Research Funding

  • March 1, 2019 - February 29, 2024 - Targeting the Cancer Glycocalyx, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA227942
  • February 1, 2019 - January 31, 2024 - Reorienting the Glioblastoma Microenvironment to Respond to Immunotherapy, Co-Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: R01NS109911
  • February 9, 2018 - January 31, 2023 - Tissue Tension, RANK and Breast Cancer Risk, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA222508
  • September 22, 2015 - August 31, 2020 - ECM geometrical and mechanical properties modulate RTK signaling, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: U01CA202241

Education

University of Waterloo, Canada, B.Sc., 1985, Chemistry/Biochemistry
University of Ottawa, Canada, B.Sc. Honors, 1986, Biochemistry (Summa Cum Laude)
University of Ottawa, Canada, Ph.D., 1992, Biochemistry
Apoptosis Research Group, NRC, Ottawa, Canada, 1992-1994, Postdoctoral Fellow
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 1994-1998, Postdoctoral Fellow

Honors & Awards

  • 1986
    University of Ottawa Gold Medal Highest Academic Standing Science
  • 1986
    Society of Chemical Industry Prize
  • 1986
    Alumni & Faculty Plaque Biochemistry
  • 1987
    Mary Eccelstone Research Award Wyeth Canadian Society of Nutrition Sciences
  • 1988
    American Institute of Nutrition Research Award Proctor & Gamble Graduate student award
  • 1996
    Lawrence Berkeley National Laboratory Achievement Award
  • 2000-01
    ACS-New Investigator Pilot Project Award, UPenn Cancer Center Grant
  • 2001-05
    DOD Career Development Award
  • 2002
    International Society of Differentiation Young Investigator Travel Award
  • 2003
    ASCB Co-Chair Mini Symposium ECM & Cancer
  • 2004
    AACR Co-Chair Major Symposium Reversibility of Tumors
  • 2004
    Co-Organizer HOX and Mammary Gland Workshop
  • 2004-10
    DOD Scholar Award
  • 2005
    Chair Engineering Cell Biology Symposium Model Systems for Complex Behaviors
  • 2006
    Co-Chair AACR Educational Session Organotypic Cancer Models
  • 2007
    Co-organizer, Conference on Engineering and Cell Biology
  • 2007
    Co-organizer TUMIC conference
  • 2007
    Chair and speaker AACR Cancer Therapy Symposium on Tumor Microenvironment
  • 2008
    Plenary Speaker Huntsman Cancer Retreat
  • 2009
    Co-Organizer Institute for Regenerative Medicine Retreat
  • 2010
    Speaker at The National Cancer Institute (NCI) and Tumor Microenvironment Network (TMEN) (2010), Speaker at Joint Metastasis Research Society - AACR Conference
  • 2010
    ASCB Co-Chair Mini Symp 50th Anniversary Meeting

Selected Publications

  1. Hayward MK, Louise Jones J, Hall A, King L, Ironside AJ, Nelson AC, Shelley Hwang E, Weaver VM Derivation of a nuclear heterogeneity image index to grade DCIS.  View on PubMed
  2. Barkovskaya A, Buffone A, Žídek M, Weaver VM Proteoglycans as Mediators of Cancer Tissue Mechanics.  View on PubMed
  3. Maller O, Drain AP, Barrett AS, Borgquist S, Ruffell B, Zakharevich I, Pham TT, Gruosso T, Kuasne H, Lakins JN, Acerbi I, Barnes JM, Nemkov T, Chauhan A, Gruenberg J, Nasir A, Bjarnadottir O, Werb Z, Kabos P, Chen YY, Hwang ES, Park M, Coussens LM, Nelson AC, Hansen KC, Weaver VM Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression.  View on PubMed
  4. Muncie JM, Ayad NME, Lakins JN, Xue X, Fu J, Weaver VM Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells.  View on PubMed
  5. Northey JJ, Barrett AS, Acerbi I, Hayward MK, Talamantes S, Dean IS, Mouw JK, Ponik SM, Lakins JN, Huang PJ, Wu J, Shi Q, Samson S, Keely PJ, Mukhtar RA, Liphardt JT, Shepherd JA, Hwang ES, Chen YY, Hansen KC, Littlepage LE, Weaver VM Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217.  View on PubMed
  6. Weaver VM, Bissell MJ Zena Werb (1945-2020): Mourning the loss of a tissue microenvironment icon.  View on PubMed
  7. Barcellos-Hoff MH, Weaver VM In Memoriam - Zena Werb 1945-2020.  View on PubMed
  8. Jiang H, Torphy RJ, Steiger K, Hongo H, Ritchie AJ, Kriegsmann M, Horst D, Umetsu SE, Joseph NM, McGregor K, Pishvaian MJ, Blais EM, Lu B, Li M, Hollingsworth M, Stashko C, Volmar K, Yeh JJ, Weaver VM, Wang ZJ, Tempero MA, Weichert W, Collisson EA Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix.  View on PubMed
  9. Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.  View on PubMed
  10. Piersma B, Hayward MK, Weaver VM Fibrosis and cancer: A strained relationship.  View on PubMed
  11. Ayad NME, Weaver VM Tension in tumour cells keeps metabolism high.  View on PubMed
  12. Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, Kolonin MG, Maki RG, Powers RS, Puré E, Ramirez DC, Scherz-Shouval R, Sherman MH, Stewart S, Tlsty TD, Tuveson DA, Watt FM, Weaver V, Weeraratna AT, Werb Z A framework for advancing our understanding of cancer-associated fibroblasts.  View on PubMed
  13. Buffone A, Weaver VM Don't sugarcoat it: How glycocalyx composition influences cancer progression.  View on PubMed
  14. Muncie JM, Falcón-Banchs R, Lakins JN, Sohn LL, Weaver VM Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics.  View on PubMed
  15. Zheng Y, Xue X, Shao Y, Wang S, Esfahani SN, Li Z, Muncie JM, Lakins JN, Weaver VM, Gumucio DL, Fu J Controlled modelling of human epiblast and amnion development using stem cells.  View on PubMed
  16. Eliazer S, Muncie JM, Christensen J, Sun X, D'Urso RS, Weaver VM, Brack AS Wnt4 from the Niche Controls the Mechano-Properties and Quiescent State of Muscle Stem Cells.  View on PubMed
  17. Ayad NME, Kaushik S, Weaver VM Tissue mechanics, an important regulator of development and disease.  View on PubMed
  18. Kai F, Drain AP, Weaver VM The Extracellular Matrix Modulates the Metastatic Journey.  View on PubMed
  19. Libby AR, Joy DA, So PL, Mandegar MA, Muncie JM, Mendoza-Camacho FN, Weaver VM, Conklin BR, McDevitt TC Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference.  View on PubMed
  20. Barnes JM, Kaushik S, Bainer RO, Sa JK, Woods EC, Kai F, Przybyla L, Lee M, Lee HW, Tung JC, Maller O, Barrett AS, Lu KV, Lakins JN, Hansen KC, Obernier K, Alvarez-Buylla A, Bergers G, Phillips JJ, Nam DH, Bertozzi CR, Weaver VM A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma.  View on PubMed

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