Research Summary

Dr. Rosanna Wustrack is the Chief of Orthopedic Oncology and an orthopedic surgeon who specializes in the surgical diagnosis and treatment of musculoskeletal tumors and fragility fractures. Her research focuses on immunotherapy for sarcomas, functional outcomes in cancer patients, osseointegration and optimizing treatment for metastatic disease. She also is interested in global health and osteoporosis in cancer survivors.

Dr. Wustrack received an undergraduate degree from Yale University before earning a medical degree from Washington University School of Medicine in St. Louis. She completed an internship and residency in orthopedic surgery at UCSF. Subsequently, she completed fellowship training in musculoskeletal oncology at Memorial Sloan Kettering Cancer Center in New York.

Research Funding

  • September 30, 2017 - October 1, 2022 - Transfemoral Amputee Osseointegration Study , Co-Investigator . Sponsor: Department of Defense, United States Army Medical Research and Materiel Command, Sponsor Award ID: W81XWH-17-2-0060, USAMRMC-BA160465
  • April 15, 2019 - April 14, 2022 - An Osseo-Neural Transtibial Prosthesis with Efferent-Afferent Neural Control , Co-Investigator . Sponsor: Department of Defense, United States Army Medical Research and Materiel Command, Sponsor Award ID: W81XWH-19-1-0151
  • July 1, 2019 - June 30, 2021 - Identifying and enhancing the host immune response in adult soft tissue sarcoma , Principal Investigator . Sponsor: Musculoskeletal Tumor Society, Sponsor Award ID:

Education

Yale University, BA, 1999, Biology
Washington University in St. Louis School of Medicine, MD, 2006
University of California San Francisco, Intern, 2007, Orthopedic Surgery
University of California San Francisco, Resident, 2012, Orthopedic Surgery
Memorial Sloan Kettering Cancer Center, Fellow, 2013, Musculoskeletal Oncology
University of California San Francisco, Advanced Training in Clinical Research Certificate Program Certificate, 2014, Clinical Research

Honors & Awards

  • 2002
    Distinguished Student Merit Scholarship, Washington University School of Medicine., Washington University in St. Louis School of Medicine
  • 2006
    Class of 2002 Award, Washington University School of Medicine, Washington University in St. Louis School of Medicine
  • 2008
    Mauer Award for best junior resident, UCSF Department Orthopedic Surgery, UCSF Department of Orthopedic Surgery
  • 2010
    2nd Place Resident Paper Award, 55th Annual LeRoy Abbott Society Scientific Program, UCSF Department Orthopedic Surgery, UCSF Department of Orthopedic Surgery
  • 2011
    1st Place Clinical Science Resident Research Symposium, 3rd Annual OREF/ORS Southwest Regional Resident Research Symposium, Orthopedic Research and Education Foundation
  • 2012
    Outstanding Resident Paper Award, 3rd Annual Lumbar Spine Research Society Meeting, Lumbar Spine Research Society
  • 2012
    Resident Paper Award, Western Orthopedic Association 76th Annual Meeting, Western Orthopedic Association
  • 2012
    Mauer Award for Best Chief Resident, UCSF Department Orthopedic Surgery
  • 2016
    James O. Johnston Teaching Award, UCSF Department of Orthopedic Surgery, graduating class of 2016
  • 2018
    The UCSF School of Medicine Excellence in Teaching Award, UCSF School of Medicine
  • 2018
    Best Paper Award, MSTS Annual Meeting, Musculoskeletal Tumor Society

Selected Publications

  1. Schott CR, Koehne AL, Sayles LC, Young EP, Luck C, Yu K, Lee AG, Breese MR, Leung SG, Xu H, Shah AT, Liu HY, Spillinger A, Behroozfard IH, Marini KD, Dinh PT, Pons Ventura MAV, Vanderboon EN, Hazard FK, Cho SJ, Avedian RS, Mohler DG, Zimel M, Wustrack R, Curtis C, Sirota M, Sweet-Cordero EA. Development and characterization of new patient-derived xenograft (PDX) models of osteosarcoma with distinct metastatic capacities. bioRxiv. 2023 Jan 20.  View on PubMed
  2. Tanaka KS, Andaya VR, Thorpe SW, Gundle KR, Hayden JB, Duong YC, Avedian RS, Mohler DG, Morse LJ, Zimel MN, O'Donnell RJ, Fang A, Randall RL, Tran TH, New C, Wustrack RL, other members of Study Group FORCE. Survival and failure modes of the Compress® spindle and expandable distal femur endoprosthesis among pediatric patients: A multi-institutional study. J Surg Oncol. 2023 Jan; 127(1):148-158.  View on PubMed
  3. Geiger EJ, Liu W, Srivastava DK, Bernthal NM, Weil BR, Yasui Y, Ness KK, Krull KR, Goldsby RE, Oeffinger KC, Robison LL, Dieffenbach BV, Weldon CB, Gebhardt MC, Howell R, Murphy AJ, Leisenring WM, Armstrong GT, Chow EJ, Wustrack RL. What Are Risk Factors for and Outcomes of Late Amputation After Treatment for Lower Extremity Sarcoma: A Childhood Cancer Survivor Study Report. Clin Orthop Relat Res. 2023 03 01; 481(3):526-538.  View on PubMed
  4. Stroud SG, Geiger EJ, Lichtensztajn DY, Goldsby RE, Cheng I, Wustrack R, Theologis AA. Survival of Patients With Primary Osseous Malignancies of the Mobile Spine Is Associated With Access to "Standard Treatment" Protocols. J Am Acad Orthop Surg. 2022 Sep 01; 30(17):841-850.  View on PubMed
  5. Andrew S. Jack, Christopher Witiw, Aaron Hockley, Charlotte J. Huie, Rosanna Wustrack, Line G. Jacques. Malignant triton tumor in the setting of segmental neurofibromatosis: A rare case report and review of the literature. Interdisciplinary Neurosurgery. 2021 Jun 1; 24:101073.  View on PubMed
  6. Wustrack RL, Shao E, Sheridan J, Zimel M, Cho SJ, Horvai AE, Luong D, Kwek SS, Fong L, Okimoto RA. Tumor morphology and location associate with immune cell composition in pleomorphic sarcoma. Cancer Immunol Immunother. 2021 Oct; 70(10):3031-3040.  View on PubMed
  7. Guinn JMV, Mayer RR, Li B, Dang ABC, Dang A, Wustrack R, Chou D. En bloc excision of sacroiliac chondrosarcoma aided by 3D laser printed modeling and stereotactic navigation. J Clin Neurosci. 2021 Mar; 85:64-66.  View on PubMed
  8. Fang AS, Morse LJ, Wustrack R, Huber R, Pan M. Complete Regression of Rhabdomyosarcoma in an Adult Secondary to Postoperative Wound Infection Following Limb Salvage Surgery: A Case Report. Perm J. 2020 12; 25:1.  View on PubMed
  9. W.S. Chen, M. Lometti, R.L. Wustrack, M.N. Zimel, R.J. O'Donnell, A.E. Horvai, S.J. Cho, R.A. Okimoto, T.M. Jahan, A.R. Gottschalk, S.E. Braunstein. Intraoperative Radiotherapy Without External Beam Radiotherapy in the Management of Primary Soft Tissue Sarcomas of the Extremities. International Journal of Radiation Oncology • Biology • Physics. 2020 Nov 1; 108(3):e5.  View on PubMed
  10. J. Chew, S.A. Lloyd, R.A. Okimoto, A. Sabnis, E. Nakakura, C. Corvera, M.N. Zimel, A.E. Horvai, S.J. Cho, R.L. Wustrack, A.R. Gottschalk, R.J. O'Donnell, T.M. Jahan, S.E. Braunstein. Outcomes of Elderly Patients with Soft Tissue Sarcoma of the Extremities. International Journal of Radiation Oncology • Biology • Physics. 2020 Nov 1; 108(3):e6.  View on PubMed
  11. Wustrack R, Rao SS, Morris CD. Musculoskeletal Effects of Cancer and Cancer Treatment. J Am Acad Orthop Surg. 2020 Aug 15; 28(16):e716-e728.  View on PubMed
  12. Zara Butte, Kara Tanaka, Veronica Andaya, Melissa Zimel, Richard J O’Donnell, Rosanna Wustrack. Risk of endoprosthetic infection and impact of health-related quality of life in patients with osteosarcoma and giant cell tumor of bone; a retrospective case-control study. Annals of Joint. 2020 Jul 1; 5(0):27-27.  View on PubMed
  13. Penumarthy NL, Goldsby RE, Shiboski SC, Wustrack R, Murphy P, Winestone LE. Insurance impacts survival for children, adolescents, and young adults with bone and soft tissue sarcomas. Cancer Med. 2020 02; 9(3):951-958.  View on PubMed
  14. Guy Ledergor, Elizabeth McCarthy, Nina Shah, Sandy Wong, Hewitt Chang, Frances Fan, Evans Shao, Lissa Gray, Alexander Cheung, Serena Kwek, Sophia Bylsma, Samuel Del Favero, Rosanna Wustrack, Matthew Spitzer, Jeffrey Wolf, Thomas Martin, Jimmie Ye, Lawrence Fong. Single cell Dissection of Resistance to anti-BCMA CAR-T cell Therapy. Clinical Lymphoma Myeloma & Leukemia. 2019 Oct 1; 19(10):e25-e26.  View on PubMed
  15. Heunis JC, Cheah JW, Sabnis AJ, Wustrack RL. Use of three-dimensional printing and intraoperative navigation in the surgical resection of metastatic acetabular osteosarcoma. BMJ Case Rep. 2019 Sep 30; 12(9).  View on PubMed
  16. Musa B. Zaid, Rosanna L. Wustrack, Matthew Garibaldi, Erik Geiger, Veronica Andaya, Richard J. O'Donnell. Prospective study of percutaneous bone-anchored implants in transfemoral amputees: Brain-machine platform technology for external prosthetic control and feedback. 2013 6th International IEEE/EMBS Conference on Neural Engineering (NER). 2019 Mar 1; 13-16.  View on PubMed
  17. Pandya NK, Wustrack R, Metz L, Ward D. Current Concepts in Orthopaedic Care Disparities. J Am Acad Orthop Surg. 2018 Dec 01; 26(23):823-832.  View on PubMed
  18. Shaw JD, Miller S, Plourde A, Shaw DL, Wustrack R, Hansen EN. Methylene Blue-Guided Debridement as an Intraoperative Adjunct for the Surgical Treatment of Periprosthetic Joint Infection. J Arthroplasty. 2017 12; 32(12):3718-3723.  View on PubMed
  19. Morris CD, Wustrack RL, Levin AS. Limb-Salvage Options in Growing Children with Malignant Bone Tumors of the Lower Extremity: A Critical Analysis Review. JBJS Rev. 2017 07; 5(7):e7.  View on PubMed
  20. Sherborne AL, Lavergne V, Yu K, Lee L, Davidson PR, Mazor T, Smirnoff IV, Horvai AE, Loh M, DuBois SG, Goldsby RE, Neglia JP, Hammond S, Robison LL, Wustrack R, Costello JF, Nakamura AO, Shannon KM, Bhatia S, Nakamura JL. Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors. Clin Cancer Res. 2017 Apr 01; 23(7):1852-1861.  View on PubMed

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