Over the past decade, my laboratory has pioneered multiple approaches for perturbing, quantifying, and interpreting cancer heterogeneity in normal and diseased tissues. We investigate phenotypic heterogeneity, whether arising from microenvironment, epigenetic or genetic sources, and its impact on cancer evolution, drug tolerance and effective treatment strategies.
August 1, 2014 - March 31, 2026 - Maximizing the predictive power of high-throughput, microscopy-based phenotypic screens , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA184984
April 1, 2020 - March 31, 2025 - Scalable Image-Based Approach for Profiling and Annotating Very Large Compound Libraries , Principal Investigator . Sponsor: NIH/NCI, Sponsor Award ID: 2R01 CA184984-06A1
September 1, 2019 - August 31, 2024 - A drug discovery paradigm for fast-tracking adaptations to high altitude , Principal Investigator . Sponsor: DARPA, Sponsor Award ID: Panacea
August 1, 2014 - July 31, 2019 - (PQD1) An Iterative Approach for Overcoming Evolving Targeted Therapy Resistance , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA185404
National Taiwan University, BA, 1985, Mathematics
University of California, San Diego, MA, 1987, Mathematics
University of California, San Diego, PhD, 1990, Mathematics (Advisor: Dr. Richard Hamilton)