Research Summary

I am a dermatopathologist with a PhD in Biomedical Informatics. I maintain an active academic clinical dermatopathology practice with a specialization in the diagnosis of melanocytic tumors and lead a basic and translational research laboratory focused on the genetics and biology of melanocytic tumors and the use of molecular assessments to improve diagnosis. Our multi-disciplinary team works on identifying and characterizing novel oncogenes and tumor suppressors in melanocytic neoplasia and understanding their biology.

Education

Harvard College, AB, 1988-1992, Biochemistry
Duke University Medical School, MD, 1992-1996, Medicine
Beth Israel Medical Center, Boston, 1996-1997, Medicine Internship
UCSF, Department of Radiology, 1997-2001, Radiology Residency
UCSF, Department of Radiology, 2001-2002, Abdominal Imaging Fellowship

Honors & Awards

  • 1997
    Phi Beta Kappa, Harvard College Chapter, Cambridge, MA
  • 1998
    Medical Scientist Training Program, Predoctoral Fellowship, National Institutes of Health
  • 2003
    Graduate Fellowship, National Library of Medicine
  • 2006
    Doctoral Commencement Speaker, Stanford Medical School
  • 2014
    American Cancer Society Individual Research Award
  • 2014
    Melanoma Research Alliance Career Development Award
  • 2014
    Dermatology Foundation Career Development Award
  • 2014
    Melanoma Research Foundation Mucosal Melanoma Career Development Award
  • 2020
    Stiefel Scholar Award in Skin Cancer

    Selected Publications

    1. Sheahon KM, Jankowski T, Yeh I, North JP, Pincus LB, LeBoit PE, McCalmont TH, Lang UE. Primary Cilia Are Preserved in Cellular Blue and Atypical Blue Nevi and Lost in Blue Nevus-like Melanoma. Am J Surg Pathol. 2021 Sep 01; 45(9):1205-1212.  View on PubMed
    2. Gu W, Talevich E, Hsu E, Qi Z, Urisman A, Federman S, Gopez A, Arevalo S, Gottschall M, Liao L, Tung J, Chen L, Lim H, Ho C, Kasowski M, Oak J, Holmes BJ, Yeh I, Yu J, Wang L, Miller S, DeRisi JL, Prakash S, Simko J, Chiu CY. Detection of cryptogenic malignancies from metagenomic whole genome sequencing of body fluids. Genome Med. 2021 Jun 01; 13(1):98.  View on PubMed
    3. Cohen JN, Yeh I, Mully TW, LeBoit PE, McCalmont TH. Response To: Feasibility of a Tumor Progression Model in PRKAR1A-inactivated Melanomas. Am J Surg Pathol. 2021 06 01; 45(6):869-870.  View on PubMed
    4. Yeh I, Bastian BC. Melanoma pathology: new approaches and classification. Br J Dermatol. 2021 Aug; 185(2):282-293.  View on PubMed
    5. Chenbhanich J, Hu Y, Hetts S, Cooke D, Dowd C, Devine P, UCLA Clinical Genomics Center , Russell B, Kang SHL, Chang VY, Abla AA, Cornett P, Yeh I, Lee H, Martinez-Agosto JA, Frieden IJ, Shieh JT. Segmental overgrowth and aneurysms due to mosaic PDGFRB p.(Tyr562Cys). Am J Med Genet A. 2021 05; 185(5):1430-1436.  View on PubMed
    6. Patton EE, Mueller KL, Adams DJ, Anandasabapathy N, Aplin AE, Bertolotto C, Bosenberg M, Ceol CJ, Burd CE, Chi P, Herlyn M, Holmen SL, Karreth FA, Kaufman CK, Khan S, Kobold S, Leucci E, Levy C, Lombard DB, Lund AW, Marie KL, Marine JC, Marais R, McMahon M, Robles-Espinoza CD, Ronai ZA, Samuels Y, Soengas MS, Villanueva J, Weeraratna AT, White RM, Yeh I, Zhu J, Zon LI, Hurlbert MS, Merlino G. Melanoma models for the next generation of therapies. Cancer Cell. 2021 May 10; 39(5):610-631.  View on PubMed
    7. Lezcano CM, Yeh I, Eslamdoost N, Fang Y, LeBoit PE, McCalmont TH, Moy AP, Zhang Y, Busam KJ. Expanding the Spectrum of Microscopic and Cytogenetic Findings Associated With Spitz Tumors With 11p Gains. Am J Surg Pathol. 2021 02 01; 45(2):277-285.  View on PubMed
    8. Roy SF, Bastian BC, Maguiness S, Giubellino A, Vemula SS, McCalmont TH, Yeh I. Multiple desmoplastic Spitz nevi with BRAF fusions in a patient with ring chromosome 7 syndrome. Pigment Cell Melanoma Res. 2021 Sep; 34(5):987-993.  View on PubMed
    9. Tang J, Fewings E, Chang D, Zeng H, Liu S, Jorapur A, Belote RL, McNeal AS, Tan TM, Yeh I, Arron ST, Judson-Torres RL, Bastian BC, Shain AH. Publisher Correction: The genomic landscapes of individual melanocytes from human skin. Nature. 2021 Feb; 590(7844):E20.  View on PubMed
    10. Tang J, Fewings E, Chang D, Zeng H, Liu S, Jorapur A, Belote RL, McNeal AS, Tan TM, Yeh I, Arron ST, Judson-Torres RL, Bastian BC, Shain AH. The genomic landscapes of individual melanocytes from human skin. Nature. 2020 10; 586(7830):600-605.  View on PubMed
    11. Raghavan SS, Kapler ES, Dinges MM, Bastian BC, Yeh I. Eruptive Spitz nevus, a striking example of benign metastasis. Sci Rep. 2020 10 01; 10(1):16216.  View on PubMed
    12. de la Fouchardière A, Tee MK, Peternel S, Valdebran M, Pissaloux D, Tirode F, Busam KJ, LeBoit PE, McCalmont TH, Bastian BC, Yeh I. Fusion partners of NTRK3 affect subcellular localization of the fusion kinase and cytomorphology of melanocytes. Mod Pathol. 2021 04; 34(4):735-747.  View on PubMed
    13. Liu HL, Yeh IJ, Phan NN, Wu YH, Yen MC, Hung JH, Chiao CC, Chen CF, Sun Z, Jiang JZ, Hsu HP, Wang CY, Lai MD. Gene signatures of SARS-CoV/SARS-CoV-2-infected ferret lungs in short- and long-term models. Infect Genet Evol. 2020 11; 85:104438.  View on PubMed
    14. Cohen JN, Yeh I, Mully TW, LeBoit PE, McCalmont TH. Genomic and Clinicopathologic Characteristics of PRKAR1A-inactivated Melanomas: Toward Genetic Distinctions of Animal-type Melanoma/Pigment Synthesizing Melanoma. Am J Surg Pathol. 2020 06; 44(6):805-816.  View on PubMed
    15. Raghavan SS, Peternel S, Mully TW, North JP, Pincus LB, LeBoit PE, McCalmont TH, Bastian BC, Yeh I. Spitz melanoma is a distinct subset of spitzoid melanoma. Mod Pathol. 2020 06; 33(6):1122-1134.  View on PubMed
    16. Cohen JN, Yeh I, LeBoit PE. Melanotic Schwannoma of the Vulva: A Case Report and Review of the Literature. Am J Dermatopathol. 2020 Jan; 42(1):46-51.  View on PubMed
    17. Urtatiz O, Cook C, Huang JL, Yeh I, Van Raamsdonk CD. GNAQQ209L expression initiated in multipotent neural crest cells drives aggressive melanoma of the central nervous system. Pigment Cell Melanoma Res. 2020 01; 33(1):96-111.  View on PubMed
    18. Houlier A, Pissaloux D, Masse I, Tirode F, Karanian M, Pincus LB, McCalmont TH, LeBoit PE, Bastian BC, Yeh I, de la Fouchardière A. Melanocytic tumors with MAP3K8 fusions: report of 33 cases with morphological-genetic correlations. Mod Pathol. 2020 05; 33(5):846-857.  View on PubMed
    19. Yeh I. New and evolving concepts of melanocytic nevi and melanocytomas. Mod Pathol. 2020 01; 33(Suppl 1):1-14.  View on PubMed
    20. Botton T, Talevich E, Mishra VK, Zhang T, Shain AH, Berquet C, Gagnon A, Judson RL, Ballotti R, Ribas A, Herlyn M, Rocchi S, Brown KM, Hayward NK, Yeh I, Bastian BC. Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses. Cell Rep. 2019 10 15; 29(3):573-588.e7.  View on PubMed

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