Chemical validation of a druggable site on Hsp27/HSPB1 using in silico solvent mapping and biophysical methods. Read more about Chemical validation of a druggable site on Hsp27/HSPB1 using in silico solvent mapping and biophysical methods.
Covalent peptides and proteins for therapeutics. Read more about Covalent peptides and proteins for therapeutics.
The splicing modulator sulfonamide indisulam reduces AR-V7 in prostate cancer cells. Read more about The splicing modulator sulfonamide indisulam reduces AR-V7 in prostate cancer cells.
Genetically encoding thyronine for fluorescent detection of peroxynitrite. Read more about Genetically encoding thyronine for fluorescent detection of peroxynitrite.
Generation of highly potent DYRK1A-dependent inducers of human β-Cell replication via Multi-Dimensional compound optimization. Read more about Generation of highly potent DYRK1A-dependent inducers of human β-Cell replication via Multi-Dimensional compound optimization.
Rational design and screening of peptide-based inhibitors of heat shock factor 1 (HSF1). Read more about Rational design and screening of peptide-based inhibitors of heat shock factor 1 (HSF1).
Substrate-guided optimization of the syringolins yields potent proteasome inhibitors with activity against leukemia cell lines. Read more about Substrate-guided optimization of the syringolins yields potent proteasome inhibitors with activity against leukemia cell lines.
Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1. Read more about Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1.
Structural optimization of a retrograde trafficking inhibitor that protects cells from infections by human polyoma- and papillomaviruses. Read more about Structural optimization of a retrograde trafficking inhibitor that protects cells from infections by human polyoma- and papillomaviruses.
Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells. Read more about Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells.
