT) consortium. Journal of Clinical Oncology. 2022 Jun 1; 40(16_suppl):e22003-e22003.  View on PubMed
  4. Bradley DeNardo, Jennie Foster, Navin R. Pinto, Giselle Linda Saulnier Sholler, Kieuhoa Tran Vo, Ami Vijay Desai, Jessica Sun, Lars M. Wagner, Margaret E Macy, Rajen Mody, Javier E. Oesterheld, Thomas Cash, Roma Bhuta, Eveline Barbieri, Andrew DJ Pearson, Ludimila Cavalcante, Francis J. Giles, Rishi Ramesh Lulla. Phase 1/2 study of elraglusib (9-ING-41), a small molecule selective glycogen synthase kinase-3 beta (GSK-3ß) inhibitor, alone or with irinotecan, temozolomide/irinotecan or cyclophosphamide/topotecan in pediatric patients with refractory malignancies: Interim results. Journal of Clinical Oncology. 2022 Jun 1; 40(16_suppl):e22015-e22015.  View on PubMed
  5. Kieuhoa Tran Vo, Amit J. Sabnis, Paul M. Williams, Sinchita Roy-Chowdhuri, David R. Patton, Brent Coffey, Joel M. Reid, Jin Piao, Lauren Saguilig, Todd Allen Alonzo, Stacey L. Berg, Alok Jaju, Elizabeth Fox, Douglas S. Hawkins, Margaret M. Mooney, Naoko Takebe, James V. Tricoli, Katherine A. Janeway, Nita Seibel, Donald Williams Parsons. Ulixertinib in patients with tumors with MAPK pathway alterations: Results from NCI-COG Pediatric MATCH trial Arm J (APEC1621J). Journal of Clinical Oncology. 2022 Jun 1; 40(16_suppl):3009-3009.  View on PubMed
  6. Liu G, Poon M, Zapala MA, Temple WC, Vo KT, Matthay KK, Mitra D, Seo Y. Incorporating Radiomics into Machine Learning Models to Predict Outcomes of Neuroblastoma. J Digit Imaging. 2022 06; 35(3):605-612.  View on PubMed
  7. Vo KT, DuBois SG, Neuhaus J, Braunstein SE, Weil BR, Naranjo A, Irtan S, Balaguer J, Matthay KK. Pattern and predictors of sites of relapse in neuroblastoma: A report from the International Neuroblastoma Risk Group (INRG) project. Pediatr Blood Cancer. 2022 09; 69(9):e29616.  View on PubMed
  8. Shah AT, Azad TD, Breese MR, Chabon JJ, Hamilton EG, Straessler K, Kurtz DM, Leung SG, Spillinger A, Liu HY, Behroozfard IH, Wittber FM, Hazard FK, Cho SJ, Daldrup-Link HE, Vo KT, Rangaswami A, Pribnow A, Spunt SL, Lacayo NJ, Diehn M, Alizadeh AA, Sweet-Cordero EA. A Comprehensive Circulating Tumor DNA Assay for Detection of Translocation and Copy-Number Changes in Pediatric Sarcomas. Mol Cancer Ther. 2021 10; 20(10):2016-2025.  View on PubMed
  9. DuBois SG, Granger MM, Groshen S, Tsao-Wei D, Ji L, Shamirian A, Czarnecki S, Goodarzian F, Berkovich R, Shimada H, Villablanca JG, Vo KT, Pinto N, Mosse YP, Maris JM, Shusterman S, Cohn SL, Goldsmith KC, Weiss B, Yanik GA, Twist CJ, Irwin MS, Haas-Kogan DA, Park JR, Marachelian A, Matthay KK. Randomized Phase II Trial of MIBG Versus MIBG, Vincristine, and Irinotecan Versus MIBG and Vorinostat for Patients With Relapsed or Refractory Neuroblastoma: A Report From NANT Consortium. J Clin Oncol. 2021 11 01; 39(31):3506-3514.  View on PubMed
  10. Temple WC, Vo KT, Matthay KK, Balliu B, Coleman C, Michlitsch J, Phelps A, Behr S, Zapala MA. Association of image-defined risk factors with clinical features, histopathology, and outcomes in neuroblastoma. Cancer Med. 2021 04; 10(7):2232-2241.  View on PubMed
  11. Aboian MS, Huang SY, Hernandez-Pampaloni M, Hawkins RA, VanBrocklin HF, Huh Y, Vo KT, Gustafson WC, Matthay KK, Seo Y. 124I-MIBG PET/CT to Monitor Metastatic Disease in Children with Relapsed Neuroblastoma. J Nucl Med. 2021 01; 62(1):43-47.  View on PubMed
  12. Vo KT, Parsons DW, Seibel NL. Precision Medicine in Pediatric Oncology. Surg Oncol Clin N Am. 2020 01; 29(1):63-72.  View on PubMed
  13. David S. Shulman, Kieuhoa T. Vo, Elizabeth Fox, Jodi A. Muscal, Loren D. Walensky, Yana Pikman, Kimberly Stegmaier, Alanna Church, Brian D. Crompton, Andrew E. Place, Susan N. Chi, Allison F. O'Neill, Junne Kamihara, Suzanne Ezrre, Cecilia Carlowicz, Dawn Pinchasik, Hasan Al-Sayegh, Clement Ma, Wendy B. London, Steven G. DuBois. Abstract CT112: A Phase I multicenter trial of the dual MDM2/MDMX inhibitor ALRN-6924 in children and young adults with relapsed/refractory pediatric cancers. Clinical Trials. 2019 Jul 1; ct112-ct112.  View on PubMed
  14. Tolbert VP, Dvorak CC, Golden C, Vissa M, El-Haj N, Perwad F, Matthay KK, Vo KT. Risk Factors for Transplant-Associated Thrombotic Microangiopathy after Autologous Hematopoietic Cell Transplant in High-Risk Neuroblastoma. Biol Blood Marrow Transplant. 2019 10; 25(10):2031-2039.  View on PubMed
  15. Seo Y, Huh Y, Huang SY, Hernandez-Pampaloni JM, Hawkins RA, Gustafson WC, Vo KT, Matthay KK. Technical Note: Simplified and practical pretherapy tumor dosimetry - A feasibility study for 131 I-MIBG therapy of neuroblastoma using 124 I-MIBG PET/CT. Med Phys. 2019 May; 46(5):2477-2486.  View on PubMed
  16. Shulman DS, Klega K, Imamovic-Tuco A, Clapp A, Nag A, Thorner AR, Van Allen E, Ha G, Lessnick SL, Gorlick R, Janeway KA, Leavey PJ, Mascarenhas L, London WB, Vo KT, Stegmaier K, Hall D, Krailo MD, Barkauskas DA, DuBois SG, Crompton BD. Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group. Br J Cancer. 2018 08; 119(5):615-621.  View on PubMed
  17. Vo KT, Karski EE, Nasholm NM, Allen S, Hollinger F, Gustafson WC, Long-Boyle JR, Shiboski S, Matthay KK, DuBois SG. Phase 1 study of sirolimus in combination with oral cyclophosphamide and topotecan in children and young adults with relapsed and refractory solid tumors. Oncotarget. 2017 Apr 04; 8(14):23851-23861.  View on PubMed
  18. Huibregtse KE, Vo KT, DuBois SG, Fetzko S, Neuhaus J, Batra V, Maris JM, Weiss B, Marachelian A, Yanik GA, Matthay KK. Incidence and risk factors for secondary malignancy in patients with neuroblastoma after treatment with (131)I-metaiodobenzylguanidine. Eur J Cancer. 2016 10; 66:144-52.  View on PubMed
  19. Vo KT, Matthay KK, DuBois SG. Targeted antiangiogenic agents in combination with cytotoxic chemotherapy in preclinical and clinical studies in sarcoma. Clin Sarcoma Res. 2016; 6:9.  View on PubMed
  20. Davenport JR, Vo KT, Goldsby R, West DC, DuBois SG. Conditional Survival and Predictors of Late Death in Patients With Ewing Sarcoma. Pediatr Blood Cancer. 2016 Jun; 63(6):1091-5.  View on PubMed

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