Research Summary

Within my department, I am the vice chair of strategic advisory and hold the Jacobs Distinguished Professorship in Head and Neck Cancer Radiation Oncology. I am a full-time practicing clinician and my research draws from what I learn from my patients. My primary interests include head and neck, thoracic, and cutaneous malignancies, where I have developed and led multiple clinical trials, both within UCSF and across sites nationwide and overseas. I am interested in the development and evaluation of new therapeutic techniques, which to me include novel molecular targeted agents and immunotherapies as well as state-of-the-art technical advances in radiation therapy. I have special interests in virally driven malignancies associated with humanpapillomavirus (HPV), Epstein-Barr virus (EBV), and Merkel cell polyomavirus (MCPyV). My research has entailed collaborating with laboratory-based investigators to identify patient, tumor, and technical characteristics that influence prognosis and response to specific therapies, including tissue-, blood-, and imaging-based biomarkers. I have also conducted clinical trials focused on symptom management, radioprotectants, and supporting patients' quality of life and decision making. University responsibilities include co-leading the site committee for clinical trial development in head and neck cancers at the UCSF HDFCCC and serving as the principal investigator for NRG Oncology cooperative group activities at UCSF. I previously served on the Cancer Committee which maintains our accreditation through the American College of Surgeons. Nationally, I am the co-chair of the National Cancer Institute (NCI) steering committee for head and neck cancers, president of the American Radium Society (ARS), writing member and imaging panel subcommittee chair of the National Comprehensive Cancer Network guidelines panel on head and neck cancers, and deputy editor at the International Journal for Radiation Oncology Biology Physics, the top-ranked journal in radiation oncology. Previously I served as chair of the scientific program and nominating committees of ARS, chair of the Appropriateness Committee guidelines for radiation oncology at the American College of Radiology, and member of the NCI's Head and Neck Recurrent/Metastatic Disease Task Force. I have been on the scientific program committees of the American Society for Radiation Oncology, the International Association for the Study of Lung Cancer, and the American Head and Neck Society, among others. I am a national boards examiner for the American Board of Radiology.

Education

2002, University of Pennsylvania, Philadelphia, PA, M.D., Ph.D., Medicine/English
2003, U. T. – M. D. Anderson Cancer Center, Internship, Medicine/Surgery
2007, U. T. – M. D. Anderson Cancer Center, Residency, Radiation Oncology

Honors & Awards

  • 1992
    Mellon Fellow in the Humanities, Andrew W. Mellon Foundation
  • 1995
    Benjamin Franklin Medical Scholar Fellowship, University of Pennsylvania
  • 2004
    Thomas Barkley Award, M. D. Anderson Cancer Center
  • 2004
    Clinical Biostatistics and Trial Design Workshop, Cancer Education Consortium
  • 2005
    Fellowship, Korean American Society for Therapeutic Radiology & Oncology
  • 2006
    Jesse H. Jones Fellowship in Cancer Education, M. D. Anderson Cancer Center
  • 2006
    Outstanding Resident Presentation Award, Texas Radiological Society
  • 2006
    A. Lavoy Moore Endowment Fund, M. D. Anderson Cancer Center
  • 2006
    Eleanor Montague Distinguished Resident Award, American Association of Women Radiologists
  • 2007
    Vail Workshop on Methods in Clinical Cancer Research, American Society of Clinical Oncology (ASCO)/American Association for Cancer Research (AACR)
  • 2008
    Joan F. Giambalvo Memorial Scholarship, AMA Women Physicians Congress
  • 2009
    Best Doctors in America, 2009-2014
  • 2011
    Educator of the Year Award, Association of Residents in Radiation Oncology
  • 2019
    Duke TIP Distinguished Alumni Award, Duke Talent Identification Program (TIP)
  • 2019
    Exceptional Mentor Award, American Medical Women's Association (AMWA)
  • 2019
    Steven A. Leibel Memorial Award, American Society for Radiation Oncology (ASTRO) and American Board of Radiology (ABR) Foundation
  • 2020
    Fellow of the American Society for Radiation Oncology (FASTRO), American Society for Radiation Oncology (ASTRO)

Selected Publications

  1. Yom SS, Torres-Saavedra P, Caudell JJ, Waldron JN, Gillison ML, Xia P, Truong MT, Kong C, Jordan R, Subramaniam RM, Yao M, Chung CH, Geiger JL, Chan JW, O'Sullivan B, Blakaj DM, Mell LK, Thorstad WL, Jones CU, Banerjee RN, Lominska C, Le QT Reduced-Dose Radiation Therapy for HPV-Associated Oropharyngeal Carcinoma (NRG Oncology HN002).  View on PubMed
  2. Chen YP, Ismaila N, Chua MLK, Colevas AD, Haddad R, Huang SH, Wee JTS, Whitley AC, Yi JL, Yom SS, Chan ATC, Hu CS, Lang JY, Le QT, Lee AWM, Lee N, Lin JC, Ma B, Morgan TJ, Shah J, Sun Y, Ma J Chemotherapy in Combination With Radiotherapy for Definitive-Intent Treatment of Stage II-IVA Nasopharyngeal Carcinoma: CSCO and ASCO Guideline.  View on PubMed
  3. Zietman AL, Yom SS The Red Journal's Outstanding Reviewers of 2019.  View on PubMed
  4. Margalit DN, Sacco AG, Cooper JS, Ridge JA, Bakst RL, Beadle BM, Beitler JJ, Chang SS, Chen AM, Galloway TJ, Koyfman SA, Mita C, Robbins JR, Tsai CJ, Truong MT, Yom SS, Siddiqui F Systematic review of postoperative therapy for resected squamous cell carcinoma of the head and neck: Executive summary of the American Radium Society appropriate use criteria.  View on PubMed
  5. Lawhn-Heath C, Yom SS, Liu C, Villanueva-Meyer JE, Aslam M, Smith R, Narwal M, Juarez R, Behr SC, Pampaloni MH, Chan JW, Glastonbury CM, Hope TA, Flavell RR Gallium-68 prostate-specific membrane antigen ([68Ga]Ga-PSMA-11) PET for imaging of thyroid cancer: a feasibility study.  View on PubMed
  6. Tsai CJ, Galloway TJ, Margalit DN, Bakst RL, Beadle BM, Beitler JJ, Chang S, Chen A, Cooper J, Koyfman SA, Ridge JA, Robbins J, Truong MT, Yom SS, Siddiqui F Ipsilateral radiation for squamous cell carcinoma of the tonsil: American Radium Society appropriate use criteria executive summary.  View on PubMed
  7. Gensheimer MF, Yom SS, Soto N, Dignam JJ, Le QT, Machtay M, Curran WJ Multicenter Clinical Cancer Research After COVID-19: A Perspective From NRG Oncology.  View on PubMed
  8. Wu SY, Lazar AA, Gubens MA, Blakely CM, Gottschalk AR, Jablons DM, Jahan TM, Wang VEH, Dunbar TL, Wong ML, Chan JW, Guthrie W, Belkora J, Yom SS Evaluation of a National Comprehensive Cancer Network Guidelines-Based Decision Support Tool in Patients With Non-Small Cell Lung Cancer: A Nonrandomized Clinical Trial.  View on PubMed
  9. Zietman AL, Yom SS Radiation Therapy and the Immune System: A Scientific Revolution in the Making.  View on PubMed
  10. Marshall DC, Tarras ES, Rosenzweig K, Yom SS, Hattangadi-Gluth J, Murphy J, Korenstein D, Chimonas S Trends in Financial Relationships Between Industry and Radiation Oncologists Versus Other Physicians in the United States from 2014 to 2018.  View on PubMed
  11. Thomson DJ, Yom SS, Saeed H, El Naqa I, Ballas L, Bentzen SM, Chao ST, Choudhury A, Coles CE, Dover L, Guadagnolo BA, Guckenberger M, Hoskin P, Jabbour SK, Katz MS, Mukherjee S, Rembielak A, Sebag-Montefiore D, Sher DJ, Terezakis SA, Thomas TV, Vogel J, Estes C Radiation Fractionation Schedules Published During the COVID-19 Pandemic: A Systematic Review of the Quality of Evidence and Recommendations for Future Development.  View on PubMed
  12. Yom SS, Zietman AL Imagining Our Lives Post-Pandemic.  View on PubMed
  13. Strohl MP, Ha PK, Flavell RR, Yom SS PET/CT in Surgical Planning for Head and Neck Cancer.  View on PubMed
  14. Thomson DJ, Palma D, Guckenberger M, Balermpas P, Beitler JJ, Blanchard P, Brizel D, Budach W, Caudell J, Corry J, Corvo R, Evans M, Garden AS, Giralt J, Gregoire V, Harari PM, Harrington K, Hitchcock YJ, Johansen J, Kaanders J, Koyfman S, Langendijk JA, Le QT, Lee N, Margalit D, Mierzwa M, Porceddu S, Soong YL, Sun Y, Thariat J, Waldron J, Yom SS Practice recommendations for risk-adapted head and neck cancer radiotherapy during the COVID-19 pandemic: An ASTRO-ESTRO consensus statement.  View on PubMed
  15. Guckenberger M, Belka C, Bezjak A, Bradley J, Daly ME, DeRuysscher D, Dziadziuszko R, Faivre-Finn C, Flentje M, Gore E, Higgins KA, Iyengar P, Kavanagh BD, Kumar S, Le Pechoux C, Lievens Y, Lindberg K, McDonald F, Ramella S, Rengan R, Ricardi U, Rimner A, Rodrigues GB, Schild SE, Senan S, Simone CB 2nd, Slotman BJ, Stuschke M, Videtic G, Widder J, Yom SS, Palma D Practice Recommendations for Lung Cancer Radiotherapy During the COVID-19 Pandemic: An ESTRO-ASTRO Consensus Statement.  View on PubMed
  16. Park S, Vora M, van Zante A, Humtsoe J, Kim HS, Yom S, Agarwal S, Ha P Clinicopathologic implications of Myb and Beta-catenin expression in adenoid cystic carcinoma.  View on PubMed
  17. Kearney V, Chan JW, Wang T, Perry A, Descovich M, Morin O, Yom SS, Solberg TD DoseGAN: a generative adversarial network for synthetic dose prediction using attention-gated discrimination and generation.  View on PubMed
  18. Vasudevan HN, Yom SS Combining Systemic Therapy With Radiation: Head and Neck Cancer Treatments in an Era of Targeted Agents and Immunotherapy.  View on PubMed
  19. Pfister DG, Spencer S, Adelstein D, Adkins D, Anzai Y, Brizel DM, Bruce JY, Busse PM, Caudell JJ, Cmelak AJ, Colevas AD, Eisele DW, Fenton M, Foote RL, Galloway T, Gillison ML, Haddad RI, Hicks WL, Hitchcock YJ, Jimeno A, Leizman D, Maghami E, Mell LK, Mittal BB, Pinto HA, Ridge JA, Rocco JW, Rodriguez CP, Shah JP, Weber RS, Weinstein G, Witek M, Worden F, Yom SS, Zhen W, Burns JL, Darlow SD Head and Neck Cancers, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.  View on PubMed
  20. Foster CC, Fan M, Lee NY, Yom SS, Heaton CM, Deraniyagala R, Amdur R, Weichselbaum RR, Haraf DJ Is It Worth It? Consequences of Definitive Head and Neck Reirradiation.  View on PubMed

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