Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells. Read more about Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells.
Target identification for a promising anti-lupus drug. Read more about Target identification for a promising anti-lupus drug.
Dissecting the Engrailed homeodomain-DNA interaction by phage-displayed shotgun scanning. Read more about Dissecting the Engrailed homeodomain-DNA interaction by phage-displayed shotgun scanning.
Identification of a novel protein regulating microtubule stability through a chemical approach. Read more about Identification of a novel protein regulating microtubule stability through a chemical approach.
Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90. Read more about Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90.
Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase. Read more about Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase.
Cell aggregation by scaffolded receptor clusters. Read more about Cell aggregation by scaffolded receptor clusters.
Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme. Read more about Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme.
A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway. Read more about A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway.
Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase. Read more about Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase.
