Research Summary

Dr. Rosanna Wustrack is the Chief of Orthopedic Oncology and an orthopedic surgeon who specializes in the surgical diagnosis and treatment of musculoskeletal tumors and fragility fractures. Her research focuses on immunotherapy for sarcomas, functional outcomes in cancer patients, osseointegration and optimizing treatment for metastatic disease. She also is interested in global health and osteoporosis in cancer survivors.

Dr. Wustrack received an undergraduate degree from Yale University before earning a medical degree from Washington University School of Medicine in St. Louis. She completed an internship and residency in orthopedic surgery at UCSF. Subsequently, she completed fellowship training in musculoskeletal oncology at Memorial Sloan Kettering Cancer Center in New York.

Research Funding

  • September 30, 2017 - October 1, 2022 - Transfemoral Amputee Osseointegration Study , Co-Investigator . Sponsor: Department of Defense, United States Army Medical Research and Materiel Command, Sponsor Award ID: W81XWH-17-2-0060, USAMRMC-BA160465
  • April 15, 2019 - April 14, 2022 - An Osseo-Neural Transtibial Prosthesis with Efferent-Afferent Neural Control , Co-Investigator . Sponsor: Department of Defense, United States Army Medical Research and Materiel Command, Sponsor Award ID: W81XWH-19-1-0151
  • July 1, 2019 - June 30, 2021 - Identifying and enhancing the host immune response in adult soft tissue sarcoma , Principal Investigator . Sponsor: Musculoskeletal Tumor Society, Sponsor Award ID:

Education

Yale University, BA, 1999, Biology
Washington University in St. Louis School of Medicine, MD, 2006
University of California San Francisco, Intern, 2007, Orthopedic Surgery
University of California San Francisco, Resident, 2012, Orthopedic Surgery
Memorial Sloan Kettering Cancer Center, Fellow, 2013, Musculoskeletal Oncology
University of California San Francisco, Advanced Training in Clinical Research Certificate Program Certificate, 2014, Clinical Research

Honors & Awards

  • 2002
    Distinguished Student Merit Scholarship, Washington University School of Medicine., Washington University in St. Louis School of Medicine
  • 2006
    Class of 2002 Award, Washington University School of Medicine, Washington University in St. Louis School of Medicine
  • 2008
    Mauer Award for best junior resident, UCSF Department Orthopedic Surgery, UCSF Department of Orthopedic Surgery
  • 2010
    2nd Place Resident Paper Award, 55th Annual LeRoy Abbott Society Scientific Program, UCSF Department Orthopedic Surgery, UCSF Department of Orthopedic Surgery
  • 2011
    1st Place Clinical Science Resident Research Symposium, 3rd Annual OREF/ORS Southwest Regional Resident Research Symposium, Orthopedic Research and Education Foundation
  • 2012
    Outstanding Resident Paper Award, 3rd Annual Lumbar Spine Research Society Meeting, Lumbar Spine Research Society
  • 2012
    Resident Paper Award, Western Orthopedic Association 76th Annual Meeting, Western Orthopedic Association
  • 2012
    Mauer Award for Best Chief Resident, UCSF Department Orthopedic Surgery
  • 2016
    James O. Johnston Teaching Award, UCSF Department of Orthopedic Surgery, graduating class of 2016
  • 2018
    The UCSF School of Medicine Excellence in Teaching Award, UCSF School of Medicine
  • 2018
    Best Paper Award, MSTS Annual Meeting, Musculoskeletal Tumor Society

Selected Publications

  1. Hunter Seneca Yamada, Vardhaan Sai Ambati, Timothy Joseph Yee, Abraham Dada, Line G. Jacques, Melissa Zimel, Rosanna Wustrack, Winson Ho, Harish Vasudevan, Praveen V. Mummaneni. 2044 Next Generation Genetic Sequencing of Malignant Peripheral Nerve Sheath Tumors: A 5-Year Institutional Experience. Neurosurgery. 2025 Apr 1; 71(Supplement_1):254-254.  View on PubMed
  2. Biermann JS, Hirbe A, Ahlawat S, Bernthal NM, Binitie O, Boles S, Brigman B, Callan AK, Cipriano C, Cranmer LD, Davis J, Donnelly E, Ferguson M, Graham A, Groundland J, Hess M, Hiniker SM, Hoover-Regan ML, Hornick JL, Jonard B, Kuechle JB, Lindskog D, Mayerson JL, McGarry SV, Morris CD, Olson D, Rose PS, Santana VM, Satcher RL, Schwartz H, Shulman RM, Thorpe SW, Wilky BA, Wustrack RL, Yoon J, Hang LE, Jones F, Sansone N, Lyons M. Bone Cancer, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology. J Natl Compr Canc Netw. 2025 04; 23(4).  View on PubMed
  3. Yue JK, Oh JY, Aabedi AA, Chen JS, Probst KX, Shah VN, Wustrack RL, Jacques LG. Profound Neuropathy after Penetrating Transection of the Sciatic Nerve by Femoral Cerclage Wire: Illustrative Case and Management Strategy. Neurotrauma Rep. 2025; 6(1):128-135.  View on PubMed
  4. Su F, Garcia-Lopez E, Wustrack R, Lansdown DA. Endoprosthetic Reconstruction for Proximal Humerus Tumors. Curr Rev Musculoskelet Med. 2025 Jan; 18(1):26-37.  View on PubMed
  5. Kelly T, Morse LJ, Wustrack R, Zimel M. Proximal Tibia Hemiarthroplasty Reconstruction Following Resection of Malignant Bone Tumors in Skeletally Immature Patients. J Pediatr Soc North Am. 2024 Nov; 9:100118.  View on PubMed
  6. Schott CR, Koehne AL, Sayles LC, Young EP, Luck C, Yu K, Lee AG, Breese MR, Leung SG, Xu H, Shah AT, Liu HY, Spillinger A, Behroozfard IH, Marini KD, Dinh PT, Pons Ventura MV, Vanderboon EN, Hazard FK, Cho SJ, Avedian RS, Mohler DG, Zimel M, Wustrack R, Curtis C, Sirota M, Sweet-Cordero EA. Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach. Clin Cancer Res. 2024 02 16; 30(4):849-864.  View on PubMed
  7. Pozner A, Li L, Verma SP, Wang S, Barrott JJ, Nelson ML, Yu JSE, Negri GL, Colborne S, Hughes CS, Zhu JF, Lambert SL, Carroll LS, Smith-Fry K, Stewart MG, Kannan S, Jensen B, John CM, Sikdar S, Liu H, Dang NH, Bourdage J, Li J, Vahrenkamp JM, Mortenson KL, Groundland JS, Wustrack R, Senger DL, Zemp FJ, Mahoney DJ, Gertz J, Zhang X, Lazar AJ, Hirst M, Morin GB, Nielsen TO, Shen PS, Jones KB. ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97. Nat Commun. 2024 Feb 07; 15(1):1165.  View on PubMed
  8. Pozner A, Verma SP, Li L, Wang S, Barrott JJ, Nelson ML, Yu JSE, Negri GL, Colborne S, Hughes CS, Zhu JF, Lambert SL, Carroll LS, Smith-Fry K, Stewart MG, Kannan S, Jensen B, Mortenson KL, John C, Sikdar S, Liu H, Dang NH, Bourdage J, Li J, Vahrenkamp JM, Groundland JS, Wustrack R, Senger DL, Zemp FJ, Mahoney DJ, Gertz J, Zhang X, Lazar AJ, Hirst M, Morin GB, Nielsen TO, Shen PS, Jones KB. ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97. bioRxiv. 2023 Oct 02.  View on PubMed
  9. Jackson KJ, Sullivan CD, Zimel MN, Wustrack RL, PARITY Investigators. Surgical Site Infection Is Not Associated with 1-Year Progression-Free Survival After Endoprosthetic Reconstruction for Lower-Extremity Osteosarcoma: A Secondary Analysis of PARITY Study Data. J Bone Joint Surg Am. 2023 07 19; 105(Suppl 1):49-56.  View on PubMed
  10. Niu I, Hsiao EC, Wustrack R, Wysolmerski JJ, Dann P, Masharani U. A Case of Hypercalcemia from PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy. Calcif Tissue Int. 2023 08; 113(2):246-253.  View on PubMed
  11. Schott CR, Koehne AL, Sayles LC, Young EP, Luck C, Yu K, Lee AG, Breese MR, Leung SG, Xu H, Shah AT, Liu HY, Spillinger A, Behroozfard IH, Marini KD, Dinh PT, Pons Ventura MAV, Vanderboon EN, Hazard FK, Cho SJ, Avedian RS, Mohler DG, Zimel M, Wustrack R, Curtis C, Sirota M, Sweet-Cordero EA. Development and characterization of new patient-derived xenograft (PDX) models of osteosarcoma with distinct metastatic capacities. bioRxiv. 2023 Jan 20.  View on PubMed
  12. Isabella Niu, Edward Hsiao, Rosanna Wustrack, John Wysolmerski, Pamela Dann, Umesh Masharani. PSAT208 A Case of Hypercalcemia From PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy. Journal of the Endocrine Society. 2022 Nov 1; 6(Suppl 1):a212-a213.  View on PubMed
  13. Tanaka KS, Andaya VR, Thorpe SW, Gundle KR, Hayden JB, Duong YC, Avedian RS, Mohler DG, Morse LJ, Zimel MN, O'Donnell RJ, Fang A, Randall RL, Tran TH, New C, Wustrack RL, other members of Study Group FORCE. Survival and failure modes of the Compress® spindle and expandable distal femur endoprosthesis among pediatric patients: A multi-institutional study. J Surg Oncol. 2023 Jan; 127(1):148-158.  View on PubMed
  14. Geiger EJ, Liu W, Srivastava DK, Bernthal NM, Weil BR, Yasui Y, Ness KK, Krull KR, Goldsby RE, Oeffinger KC, Robison LL, Dieffenbach BV, Weldon CB, Gebhardt MC, Howell R, Murphy AJ, Leisenring WM, Armstrong GT, Chow EJ, Wustrack RL. What Are Risk Factors for and Outcomes of Late Amputation After Treatment for Lower Extremity Sarcoma: A Childhood Cancer Survivor Study Report. Clin Orthop Relat Res. 2023 03 01; 481(3):526-538.  View on PubMed
  15. Stroud SG, Geiger EJ, Lichtensztajn DY, Goldsby RE, Cheng I, Wustrack R, Theologis AA. Survival of Patients With Primary Osseous Malignancies of the Mobile Spine Is Associated With Access to "Standard Treatment" Protocols. J Am Acad Orthop Surg. 2022 Sep 01; 30(17):841-850.  View on PubMed
  16. Andrew S. Jack, Christopher Witiw, Aaron Hockley, Charlotte J. Huie, Rosanna Wustrack, Line G. Jacques. Malignant triton tumor in the setting of segmental neurofibromatosis: A rare case report and review of the literature. Interdisciplinary Neurosurgery. 2021 Jun 1; 24:101073.  View on PubMed
  17. Wustrack RL, Shao E, Sheridan J, Zimel M, Cho SJ, Horvai AE, Luong D, Kwek SS, Fong L, Okimoto RA. Tumor morphology and location associate with immune cell composition in pleomorphic sarcoma. Cancer Immunol Immunother. 2021 Oct; 70(10):3031-3040.  View on PubMed
  18. Michelle J. Hall, Rosanna L. Wustrack, Donald R. Cummings, Richard I. Welling, Mary K. Kaleta, Kevin D. Koenig, Jennifer C. Laine, Sara J. Morgan. Innovations in Pediatric Prosthetics. Journal of the Pediatric Orthopaedic Society of North America. 2021 Feb 1; 3(1):221.  View on PubMed
  19. Guinn JMV, Mayer RR, Li B, Dang ABC, Dang A, Wustrack R, Chou D. En bloc excision of sacroiliac chondrosarcoma aided by 3D laser printed modeling and stereotactic navigation. J Clin Neurosci. 2021 Mar; 85:64-66.  View on PubMed
  20. Fang AS, Morse LJ, Wustrack R, Huber R, Pan M. Complete Regression of Rhabdomyosarcoma in an Adult Secondary to Postoperative Wound Infection Following Limb Salvage Surgery: A Case Report. Perm J. 2020 12; 25:1.  View on PubMed

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