Research Funding

  • September 24, 2014 - August 31, 2019 - Antibody Research Technology Center , Principal Investigator . Sponsor: NIH, Sponsor Award ID: P41CA196276
  • February 1, 2013 - January 31, 2019 - Generation of therapeutic antibodies to serotype F botulism , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI104579
  • June 20, 2012 - May 31, 2018 - Trispecific monoclonal antibody for botulinum neurotoxin intoxication therapy , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R33AI101539
  • March 1, 1982 - May 31, 2015 - Bio-Organic Biomedical Mass Spectrometry Resource , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P41RR001614
  • May 20, 2005 - April 30, 2015 - Pacific Southwest RCE for Biodefense & Emerging Infectious Diseases Research , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U54AI065359
  • June 1, 2012 - May 31, 2014 - Trispecific monoclonal antibody for botulinum neurotoxin intoxication therapy , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21AI101539
  • August 15, 2007 - July 31, 2013 - Development of botulinum neurotoxin immunotherapy, serotypes C, D, F, and G , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01AI075443
  • July 15, 2003 - December 31, 2008 - Development of botulinum neurotoxin immunotherapy , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01AI056493
  • September 26, 2001 - December 31, 2008 - Mechanism-Based Evaluations of ErbB-Targeted Agents , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U54CA090788
  • September 1, 2002 - August 31, 2005 - Deciphering toxin neutralization by oligoclonal antibody , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21AI053389

Education

University of California, Berkeley, Biochemistry
University of California, San Francisco, M.D., 1979, Medicine
Medical Research Council, Laboratory of Molecular Biology, Cambridge, England, Ph.D., 1992, Molecular Biology

Honors & Awards

  • (1975)
    Phi Beta Kappa
  • (1979)
    Alpha Omega Alpha
  • (1994)
    Beckman Young Investigator Award
  • (1995, 1996)
    CaPCURE Research Award

Selected Publications

  1. Steverson AB, Marano PJ, Chen C, Ma Y, Stern RJ, Feng J, Gennatas ED, Marks JD, Durstenfeld MS, Davis JD, Hsue PY, Zier LS. Predictors of All-Cause 30-Day Readmissions in Patients with Heart Failure at an Urban Safety Net Hospital: The Importance of Social Determinants of Health and Mental Health. Am J Med Open. 2023 Dec; 10:100060.  View on PubMed
  2. Sachdev DD, Petersen M, Havlir DV, Schwab J, Enanoria WTA, Nguyen TQ, Mercer MP, Scheer S, Bennett A, Tenner AG, Marks JD, Bobba N, Philip S, Colfax G. San Francisco's Citywide COVID-19 Response: Strategies to Reduce COVID-19 Severity and Health Disparities, March 2020 Through May 2022. Public Health Rep. 2023 Sep-Oct; 138(5):747-755.  View on PubMed
  3. Fan Y, Lou J, Tam CC, Wen W, Conrad F, Leal da Silva Alves P, Cheng LW, Garcia-Rodriguez C, Farr-Jones S, Marks JD. A Three-Monoclonal Antibody Combination Potently Neutralizes BoNT/G Toxin in Mice. Toxins (Basel). 2023 04 30; 15(5).  View on PubMed
  4. Fan Y, Sun Z, Conrad F, Wen W, Zhao L, Lou J, Zhou Y, Farr-Jones S, Marks JD. Multicolor fluorescence activated cell sorting to generate humanized monoclonal antibody binding seven subtypes of BoNT/F. PLoS One. 2022; 17(9):e0273512.  View on PubMed
  5. Tomic MT, Farr-Jones S, Syar ES, Niemuth N, Kobs D, Hackett MJ, Espinoza Y, Martinez Z, Pham K, Snow DM, Marks JD, Cobb RR. Neutralizing Concentrations of Anti-Botulinum Toxin Antibodies Positively Correlate with Mouse Neutralization Assay Results in a Guinea Pig Model. Toxins (Basel). 2021 09 21; 13(9).  View on PubMed
  6. Garcia-Rodriguez C, Yan S, Geren IN, Knopp KA, Dong J, Sun Z, Lou J, Conrad F, Wen WH, Farr-Jones S, Smith TJ, Brown JL, Skerry JC, Smith LA, Marks JD. A Four-Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotypes C and D. Toxins (Basel). 2021 09 10; 13(9).  View on PubMed
  7. Snow DM, Cobb RR, Martinez J, Finger-Baker I, Collins L, Terpening S, Syar ES, Niemuth N, Kobs D, Barnewall R, Farr-Jones S, Marks JD, Tomic MT. A Monoclonal Antibody Combination against both Serotypes A and B Botulinum Toxin Prevents Inhalational Botulism in a Guinea Pig Model. Toxins (Basel). 2021 01 05; 13(1).  View on PubMed
  8. Kamoun W, Swindell E, Pien C, Luus L, Cain J, Pham M, Kandela I, Huang ZR, Tipparaju SK, Koshkaryev A, Askoxylakis V, Kirpotin DB, Bloom T, Mino-Kenudson M, Marks JD, Zalutskaya A, Bshara W, Morrison C, Drummond DC. Targeting EphA2 in Bladder Cancer Using a Novel Antibody-Directed Nanotherapeutic. Pharmaceutics. 2020 Oct 20; 12(10).  View on PubMed
  9. Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL. Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β. Cell. 2020 02 06; 180(3):490-501.e16.  View on PubMed
  10. Fan Y, Barash JR, Conrad F, Lou J, Tam C, Cheng LW, Arnon SS, Marks JD. The Novel Clostridial Neurotoxin Produced by Strain IBCA10-7060 Is Immunologically Equivalent to BoNT/HA. Toxins (Basel). 2019 12 20; 12(1).  View on PubMed
  11. Tam EM, Fulton RB, Sampson JF, Muda M, Camblin A, Richards J, Koshkaryev A, Tang J, Kurella V, Jiao Y, Xu L, Zhang K, Kohli N, Luus L, Hutto E, Kumar S, Lulo J, Paragas V, Wong C, Suchy J, Grabow S, Dugast AS, Zhang H, Depis F, Feau S, Jakubowski A, Qiao W, Craig G, Razlog M, Qiu J, Zhou Y, Marks JD, Croft M, Drummond DC, Raue A. Antibody-mediated targeting of TNFR2 activates CD8+ T cells in mice and promotes antitumor immunity. Sci Transl Med. 2019 10 02; 11(512).  View on PubMed
  12. Snow DM, Riling K, Kimbler A, Espinoza Y, Wong D, Pham K, Martinez Z, Kraus CN, Conrad F, Garcia-Rodriguez C, Cobb RR, Marks JD, Tomic MT. Safety and Pharmacokinetics of a Four Monoclonal Antibody Combination Against Botulinum C and D Neurotoxins. Antimicrob Agents Chemother. 2019 09 09; 63(12).  View on PubMed
  13. Espinoza Y, Wong D, Ahene A, Der K, Martinez Z, Pham J, Cobb RR, Farr-Jones S, Marks JD, Tomic MT. Pharmacokinetics of Human Recombinant Anti-Botulinum Toxin Antibodies in Rats. Toxins (Basel). 2019 06 17; 11(6).  View on PubMed
  14. Tomic MT, Espinoza Y, Martinez Z, Pham K, Cobb RR, Snow DM, Earnhart CG, Pals T, Syar ES, Niemuth N, Kobs DJ, Farr-Jones S, Marks JD. Monoclonal Antibody Combinations Prevent Serotype A and Serotype B Inhalational Botulism in a Guinea Pig Model. Toxins (Basel). 2019 04 06; 11(4).  View on PubMed
  15. Kamoun WS, Kirpotin DB, Huang ZR, Tipparaju SK, Noble CO, Hayes ME, Luus L, Koshkaryev A, Kim J, Olivier K, Kornaga T, Oyama S, Askoxylakis V, Pien C, Kuesters G, Dumont N, Lugovskoy AA, Schihl SA, Wilton JH, Geddie ML, Suchy J, Grabow S, Kohli N, Reynolds CP, Blaydes R, Zhou Y, Sawyer AJ, Marks JD, Drummond DC. Antitumour activity and tolerability of an EphA2-targeted nanotherapeutic in multiple mouse models. Nat Biomed Eng. 2019 04; 3(4):264-280.  View on PubMed
  16. Lou J, Marks JD. Botulinum Neurotoxins (BoNTs)-Antibody and Vaccine. Toxins (Basel). 2018 11 26; 10(12).  View on PubMed
  17. Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron JL, Nishimura SL. Integrin αvβ8-expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells. JCI Insight. 2018 10 18; 3(20).  View on PubMed
  18. Wijesuriya SD, Pongo E, Tomic M, Zhang F, Garcia-Rodriquez C, Conrad F, Farr-Jones S, Marks JD, Horwitz AH. Antibody engineering to improve manufacturability. Protein Expr Purif. 2018 09; 149:75-83.  View on PubMed
  19. Garcia-Rodriguez C, Razai A, Geren IN, Lou J, Conrad F, Wen WH, Farr-Jones S, Smith TJ, Brown JL, Skerry JC, Smith LA, Marks JD. A Three Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotype E Subtypes. Toxins (Basel). 2018 03 01; 10(3).  View on PubMed
  20. Lou J, Wen W, Conrad F, Meng Q, Dong J, Sun Z, Garcia-Rodriguez C, Farr-Jones S, Cheng LW, Henderson TD, Brown JL, Smith TJ, Smith LA, Cormier A, Marks JD. A Single Tri-Epitopic Antibody Virtually Recapitulates the Potency of a Combination of Three Monoclonal Antibodies in Neutralization of Botulinum Neurotoxin Serotype A. Toxins (Basel). 2018 02 15; 10(2).  View on PubMed

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