Education

University of Southern California, B.S., 05/2009, Chemistry
University of Southern California, Ph.D., 06/2014, Chemical Biology
The Scripps Research Institute, Postdoctoral, 09/2017, Chemical Biology
Stanford School of Medicine, Postdoctoral, 08/2019, Stem Cell Biology and Innate Immunity

Selected Publications

  1. Mella J, Volk RF, Zaro BW, Buchwalter A C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin.  View on PubMed
  2. Sharma S, Prathigudupu V, Cable C, Serrano LR, Nerella S, Chen A, Hassan G, Lakins J, Valenzuela CL, Tsukui T, Ramamoorthi R, Kim JJ, Willenbring H, Mattis AN, Volk RF, Zaro BW, Coon JJ, Beresis R, DeGrado WF, Weaver VM, Christenson SA, Jo H, Chen JY Resolving fibrosis by stimulating HSC-dependent extracellular matrix degradation.  View on PubMed
  3. Beresis R, Prathigudupu V, Cable C, Yu A, Adler M, Ramamoorthi R, Yeon SK, Gordan JD, Sharma S, DeGrado WF, Zaro B, Chen JY, Jo H Exploration of a Class of Aryl Imidazolyl Ureas As Potent Acid Ceramidase Inhibitors for the Treatment of Fibrotic Diseases.  View on PubMed
  4. Letian A, Young K, Pi A, Gonzatti M, Volk R, Sharma I, Baker C, Benayoun BA, Zaro BW, Stratman AN, Goldberg EL Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth.  View on PubMed
  5. Boucher MJ, Banerjee S, Joshi MB, Wei AL, Nalley MJ, Huang MY, Lei S, Ciranni M, Condon A, Langen A, Goddard TD, Caradonna I, Goranov AI, Homer CM, Mortensen Y, Petnic S, Reilly MC, Xiong Y, Susa KJ, Pastore VP, Zaro BW, Madhani HD Phenotypic landscape of an invasive fungal pathogen reveals its unique biology.  View on PubMed
  6. Karner H, Mittmann T, Chen VW, Borah AA, Langen A, Yousefi H, Fish L, Zaro BW, Navickas A, Goodarzi H Integrative analysis of mRNA stability regulation uncovers a metastasis-suppressive program in breast cancer.  View on PubMed
  7. Banuelos A, Baez M, Zhang A, Yilmaz L, Kasberg W, Volk R, Georgeos N, Koren-Sedova E, Le U, Burden AT, Marjon KD, Lippincott-Schwartz J, Zaro BW, Weissman IL. Macrophages release neuraminidase and cleaved calreticulin for programmed cell removal. Proc Natl Acad Sci U S A. 2025 May 27; 122(21):e2426644122.  View on PubMed
  8. George BM, Eleftheriou M, Yankova E, Perr J, Chai P, Nestola G, Almahayni K, Evans S, Damaskou A, Hemberger H, Lebedenko CG, Rak J, Yu Q, Bapcum E, Russell J, Bagri J, Volk RF, Spiekermann M, Stone RM, Giotopoulos G, Huntly BJP, Baxter J, Camargo F, Liu J, Zaro BW, Vassiliou GS, Möckl L, de la Rosa J, Flynn RA, Tzelepis K. Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein. Nat Biotechnol. 2025 Apr 23.  View on PubMed
  9. Perr J, Langen A, Almahayni K, Nestola G, Chai P, Lebedenko CG, Volk RF, Detrés D, Caldwell RM, Spiekermann M, Hemberger H, Bisaria N, Aiba T, Sánchez-Rivera FJ, Tzelepis K, Calo E, Möckl L, Zaro BW, Flynn RA. RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry. Cell. 2025 Apr 03; 188(7):1878-1895.e25.  View on PubMed
  10. Mella J, Volk R, Zaro B, Buchwalter A. C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin. bioRxiv. 2025 Jan 20.  View on PubMed
  11. Boucher MJ, Banerjee S, Joshi MB, Wei AL, Huang MY, Lei S, Ciranni M, Condon A, Langen A, Goddard TD, Caradonna I, Goranov AI, Homer CM, Mortensen Y, Petnic S, Reilly MC, Xiong Y, Susa KJ, Pastore VP, Zaro BW, Madhani HD. Phenotypic landscape of a fungal meningitis pathogen reveals its unique biology. bioRxiv. 2024 Oct 29.  View on PubMed
  12. Javed A, Johnson OT, Balana AT, Volk RF, Langen A, Ahn BS, Zaro BW, Gestwicki JE, Pratt MR. O-GlcNAc modification of HSP27 alters its protein interactions and promotes refolding of proteins through the BAG3/HSP70 co-chaperone. Protein Sci. 2024 Oct; 33(10):e5173.  View on PubMed
  13. Tal MC, Hansen PS, Ogasawara HA, Feng Q, Volk RF, Lee B, Casebeer SE, Blacker GS, Shoham M, Galloway SD, Sapiro AL, Hayes B, Torrez Dulgeroff LB, Raveh T, Pothineni VR, Potula HS, Rajadas J, Bastounis EE, Chou S, Robinson WH, Coburn J, Weissman IL, Zaro BW. P66 is a bacterial mimic of CD47 that binds the anti-phagocytic receptor SIRPα and facilitates macrophage evasion by Borrelia burgdorferi. bioRxiv. 2024 Apr 30.  View on PubMed
  14. Chuh KN, Zaro BW, Piller F, Piller V, Pratt MR. Correction to "Changes in Metabolic Chemical Reporter Structure Yield a Selective Probe of O-GlcNAc Modification". J Am Chem Soc. 2023 Oct 11; 145(40):22284.  View on PubMed
  15. Sapiro AL, Hayes BM, Volk RF, Zhang JY, Brooks DM, Martyn C, Radkov A, Zhao Z, Kinnersley M, Secor PR, Zaro BW, Chou S. Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission. Elife. 2023 Jul 14; 12.  View on PubMed
  16. Chen Z, Mondal A, Abderemane-Ali F, Jang S, Niranjan S, Montaño JL, Zaro BW, Minor DL. EMC chaperone-CaV structure reveals an ion channel assembly intermediate. Nature. 2023 Jul; 619(7969):410-419.  View on PubMed
  17. Datta R, Gholampour MA, Yang CD, Volk R, Lin S, Podolsky MJ, Arnold T, Rieder F, Zaro BW, Verzi M, Lehner R, Abumrad N, Lizama CO, Atabai K. MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes. Cell Rep. 2023 03 28; 42(3):112249.  View on PubMed
  18. Zhang K, Yao E, Chuang E, Chen B, Chuang EY, Volk RF, Hofmann KL, Zaro B, Chuang PT. Wnt5a-Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions. PLoS Biol. 2022 08; 20(8):e3001759.  View on PubMed
  19. Dang EV, Lei S, Radkov A, Volk RF, Zaro BW, Madhani HD. Secreted fungal virulence effector triggers allergic inflammation via TLR4. Nature. 2022 08; 608(7921):161-167.  View on PubMed
  20. Montaño JL, Wang BJ, Volk RF, Warrington SE, Garda VG, Hofmann KL, Chen LC, Zaro BW. Improved Electrophile Design for Exquisite Covalent Molecule Selectivity. ACS Chem Biol. 2022 06 17; 17(6):1440-1449.  View on PubMed

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