Improved synthesis of 15-deoxyspergualin analogs using the Ugi multi-component reaction. Read more about Improved synthesis of 15-deoxyspergualin analogs using the Ugi multi-component reaction.
Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor. Read more about Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.
Structure-activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists. Read more about Structure-activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists.
Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK. Read more about Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK.
Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists. Read more about Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists.
Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Read more about Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases.
A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta. Read more about A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.
Improving the species cross-reactivity of an antibody using computational design. Read more about Improving the species cross-reactivity of an antibody using computational design.
A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties. Read more about A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties.
Tags for labeling protein N-termini with subtiligase for proteomics. Read more about Tags for labeling protein N-termini with subtiligase for proteomics.
