University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Diane L. Barber, PhD

Diane L. Barber, PhD

Professor and Vice Chair, Department of Cell and Tissue Biology, UCSF
Leland and Gladys Barber Endowed Chair in Dentistry, UCSF

Cancer Center Program Memberships

Cancer Genetics

Education

University of California, Davis, B.S., 1975, Biological Sciences
University of California, Davis, M.S., 1977, Physiology
University of California, Los Angeles, Ph.D., 1985, Anatomy


Professional Experience

  • 1977-1980
    Lecturer, Department of Biology, University of California, Los Angeles
  • 1980-1985
    Predoctoral Fellow, Department of Anatomy, University of California, Los Angeles
  • 1985-1987
    NIH Postdoctoral Fellow (NRSA), Department of Physiology, University of Massachusetts Medical Center, Worcester, MA
  • 1987-1991
    Assistant Professor, Department of Surgery/Section of Anatomy, Yale University
  • 1991-1995
    Assistant Professor, Departments of Stomatology and Surgery, UCSF
  • 1993-present
    Member, Biomedical Sciences Graduate Program, UCSF
  • 1995-2001
    Associate Professor, Departments of Stomatology and Surgery, UCSF
  • 2001-present
    Professor, Department of Cell and Tissue Biology (previously Stomatology), UCSF
  • 2005- present
    Vice Chair, Department of Cell and Tissue Biology, UCSF

Honors & Awards

  • 1985-87
    NIH Individual NRSA Postdoctoral Fellowship
  • 1986
    Joseph P. Healy Research Award, University of Massachusetts
  • 1995-2000
    Established Investigator, American Heart Association
  • 1998-present
    Editorial Board, American Journal of Physiology: Cell Physiology
  • 1998-1999
    American Heart Association, National Review Committee for Transport and Metabolism
  • 1998
    Innovation in Basic Sciences Award, UCSF
  • 2000-2002
    American Heart Association, Co-chair National Review Committee for Transport and Metabolism
  • 2001/2003
    Vice-chair/Chair, Gordon Conference on Molecular Pharmacology
  • 2001-2003
    Member, NIH CDF3 Study Section
  • 2003-present
    Editorial Board, Journal of Biological Chemistry
  • 2005
    Sandler Program Integrative Award

Selected Publications

  1. White KA, Kisor K, Barber DL. Intracellular pH dynamics and charge-changing somatic mutations in cancer. Cancer Metastasis Rev. 2019 Jun; 38(1-2):17-24.
    View on PubMed
  2. Benitez M, Tatapudy S, Liu Y, Barber DL, Nystul TG. Drosophila anion exchanger 2 is required for proper ovary development and oogenesis. Dev Biol. 2019 Aug 15; 452(2):127-133.
    View on PubMed
  3. Charafeddine RA, Cortopassi WA, Lak P, Tan R, McKenney RJ, Jacobson MP, Barber DL, Wittmann T. Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH. J Biol Chem. 2019 May 31; 294(22):8779-8790.
    View on PubMed
  4. White KA, Grillo-Hill BK, Esquivel M, Peralta J, Bui VN, Chire I, Barber DL. ß-Catenin is a pH sensor with decreased stability at higher intracellular pH. J Cell Biol. 2018 11 05; 217(11):3965-3976.
    View on PubMed
  5. Rana MK, Aloisio FM, Choi C, Barber DL. Formin-dependent TGF-ß signaling for epithelial to mesenchymal transition. Mol Biol Cell. 2018 06 15; 29(12):1465-1475.
    View on PubMed
  6. Tatapudy S, Aloisio F, Barber D, Nystul T. Cell fate decisions: emerging roles for metabolic signals and cell morphology. EMBO Rep. 2017 12; 18(12):2105-2118.
    View on PubMed
  7. Vercoulen Y, Kondo Y, Iwig JS, Janssen AB, White KA, Amini M, Barber DL, Kuriyan J, Roose JP. A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1. Elife. 2017 09 27; 6.
    View on PubMed
  8. White KA, Ruiz DG, Szpiech ZA, Strauli NB, Hernandez RD, Jacobson MP, Barber DL. Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins. Sci Signal. 2017 Sep 05; 10(495).
    View on PubMed
  9. Szpiech ZA, Strauli NB, White KA, Ruiz DG, Jacobson MP, Barber DL, Hernandez RD. Prominent features of the amino acid mutation landscape in cancer. PLoS One. 2017; 12(8):e0183273.
    View on PubMed
  10. Webb BA, Dosey AM, Wittmann T, Kollman JM, Barber DL. The glycolytic enzyme phosphofructokinase-1 assembles into filaments. J Cell Biol. 2017 08 07; 216(8):2305-2313.
    View on PubMed
  11. White KA, Grillo-Hill BK, Barber DL. Cancer cell behaviors mediated by dysregulated pH dynamics at a glance. J Cell Sci. 2017 02 15; 130(4):663-669.
    View on PubMed
  12. Ulmschneider B, Grillo-Hill BK, Benitez M, Azimova DR, Barber DL, Nystul TG. Increased intracellular pH is necessary for adult epithelial and embryonic stem cell differentiation. J Cell Biol. 2016 Nov 07; 215(3):345-355.
    View on PubMed
  13. Webb BA, White KA, Grillo-Hill BK, Schönichen A, Choi C, Barber DL. A Histidine Cluster in the Cytoplasmic Domain of the Na-H Exchanger NHE1 Confers pH-sensitive Phospholipid Binding and Regulates Transporter Activity. J Biol Chem. 2016 Nov 11; 291(46):24096-24104.
    View on PubMed
  14. Webb BA, Forouhar F, Szu FE, Seetharaman J, Tong L, Barber DL. Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations. Nature. 2015 Jul 02; 523(7558):111-4.
    View on PubMed
  15. Grillo-Hill BK, Choi C, Jimenez-Vidal M, Barber DL. Increased H? efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression. Elife. 2015 Mar 20; 4.
    View on PubMed
  16. Rana MK, Srivastava J, Yang M, Chen CS, Barber DL. Hypoxia increases the abundance but not the assembly of extracellular fibronectin during epithelial cell transdifferentiation. J Cell Sci. 2015 Mar 15; 128(6):1083-9.
    View on PubMed
  17. LeClaire LL, Rana M, Baumgartner M, Barber DL. The Nck-interacting kinase NIK increases Arp2/3 complex activity by phosphorylating the Arp2 subunit. J Cell Biol. 2015 Jan 19; 208(2):161-70.
    View on PubMed
  18. Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF. Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity. Cancer Cell. 2014 Dec 08; 26(6):938.
    View on PubMed
  19. Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell. 2014 Nov 10; 26(5):638-52.
    View on PubMed
  20. Grillo-Hill BK, Webb BA, Barber DL. Ratiometric imaging of pH probes. Methods Cell Biol. 2014; 123:429-48.
    View on PubMed

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