Education

  • The University of Edinburgh, Edinburgh, UK, BSc, 2007, Biological Sciences
  • The University of Edinburgh, Edinburgh, UK, PhD, 2012, Biomedical Sciences
  • University of California, San Francisco, Postdoc, 2017, Neurology

Honors & Awards

  • 2017
    Simons Foundation for Autism Research Bridge to Independence Award
  • 2017
    Broad Foundation Innovation Award
  • 2017
    Cajal Club Krieg Cortical Explorer Award
  • 2018
    NARSAD Young Investigator Award
  • 2018
    Leichtung Family Investigator
  • 2018
    Eppendorf & Science Prize for Neurobiology, finalist
  • 2018
    Chan-Zuckerberg Biohub Investigator
  • 2018-21
    Next Generation Leader, Allen Institute for Brain Science
  • 2021
    Scholar, Shurl & Kay Curci Foundation
  • 2021
    Investigator, Weill Neurohub
  • 2021
    Daniel X. Freedman Prize, Honorable Mention
  • 2021
    Klingenstein-Simons Fellowship in Neuroscience Award
  • 2021
    Sontag Foundation Distinguished Scientist Award

Selected Publications

  1. Keefe MG, Steyert MR, Nowakowski TJ Lineage-resolved atlas of the developing human cortex.  View on PubMed
  2. Nowakowski TJ, Nano PR, Matho KS, Chen X, Corrigan EK, Ding W, Gao Y, Heffel M, Jayakumar J, Kaplan HS, Kronman FN, Kovner R, Mannens CCA, Song M, Steyert MR, Venkatesan S, Wallace JL, Wang L, Werner JM, Zhang D, Yuan G, Zuo G, Ament SA, Colantuoni C, Dulac C, Fan R, Gillis J, Kriegstein AR, Krienen FM, Kim Y, Linnarsson S, Mitra PP, Pollen AA, Sestan N, Tward DJ, van Velthoven CTJ, Yao Z, Bhaduri A, Zeng H The new frontier in understanding human and mammalian brain development.  View on PubMed
  3. Hennick K, Sui Y, Karunakaran D, Nicollela A, Leonard R, Meyer-Schuman R, Berk-Rauch H, Wang T, Chakravarti A, Zoghbi HY, Eichler EE, Nowakowski TJ Sex differences in the developing human cortex intersect with genetic risk of neurodevelopmental disorders.  View on PubMed
  4. Yu D, Jain S, Wangzhou A, Zhu B, Shao W, Coley-O'Rourke EJ, De Florencio S, Kim J, Choi JJ, Paredes MF, Nowakowski TJ, Huang EJ, Piao X Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1.  View on PubMed
  5. Zhu B, Wangzhou A, Yu D, Li T, Schmidt R, De Florencio SL, Chao L, Thurber AL, Zhou M, Msheik Z, Perez Y, Grinberg LT, Spina S, Ransohoff RM, Kriegstein AR, Seeley WW, Nowakowski T, Piao X G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation.  View on PubMed
  6. Steyert MR, Li T, Piao X, Nowakowski TJ Molecular Signatures in Cortical Development.  View on PubMed
  7. Majd H, Samuel RM, Cesiulis A, Ramirez JT, Kalantari A, Barber K, Farahvashi S, Ghazizadeh Z, Majd A, Chemel AK, Richter MN, Das S, Bendrick JL, Keefe MG, Wang J, Shiv RK, Bhat S, Khoroshkin M, Yu J, Nowakowski TJ, Wen KW, Goodarzi H, Thapar N, Kaltschmidt JA, McCann CJ, Fattahi F. Engrafted nitrergic neurons derived from hPSCs improve gut dysmotility in mice. Nature. 2025 Jun 25.  View on PubMed
  8. Teerikorpi N, McCluskey KE, Bader E, Lasser MC, Wang S, Nguyen CH, Schmidt JD, Kostyanovskaya E, Sun N, Dea J, Nowakowski TJ, Willsey AJ, Willsey HR Ciliary biology intersects autism and congenital heart disease.  View on PubMed
  9. Nowakowski T, Malinowski K, Natorska J, Undas A Neutrophil extracellular traps-related markers in chronic limb threatening ischemia - a relation with progression and prognosis.  View on PubMed
  10. Furlanis E, Dai M, Leyva Garcia B, Tran T, Vergara J, Pereira A, Gorissen BL, Wills S, Vlachos A, Hairston A, Dwivedi D, Du S, McMahon J, Huang S, Morabito A, Vazquez A, Kim S, Lee AT, Chang EF, Razzaq T, Qazi A, Vargish G, Yuan X, Caccavano A, Hunt S, Chittajallu R, McLean N, Hewitt L, Paranzino E, Rice H, Cummins AC, Plotnikova A, Mohanty A, Tangen AC, Shin JH, Azadi R, Eldridge MAG, Alvarez VA, Averbeck BB, Alyahyay M, Vallejo TR, Soheib M, Vattino LG, MacGregor CP, Chatain CP, Banks E, Olah VJ, Naskar S, Hill S, Liebergall S, Badiani R, Hyde L, Hanley E, Xu Q, Allaway KC, Goldberg EM, Rowan MJM, Nowakowski TJ, Lee S, Favuzzi E, Kaeser PS, Sjulson L, Batista-Brito R, Takesian AE, Ibrahim LA, Iqbal A, Pelkey KA, McBain CJ, Dimidschstein J, Fishell G, Wang Y. An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes. Neuron. 2025 May 21; 113(10):1525-1547.e15.  View on PubMed
  11. Furlanis E, Dai M, Garcia BL, Tran T, Vergara J, Pereira A, Gorissen BL, Wills S, Vlachos A, Hairston A, Dwivedi D, Du S, McMahon J, Huang S, Morabito A, Vazquez A, Kim S, Lee AT, Chang EF, Razzaq T, Qazi A, Vargish G, Yuan X, Caccavano A, Hunt S, Chittajallu R, McLean N, Hewitt L, Paranzino E, Rice H, Cummins AC, Plotnikova A, Mohanty A, Tangen AC, Shin JH, Azadi R, Eldridge MAG, Alvarez VA, Averbeck BB, Alyahyay M, Vallejo TR, Soheib M, Vattino LG, MacGregor CP, Chatain CP, Banks E, Olah VJ, Naskar S, Hill S, Liebergall S, Badiani R, Hyde L, Hanley E, Xu Q, Allaway KC, Goldberg EM, Rowan MJM, Nowakowski TJ, Lee S, Favuzzi E, Kaeser PS, Sjulson L, Batista-Brito R, Takesian AE, Ibrahim LA, Iqbal A, Pelkey KA, McBain CJ, Dimidschstein J, Fishell G, Wang Y. An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes. bioRxiv. 2025 Apr 22.  View on PubMed
  12. Teter OM, McQuade A, Hagan V, Liang W, Dräger NM, Sattler SM, Holmes BB, Castillo VC, Papakis V, Leng K, Boggess S, Nowakowski TJ, Wells J, Kampmann M. CRISPRi-based screen of autism spectrum disorder risk genes in microglia uncovers roles of ADNP in microglia endocytosis and synaptic pruning. Mol Psychiatry. 2025 Apr 06.  View on PubMed
  13. Wu SR, Nowakowski TJ. Exploring human brain development and disease using assembloids. Neuron. 2025 Apr 16; 113(8):1133-1150.  View on PubMed
  14. Elliott MAT, Andrews JP, van der Molen T, Geng J, Spaeth A, Toledo A, Voitiuk K, Core C, Gillespie T, Sinervo A, Parks DF, Robbins A, Solís D, Chang EF, Nowakowski TJ, Teodorescu M, Haussler D, Sharf T. Pathological microcircuits and epileptiform events in patient hippocampal slices. bioRxiv. 2025 Mar 18.  View on PubMed
  15. Nowakowski T, Undas KW, Undas A Low-dose rivaroxaban added to aspirin decreases thrombin generation but does not affect fibrin clot properties: a preliminary study.  View on PubMed
  16. Bonev B, Castelo-Branco G, Chen F, Codeluppi S, Corces MR, Fan J, Heiman M, Harris K, Inoue F, Kellis M, Levine A, Lotfollahi M, Luo C, Maynard KR, Nitzan M, Ramani V, Satijia R, Schirmer L, Shen Y, Sun N, Green GS, Theis F, Wang X, Welch JD, Gokce O, Konopka G, Liddelow S, Macosko E, Ali Bayraktar O, Habib N, Nowakowski TJ. Author Correction: Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery. Nat Neurosci. 2025 Jan; 28(1):216.  View on PubMed
  17. Geng J, Voitiuk K, Parks DF, Robbins A, Spaeth A, Sevetson JL, Hernandez S, Schweiger HE, Andrews JP, Seiler ST, Elliott MAT, Chang EF, Nowakowski TJ, Currie R, Mostajo-Radji MA, Haussler D, Sharf T, Salama SR, Teodorescu M. Multiscale Cloud-Based Pipeline for Neuronal Electrophysiology Analysis and Visualization. bioRxiv. 2024 Dec 14.  View on PubMed
  18. Shin D, Urbanek ME, Larson HH, Moussa AJ, Lee KY, Baker DL, Standen-Bloom E, Ramachandran S, Bogdanoff D, Cadwell CR, Nowakowski TJ. High-Complexity Barcoded Rabies Virus for Scalable Circuit Mapping Using Single-Cell and Single-Nucleus Sequencing. bioRxiv. 2024 Dec 11.  View on PubMed
  19. Adameyko I, Bakken T, Bhaduri A, Chhatbar C, Filbin MG, Gate D, Hochgerner H, Kim CN, Krull J, La Manno G, Li Q, Linnarsson S, Ma Q, Mayer C, Menon V, Nano P, Prinz M, Quake S, Walsh CA, Yang J, Bayraktar OA, Gokce O, Habib N, Konopka G, Liddelow SA, Nowakowski TJ. Applying single-cell and single-nucleus genomics to studies of cellular heterogeneity and cell fate transitions in the nervous system. Nat Neurosci. 2024 Dec; 27(12):2278-2291.  View on PubMed
  20. Colonna M, Konopka G, Liddelow SA, Nowakowski T, Awatramani R, Bateup HS, Cadwell CR, Caglayan E, Chen JL, Gillis J, Kampmann M, Krienen F, Marsh SE, Monje M, O'Dea MR, Patani R, Pollen AA, Quintana FJ, Scavuzzo M, Schmitz M, Sloan SA, Tesar PJ, Tollkuhn J, Tosches MA, Urbanek ME, Werner JM, Bayraktar OA, Gokce O, Habib N. Implementation and validation of single-cell genomics experiments in neuroscience. Nat Neurosci. 2024 Dec; 27(12):2310-2325.  View on PubMed

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