Small molecule recognition of c-Src via the Imatinib-binding conformation. Read more about Small molecule recognition of c-Src via the Imatinib-binding conformation.
Halogenation strategies in natural product biosynthesis. Read more about Halogenation strategies in natural product biosynthesis.
A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Read more about A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration.
Beta strand peptidomimetics as potent PDZ domain ligands. Read more about Beta strand peptidomimetics as potent PDZ domain ligands.
Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete. Read more about Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete.
Selective kinase inhibition by exploiting differential pathway sensitivity. Read more about Selective kinase inhibition by exploiting differential pathway sensitivity.
Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity. Read more about Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity.
Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells. Read more about Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells.
Target identification for a promising anti-lupus drug. Read more about Target identification for a promising anti-lupus drug.
