Research Summary

My primary interests are in the application of statistical methods to medical and social-science research. I have a long history of research in psychiatry and psychology with an emphasis on studies of addiction. My work in modeling latent variables has also lead to a productive collaboration which has uncovered sub-phenotypes among patients with acute respiratory distress syndrome. As other colleagues do, I also consult with scientists across a wide range of research areas.

Research Funding

  • September 30, 1991 - June 30, 2029 - Substance Use Disorders Treatment/Services Research Training Program , Co-Investigator . Sponsor: NIH, Sponsor Award ID: T32DA007250
  • September 29, 1994 - May 31, 2016 - Treatment for Complex Patients: Continuing and Extended Care , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P50DA009253
  • August 1, 1994 - December 31, 2011 - Impact of Services on Problem Drinking Trajectories , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AA009750

Education

University of San Francisco, BA, 1976, Psychology
University of California, Berkeley, MA, 1979, Quantitative Methods
University of California, Berkeley, PhD, 1986, Quantitative Methods

Honors & Awards

  • 2003-2009
    Faculty, American Psychiatric Association Research Colloq for Jr Investigators
  • 2004-present
    Member, Special Emphasis Panels, NIH
  • 2007-present
    Chartered Member, CSR Study Section: Relapse, Prevention, and Intervention in Addictions

Selected Publications

  1. Barnhofer T, Niemi M, Michalak J, Velana M, Williams JMG, Chiesa A, Eisendrath SJ, Delucchi KL, Segal ZV, Cladder-Micus M, Speckens A, Garcia-Toro M, Montero-Marin J, Dunn BD, Strauss C, Ruths FA, Ryan M, Young AH, Cuijpers P, Harrer M. Efficacy and Moderators of Mindfulness-Based Cognitive Therapy in Difficult-to-Treat Depression: A Systematic Review and Individual Participant Data Meta-Analysis. Psychother Psychosom. 2026 Jun 12; 1-21. View on PubMed
  2. Reddy K, Sinha P, Antcliffe DB, McDowell C, Bradley PA, Black L, Murphy L, Barbaras J, Conlon J, Camporota L, Ostermann M, Hopkins P, Szakmany T, Cherian S, Welters I, Brealey D, Parekh D, Rostron AJ, Bos LDJ, Nichol A, Shankar-Hari M, Gordon AC, Delucchi K, O'Kane CM, Matthay MA, Calfee CS, McAuley DF, PHIND Investigators. Bedside identification of subphenotypes in acute respiratory failure (PHIND): a multicentre, observational cohort study. Lancet Respir Med. 2026 Jul; 14(7):589-600. View on PubMed
  3. Matthay MA, Zhuo H, Sarma A, Alipanah-Lechner N, Hendrickson C, Kornblith LZ, Schreiber M, Zonies D, Khan A, Robinson B, Johnson NJ, Ware LB, Guillamondegui O, Casey J, Moore L, Patel B, Kao L, Wade CE, Fox E, Cox C, Khawanja F, Aguillon Prada R, Hossri S, Callcut R, Albertson T, Delucchi KL, McMillan M, Langelier CR, Pati S, McKenna DH, Leroux C, Calfee CS, Liu KD. Treatment with Allogeneic Mesenchymal Stromal Cells for Moderate to Severe Acute Respiratory Distress Syndrome: A Double-Blind, Placebo-controlled, Multicenter Phase 2b Clinical Trial (STAT). Am J Respir Crit Care Med. 2026 02 01; 212(3):428-439. View on PubMed
  4. Liu KD, Siew ED, Tuot DS, Vijayan A, Matzumura Umemoto G, Birkelo BC, Lee BJ, Kwong YD, McCoy IE, Delucchi K, Zhuo H, Hsu CY. A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury: The Liberation From Acute Dialysis (LIBERATE-D) Randomized Clinical Trial. JAMA. 2026 01 27; 335(4):326-335. View on PubMed
  5. Ciharova M, Karyotaki E, Harrer M, Weitz E, Miguel C, Amarnath A, Furukawa TA, Plessen CY, Driessen E, Buntrock C, Tong L, Hellerstein D, Samstag LW, Chen Y, Rentala S, Hemanny C, Reis de Oliveira I, Blom MBJ, Burnand Y, Andreoli A, Wittenborn AK, Delucchi KL, Husain N, DeRubeis RJ, Town JM, Röhricht F, Choi H, Dekker J, Dozois DJA, Keller MB, Lam RW, Lespérance F, Maina G, Rosso G, Milgrom J, Ravindran A, Reynolds Iii CF, Wiles N, Gaudiano BA, Hartmann de Souza L, Nakagawa A, Vega BR, Palao A, Rodríguez JL, Salcedo VV, Zobel I, Schramm E, Hollon SD, Riper H, Cuijpers P. Modifiers in Effects of Combined Pharmacotherapy and Psychotherapy versus Pharmacotherapy Alone for Adult Depression: An Individual Participant Data Meta-Analysis. Psychother Psychosom. 2026 Jan 21; 1-18. View on PubMed
  6. Barnhofer T, Niemi M, Michalak J, Velana M, Williams JMG, Chiesa A, Eisendrath S, Delucchi K, Segal Z, Cladder-Micus M, Speckens A, Foroughi AA, García-Toro M, Montero-Marin J, Dunn B, Strauss C, Ruths FA, Ryan M, Harrer M. Efficacy and moderators of mindfulness-based cognitive therapy (MBCT) in 'Difficult to Treat' depression: protocol for a systematic review and individual participant data meta-analysis of randomised controlled trials. BMJ Open. 2025 Dec 08; 15(12):e106350. View on PubMed
  7. Madotto F, Ferrari F, Florio G, Guzzardella A, Carlesso E, Calfee CS, Delucchi K, Scaravilli V, Panigada M, Ferraris Fusarini C, Tornese M, Trombetta E, Zanella A, Grasselli G. Biomarkers trajectories in critically ill patients with COVID-19 acute respiratory distress syndrome: insights from latent class growth analysis. BMC Pulm Med. 2025 Oct 28; 25(1):497. View on PubMed
  8. Zalucky AA, Evrard B, Delucchi K, Zhuo H, Wu N, Liu KD, Hendrickson CM, Matthay MA, Kangelaris KN, Calfee CS. Agreement between Sepsis-2 and Sepsis-3 Definitions among Patients Admitted to the Intensive Care Unit. Ann Am Thorac Soc. 2025 Mar; 22(3):460-462. View on PubMed
  9. Rezoagli E, Xin Y, Signori D, Sun W, Gerard S, Delucchi KL, Magliocca A, Vitale G, Giacomini M, Mussoni L, Montomoli J, Subert M, Ponti A, Spadaro S, Poli G, Casola F, Herrmann J, Foti G, Calfee CS, Laffey J, Bellani G, Cereda M, CT-COVID19 Multicenter Study Group. Phenotyping COVID-19 respiratory failure in spontaneously breathing patients with AI on lung CT-scan. Crit Care. 2024 08 05; 28(1):263. View on PubMed
  10. Nelson JC, Delucchi KL. Commentary on Differential Psychological Treatment Effects in Patients With Late-Life Depression and a History of Childhood Maltreatment. Am J Geriatr Psychiatry. 2024 11; 32(11):1337-1339. View on PubMed
  11. Vijayaraghavan M, Elser H, Delucchi K, Tsoh JY, Lynch K, Weiser SD, Riley ED. Distinct patterns of cigarette smoking intensity and other substance use among women who experience housing instability. Addict Behav. 2024 09; 156:108066. View on PubMed
  12. Evrard B, Sinha P, Delucchi K, Hendrickson CM, Kangelaris KN, Liu KD, Willmore A, Wu N, Neyton L, Schmiege E, Gomez A, Kerchberger VE, Zalucky A, Matthay MA, Ware LB, Calfee CS. Causes and attributable fraction of death from ARDS in inflammatory phenotypes of sepsis. Crit Care. 2024 05 14; 28(1):164. View on PubMed
  13. Valda Toro PL, Willmore A, Wu NE, Delucchi KL, Jauregui A, Sinha P, Liu KD, Hendrickson CM, Sarma A, Neyton LPA, Leligdowicz A, Langelier CR, Zhuo H, Jones C, Kangelaris KN, Gomez AD, Matthay MA, Calfee CS. Rapidly improving ARDS differs clinically and biologically from persistent ARDS. Crit Care. 2024 04 22; 28(1):132. View on PubMed
  14. Neyton LPA, Sinha P, Sarma A, Mick E, Kalantar K, Chen S, Wu N, Delucchi K, Zhuo H, Bos LDJ, Jauregui A, Gomez A, Hendrickson CM, Kangelaris KN, Leligdowicz A, Liu KD, Matthay MA, Langelier CR, Calfee CS. Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes. Am J Respir Crit Care Med. 2024 04 01; 209(7):805-815. View on PubMed
  15. Sinha P, Neyton L, Sarma A, Wu N, Jones C, Zhuo H, Liu KD, Sanchez Guerrero E, Ghale R, Love C, Mick E, Delucchi KL, Langelier CR, Thompson BT, Matthay MA, Calfee CS. Molecular Phenotypes of Acute Respiratory Distress Syndrome in the ROSE Trial Have Differential Outcomes and Gene Expression Patterns That Differ at Baseline and Longitudinally over Time. Am J Respir Crit Care Med. 2024 04 01; 209(7):816-828. View on PubMed
  16. DeMerle KM, Kennedy JN, Chang CH, Delucchi K, Huang DT, Kravitz MS, Shapiro NI, Yealy DM, Angus DC, Calfee CS, Seymour CW. Identification of a hyperinflammatory sepsis phenotype using protein biomarker and clinical data in the ProCESS randomized trial. Sci Rep. 2024 03 14; 14(1):6234. View on PubMed
  17. Alipanah-Lechner N, Hurst-Hopf J, Delucchi K, Swigart L, Willmore A, LaCombe B, Dewar R, Lane HC, Lallemand P, Liu KD, Esserman L, Matthay MA, Calfee CS, I-SPY COVID Consortium. Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial. Crit Care. 2024 02 21; 28(1):56. View on PubMed
  18. Campbell BK, Le T, McCuistian C, Bonniot C, Delucchi K, Guydish J. Policy and Practice Changes Associated with a Tobacco-Free Initiative in Residential Substance Use Disorder Treatment. J Psychoactive Drugs. 2025 Apr-Jun; 57(2):203-212. View on PubMed
  19. Sinha P, Kerchberger VE, Willmore A, Chambers J, Zhuo H, Abbott J, Jones C, Wickersham N, Wu N, Neyton L, Langelier CR, Mick E, He J, Jauregui A, Churpek MM, Gomez AD, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Delucchi KL, Liu KD, Russell JA, Matthay MA, Walley KR, Ware LB, Calfee CS. Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials. Lancet Respir Med. 2023 11; 11(11):965-974. View on PubMed
  20. Pagano A, Le T, Fong T, Reid R, Delucchi K, Guydish J. Gambling, tobacco use, and health among individuals in substance use disorder treatment. Am J Addict. 2023 11; 32(6):563-573. View on PubMed

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