Education

  • The University of Edinburgh, Edinburgh, UK, BSc, 2007, Biological Sciences
  • The University of Edinburgh, Edinburgh, UK, PhD, 2012, Biomedical Sciences
  • University of California, San Francisco, Postdoc, 2017, Neurology

Honors & Awards

  • 2017
    Simons Foundation for Autism Research Bridge to Independence Award
  • 2017
    Broad Foundation Innovation Award
  • 2017
    Cajal Club Krieg Cortical Explorer Award
  • 2018
    NARSAD Young Investigator Award
  • 2018
    Leichtung Family Investigator
  • 2018
    Eppendorf & Science Prize for Neurobiology, finalist
  • 2018
    Chan-Zuckerberg Biohub Investigator
  • 2018-21
    Next Generation Leader, Allen Institute for Brain Science
  • 2021
    Scholar, Shurl & Kay Curci Foundation
  • 2021
    Investigator, Weill Neurohub
  • 2021
    Daniel X. Freedman Prize, Honorable Mention
  • 2021
    Klingenstein-Simons Fellowship in Neuroscience Award
  • 2021
    Sontag Foundation Distinguished Scientist Award

Selected Publications

  1. Allen DE, Donohue KC, Cadwell CR, Shin D, Keefe MG, Sohal VS, Nowakowski TJ. Fate mapping of neural stem cell niches reveals distinct origins of human cortical astrocytes. Science. 2022 May 19; eabm5224.  View on PubMed
  2. Yu D, Li T, Delpech JC, Zhu B, Kishore P, Koshi T, Luo R, Pratt KJB, Popova G, Nowakowski TJ, Villeda SA, Piao X. Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits. Sci Adv. 2022 May 06; 8(18):eabm2545.  View on PubMed
  3. Schmitz MT, Sandoval K, Chen CP, Mostajo-Radji MA, Seeley WW, Nowakowski TJ, Ye CJ, Paredes MF, Pollen AA. The development and evolution of inhibitory neurons in primate cerebrum. Nature. 2022 03; 603(7903):871-877.  View on PubMed
  4. Winkler EA, Kim CN, Ross JM, Garcia JH, Gil E, Oh I, Chen LQ, Wu D, Catapano JS, Raygor K, Narsinh K, Kim H, Weinsheimer S, Cooke DL, Walcott BP, Lawton MT, Gupta N, Zlokovic BV, Chang EF, Abla AA, Lim DA, Nowakowski TJ. A single-cell atlas of the normal and malformed human brain vasculature. Science. 2022 03 04; 375(6584):eabi7377.  View on PubMed
  5. Winkler E, Wu D, Gil E, McCoy D, Narsinh K, Sun Z, Mueller K, Ross J, Kim H, Weinsheimer S, Berger M, Nowakowski T, Lim D, Abla A, Cooke D. Endoluminal Biopsy for Molecular Profiling of Human Brain Vascular Malformations. Neurology. 2022 Apr 19; 98(16):e1637-e1647.  View on PubMed
  6. Wu Z, Chhun BB, Popova G, Guo SM, Kim CN, Yeh LH, Nowakowski T, Zou J, Mehta SB. DynaMorph: self-supervised learning of morphodynamic states of live cells. Mol Biol Cell. 2022 Feb 09; mbcE21110561.  View on PubMed
  7. Paredes MF, Mora C, Flores-Ramirez Q, Cebrian-Silla A, Del Dosso A, Larimer P, Chen J, Kang G, Gonzalez Granero S, Garcia E, Chu J, Delgado R, Cotter JA, Tang V, Spatazza J, Obernier K, Ferrer Lozano J, Vento M, Scott J, Studholme C, Nowakowski TJ, Kriegstein AR, Oldham MC, Hasenstaub A, Garcia-Verdugo JM, Alvarez-Buylla A, Huang EJ. Nests of dividing neuroblasts sustain interneuron production for the developing human brain. Science. 2022 01 28; 375(6579):eabk2346.  View on PubMed
  8. Delgado RN, Allen DE, Keefe MG, Mancia Leon WR, Ziffra RS, Crouch EE, Alvarez-Buylla A, Nowakowski TJ. Individual human cortical progenitors can produce excitatory and inhibitory neurons. Nature. 2022 01; 601(7893):397-403.  View on PubMed
  9. Bandler RC, Vitali I, Delgado RN, Ho MC, Dvoretskova E, Ibarra Molinas JS, Frazel PW, Mohammadkhani M, Machold R, Maedler S, Liddelow SA, Nowakowski TJ, Fishell G, Mayer C. Single-cell delineation of lineage and genetic identity in the mouse brain. Nature. 2022 01; 601(7893):404-409.  View on PubMed
  10. Narsinh KH, Narsinh K, McCoy DB, Sun Z, Halabi C, Meisel K, Tihan T, Chaganti K, Amans MR, Halbach VV, Higashida RT, Hetts SW, Dowd CF, Winkler EA, Abla AA, Nowakowski TJ, Cooke DL. Endovascular Biopsy of Vertebrobasilar Aneurysm in Patient With Polyarteritis Nodosa. Front Neurol. 2021; 12:697105.  View on PubMed
  11. Voitiuk K, Geng J, Keefe MG, Parks DF, Sanso SE, Hawthorne N, Freeman DB, Currie R, Mostajo-Radji MA, Pollen AA, Nowakowski TJ, Salama SR, Teodorescu M, Haussler D. Light-weight electrophysiology hardware and software platform for cloud-based neural recording experiments. J Neural Eng. 2021 11 12; 18(6).  View on PubMed
  12. Ly VT, Baudin PV, Pansodtee P, Jung EA, Voitiuk K, Rosen YM, Willsey HR, Mantalas GL, Seiler ST, Selberg JA, Cordero SA, Ross JM, Rolandi M, Pollen AA, Nowakowski TJ, Haussler D, Mostajo-Radji MA, Salama SR, Teodorescu M. Picroscope: low-cost system for simultaneous longitudinal biological imaging. Commun Biol. 2021 11 04; 4(1):1261.  View on PubMed
  13. Bhaduri A, Sandoval-Espinosa C, Otero-Garcia M, Oh I, Yin R, Eze UC, Nowakowski TJ, Kriegstein AR. An atlas of cortical arealization identifies dynamic molecular signatures. Nature. 2021 10; 598(7879):200-204.  View on PubMed
  14. Ziffra RS, Kim CN, Ross JM, Wilfert A, Turner TN, Haeussler M, Casella AM, Przytycki PF, Keough KC, Shin D, Bogdanoff D, Kreimer A, Pollard KS, Ament SA, Eichler EE, Ahituv N, Nowakowski TJ. Single-cell epigenomics reveals mechanisms of human cortical development. Nature. 2021 10; 598(7879):205-213.  View on PubMed
  15. Popova G, Soliman SS, Kim CN, Keefe MG, Hennick KM, Jain S, Li T, Tejera D, Shin D, Chhun BB, McGinnis CS, Speir M, Gartner ZJ, Mehta SB, Haeussler M, Hengen KB, Ransohoff RR, Piao X, Nowakowski TJ. Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids. Cell Stem Cell. 2021 12 02; 28(12):2153-2166.e6.  View on PubMed
  16. Pierre V. Baudin, Victoria T. Ly, Pattawong Pansodtee, Erik A. Jung, Robert Currie, Ryan Hoffman, Helen Rankin Willsey, Alex A. Pollen, Tomasz J. Nowakowski, David Haussler, Mohammed A. Mostajo-Radji, Sofie Salama, Mircea Teodorescu. Low cost cloud based remote microscopy for biological sciences. Internet of Things. 2021 Sep 1; 100454.  View on PubMed
  17. Speir ML, Bhaduri A, Markov NS, Moreno P, Nowakowski TJ, Papatheodorou I, Pollen AA, Raney BJ, Seninge L, Kent WJ, Haeussler M. UCSC Cell Browser: Visualize Your Single-Cell Data. Bioinformatics. 2021 Jul 09.  View on PubMed
  18. Ahanger SH, Delgado RN, Gil E, Cole MA, Zhao J, Hong SJ, Kriegstein AR, Nowakowski TJ, Pollen AA, Lim DA. Distinct nuclear compartment-associated genome architecture in the developing mammalian brain. Nat Neurosci. 2021 09; 24(9):1235-1242.  View on PubMed
  19. Coll-Tané M, Gong NN, Belfer SJ, van Renssen LV, Kurtz-Nelson EC, Szuperak M, Eidhof I, van Reijmersdal B, Terwindt I, Durkin J, Verheij MMM, Kim CN, Hudac CM, Nowakowski TJ, Bernier RA, Pillen S, Earl RK, Eichler EE, Kleefstra T, Kayser MS, Schenck A. The CHD8/CHD7/Kismet family links blood-brain barrier glia and serotonin to ASD-associated sleep defects. Sci Adv. 2021 06; 7(23).  View on PubMed
  20. Willsey HR, Exner CRT, Xu Y, Everitt A, Sun N, Wang B, Dea J, Schmunk G, Zaltsman Y, Teerikorpi N, Kim A, Anderson AS, Shin D, Seyler M, Nowakowski TJ, Harland RM, Willsey AJ, State MW. Parallel in vivo analysis of large-effect autism genes implicates cortical neurogenesis and estrogen in risk and resilience. Neuron. 2021 Apr 21; 109(8):1409.  View on PubMed

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