My lab studies how the different cell types in the liver, in particular the hepatocyte, are generated during development, patterned and maintained during adulthood, and regenerate after injury. Our long-term goals are to improve the understanding of liver disease pathophysiology and develop novel methods of treatment for liver diseases, including cell replacement therapy. Currently, we have two major research focuses: 1) understanding the biology of adult hepatocyte stem cells and 2) developing a liver cell atlas. We take innovative and integrated approaches to address these two areas using the tools of stem cell biology, developmental biology, genomics and tissue engineering.
I also study the porphyrias, a group of inherited diseases related to defects in heme synthesis pathway. I am a member of the Porphyrias Consortium, a NIH sponsored Rare Disease Clinical Research Consortium. The purpose of the network is to integrate translational studies of the porphyrias with clinical trials testing new therapeutics.
September 30, 2009 - August 31, 2024 - Porphyrias Consortium, Co-Investigator. Sponsor: NIH, Sponsor Award ID: U54DK083909
September 1, 2020 - August 31, 2022 - Single cell resolution atlas of liver inflammation, Principle Investigator. Sponsor: Chan Zuckerberg Initiative, Sponsor Award ID:
January 1, 2017 - December 31, 2021 - Wnt signaling and hepatocyte stem cells in liver homeostasis and cancer, Principle Investigator. Sponsor: Burroughs Wellcome Fund, Sponsor Award ID: CAMS
March 15, 2015 - February 29, 2020 - Wnt signaling in hepatocyte homeostasis, Principal Investigator. Sponsor: NIH/NIDDK, Sponsor Award ID: K08DK101603
Stanford University, B.A.S., 06/2000, Philosophy, Biological Sciences
University of California San Francisco, MD, 06/2007, Medicine