Research Summary

CLINICAL INTERESTS: Dr. Yerem Yeghiazarians is an interventional cardiologist with expertise in managing patients with coronary artery disease, acute coronary syndromes, valvular heart disease, cardiomyopathies, patent foramen ovale, and peripheral arterial diseases. Yeghiazarians earned an undergraduate degree from Brandeis University and a medical degree from the Johns Hopkins School of Medicine. He trained in internal medicine at Brigham and Women's Hospital, Harvard Medical School, where he served as chief medical resident and instructor in medicine. He also completed general and interventional adult cardiology training at the Brigham and Women's Hospital. He has been at UCSF since 2003.

RESEARCH INTERESTS: Dr. Yeghiazarians is the Director of the Translational Cardiac Stem Cell Program at UCSF. His research interests are to study the role of stem cells in improving the cardiac function after a myocardial infarction.

Education

Brandeis University, Waltham, MA, B.A., 1991, Biochemistry/Biology
Johns Hopkins School of Medicine, Baltimore, MD, M.D., 1995, Medicine
Brigham and Women’s Hospital/Harvard Medical School, 1995-1998, Intern/Resident, Internal Medicine
Brigham and Women’s Hospital/Harvard Medical School, 2000-2001, Chief Resident, Internal Medicine
Brigham and Women’s Hospital/Harvard Medical School, 1998-2003, Cardiology/Interventional Fellow

Selected Publications

  1. Nguyen V, Ameri K, Huynh K, Fredkin M, Grona R, Larpthaveesarp A, Gonzalez F, Yeghiazarians Y. Interleukin-15 modulates the response of cortical neurons to ischemia. Mol Cell Neurosci. 2021 Sep; 115:103658.  View on PubMed
  2. Yeghiazarians Y, Jneid H, Tietjens JR, Redline S, Brown DL, El-Sherif N, Mehra R, Bozkurt B, Ndumele CE, Somers VK. Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation. 2021 Jul 20; 144(3):e56-e67.  View on PubMed
  3. Stein NR, Ramakrishna S, Yeghiazarians Y. Premature coronary disease, in-stent restenosis and vascular complications in a young man with Behçet syndrome. BMJ Case Rep. 2020 Aug 24; 13(8).  View on PubMed
  4. Ameri K, Bayardorj D, Samurkashian R, Fredkin M, Fuh E, Nguyen V, Yeghiazarians Y. Administration of Interleukin-15 Peptide Improves Cardiac Function in a Mouse Model of Myocardial Infarction. J Cardiovasc Pharmacol. 2020 01; 75(1):98-102.  View on PubMed
  5. Papolos A, Fan E, Wagle RR, Foster E, Boyle AJ, Yeghiazarians Y, MacGregor JS, Grossman W, Schiller NB, Ganz P, Tison GH. Echocardiographic determination of pulmonary arterial capacitance. Int J Cardiovasc Imaging. 2019 Sep; 35(9):1581-1586.  View on PubMed
  6. Tietjens JR, Claman D, Kezirian EJ, De Marco T, Mirzayan A, Sadroonri B, Goldberg AN, Long C, Gerstenfeld EP, Yeghiazarians Y. Obstructive Sleep Apnea in Cardiovascular Disease: A Review of the Literature and Proposed Multidisciplinary Clinical Management Strategy. J Am Heart Assoc. 2019 01 08; 8(1):e010440.  View on PubMed
  7. Browne S, Jha AK, Ameri K, Marcus SG, Yeghiazarians Y, Healy KE. TGF-ß1/CD105 signaling controls vascular network formation within growth factor sequestering hyaluronic acid hydrogels. PLoS One. 2018; 13(3):e0194679.  View on PubMed
  8. Geng X, Hwang J, Ye J, Shih H, Coulter B, Naudin C, Jun K, Sievers R, Yeghiazarians Y, Lee RJ, Boyle AJ. Aging is protective against pressure overload cardiomyopathy via adaptive extracellular matrix remodeling. Am J Cardiovasc Dis. 2017; 7(3):72-82.  View on PubMed
  9. Ameri K, Samurkashian R, Yeghiazarians Y. Three-Dimensional Bioprinting: Emerging Technology in Cardiovascular Medicine. Circulation. 2017 04 04; 135(14):1281-1283.  View on PubMed
  10. Kallianos K, Henry TS, Yeghiazarians Y, Zimmet J, Shunk KA, Tseng EE, Mahadevan V, Hope MD. Ferumoxytol MRA for transcatheter aortic valve replacement planning with renal insufficiency. Int J Cardiol. 2017 Mar 15; 231:255-257.  View on PubMed
  11. Jha AK, Tharp KM, Browne S, Ye J, Stahl A, Yeghiazarians Y, Healy KE. Matrix metalloproteinase-13 mediated degradation of hyaluronic acid-based matrices orchestrates stem cell engraftment through vascular integration. Biomaterials. 2016 May; 89:136-47.  View on PubMed
  12. Chen Q, Varga M, Wang X, Haddad DJ, An S, Medzikovic L, Derakhshandeh R, Kostyushev DS, Zhang Y, Clifford BT, Luu E, Danforth OM, Rafikov R, Gong W, Black SM, Suchkov SV, Fineman JR, Heiss C, Aschbacher K, Yeghiazarians Y, Springer ML. Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction. J Am Heart Assoc. 2016 Jan 06; 5(1).  View on PubMed
  13. Shrestha U, Sciammarella M, Alhassen F, Yeghiazarians Y, Ellin J, Verdin E, Boyle A, Seo Y, Botvinick EH, Gullberg GT. Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and 99mTc-tetrofosmin: Method and validation. J Nucl Cardiol. 2017 02; 24(1):268-277.  View on PubMed
  14. Ye J, Yeghiazarians Y. Cardiac stem cell therapy: Have we put too much hype in which cell type to use? Heart Fail Rev. 2015 Sep; 20(5):613-9.  View on PubMed
  15. Ye J, Gaur M, Zhang Y, Sievers RE, Woods BJ, Aurigui J, Bernstein HS, Yeghiazarians Y. Treatment with hESC-Derived Myocardial Precursors Improves Cardiac Function after a Myocardial Infarction. PLoS One. 2015; 10(7):e0131123.  View on PubMed
  16. Genet M, Chuan Lee L, Ge L, Acevedo-Bolton G, Jeung N, Martin A, Cambronero N, Boyle A, Yeghiazarians Y, Kozerke S, Guccione JM. A Novel Method for Quantifying Smooth Regional Variations in Myocardial Contractility Within an Infarcted Human Left Ventricle Based on Delay-Enhanced Magnetic Resonance Imaging. J Biomech Eng. 2015 Aug; 137(8):081009.  View on PubMed
  17. Jha AK, Mathur A, Svedlund FL, Ye J, Yeghiazarians Y, Healy KE. Molecular weight and concentration of heparin in hyaluronic acid-based matrices modulates growth factor retention kinetics and stem cell fate. J Control Release. 2015 Jul 10; 209:308-16.  View on PubMed
  18. Ameri K, Jahangiri A, Rajah AM, Tormos KV, Nagarajan R, Pekmezci M, Nguyen V, Wheeler ML, Murphy MP, Sanders TA, Jeffrey SS, Yeghiazarians Y, Rinaudo PF, Costello JF, Aghi MK, Maltepe E. HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth. Cell Rep. 2015 Feb 17; 10(6):891-899.  View on PubMed
  19. Jha AK, Tharp KM, Ye J, Santiago-Ortiz JL, Jackson WM, Stahl A, Schaffer DV, Yeghiazarians Y, Healy KE. Enhanced survival and engraftment of transplanted stem cells using growth factor sequestering hydrogels. Biomaterials. 2015 Apr; 47:1-12.  View on PubMed
  20. Glenn DJ, Cardema MC, Ni W, Zhang Y, Yeghiazarians Y, Grapov D, Fiehn O, Gardner DG. Cardiac steatosis potentiates angiotensin II effects in the heart. . 2015 Feb 15; 308(4):H339-50.  View on PubMed

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