Research Summary

I am a dermatopathologist with a PhD in Biomedical Informatics. I maintain an active academic clinical dermatopathology practice with a specialization in the diagnosis of melanocytic tumors and lead a basic and translational research laboratory focused on the genetics and biology of melanocytic tumors and the use of molecular assessments to improve diagnosis. Our multi-disciplinary team works on identifying and characterizing novel oncogenes and tumor suppressors in melanocytic neoplasia and understanding their biology.

Education

Harvard College, AB, 1988-1992, Biochemistry
Duke University Medical School, MD, 1992-1996, Medicine
Beth Israel Medical Center, Boston, 1996-1997, Medicine Internship
UCSF, Department of Radiology, 1997-2001, Radiology Residency
UCSF, Department of Radiology, 2001-2002, Abdominal Imaging Fellowship

Honors & Awards

  • 1997
    Phi Beta Kappa, Harvard College Chapter, Cambridge, MA
  • 1998
    Medical Scientist Training Program, Predoctoral Fellowship, National Institutes of Health
  • 2003
    Graduate Fellowship, National Library of Medicine
  • 2006
    Doctoral Commencement Speaker, Stanford Medical School
  • 2014
    American Cancer Society Individual Research Award
  • 2014
    Melanoma Research Alliance Career Development Award
  • 2014
    Dermatology Foundation Career Development Award
  • 2014
    Melanoma Research Foundation Mucosal Melanoma Career Development Award
  • 2020
    Stiefel Scholar Award in Skin Cancer

    Selected Publications

    1. Wang M, Banik I, Shain AH, Yeh I, Bastian BC. Integrated genomic analyses of acral and mucosal melanomas nominate novel driver genes. Genome Med. 2022 06 16; 14(1):65.  View on PubMed
    2. Jiang H, Muir RK, Gonciarz RL, Olshen AB, Yeh I, Hann BC, Zhao N, Wang YH, Behr SC, Korkola JE, Evans MJ, Collisson EA, Renslo AR. Ferrous iron-activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors. J Exp Med. 2022 04 04; 219(4).  View on PubMed
    3. Yeh I. Update on classification of melanocytic tumors and the role of immunohistochemistry and molecular techniques. Semin Diagn Pathol. 2022 Jul; 39(4):248-256.  View on PubMed
    4. Chen JY, Keiser E, LeBoit P, Yeh I, Wei ML. A rare case of axillary keratoacanthoma arising in hidradenitis suppurativa. JAAD Case Rep. 2022 Mar; 21:49-51.  View on PubMed
    5. Yeh I, Busam KJ. Spitz melanocytic tumours - a review. Histopathology. 2022 Jan; 80(1):122-134.  View on PubMed
    6. Benton S, Zhao J, Zhang B, Bahrami A, Barnhill RL, Busam K, Cerroni L, Cook MG, de la Fouchardière A, Elder DE, Johansson I, Landman G, Lazar A, LeBoit P, Lowe L, Massi D, Duncan LM, Messina J, Mihic-Probst D, Mihm MC, Piepkorn MW, Schmidt B, Scolyer RA, Shea CR, Tetzlaff MT, Tron VA, Xu X, Yeh I, Yun SJ, Zembowicz A, Gerami P. Impact of Next-generation Sequencing on Interobserver Agreement and Diagnosis of Spitzoid Neoplasms. Am J Surg Pathol. 2021 12 01; 45(12):1597-1605.  View on PubMed
    7. Sheahon KM, Jankowski T, Yeh I, North JP, Pincus LB, LeBoit PE, McCalmont TH, Lang UE. Primary Cilia Are Preserved in Cellular Blue and Atypical Blue Nevi and Lost in Blue Nevus-like Melanoma. Am J Surg Pathol. 2021 09 01; 45(9):1205-1212.  View on PubMed
    8. Robertson SJ, Orme L, Teixeira R, Shamassi M, Newell F, Patch AM, Yeh I, Gard G, Wilmott J, Jackett L, LeBoit P, Fellowes A, MacArthur G, Fox S, Hayward NK, Bastian B, Scolyer R, Waddell N, Penington A, Shackleton M. Evaluation of Crizotinib Treatment in a Patient With Unresectable GOPC-ROS1 Fusion Agminated Spitz Nevi. JAMA Dermatol. 2021 Jul 01; 157(7):836-841.  View on PubMed
    9. Gu W, Talevich E, Hsu E, Qi Z, Urisman A, Federman S, Gopez A, Arevalo S, Gottschall M, Liao L, Tung J, Chen L, Lim H, Ho C, Kasowski M, Oak J, Holmes BJ, Yeh I, Yu J, Wang L, Miller S, DeRisi JL, Prakash S, Simko J, Chiu CY. Detection of cryptogenic malignancies from metagenomic whole genome sequencing of body fluids. Genome Med. 2021 06 01; 13(1):98.  View on PubMed
    10. Cohen JN, Yeh I, Mully TW, LeBoit PE, McCalmont TH. Response To: Feasibility of a Tumor Progression Model in PRKAR1A-inactivated Melanomas. Am J Surg Pathol. 2021 06 01; 45(6):869-870.  View on PubMed
    11. Yeh I, Bastian BC. Melanoma pathology: new approaches and classification. Br J Dermatol. 2021 08; 185(2):282-293.  View on PubMed
    12. Roy SF, Bastian BC, Maguiness S, Giubellino A, Vemula SS, McCalmont TH, Yeh I. Multiple desmoplastic Spitz nevi with BRAF fusions in a patient with ring chromosome 7 syndrome. Pigment Cell Melanoma Res. 2021 09; 34(5):987-993.  View on PubMed
    13. Chenbhanich J, Hu Y, Hetts S, Cooke D, Dowd C, Devine P, UCLA Clinical Genomics Center, Russell B, Kang SHL, Chang VY, Abla AA, Cornett P, Yeh I, Lee H, Martinez-Agosto JA, Frieden IJ, Shieh JT. Segmental overgrowth and aneurysms due to mosaic PDGFRB p.(Tyr562Cys). Am J Med Genet A. 2021 05; 185(5):1430-1436.  View on PubMed
    14. Patton EE, Mueller KL, Adams DJ, Anandasabapathy N, Aplin AE, Bertolotto C, Bosenberg M, Ceol CJ, Burd CE, Chi P, Herlyn M, Holmen SL, Karreth FA, Kaufman CK, Khan S, Kobold S, Leucci E, Levy C, Lombard DB, Lund AW, Marie KL, Marine JC, Marais R, McMahon M, Robles-Espinoza CD, Ronai ZA, Samuels Y, Soengas MS, Villanueva J, Weeraratna AT, White RM, Yeh I, Zhu J, Zon LI, Hurlbert MS, Merlino G. Melanoma models for the next generation of therapies. Cancer Cell. 2021 05 10; 39(5):610-631.  View on PubMed
    15. Lezcano CM, Yeh I, Eslamdoost N, Fang Y, LeBoit PE, McCalmont TH, Moy AP, Zhang Y, Busam KJ. Expanding the Spectrum of Microscopic and Cytogenetic Findings Associated With Spitz Tumors With 11p Gains. Am J Surg Pathol. 2021 02 01; 45(2):277-285.  View on PubMed
    16. Tang J, Fewings E, Chang D, Zeng H, Liu S, Jorapur A, Belote RL, McNeal AS, Tan TM, Yeh I, Arron ST, Judson-Torres RL, Bastian BC, Shain AH. Publisher Correction: The genomic landscapes of individual melanocytes from human skin. Nature. 2021 Feb; 590(7844):E20.  View on PubMed
    17. Tang J, Fewings E, Chang D, Zeng H, Liu S, Jorapur A, Belote RL, McNeal AS, Tan TM, Yeh I, Arron ST, Judson-Torres RL, Bastian BC, Shain AH. The genomic landscapes of individual melanocytes from human skin. Nature. 2020 10; 586(7830):600-605.  View on PubMed
    18. Raghavan SS, Kapler ES, Dinges MM, Bastian BC, Yeh I. Eruptive Spitz nevus, a striking example of benign metastasis. Sci Rep. 2020 10 01; 10(1):16216.  View on PubMed
    19. de la Fouchardière A, Tee MK, Peternel S, Valdebran M, Pissaloux D, Tirode F, Busam KJ, LeBoit PE, McCalmont TH, Bastian BC, Yeh I. Fusion partners of NTRK3 affect subcellular localization of the fusion kinase and cytomorphology of melanocytes. Mod Pathol. 2021 04; 34(4):735-747.  View on PubMed
    20. Liu HL, Yeh IJ, Phan NN, Wu YH, Yen MC, Hung JH, Chiao CC, Chen CF, Sun Z, Jiang JZ, Hsu HP, Wang CY, Lai MD. Gene signatures of SARS-CoV/SARS-CoV-2-infected ferret lungs in short- and long-term models. Infect Genet Evol. 2020 11; 85:104438.  View on PubMed

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