University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Diane L. Barber, PhD

Diane L. Barber, PhD

Professor and Vice Chair, Department of Cell and Tissue Biology, UCSF
Leland and Gladys Barber Endowed Chair in Dentistry, UCSF

Cancer Center Program Memberships

Cancer Genetics

Education

University of California, Davis, B.S., 1975, Biological Sciences
University of California, Davis, M.S., 1977, Physiology
University of California, Los Angeles, Ph.D., 1985, Anatomy

Honors & Awards

  • 1985-87
    NIH Individual NRSA Postdoctoral Fellowship
  • 1986
    Joseph P. Healy Research Award, University of Massachusetts
  • 1995-2000
    Established Investigator, American Heart Association
  • 1998-present
    Editorial Board, American Journal of Physiology: Cell Physiology
  • 1998-1999
    American Heart Association, National Review Committee for Transport and Metabolism
  • 1998
    Innovation in Basic Sciences Award, UCSF
  • 2000-2002
    American Heart Association, Co-chair National Review Committee for Transport and Metabolism
  • 2001/2003
    Vice-chair/Chair, Gordon Conference on Molecular Pharmacology
  • 2001-2003
    Member, NIH CDF3 Study Section
  • 2003-present
    Editorial Board, Journal of Biological Chemistry
  • 2005
    Sandler Program Integrative Award

Selected Publications

  1. Barber DL, Trepat X. Editorial overview: Cell dynamics: Integrating cell dynamics across scales. Curr Opin Cell Biol. 2020 Aug 10; 66:130-132.
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  2. Luna LA, Lesecq Z, White KA, Hoang A, Scott DA, Zagnitko O, Bobkov AA, Barber DL, Schiffer JM, Isom DG, Sohl CD. An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity. Biochem J. 2020 Jul 30.
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  3. White KA, Kisor K, Barber DL. Intracellular pH dynamics and charge-changing somatic mutations in cancer. Cancer Metastasis Rev. 2019 06; 38(1-2):17-24.
    View on PubMed
  4. Benitez M, Tatapudy S, Liu Y, Barber DL, Nystul TG. Drosophila anion exchanger 2 is required for proper ovary development and oogenesis. Dev Biol. 2019 08 15; 452(2):127-133.
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  5. Charafeddine RA, Cortopassi WA, Lak P, Tan R, McKenney RJ, Jacobson MP, Barber DL, Wittmann T. Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH. J Biol Chem. 2019 05 31; 294(22):8779-8790.
    View on PubMed
  6. White KA, Grillo-Hill BK, Esquivel M, Peralta J, Bui VN, Chire I, Barber DL. ß-Catenin is a pH sensor with decreased stability at higher intracellular pH. J Cell Biol. 2018 11 05; 217(11):3965-3976.
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  7. Rana MK, Aloisio FM, Choi C, Barber DL. Formin-dependent TGF-ß signaling for epithelial to mesenchymal transition. Mol Biol Cell. 2018 06 15; 29(12):1465-1475.
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  8. Bradley Webb, Annie Dosey, Torsten Wittmann, Justin Kollman, Diane Barber. The Glycolytic Enzyme Phosphofructokinase-1 Assembles into Filaments. Biophysical Journal. 2018 Feb 1; 114(3):228a.
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  9. Tatapudy S, Aloisio F, Barber D, Nystul T. Cell fate decisions: emerging roles for metabolic signals and cell morphology. EMBO Rep. 2017 12; 18(12):2105-2118.
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  10. Vercoulen Y, Kondo Y, Iwig JS, Janssen AB, White KA, Amini M, Barber DL, Kuriyan J, Roose JP. A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1. Elife. 2017 09 27; 6.
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  11. White KA, Ruiz DG, Szpiech ZA, Strauli NB, Hernandez RD, Jacobson MP, Barber DL. Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins. Sci Signal. 2017 Sep 05; 10(495).
    View on PubMed
  12. Szpiech ZA, Strauli NB, White KA, Ruiz DG, Jacobson MP, Barber DL, Hernandez RD. Prominent features of the amino acid mutation landscape in cancer. PLoS One. 2017; 12(8):e0183273.
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  13. Webb BA, Dosey AM, Wittmann T, Kollman JM, Barber DL. The glycolytic enzyme phosphofructokinase-1 assembles into filaments. J Cell Biol. 2017 08 07; 216(8):2305-2313.
    View on PubMed
  14. White KA, Grillo-Hill BK, Barber DL. Cancer cell behaviors mediated by dysregulated pH dynamics at a glance. J Cell Sci. 2017 02 15; 130(4):663-669.
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  15. Ulmschneider B, Grillo-Hill BK, Benitez M, Azimova DR, Barber DL, Nystul TG. Increased intracellular pH is necessary for adult epithelial and embryonic stem cell differentiation. J Cell Biol. 2016 Nov 07; 215(3):345-355.
    View on PubMed
  16. Webb BA, White KA, Grillo-Hill BK, Schönichen A, Choi C, Barber DL. A Histidine Cluster in the Cytoplasmic Domain of the Na-H Exchanger NHE1 Confers pH-sensitive Phospholipid Binding and Regulates Transporter Activity. J Biol Chem. 2016 Nov 11; 291(46):24096-24104.
    View on PubMed
  17. Bradley Webb, Farhad Forouhar, Fu-En Szu, Jayaraman Seetharaman, Liang Tong, Diane Barber. Structures of Human Phosphofructokinase-1 and Atomic Basis of Cancer-Associated Mutations. Biophysical Journal. 2016 Feb 1; 110(3):206a-207a.
    View on PubMed
  18. Webb BA, Forouhar F, Szu FE, Seetharaman J, Tong L, Barber DL. Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations. Nature. 2015 Jul 02; 523(7558):111-4.
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  19. Grillo-Hill BK, Choi C, Jimenez-Vidal M, Barber DL. Increased H? efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression. Elife. 2015 Mar 20; 4.
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  20. Rana MK, Srivastava J, Yang M, Chen CS, Barber DL. Hypoxia increases the abundance but not the assembly of extracellular fibronectin during epithelial cell transdifferentiation. J Cell Sci. 2015 Mar 15; 128(6):1083-9.
    View on PubMed

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