Research Summary

Dr. Jacob Young is a neurosurgeon who cares for patients with brain tumors, including low- and high-grade gliomas, meningiomas and brain metastases (cancer that has spread to the brain). He specializes in brain mapping techniques that identify areas important for motor, language and sensory functions, enabling surgeons to minimize the impact on these areas during surgery to remove a tumor. His clinical research explores how to optimize functional outcomes and minimize complications after surgery for intrinsic brain tumors.

Dr. Young's translational research interests include first-in-human early-phase clinical trials of new immunotherapies and innovative ways to deliver drugs to treat cancerous brain tumors. In his lab, he focuses on understanding the microenvironment of glioma and how it contributes to intratumoral heterogeneity (differences between cancer cells within the same tumor), treatment resistance and cancer evolution at the time of progression. Working with numerous collaborators, his ultimate goal is to design treatment strategies that improve outcomes for patients with brain tumors. His glioblastoma research has been recognized at the institutional, regional, and national levels. During his postdoctoral training, he was awarded the Chan Zuckerberg Biohub Physician-Scientist fellowship, the Andrew J. Lockhart Focused Ultrasound and Immuno-Oncology fellowship, and the American Society of Clinical Oncology Young Investigator Award.

Dr. Young earned his medical degree from the University of Chicago Pritzker School of Medicine, where he was elected to the Alpha Omega Alpha Honor Medical Society. He completed a residency in neurosurgery and a postdoctoral fellowship in tumor immunology at UCSF, where he received an Exceptional Physician Award during his training. He was recognized with the Krevan's Award for excellence in patient care at the Zuckerberg San Francisco General Hospital and the Howard Naffziger Award for Outstanding Clinical Service from the department of neurological surgery.

Research Funding

  • December 11, 2024 - December 11, 2024 - Development of a AI-guided Neuro-Oncology Patient Navigator (BrainGPT) , PI . Sponsor: Department of Energy, Sponsor Award ID: NAIRR240060

Education

Residency, 06/2024 - Neurosurgery, University of California, San Francisco
MD, 06/2017 - Medicine, University of Chicago
BS, 05/2012 - Neuroscience, Duke University

Honors & Awards

  • Harold Rosegay Resident Teaching Award, UCSF Department of Neurological Surgery, 2024
  • Edwin Boldrey Award, San Francisco Neurosurgical Society, 2023
  • Harold Rosegay Resident Teaching Award, UCSF Department of Neurological Surgery, 2023
  • Young Investigator Award, American Society of Clinical Oncology (ASCO), 2022-2023
  • Donald O. Quest Award, American Association of Neurological Surgeons (AANS), 2022
  • National Brain Tumor Society Award, American Association of Neurological Surgeons (AANS), 2022
  • Best Senior Resident Translational Paper Award, UCSF Department of Neurological Surgery, 2022
  • Best Basic Science Abstract, Western Neurosurgical Society, 2022
  • Chan-Zuckerberg Physician Scientist Fellow, Chan-Zuckerberg Biohub, UCSF, 2021-2022
  • Donald O. Quest Award, American Association of Neurological Surgeons (AANS), 2021
  • Neil Peart Neurosurgery Research Award, Glioblastoma Foundation, 2021
  • Harold Rosegay Award, San Francisco Neurosurgical Society, 2021
  • Harold Rosegay Award, San Francisco Neurosurgical Society, 2020
  • UCSF Exceptional Physician Award, UCSF, 2020
  • Best Junior Research Paper Award, UCSF Department of Neurological Surgery, 2019
  • Howard Naffziger Award, UCSF Department of Neurological Surgery, 2019
  • Krevans Award for Excellence in Patient Care, San Francisco General Hospital, UCSF, 2018

Selected Publications

  1. Elguindy MM, Young JS, Ho WS, Lu RO. Co-evolution of glioma and immune microenvironment. J Immunother Cancer. 2024 Dec 03; 12(12).  View on PubMed
  2. Lucas CG, Al-Adli NN, Young JS, Gupta R, Morshed RA, Wu J, Ravindranathan A, Shai A, Oberheim Bush NA, Taylor JW, de Groot J, Villanueva-Meyer JE, Pekmezci M, Perry A, Bollen AW, Theodosopoulos PV, Aghi MK, Chang EF, Hervey-Jumper SL, Raleigh DR, Molinaro AM, Costello JF, Diaz AA, Clarke JL, Butowski NA, Phillips JJ, Chang SM, Berger MS, Solomon DA. Longitudinal multimodal profiling of IDH-wildtype glioblastoma reveals the molecular evolution and cellular phenotypes underlying prognostically different treatment responses. Neuro Oncol. 2024 Nov 19.  View on PubMed
  3. Nadeem N Al-Adli, Jacob S Young, Jing Li, Daniel Quintana, Abraham Dada, Grazia Menna, Jasper K W Gerritsen, Ramin A Morshed, Shawn L Hervey-Jumper, Mitchel S Berger. SURG-24. MAXIMAL SAFE RESECTION OF INSULAR GLIOMAS: AN EVALUATION OF SURGICAL AND PROGNOSTIC OUTCOMES IN 461 CASES. Neuro-Oncology. 2024 Nov 11; 26(Supplement_8):viii279-viii279.  View on PubMed
  4. P Karschnia, J S Young, G C Youssef, A Dono, L Häni, T Sciortino, F Bruno, S T Juenger, N Teske, J Dietrich, M Weller, M A Vogelbaum, M van den Bent, J Beck, N Thon, J K Gerritsen, S Hervey-Jumper, D P Cahill, S M Chang, R Rudà, L Bello, O Schnell, Y Esquenazi, M I Ruge, S J Grau, R Y Huang, P Y Wen, M S Berger, A M Molinaro, J Tonn. P18.54.B DEVELOPMENT AND VALIDATION OF A CLINICAL RISK SCORE FOR POSTOPERATIVE OUTCOME IN NEWLY DIAGNOSED GLIOBLASTOMA: A REPORT OF THE RANO RESECT GROUP. Neuro-Oncology. 2024 Oct 17; 26(Supplement_5):v110-v110.  View on PubMed
  5. Gerritsen JKW, Young JS, Krieg SM, Jungk C, Ille S, Schucht P, Nahed BV, Broekman MLD, Berger M, De Vleeschouwer S, Vincent AJPE. Resection versus biopsy in patients with glioblastoma (RESBIOP study): study protocol for an international multicentre prospective cohort study (ENCRAM 2202). BMJ Open. 2024 Sep 10; 14(9):e081689.  View on PubMed
  6. Lad M, Beniwal AS, Jain S, Shukla P, Kalistratova V, Jung J, Shah SS, Yagnik G, Saha A, Sati A, Babikir H, Nguyen AT, Gill S, Rios J, Young JS, Lui A, Salha D, Diaz A, Aghi MK. Glioblastoma induces the recruitment and differentiation of dendritic-like "hybrid" neutrophils from skull bone marrow. Cancer Cell. 2024 Sep 09; 42(9):1549-1569.e16.  View on PubMed
  7. Eaton CD, Avalos L, Liu SJ, Chen Z, Zakimi N, Casey-Clyde T, Bisignano P, Lucas CG, Stevenson E, Choudhury A, Vasudevan HN, Magill ST, Young JS, Krogan NJ, Villanueva-Meyer JE, Swaney DL, Raleigh DR. MerlinS13 phosphorylation regulates meningioma Wnt signaling and magnetic resonance imaging features. Nat Commun. 2024 Sep 09; 15(1):7873.  View on PubMed
  8. Ekert JO, Goyal A, Young JS, Hervey-Jumper SL, Berger MS. Interventional neurorehabilitation for glioma patients: A systematic review. Neurooncol Pract. 2024 Dec; 11(6):679-690.  View on PubMed
  9. Philipp Karschnia, Jacob S Young, Antonio Dono, Levin Häni, Stephanie T. Jünger, Tommaso Sciortino, Nico Teske, Gilbert Youssef, Francesco Bruno, Michael A. Vogelbaum, Roberta Rudà, Raymond Yi-kun Huang, Patrick Y. Wen, Lorenzo Bello, Stefan J. Grau, Oliver Schnell, Yoshua Esquenazi, Susan Marina Chang, Mitchel S. Berger, Joerg Tonn. Development and validation of a clinical risk score for postoperative outcome in newly diagnosed glioblastoma: A report of the RANO Resect group. Journal of Clinical Oncology. 2024 Jun 1; 42(16_suppl):2060-2060.  View on PubMed
  10. Gerritsen JKW, Young JS, Chang SM, Krieg SM, Jungk C, van den Bent MJ, Satoer DD, Ille S, Schucht P, Nahed BV, Broekman MLD, Berger M, De Vleeschouwer S, Vincent AJPE. SUPRAMAX-study: supramaximal resection versus maximal resection for glioblastoma patients: study protocol for an international multicentre prospective cohort study (ENCRAM 2201). BMJ Open. 2024 Apr 29; 14(4):e082274.  View on PubMed
  11. Narsinh KH, Perez E, Haddad AF, Young JS, Savastano L, Villanueva-Meyer JE, Winkler E, de Groot J. Strategies to Improve Drug Delivery Across the Blood-Brain Barrier for Glioblastoma. Curr Neurol Neurosci Rep. 2024 05; 24(5):123-139.  View on PubMed
  12. Karschnia P, Dono A, Young JS, Juenger ST, Teske N, Häni L, Sciortino T, Mau CY, Bruno F, Nunez L, Morshed RA, Haddad AF, Weller M, van den Bent M, Thon N, Beck J, Hervey-Jumper S, Molinaro AM, Tandon N, Rudà R, Vogelbaum MA, Bello L, Schnell O, Grau SJ, Chang SM, Berger MS, Esquenazi Y, Tonn JC. Associations between recurrence patterns and outcome in glioblastoma patients undergoing re-resection: A complementary report of the RANO resect group. Neuro Oncol. 2024 03 04; 26(3):584-586.  View on PubMed
  13. Mirian C, Jensen LR, Juratli TA, Maier AD, Torp SH, Shih HA, Morshed RA, Young JS, Magill ST, Bertero L, Stummer W, Spille DC, Brokinkel B, Oya S, Miyawaki S, Saito N, Proescholdt M, Kuroi Y, Gousias K, Simon M, Moliterno J, Prat-Acin R, Goutagny S, Prabhu VC, Tsiang JT, Wach J, Güresir E, Yamamoto J, Kim YZ, Lee JH, Koshy M, Perumal K, Baskaya MK, Cannon DM, Shrieve DC, Suh CO, Chang JH, Kamenova M, Straumann S, Soleman J, Eyüpoglu IY, Catalan T, Lui A, Theodosopoulos PV, McDermott MW, Wang F, Guo F, Góes P, de Paiva Neto MA, Jamshidi A, Komotar R, Ivan M, Luther E, Souhami L, Guiot MC, Csonka T, Endo T, Barrett OC, Jensen R, Gupta T, Patel AJ, Klisch TJ, Kim JW, Maiuri F, Barresi V, Tabernero MD, Skyrman S, Broechner A, Bach MJ, Law I, Scheie D, Kristensen BW, Munch TN, Meling T, Fugleholm K, Blanche P, Mathiesen T. The importance of considering competing risks in recurrence analysis of intracranial meningioma. J Neurooncol. 2024 Feb; 166(3):503-511.  View on PubMed
  14. Elguindy M, Young JS, Mondal I, Lu RO, Ho WS. Glioma-Immune Cell Crosstalk in Tumor Progression. Cancers (Basel). 2024 Jan 11; 16(2).  View on PubMed
  15. Karschnia P, Dietrich J, Bruno F, Dono A, Juenger ST, Teske N, Young JS, Sciortino T, Häni L, van den Bent M, Weller M, Vogelbaum MA, Morshed RA, Haddad AF, Molinaro AM, Tandon N, Beck J, Schnell O, Bello L, Hervey-Jumper S, Thon N, Grau SJ, Esquenazi Y, Rudà R, Chang SM, Berger MS, Cahill DP, Tonn JC. Surgical management and outcome of newly diagnosed glioblastoma without contrast enhancement (low-grade appearance): a report of the RANO resect group. Neuro Oncol. 2024 01 05; 26(1):166-177.  View on PubMed
  16. Hadad S, Gupta R, Oberheim Bush NA, Taylor JW, Villanueva-Meyer JE, Young JS, Wu J, Ravindranathan A, Zhang Y, Warrier G, McCoy L, Shai A, Pekmezci M, Perry A, Bollen AW, Phillips JJ, Braunstein SE, Raleigh DR, Theodosopoulos P, Aghi MK, Chang EF, Hervey-Jumper SL, Costello JF, de Groot J, Butowski NA, Clarke JL, Chang SM, Berger MS, Molinaro AM, Solomon DA. "De novo replication repair deficient glioblastoma, IDH-wildtype" is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade. Acta Neuropathol. 2023 12 11; 147(1):3.  View on PubMed
  17. Young JS, Morshed RA, Hervey-Jumper SL, Berger MS. The surgical management of diffuse gliomas: Current state of neurosurgical management and future directions. Neuro Oncol. 2023 12 08; 25(12):2117-2133.  View on PubMed
  18. Al-Adli NN, Young JS, Scotford K, Sibih YE, Payne J, Berger MS. Advances in Intraoperative Glioma Tissue Sampling and Infiltration Assessment. Brain Sci. 2023 Nov 25; 13(12).  View on PubMed
  19. Chen WC, Choudhury A, Youngblood MW, Polley MC, Lucas CG, Mirchia K, Maas SLN, Suwala AK, Won M, Bayley JC, Harmanci AS, Harmanci AO, Klisch TJ, Nguyen MP, Vasudevan HN, McCortney K, Yu TJ, Bhave V, Lam TC, Pu JK, Li LF, Leung GK, Chan JW, Perlow HK, Palmer JD, Haberler C, Berghoff AS, Preusser M, Nicolaides TP, Mawrin C, Agnihotri S, Resnick A, Rood BR, Chew J, Young JS, Boreta L, Braunstein SE, Schulte J, Butowski N, Santagata S, Spetzler D, Bush NAO, Villanueva-Meyer JE, Chandler JP, Solomon DA, Rogers CL, Pugh SL, Mehta MP, Sneed PK, Berger MS, Horbinski CM, McDermott MW, Perry A, Bi WL, Patel AJ, Sahm F, Magill ST, Raleigh DR. Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses. Nat Med. 2023 Dec; 29(12):3067-3076.  View on PubMed
  20. Ramin A. Morshed, Jacob S. Young, Alexander F. Haddad, Mitchel S. Berger. Insular Gliomas: A Review of Surgical Anatomy and Operative Considerations. Functional Anatomy of the Brain: A View from the Surgeon’s Eye. 2023 Oct 25; 211-218.  View on PubMed

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