Research Funding

  • May 22, 2017 - April 30, 2022 - In Vivo Functional Analysis of Chromosome 7q22 Deletions in Myeloid Malignancies, Co-Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA216352
  • September 15, 2016 - August 31, 2021 - Biologic and Preclinical Studies of Myeloid Malignancies, Principal Investigator. Sponsor: NIH, Sponsor Award ID: R50CA211452
  • May 22, 2017 - April 30, 2022 - In Vivo Functional Analysis of Chromosome 7q22 Deletions in Myeloid Malignancies, Co-Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA216352
  • September 15, 2016 - August 31, 2021 - Biologic and Preclinical Studies of Myeloid Malignancies, Principal Investigator. Sponsor: NIH, Sponsor Award ID: R50CA211452

Education

Postdoctoral Fellow, - Pediatrics (hematology/oncology), University of California, San Francisco
M.Sc., - Molecular and Medical Genetics, University of Toronto
Ph.D., - Molecular and Medical Genetics, University of Toronto
B.Sc., - Biochemistry (Biotechnology option), University of Waterloo
Postdoctoral Fellow, - Pediatrics (hematology/oncology), University of California, San Francisco
M.Sc., - Molecular and Medical Genetics, University of Toronto
Ph.D., - Molecular and Medical Genetics, University of Toronto
B.Sc., - Biochemistry (Biotechnology option), University of Waterloo
Postdoctoral Fellow, - Pediatrics (hematology/oncology), University of California, San Francisco
M.Sc., - Molecular and Medical Genetics, University of Toronto
Ph.D., - Molecular and Medical Genetics, University of Toronto
B.Sc., - Biochemistry (Biotechnology option), University of Waterloo
Postdoctoral Fellow, - Pediatrics (hematology/oncology), University of California, San Francisco
M.Sc., - Molecular and Medical Genetics, University of Toronto
Ph.D., - Molecular and Medical Genetics, University of Toronto
B.Sc., - Biochemistry (Biotechnology option), University of Waterloo
Postdoctoral Fellow, - Pediatrics (hematology/oncology), University of California, San Francisco
M.Sc., - Molecular and Medical Genetics, University of Toronto
Ph.D., - Molecular and Medical Genetics, University of Toronto
B.Sc., - Biochemistry (Biotechnology option), University of Waterloo
Postdoctoral Fellow, - Pediatrics (hematology/oncology), University of California, San Francisco
M.Sc., - Molecular and Medical Genetics, University of Toronto
Ph.D., - Molecular and Medical Genetics, University of Toronto
B.Sc., - Biochemistry (Biotechnology option), University of Waterloo
Postdoctoral Fellow, - Pediatrics (hematology/oncology), University of California, San Francisco
M.Sc., - Molecular and Medical Genetics, University of Toronto
Ph.D., - Molecular and Medical Genetics, University of Toronto
B.Sc., - Biochemistry (Biotechnology option), University of Waterloo
Postdoctoral Fellow, - Pediatrics (hematology/oncology), University of California, San Francisco
M.Sc., - Molecular and Medical Genetics, University of Toronto
Ph.D., - Molecular and Medical Genetics, University of Toronto
B.Sc., - Biochemistry (Biotechnology option), University of Waterloo
Postdoctoral Fellow, - Pediatrics (hematology/oncology), University of California, San Francisco
M.Sc., - Molecular and Medical Genetics, University of Toronto
Ph.D., - Molecular and Medical Genetics, University of Toronto
B.Sc., - Biochemistry (Biotechnology option), University of Waterloo
Postdoctoral Fellow, - Pediatrics (hematology/oncology), University of California, San Francisco
M.Sc., - Molecular and Medical Genetics, University of Toronto
Ph.D., - Molecular and Medical Genetics, University of Toronto
B.Sc., - Biochemistry (Biotechnology option), University of Waterloo
Postdoctoral Fellow, - Pediatrics (hematology/oncology), University of California, San Francisco
M.Sc., - Molecular and Medical Genetics, University of Toronto
Ph.D., - Molecular and Medical Genetics, University of Toronto
B.Sc., - Biochemistry (Biotechnology option), University of Waterloo
Postdoctoral Fellow, - Pediatrics (hematology/oncology), University of California, San Francisco
M.Sc., - Molecular and Medical Genetics, University of Toronto
Ph.D., - Molecular and Medical Genetics, University of Toronto
B.Sc., - Biochemistry (Biotechnology option), University of Waterloo
Postdoctoral Fellow, - Pediatrics (hematology/oncology), University of California, San Francisco
M.Sc., - Molecular and Medical Genetics, University of Toronto
Ph.D., - Molecular and Medical Genetics, University of Toronto
B.Sc., - Biochemistry (Biotechnology option), University of Waterloo
Postdoctoral Fellow, - Pediatrics (hematology/oncology), University of California, San Francisco
M.Sc., - Molecular and Medical Genetics, University of Toronto
Ph.D., - Molecular and Medical Genetics, University of Toronto
B.Sc., - Biochemistry (Biotechnology option), University of Waterloo
Postdoctoral Fellow, - Pediatrics (hematology/oncology), University of California, San Francisco
M.Sc., - Molecular and Medical Genetics, University of Toronto
Ph.D., - Molecular and Medical Genetics, University of Toronto
B.Sc., - Biochemistry (Biotechnology option), University of Waterloo

Selected Publications

  1. Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Del Pilar Alzamora M, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein OD, Tuveson DA, Braun BS, Shannon K. KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice. JCI Insight. 2020 11 05; 5(21).  View on PubMed
  2. Zambetti NA, Firestone AJ, Remsberg JR, Huang BJ, Wong JC, Long AM, Predovic M, Suciu RM, Inguva A, Kogan SC, Haigis KM, Cravatt BF, Shannon K. Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice. Blood. 2020 05 14; 135(20):1772-1782.  View on PubMed
  3. Wandler AM, Huang BJ, Craig JW, Hayes K, Yan H, Meyer LK, Scacchetti A, Monsalve G, Dail M, Li Q, Wong JC, Weinberg O, Hasserjian RP, Kogan SC, Jonsson P, Yamamoto K, Sampath D, Nakitandwe J, Downing JR, Zhang J, Aster JC, Taylor BS, Shannon K. Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia. Leukemia. 2020 08; 34(8):2025-2037.  View on PubMed
  4. Huang BJ, Wandler AM, Meyer LK, Dail M, Daemen A, Sampath D, Li Q, Wang X, Wong JC, Nakitandwe J, Downing JR, Zhang J, Taylor BS, Shannon K. Convergent genetic aberrations in murine and human T lineage acute lymphoblastic leukemias. PLoS Genet. 2019 06; 15(6):e1008168.  View on PubMed
  5. Wong JC, Bryant V, Lamprecht T, Ma J, Walsh M, Schwartz J, Del Pilar Alzamora M, Mullighan CG, Loh ML, Ribeiro R, Downing JR, Carroll WL, Davis J, Gold S, Rogers PC, Israels S, Yanofsky R, Shannon K, Klco JM. Germline SAMD9 and SAMD9L mutations are associated with extensive genetic evolution and diverse hematologic outcomes. JCI Insight. 2018 07 26; 3(14).  View on PubMed
  6. Wong JC, Weinfurtner KM, Alzamora Mdel P, Kogan SC, Burgess MR, Zhang Y, Nakitandwe J, Ma J, Cheng J, Chen SC, Ho TT, Flach J, Reynaud D, Passegu√© E, Downing JR, Shannon K. Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis. Elife. 2015 Jul 20; 4.  View on PubMed
  7. Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun BS, Wolff L, Jacks T, Shannon K. Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood. 2011 Feb 10; 117(6):2022-32.  View on PubMed
  8. Jones L, Wei G, Sevcikova S, Phan V, Jain S, Shieh A, Wong JC, Li M, Dubansky J, Maunakea ML, Ochoa R, Zhu G, Tennant TR, Shannon KM, Lowe SW, Le Beau MM, Kogan SC. Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia. J Exp Med. 2010 Nov 22; 207(12):2581-94.  View on PubMed
  9. Wong JC, Zhang Y, Lieuw KH, Tran MT, Forgo E, Weinfurtner K, Alzamora P, Kogan SC, Akagi K, Wolff L, Le Beau MM, Killeen N, Shannon K. Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies. Blood. 2010 Jun 03; 115(22):4524-32.  View on PubMed
  10. Wong JC, Le Beau MM, Shannon K. Tumor suppressor gene inactivation in myeloid malignancies. Best Pract Res Clin Haematol. 2008 Dec; 21(4):601-14.  View on PubMed
  11. Zhang Y, Wong J, Klinger M, Tran MT, Shannon KM, Killeen N. MLL5 contributes to hematopoietic stem cell fitness and homeostasis. Blood. 2009 Feb 12; 113(7):1455-63.  View on PubMed
  12. Wong JCY, Gokgoz N, Alon N, Andrulis IL, Buchwald M. Cloning and mutation analysis of ZFP276 as a candidate tumor suppressor in breast cancer. J Hum Genet. 2003; 48(12):668-671.  View on PubMed
  13. Wong JC, Alon N, Mckerlie C, Huang JR, Meyn MS, Buchwald M. Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia. Hum Mol Genet. 2003 Aug 15; 12(16):2063-76.  View on PubMed
  14. Wong JC, Buchwald M. Disease model: Fanconi anemia. Trends Mol Med. 2002 Mar; 8(3):139-42.  View on PubMed
  15. Wong JC, Alon N, Norga K, Kruyt FA, Youssoufian H, Buchwald M. Cloning and analysis of the mouse Fanconi anemia group A cDNA and an overlapping penta zinc finger cDNA. Genomics. 2000 Aug 01; 67(3):273-83.  View on PubMed

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