Research Summary

Within my department, I am the vice chair of strategic advisory and hold the Jacobs Distinguished Professorship in Head and Neck Cancer Radiation Oncology. I am a full-time practicing clinician and my research draws from what I learn from my patients. My primary interests include head and neck, thoracic, and cutaneous malignancies, where I have developed and led multiple clinical trials, both within UCSF and across sites nationwide and overseas. I am interested in the development and evaluation of new therapeutic techniques, which to me include novel molecular targeted agents and immunotherapies as well as state-of-the-art technical advances in radiation therapy. I have special interests in virally driven malignancies associated with humanpapillomavirus (HPV), Epstein-Barr virus (EBV), and Merkel cell polyomavirus (MCPyV). My research has entailed collaborating with laboratory-based investigators to identify patient, tumor, and technical characteristics that influence prognosis and response to specific therapies, including tissue-, blood-, and imaging-based biomarkers. I have also conducted clinical trials focused on symptom management, radioprotectants, and supporting patients' quality of life and decision making.

University responsibilities include co-leading the site committee for clinical trial development in head and neck cancers at the UCSF HDFCCC and serving as the principal investigator for NRG Oncology cooperative group activities at UCSF. I previously served on the Cancer Committee which maintains our accreditation through the American College of Surgeons. Nationally, I am the Editor in Chief of the International Journal of Radiation Oncology Biology Physics, Chair of the NRG Oncology Head and Neck Cancer Committee, and a Board Member and the Guidelines and Protocols Committee Co-Chair for the Head and Neck Cancer International Group. I am a member of the NCCN Head and Neck Cancers guidelines committee as well as the Head and Neck Cancer Resource Panel, Education and Science Education Committees, and Education Committee of the Health Equity Diversity Inclusion Education Council of the American Society of Radiation Oncology. I was previously co-chair of the National Cancer Institute (NCI) steering committee for head and neck cancers, president of the American Radium Society (ARS), chair of the scientific program and nominating committees of ARS, chair of the Appropriateness Committee guidelines for radiation oncology at the American College of Radiology, and member of the NCI's Head and Neck Recurrent/Metastatic Disease Task Force. I have been on the scientific program committees of the American Society for Radiation Oncology, the International Association for the Study of Lung Cancer, and the American Head and Neck Society, among others. I am a national boards examiner for the American Board of Radiology. I have contributed to about 250 publications in the medical literature.

Education

2002, University of Pennsylvania, Philadelphia, PA, M.D., Ph.D., Medicine/English
2003, U. T. – M. D. Anderson Cancer Center, Internship, Medicine/Surgery
2007, U. T. – M. D. Anderson Cancer Center, Residency, Radiation Oncology

Honors & Awards

  • 1992
    Mellon Fellow in the Humanities, Andrew W. Mellon Foundation
  • 1995
    Benjamin Franklin Medical Scholar Fellowship, University of Pennsylvania
  • 2004
    Thomas Barkley Award, M. D. Anderson Cancer Center
  • 2004
    Clinical Biostatistics and Trial Design Workshop, Cancer Education Consortium
  • 2005
    Fellowship, Korean American Society for Therapeutic Radiology & Oncology
  • 2006
    Jesse H. Jones Fellowship in Cancer Education, M. D. Anderson Cancer Center
  • 2006
    Outstanding Resident Presentation Award, Texas Radiological Society
  • 2006
    A. Lavoy Moore Endowment Fund, M. D. Anderson Cancer Center
  • 2006
    Eleanor Montague Distinguished Resident Award, American Association of Women Radiologists
  • 2007
    Vail Workshop on Methods in Clinical Cancer Research, American Society of Clinical Oncology (ASCO)/American Association for Cancer Research (AACR)
  • 2008
    Joan F. Giambalvo Memorial Scholarship, AMA Women Physicians Congress
  • 2009
    Best Doctors in America, 2009-2014
  • 2011
    Educator of the Year Award, Association of Residents in Radiation Oncology
  • 2019
    Duke TIP Distinguished Alumni Award, Duke Talent Identification Program (TIP)
  • 2019
    Exceptional Mentor Award, American Medical Women's Association (AMWA)
  • 2019
    Steven A. Leibel Memorial Award, American Society for Radiation Oncology (ASTRO) and American Board of Radiology (ABR) Foundation
  • 2020
    Fellow of the American Society for Radiation Oncology (FASTRO), American Society for Radiation Oncology (ASTRO)

Selected Publications

  1. Lichter KE, Drew T, Demeulenaere S, Wong E, Mohamad O, Yom SS, Bagshaw HP. Environmental Outcomes Associated With Transition From In-Person to a Virtual Oncology Conference During the COVID-19 Pandemic. JAMA Oncol. 2022 09 01; 8(9):1351-1352.  View on PubMed
  2. Cheung CK, Chew J, Wai K, Calkins SM, Ha PK, Ryan WR, Cunha A, Yom SS, Hsu IC, Chan JW. Feasibility of accelerated image-guided high-dose-rate interstitial brachytherapy with inverse planning simulated annealing (IPSA-HDRBT) for post-operative treatment of pathologically node-negative squamous cell carcinomas of the oral tongue. Brachytherapy. 2022 Sep-Oct; 21(5):686-691.  View on PubMed
  3. Katsoulakis E, Kudner R, Chapman C, Park J, Puckett L, Solanki A, Kapoor R, Hagan M, Kelly M, Palta J, Tishler R, Hitchcock Y, Chera B, Feygelman V, Walker G, Sher D, Kujundzic K, Wilson E, Dawes S, Yom SS, Harrison L. Consensus Quality Measures and Dose Constraints for Head and Neck Cancer with an emphasis on Oropharyngeal and Laryngeal Cancer from the Veterans Affairs Radiation Oncology Quality Surveillance Program and American Society for Radiation Oncology Expert Panel. Pract Radiat Oncol. 2022 Sep-Oct; 12(5):409-423.  View on PubMed
  4. Saba NF, Mody MD, Rocco JW, Haddad RI, Yom SS. Head and neck cancer: high-end technology is no guarantee of high-quality care - Authors' reply. Lancet. 2022 06 04; 399(10341):2102.  View on PubMed
  5. Yom SS. Diving into the Wreck: To Search for the Thing Itself. Pract Radiat Oncol. 2022 Sep-Oct; 12(5):e365-e367.  View on PubMed
  6. Yom SS. The Red Journal Outstanding Reviewer Awards for 2021. Int J Radiat Oncol Biol Phys. 2022 Jun 01; 113(2):241-242.  View on PubMed
  7. Scholey J, Vinas L, Kearney V, Yom S, Larson PEZ, Descovich M, Sudhyadhom A. Improved accuracy of relative electron density and proton stopping power ratio through CycleGAN machine learning. Phys Med Biol. 2022 05 02; 67(10).  View on PubMed
  8. Yom SS, Deville C, Boerma M, Carlson D, Jabbour SK, Braverman L. Evaluating the Generalizability and Reproducibility of Scientific Research. Int J Radiat Oncol Biol Phys. 2022 05 01; 113(1):1-4.  View on PubMed
  9. Ward MC, Koyfman SA, Bakst RL, Margalit DN, Beadle BM, Beitler JJ, Chang SS, Cooper JS, Galloway TJ, Ridge JA, Robbins JR, Sacco AG, Tsai CJ, Yom SS, Siddiqui F. Retreatment of Recurrent or Second Primary Head and Neck Cancer After Prior Radiation: Executive Summary of the American Radium Society Appropriate Use Criteria. Int J Radiat Oncol Biol Phys. 2022 07 15; 113(4):759-786.  View on PubMed
  10. Guix I, Liu Q, Pujana MA, Ha P, Piulats J, Linares I, Guedea F, Mao JH, Lazar A, Chapman J, Yom SS, Ashworth A, Barcellos-Hoff MH. Validation of Anticorrelated TGFβ Signaling and Alternative End-Joining DNA Repair Signatures that Predict Response to Genotoxic Cancer Therapy. Clin Cancer Res. 2022 04 01; 28(7):1372-1382.  View on PubMed
  11. Caudell JJ, Gillison ML, Maghami E, Spencer S, Pfister DG, Adkins D, Birkeland AC, Brizel DM, Busse PM, Cmelak AJ, Colevas AD, Eisele DW, Galloway T, Geiger JL, Haddad RI, Hicks WL, Hitchcock YJ, Jimeno A, Leizman D, Mell LK, Mittal BB, Pinto HA, Rocco JW, Rodriguez CP, Savvides PS, Schwartz D, Shah JP, Sher D, St John M, Weber RS, Weinstein G, Worden F, Yang Bruce J, Yom SS, Zhen W, Burns JL, Darlow SD. NCCN Guidelines® Insights: Head and Neck Cancers, Version 1.2022. J Natl Compr Canc Netw. 2022 03; 20(3):224-234.  View on PubMed
  12. Beddok A, Guzene L, Coutte A, Thomson D, Yom SS, Calugaru V, Blais E, Gilliot O, Racadot S, Pointreau Y, Corry J, Jensen K, Porceddu S, Khalladi N, Bastit V, Lasne-Cardon A, Marcy PY, Carsuzaa F, Nioche C, Bourhis J, Salleron J, Thariat J, GORTEC. International assessment of interobserver reproducibility of flap delineation in head and neck carcinoma. Acta Oncol. 2022 Jun; 61(6):672-679.  View on PubMed
  13. Yom SS. Endings and Beginnings, and What Twists and Turns Could Lie on the Road Ahead. Int J Radiat Oncol Biol Phys. 2022 01 01; 112(1):1-3.  View on PubMed
  14. Chan JW, Hohenstein N, Carpenter C, Pattison AJ, Morin O, Valdes G, Thompson M, Perkins J, Solberg TD, Yom SS. Artificial Intelligence-Guided Prediction of Dental Doses Before Planning of Radiation Therapy for Oropharyngeal Cancer: Technical Development and Initial Feasibility of Implementation. Adv Radiat Oncol. 2022 Mar-Apr; 7(2):100886.  View on PubMed
  15. Rodriguez-Russo CA, Junn JC, Yom SS, Bakst RL. Radiation Therapy for Adenoid Cystic Carcinoma of the Head and Neck. Cancers (Basel). 2021 Dec 17; 13(24).  View on PubMed
  16. Campbell SR, Bennett KE, Yom SS, Jagsi R. Promoting Gender Equity at the Red Journal: A Decade's Work. Int J Radiat Oncol Biol Phys. 2021 Dec 01; 111(5):1111-1113.  View on PubMed
  17. Thomas HR, Yom SS. Right on the Nose: A Case of Locally Invasive Extranodal Lymphoma. Int J Radiat Oncol Biol Phys. 2021 Dec 01; 111(5):1101-1102.  View on PubMed
  18. Radaic A, Ganther S, Kamarajan P, Grandis J, Yom SS, Kapila YL. Paradigm shift in the pathogenesis and treatment of oral cancer and other cancers focused on the oralome and antimicrobial-based therapeutics. Periodontol 2000. 2021 10; 87(1):76-93.  View on PubMed
  19. Lee RH, Kang H, Yom SS, Smogorzewska A, Johnson DE, Grandis JR. Treatment of Fanconi Anemia-Associated Head and Neck Cancer: Opportunities to Improve Outcomes. Clin Cancer Res. 2021 10 01; 27(19):5168-5187.  View on PubMed
  20. Mody MD, Rocco JW, Yom SS, Haddad RI, Saba NF. Head and neck cancer. Lancet. 2021 12 18; 398(10318):2289-2299.  View on PubMed

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