Research Summary

I am a dermatopathologist with a PhD in Biomedical Informatics. I maintain an active academic clinical dermatopathology practice with a specialization in the diagnosis of melanocytic tumors and lead a basic and translational research laboratory focused on the genetics and biology of melanocytic tumors and the use of molecular assessments to improve diagnosis. Our multi-disciplinary team works on identifying and characterizing novel oncogenes and tumor suppressors in melanocytic neoplasia and understanding their biology.

Education

Harvard College, AB, 1988-1992, Biochemistry
Duke University Medical School, MD, 1992-1996, Medicine
Beth Israel Medical Center, Boston, 1996-1997, Medicine Internship
UCSF, Department of Radiology, 1997-2001, Radiology Residency
UCSF, Department of Radiology, 2001-2002, Abdominal Imaging Fellowship

Honors & Awards

  • 1997
    Phi Beta Kappa, Harvard College Chapter, Cambridge, MA
  • 1998
    Medical Scientist Training Program, Predoctoral Fellowship, National Institutes of Health
  • 2003
    Graduate Fellowship, National Library of Medicine
  • 2006
    Doctoral Commencement Speaker, Stanford Medical School
  • 2014
    American Cancer Society Individual Research Award
  • 2014
    Melanoma Research Alliance Career Development Award
  • 2014
    Dermatology Foundation Career Development Award
  • 2014
    Melanoma Research Foundation Mucosal Melanoma Career Development Award
  • 2020
    Stiefel Scholar Award in Skin Cancer

    Selected Publications

    1. Lezcano CM, Yeh I, Eslamdoost N, Fang Y, LeBoit PE, McCalmont TH, Moy AP, Zhang Y, Busam KJ Expanding the Spectrum of Microscopic and Cytogenetic Findings Associated With Spitz Tumors With 11p Gains.  View on PubMed
    2. Tang J, Fewings E, Chang D, Zeng H, Liu S, Jorapur A, Belote RL, McNeal AS, Tan TM, Yeh I, Arron ST, Judson-Torres RL, Bastian BC, Shain AH Publisher Correction: The genomic landscapes of individual melanocytes from human skin.  View on PubMed
    3. Tang J, Fewings E, Chang D, Zeng H, Liu S, Jorapur A, Belote RL, McNeal AS, Tan TM, Yeh I, Arron ST, Judson-Torres RL, Bastian BC, Shain AH The genomic landscapes of individual melanocytes from human skin.  View on PubMed
    4. Raghavan SS, Kapler ES, Dinges MM, Bastian BC, Yeh I Eruptive Spitz nevus, a striking example of benign metastasis.  View on PubMed
    5. de la Fouchardière A, Tee MK, Peternel S, Valdebran M, Pissaloux D, Tirode F, Busam KJ, LeBoit PE, McCalmont TH, Bastian BC, Yeh I Fusion partners of NTRK3 affect subcellular localization of the fusion kinase and cytomorphology of melanocytes.  View on PubMed
    6. Liu HL, Yeh IJ, Phan NN, Wu YH, Yen MC, Hung JH, Chiao CC, Chen CF, Sun Z, Jiang JZ, Hsu HP, Wang CY, Lai MD Gene signatures of SARS-CoV/SARS-CoV-2-infected ferret lungs in short- and long-term models.  View on PubMed
    7. Cohen JN, Yeh I, Mully TW, LeBoit PE, McCalmont TH Genomic and Clinicopathologic Characteristics of PRKAR1A-inactivated Melanomas: Toward Genetic Distinctions of Animal-type Melanoma/Pigment Synthesizing Melanoma.  View on PubMed
    8. Raghavan SS, Peternel S, Mully TW, North JP, Pincus LB, LeBoit PE, McCalmont TH, Bastian BC, Yeh I Spitz melanoma is a distinct subset of spitzoid melanoma.  View on PubMed
    9. Cohen JN, Yeh I, LeBoit PE Melanotic Schwannoma of the Vulva: A Case Report and Review of the Literature.  View on PubMed
    10. Urtatiz O, Cook C, Huang JL, Yeh I, Van Raamsdonk CD GNAQQ209L expression initiated in multipotent neural crest cells drives aggressive melanoma of the central nervous system.  View on PubMed
    11. Houlier A, Pissaloux D, Masse I, Tirode F, Karanian M, Pincus LB, McCalmont TH, LeBoit PE, Bastian BC, Yeh I, de la Fouchardière A Melanocytic tumors with MAP3K8 fusions: report of 33 cases with morphological-genetic correlations.  View on PubMed
    12. Yeh I New and evolving concepts of melanocytic nevi and melanocytomas.  View on PubMed
    13. Botton T, Talevich E, Mishra VK, Zhang T, Shain AH, Berquet C, Gagnon A, Judson RL, Ballotti R, Ribas A, Herlyn M, Rocchi S, Brown KM, Hayward NK, Yeh I, Bastian BC Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses.  View on PubMed
    14. Yeh I, Jorgenson E, Shen L, Xu M, North JP, Shain AH, Reuss D, Wu H, Robinson WA, Olshen A, von Deimling A, Kwok PY, Bastian BC, Asgari MM Targeted Genomic Profiling of Acral Melanoma.  View on PubMed
    15. Torres R, Lang UE, Hejna M, Shelton SJ, Joseph NM, Shain AH, Yeh I, Wei ML, Oldham MC, Bastian BC, Judson-Torres RL MicroRNA Ratios Distinguish Melanomas from Nevi.  View on PubMed
    16. Rotow JK, Gui P, Wu W, Raymond VM, Lanman RB, Kaye FJ, Peled N, Fece de la Cruz F, Nadres B, Corcoran RB, Yeh I, Bastian BC, Starostik P, Newsom K, Olivas VR, Wolff AM, Fraser JS, Collisson EA, McCoach CE, Camidge DR, Pacheco J, Bazhenova L, Li T, Bivona TG, Blakely CM Co-occurring Alterations in the RAS-MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer.  View on PubMed
    17. Newell F, Kong Y, Wilmott JS, Johansson PA, Ferguson PM, Cui C, Li Z, Kazakoff SH, Burke H, Dodds TJ, Patch AM, Nones K, Tembe V, Shang P, van der Weyden L, Wong K, Holmes O, Lo S, Leonard C, Wood S, Xu Q, Rawson RV, Mukhopadhyay P, Dummer R, Levesque MP, Jönsson G, Wang X, Yeh I, Wu H, Joseph N, Bastian BC, Long GV, Spillane AJ, Shannon KF, Thompson JF, Saw RPM, Adams DJ, Si L, Pearson JV, Hayward NK, Waddell N, Mann GJ, Guo J, Scolyer RA Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets.  View on PubMed
    18. Tsai KK, Khurana N, McCalmont T, Daud A, Bastian B, Yeh I PTCH1 Mutation in a Patient With Metastatic Undifferentiated Carcinoma With Clear Cell Change.  View on PubMed
    19. Yeh I, Busam KJ, McCalmont TH, LeBoit PE, Pissaloux D, Alberti L, de la Fouchardière A, Bastian BC Filigree-like Rete Ridges, Lobulated Nests, Rosette-like Structures, and Exaggerated Maturation Characterize Spitz Tumors With NTRK1 Fusion.  View on PubMed
    20. Wong K, van der Weyden L, Schott CR, Foote A, Constantino-Casas F, Smith S, Dobson JM, Murchison EP, Wu H, Yeh I, Fullen DR, Joseph N, Bastian BC, Patel RM, Martincorena I, Robles-Espinoza CD, Iyer V, Kuijjer ML, Arends MJ, Brenn T, Harms PW, Wood GA, Adams DJ Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma.  View on PubMed

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