Research Summary

CLINICAL INTERESTS: Dr. Yerem Yeghiazarians is an interventional cardiologist with expertise in managing patients with coronary artery disease, acute coronary syndromes, valvular heart disease, cardiomyopathies, patent foramen ovale, and peripheral arterial diseases. Yeghiazarians earned an undergraduate degree from Brandeis University and a medical degree from the Johns Hopkins School of Medicine. He trained in internal medicine at Brigham and Women's Hospital, Harvard Medical School, where he served as chief medical resident and instructor in medicine. He also completed general and interventional adult cardiology training at the Brigham and Women's Hospital. He has been at UCSF since 2003.

RESEARCH INTERESTS: Dr. Yeghiazarians is the Director of the Translational Cardiac Stem Cell Program at UCSF. His research interests are to study the role of stem cells in improving the cardiac function after a myocardial infarction.

Education

Brandeis University, Waltham, MA, B.A., 1991, Biochemistry/Biology
Johns Hopkins School of Medicine, Baltimore, MD, M.D., 1995, Medicine
Brigham and Women’s Hospital/Harvard Medical School, 1995-1998, Intern/Resident, Internal Medicine
Brigham and Women’s Hospital/Harvard Medical School, 2000-2001, Chief Resident, Internal Medicine
Brigham and Women’s Hospital/Harvard Medical School, 1998-2003, Cardiology/Interventional Fellow

Selected Publications

  1. Stein NR, Ramakrishna S, Yeghiazarians Y Premature coronary disease, in-stent restenosis and vascular complications in a young man with Behçet syndrome.  View on PubMed
  2. Ameri K, Bayardorj D, Samurkashian R, Fredkin M, Fuh E, Nguyen V, Yeghiazarians Y Administration of Interleukin-15 Peptide Improves Cardiac Function in a Mouse Model of Myocardial Infarction.  View on PubMed
  3. Papolos A, Fan E, Wagle RR, Foster E, Boyle AJ, Yeghiazarians Y, MacGregor JS, Grossman W, Schiller NB, Ganz P, Tison GH Echocardiographic determination of pulmonary arterial capacitance.  View on PubMed
  4. Tietjens JR, Claman D, Kezirian EJ, De Marco T, Mirzayan A, Sadroonri B, Goldberg AN, Long C, Gerstenfeld EP, Yeghiazarians Y Obstructive Sleep Apnea in Cardiovascular Disease: A Review of the Literature and Proposed Multidisciplinary Clinical Management Strategy.  View on PubMed
  5. Browne S, Jha AK, Ameri K, Marcus SG, Yeghiazarians Y, Healy KE TGF-ß1/CD105 signaling controls vascular network formation within growth factor sequestering hyaluronic acid hydrogels.  View on PubMed
  6. Geng X, Hwang J, Ye J, Shih H, Coulter B, Naudin C, Jun K, Sievers R, Yeghiazarians Y, Lee RJ, Boyle AJ Aging is protective against pressure overload cardiomyopathy via adaptive extracellular matrix remodeling.  View on PubMed
  7. Ameri K, Samurkashian R, Yeghiazarians Y Three-Dimensional Bioprinting: Emerging Technology in Cardiovascular Medicine.  View on PubMed
  8. Kallianos K, Henry TS, Yeghiazarians Y, Zimmet J, Shunk KA, Tseng EE, Mahadevan V, Hope MD Ferumoxytol MRA for transcatheter aortic valve replacement planning with renal insufficiency.  View on PubMed
  9. Jha AK, Tharp KM, Browne S, Ye J, Stahl A, Yeghiazarians Y, Healy KE Matrix metalloproteinase-13 mediated degradation of hyaluronic acid-based matrices orchestrates stem cell engraftment through vascular integration.  View on PubMed
  10. Chen Q, Varga M, Wang X, Haddad DJ, An S, Medzikovic L, Derakhshandeh R, Kostyushev DS, Zhang Y, Clifford BT, Luu E, Danforth OM, Rafikov R, Gong W, Black SM, Suchkov SV, Fineman JR, Heiss C, Aschbacher K, Yeghiazarians Y, Springer ML Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction.  View on PubMed
  11. Shrestha U, Sciammarella M, Alhassen F, Yeghiazarians Y, Ellin J, Verdin E, Boyle A, Seo Y, Botvinick EH, Gullberg GT Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and 99mTc-tetrofosmin: Method and validation.  View on PubMed
  12. Ye J, Yeghiazarians Y Cardiac stem cell therapy: Have we put too much hype in which cell type to use?  View on PubMed
  13. Ye J, Gaur M, Zhang Y, Sievers RE, Woods BJ, Aurigui J, Bernstein HS, Yeghiazarians Y Treatment with hESC-Derived Myocardial Precursors Improves Cardiac Function after a Myocardial Infarction.  View on PubMed
  14. Genet M, Chuan Lee L, Ge L, Acevedo-Bolton G, Jeung N, Martin A, Cambronero N, Boyle A, Yeghiazarians Y, Kozerke S, Guccione JM A Novel Method for Quantifying Smooth Regional Variations in Myocardial Contractility Within an Infarcted Human Left Ventricle Based on Delay-Enhanced Magnetic Resonance Imaging.  View on PubMed
  15. Jha AK, Mathur A, Svedlund FL, Ye J, Yeghiazarians Y, Healy KE Molecular weight and concentration of heparin in hyaluronic acid-based matrices modulates growth factor retention kinetics and stem cell fate.  View on PubMed
  16. Ameri K, Jahangiri A, Rajah AM, Tormos KV, Nagarajan R, Pekmezci M, Nguyen V, Wheeler ML, Murphy MP, Sanders TA, Jeffrey SS, Yeghiazarians Y, Rinaudo PF, Costello JF, Aghi MK, Maltepe E HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth.  View on PubMed
  17. Jha AK, Tharp KM, Ye J, Santiago-Ortiz JL, Jackson WM, Stahl A, Schaffer DV, Yeghiazarians Y, Healy KE Enhanced survival and engraftment of transplanted stem cells using growth factor sequestering hydrogels.  View on PubMed
  18. Glenn DJ, Cardema MC, Ni W, Zhang Y, Yeghiazarians Y, Grapov D, Fiehn O, Gardner DG Cardiac steatosis potentiates angiotensin II effects in the heart.  View on PubMed
  19. Shrestha U, Botvinick EH, Yeghiazarians Y, Seo Y, Gullberg GT Quantitative Signature of Coronary Steal in a Patient with Occluded Coronary Arteries Supported by Collateral Circulation Using Dynamic SPECT.  View on PubMed
  20. Feng K, Gupta V, Terrazas E, Yeghiazarians Y, Ports T, Gregoratos G, Tavakol M, Roberts JP, Boyle A Trans-radial versus trans-femoral access in patients with end-stage liver disease undergoing cardiac catheterization.  View on PubMed

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