Dissecting the Engrailed homeodomain-DNA interaction by phage-displayed shotgun scanning. Read more about Dissecting the Engrailed homeodomain-DNA interaction by phage-displayed shotgun scanning.
Identification of a novel protein regulating microtubule stability through a chemical approach. Read more about Identification of a novel protein regulating microtubule stability through a chemical approach.
Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90. Read more about Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90.
Cell aggregation by scaffolded receptor clusters. Read more about Cell aggregation by scaffolded receptor clusters.
Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme. Read more about Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme.
A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway. Read more about A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway.
Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase. Read more about Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase.
A general approach for the generation of orthogonal tRNAs. Read more about A general approach for the generation of orthogonal tRNAs.
Approaches to solving the rigid receptor problem by identifying a minimal set of flexible residues during ligand docking. Read more about Approaches to solving the rigid receptor problem by identifying a minimal set of flexible residues during ligand docking.
A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells. Read more about A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells.
