Research Summary

Dr. Carnevale is a physician-scientist who treats patients with gastrointestinal cancers, and also performs research into finding novel therapies for these diseases.

Research Funding

  • September 1, 2020 - August 31, 2025 - Using CRISPR engineering to develop more potent T cell therapies that are resistant to suppression in the tumor microenvironment , Principle Investigator . Sponsor: Burroughs Wellcome Fund, Sponsor Award ID: 1020881
  • July 15, 2020 - June 30, 2025 - Targeting SOCS1 and RASA2 to Engineer More Potent Adoptive T Cell Therapies for Cancer Treatment. , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K08CA252605

Education

06/2017 - Oncology - ABIM Research Pathway, UCSF
06/2013 - Internal Medicine Residency, UCSF
M.D., 05/2011 - Cancer Biology, Harvard Medical School
B.A., 05/2005 - Human Biology, Stanford University

Selected Publications

  1. Blaeschke F, Chen YY, Apathy R, Daniel B, Chen AY, Chen PA, Sandor K, Zhang W, Li Z, Mowery CT, Yamamoto TN, Nyberg WA, To A, Yu R, Bueno R, Kim MC, Schmidt R, Goodman DB, Feuchtinger T, Eyquem J, Jimmie Ye C, Carnevale J, Satpathy AT, Shifrut E, Roth TL, Marson A. Modular pooled discovery of synthetic knockin sequences to program durable cell therapies. Cell. 2023 09 14; 186(19):4216-4234.e33.  View on PubMed
  2. N. Fidelman, C. Atreya, M. Griffith, A. Milloy, J. Carnevale, A. Venook, K. Van Loon. Abstract No. 266 Phase I Prospective Trial of TAS-102 (Trifluridine and Tipiracil) and Radioembolization with 90Y Resin Microspheres for Chemo-Refractory Colorectal Liver Metastases. Journal of Vascular and Interventional Radiology. 2023 Mar 1; 34(3):s120.  View on PubMed
  3. Fidelman N, Atreya CE, Griffith M, Milloy MA, Carnevale J, Cinar P, Venook AP, Van Loon K. Phase I prospective trial of TAS-102 (trifluridine and tipiracil) and radioembolization with 90Y resin microspheres for chemo-refractory colorectal liver metastases. BMC Cancer. 2022 Dec 13; 22(1):1307.  View on PubMed
  4. O'Leary PC, Chen H, Doruk YU, Williamson T, Polacco B, McNeal AS, Shenoy T, Kale N, Carnevale J, Stevenson E, Quigley DA, Chou J, Feng FY, Swaney DL, Krogan NJ, Kim M, Diolaiti ME, Ashworth A. Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2. Cancer Res. 2022 11 02; 82(21):3950-3961.  View on PubMed
  5. Carnevale J, Shifrut E, Kale N, Nyberg WA, Blaeschke F, Chen YY, Li Z, Bapat SP, Diolaiti ME, O'Leary P, Vedova S, Belk J, Daniel B, Roth TL, Bachl S, Anido AA, Prinzing B, Ibañez-Vega J, Lange S, Haydar D, Luetke-Eversloh M, Born-Bony M, Hegde B, Kogan S, Feuchtinger T, Okada H, Satpathy AT, Shannon K, Gottschalk S, Eyquem J, Krenciute G, Ashworth A, Marson A. RASA2 ablation in T cells boosts antigen sensitivity and long-term function. Nature. 2022 09; 609(7925):174-182.  View on PubMed
  6. Belk JA, Yao W, Ly N, Freitas KA, Chen YT, Shi Q, Valencia AM, Shifrut E, Kale N, Yost KE, Duffy CV, Daniel B, Hwee MA, Miao Z, Ashworth A, Mackall CL, Marson A, Carnevale J, Vardhana SA, Satpathy AT. Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence. Cancer Cell. 2022 07 11; 40(7):768-786.e7.  View on PubMed
  7. Andrea Grace Bocobo, Renee Wang, Spencer Behr, Julia C. Carnevale, Pelin Cinar, Eric Andrew Collisson, Lawrence Fong, Bridget P Keenan, Wesley Allen Kidder, Andrew H. Ko, Kanti Pallav Kolli, Megan Kennedy, Angela Laffan, Sorbarikor Piawah, Marin Pollak, Gabriel Schwartz, Julia Whitman, Li Zhang, Katherine Van Loon, Chloe Evelyn Atreya. Phase II study of pembrolizumab plus capecitabine and bevacizumab in microsatellite stable (MSS) metastatic colorectal cancer (mCRC). Journal of Clinical Oncology. 2022 Jun 1; 40(16_suppl):3565-3565.  View on PubMed
  8. Walker EJ, Blanco AM, Carnevale J, Cinar P, Collisson EA, Tempero MA, Ko AH. The Additional Diagnostic Benefit of Pancreatic Cancer Molecular Profiling After Germline Testing. Pancreas. 2022 04 01; 51(4):302-304.  View on PubMed
  9. Byrnes JR, Weeks AM, Shifrut E, Carnevale J, Kirkemo L, Ashworth A, Marson A, Wells JA. Hypoxia Is a Dominant Remodeler of the Effector T Cell Surface Proteome Relative to Activation and Regulatory T Cell Suppression. Mol Cell Proteomics. 2022 04; 21(4):100217.  View on PubMed
  10. Walker EJ, Goldberg D, Gordon KM, Pedley C, Carnevale J, Cinar P, Collisson EA, Tempero MA, Ko AH, Blanco AM, Dhawan M. Implementation of an Embedded In-Clinic Genetic Testing Station to Optimize Germline Testing for Patients with Pancreatic Adenocarcinoma. Oncologist. 2021 11; 26(11):e1982-e1991.  View on PubMed
  11. R. Aggarwal, S. Umetsu, M. Dhawan, J. Grabowsky, J. Carnevale, M. Howell, L. Wilch, J. Chapman, E. Alvarez, S. Calabrese, S. Smith, N. Shah, E. Dean, P. Munster, E. Collisson. 512O Interim results from a phase II study of the ATR inhibitor ceralasertib in ARID1A-deficient and ARID1A-intact advanced solid tumor malignancies. Annals of Oncology. 2021 Sep 1; 32:s583.  View on PubMed
  12. Tsang ES, Walker EJ, Carnevale J, Fisher GA, Ko AH. Durable response after immune checkpoint inhibitor-related diabetes in mismatch repair-deficient pancreatic cancer. Immunotherapy. 2021 10; 13(15):1249-1254.  View on PubMed
  13. Evan Justin Walker, Sorbarikor Piawah, Ann Griffin, Julia C. Carnevale, Pelin Cinar, Eric Andrew Collisson, Margaret A. Tempero, Andrew H. Ko. Investigating tumor molecular profiling as a possible contributor to racial/ethnic disparities in pancreatic cancer. Journal of Clinical Oncology. 2021 May 20; 39(15_suppl):6522-6522.  View on PubMed
  14. Evan Justin Walker, Amie Blanco, Julia C. Carnevale, Pelin Cinar, Eric Andrew Collisson, Margaret A. Tempero, Andrew H. Ko. The marginal diagnostic benefit of pancreatic cancer molecular profiling after germline testing. Journal of Clinical Oncology. 2021 May 20; 39(15_suppl):10513-10513.  View on PubMed
  15. Andrea Grace Bocobo, Renee Wang, Spencer Behr, Julia C. Carnevale, Pelin Cinar, Eric Andrew Collisson, Lawrence Fong, Wesley Allen Kidder, Andrew H. Ko, Kanti Pallav Kolli, Megan Kennedy, Angela Laffan, Sheila Lindsay, Sneha Nalla, Gabriel Schwartz, Julia Whitman, Patricia Zendejas, Li Zhang, Katherine Van Loon, Chloe Evelyn Atreya. Phase II study of pembrolizumab plus capecitabine and bevacizumab in microsatellite stable (MSS) metastatic colorectal cancer (mCRC): Interim analysis. Journal of Clinical Oncology. 2021 Jan 20; 39(3_suppl):77-77.  View on PubMed
  16. S. Sinha, C. Greene, R.K. Kelley, P. Cinar, A.P. Venook, C. Atreya, J. Gordan, J. Carnevale, M. Anwar, M. Feng. Combined Immunotherapy and Hypofractionated Radiotherapy for Metastatic Cancers. International Journal of Radiation Oncology • Biology • Physics. 2020 Nov 1; 108(3):e648.  View on PubMed
  17. Julia Carnevale, Eric Shifrut, Victoria Tobin, Theodore Roth, Jonathan Woo, Christina Bui, Jonathan Li, Morgan Diolaiti, Alan Ashworth, Alexander Marson. Abstract PR08: Discovery of immune regulators in primary human T cells using genome-wide CRISPR screens. Cancer Immunology Research. 2020 Apr 1; 8(4_Supplement):pr08-pr08.  View on PubMed
  18. N. Fidelman, C. Atreya, M. Griffith, A. Milloy, J. Carnevale, P. Cinar, A. Venook, K. Van Loon. 3:54 PM Abstract No. 243 Phase I Prospective Trial of TAS-102 (trifluride and tipiracil) and radioembolization with 90Y resin microspheres for chemo-refractory colorectal liver metastases. Journal of Vascular and Interventional Radiology. 2020 Mar 1; 31(3):s109.  View on PubMed
  19. Nicholas Fidelman, Chloe Evelyn Atreya, Madeline J Griffith, Marion Alexandra Milloy, Julia C. Carnevale, Pelin Cinar, Alan P. Venook, Katherine Van Loon. Phase I prospective trial of TAS-102 (trifluride and tipiracil) and radioembolization with 90Y resin microspheres for chemo-refractory colorectal liver metastases. Journal of Clinical Oncology. 2020 Feb 1; 38(4_suppl):110-110.  View on PubMed
  20. Walker EJ, Carnevale J, Pedley C, Blanco A, Chan S, Collisson EA, Tempero MA, Ko AH. Referral frequency, attrition rate, and outcomes of germline testing in patients with pancreatic adenocarcinoma. Fam Cancer. 2019 04; 18(2):241-251.  View on PubMed

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